DaPKC, atypical PKC, l(2)k06403, aPKCζ, atypical protein kinase
kinase regulating asymmetric cell division - member of the conserved Par complex (aPKC/baz/par-6) that is asymmetrically localized to the apical cortex, where it phosphorylates and thus excludes the basal determinants Mira and Numb - involved in neuroblast proliferation and self-renewal.
Gene model reviewed during 5.50
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.55
Interacts with baz; the interaction is required for apical localization of aPKC in neuroblasts and epithelial cells. Interacts with Dap160; the interaction promotes aPKC apical localization and kinase activity. Interacts with and phosphorylates l(2)gl and yrt. Interacts with crb and ref(2)P. Forms a complex with baz, fz and Patj.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aPKC using the Feature Mapper tool.
In stage 13 embryos aPKC is expressed in Malpighian tubule Type II (stellate) cells, particularly those that contact the tubule lumen but is lower than in the neighboring Malpighian tubule Type I (principal) cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\aPKC in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: aPKC l(2)k06403
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG30475) in release 3 of the genome annotation.