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Gene Dmel\aPKC

General Information
Symbol	Dmel\aPKC	Species	D. melanogaster
Name	atypical protein kinase C	Annotation symbol	CG42783
Feature type	protein_coding_gene	FlyBase ID	FBgn0261854
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	DaPKC, CG10261, aPKCζ, l(2)k06403, aPKC-zeta, psu
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51D5-51D5	Sequence location	2R:10,831,963..10,850,451 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene atypical protein kinase C is referred to in FlyBase by the symbol Dmel\aPKC (CG42783, FBgn0261854). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein serine/threonine kinase activity. There is experimental evidence for 17 unique biological process terms, many of which group under: cellular process; cell fate commitment; cellular component organization or biogenesis; sensory organ development; establishment or maintenance of cell polarity; system development; germarium-derived oocyte differentiation; learning or memory; establishment or maintenance of neuroblast polarity; localization; anterior/posterior axis specification; biological regulation; open tracheal system development; establishment or maintenance of polarity of follicular epithelium. 37 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; external compound sense organ; organ system subdivision; acellular anatomical structure; portion of tissue; anatomical structure; epithelial cell; peripheral nervous system; adult; embryonic/larval integumentary system; imaginal precursor. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Diacylglycerol/phorbol-ester binding; Phox/Bem1p; Protein kinase C, zeta/iota; Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Gene sequence location is 2R:10831963..10850451.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms branching involved in open tracheal system development establishment or maintenance of polarity of follicular epithelium References Jones and Metzstein, 2011, Genetics 189(1): 153--164 Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Feng et al., 2011, EMBO Rep. 12(2): 157--163
FB2012_01	References Colosimo et al., 2010, Dev. Dyn. 239(1): 115--125 Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Cabernard et al., 2010, Nature 467(7311): 91--94 Doggett et al., 2011, BMC Dev. Biol. 11: 57 Sequence features HFA05515 BKN46374 BKN20970 HFA07639 BKN50935 BKN50836 BKN30012
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51D5-51D5   Limits computationally determined from genome sequence between P{lacW}Rpn6k00103 and P{PZ}chn02064
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51D5-51D6     (Luschnig et al., 2004) 51D7-51D8     (Wodarz, 2000.7.19) 51D7-51D8   (determined by in situ hybridisation)   (Spradling et al., 1999) 51D7-51D8   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\aPKC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	3' UTR contains an ORF that is conserved among close Drosophila species (potential peptide 117 aa in length; possible stop-codon suppression). Gene merge based on RNA-Seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) aPKC-RA FBtr0303434  NM_080153   3217   606 aPKC-RB FBtr0303429  NM_001043079   2076   526 aPKC-RC FBtr0303430  NM_001043076   2494   606 aPKC-RD FBtr0303431  NM_001043080   2500   608 aPKC-RE FBtr0303432  NM_001043078   2070   524 aPKC-RF FBtr0303433  NM_001043077   2035   503 aPKC-RG FBtr0303435  NM_001202010   3537   951 aPKC-RH FBtr0303436  NM_001202011   2314   498 aPKC-RI FBtr0303437  NM_001202012   2192   511
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein aPKC-PA   FBpp0292491   69.6   606   5.93     NP_524892   AAF58177 aPKC-PB   FBpp0292486   60.0   526   6.14     NP_001036544   ABI31093 aPKC-PC   FBpp0292487   69.6   606   5.93     NP_001036541   ABI31090 aPKC-PD   FBpp0292488   69.7   608   5.71     NP_001036545   ABI31094 aPKC-PE   FBpp0292489   59.9   524   6.33     NP_001036543   ABI31092 aPKC-PF   FBpp0292490   57.7   503   6.51     NP_001036542   ABI31091 aPKC-PG   FBpp0292492   104.1   951   6.85     NP_001188939   ADV37185 aPKC-PH   FBpp0292493   56.8   498   6.75     NP_001188940   ADV37186 aPKC-PI   FBpp0292494   58.3   511   7.05     NP_001188941   ADV37187
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phox/Bem1p (IPR000270) Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase C, zeta/iota (IPR012233) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, C-terminal (IPR017892) Diacylglycerol/phorbol-ester binding (IPR020454)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698822   AE013599 AAF58177   AE013599 ABI31090   AE013599 ABI31091   AE013599 ABI31092   AE013599 ABI31093   AE013599 ABI31094   AE013599 ADV37185   AE013599 ADV37186   AE013599 ADV37187   AF288482 AAG01528   AK259047   AQ025792   AY118402 AAM48431   BH840698   BI373600   BT056247   BT120249   CO188196   CO193435   CO193913   CO263868   CO264483   CO267794   CO270817   CO270937   CO271443   CO272159   CO277151   CO277603   CO278339   CO278806   CO287283   CO287656   CO287659   CO288929   CO297936   CO301259   CO301467   CO306168   CO308145   CO312141   CO315759   CO322638   CO323396   CO323779   CO329645   CO332825   CO342604   CZ479878   CZ479879   CZ481886   EC053045   EC053048   EC053533   EC053973   EC054974   EC055442   EC056307   EC058585   EC065491   EC066024   EC083847   EC085508   EC195752   EC196120   EC199922   EC200593   EC202821   EC204874   EC209213   EC210014   EC211549   EC211976   EC216206   EC220585   EC225106   EC226556   EC232099   EC234739   EC235178   EC239794   EC244204   EC244358   EC244743   EC245108   EC246458   EW713219   GR705773
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MT38 Q9GSZ3 A1Z9X0 Q0E971 Q0E974 Q0E972 Q0E973 A1Z9X1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism | ubiquitous   (Wodarz et al., 2000) Comment:maternally deposited embryonic stage 5   somatic cell   (Wodarz et al., 2000) embryonic stage 6 -- 8   ectoderm   (Wodarz et al., 2000) mesoderm   (Wodarz et al., 2000) cephalic furrow   (Wodarz et al., 2000) amnioproctodeal invagination   (Wodarz et al., 2000) stomodeal invagination | precursor   (Wodarz et al., 2000) embryonic stage 11   neuroblast   (Wodarz et al., 2000) epithelial cell | subset   (Wodarz et al., 2000) Comment:ectodermally-derived only; NOT amnioserosa early stomodeal invagination   • apical cortex (Wodarz et al., 2000) hindgut proper primordium   • apical cortex (Wodarz et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   somatic cell   • cell cortex (Wodarz et al., 2000) Comment:enriched at cell borders and apical cortex; forms continuous band around cell circumference embryonic stage 6 -- 8   somatic cell   • cell cortex | apical & lateral (Wodarz et al., 2000) Comment:apical-most part of lateral cortex embryonic stage 10   neuroblast   • apical cortex (Wodarz et al., 2000) Comment:NOT ganglion mother cell embryonic stage 12 -- 14   epithelial cell | subset   • apical cortex (Wodarz et al., 2000) Comment:ectodermally-derived only; NOT amnioserosa embryonic stomatogastric nervous system   • apical cortex (Wodarz et al., 2000) stomodeal invagination late   • apical cortex (Wodarz et al., 2000) hindgut proper primordium   • apical cortex (Wodarz et al., 2000) embryonic stage 14   tracheal pit   • apical cortex (Wodarz et al., 2000) Malpighian tubule   • apical cortex (Wodarz et al., 2000) third instar larval stage   NMJ bouton   (Yu et al., 2004) motor neuron   • microtubule of presynaptic active zone (Yu et al., 2004) muscle cell   (Yu et al., 2004) Comment:not in the peribouton area pupal stage   eye photoreceptor cell stalk | apical   (Nam and Choi, 2003)
Additional Descriptive Data
	aPKC localized to presynaptic boutons and muscle at cellular regions containing microtubules. Colocalizes with par-6 and baz presynaptically, but not in the postsynaptic peribouton area. (Yu et al., 2004)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with aPKCk06403) aPKCpsu265 aPKCpsu417 lethal (with aPKCpsu69) aPKCpsu265 aPKCpsu417 lethal (with aPKCpsu265) aPKCk06403 aPKCpsu69 aPKCpsu417 lethal (with aPKCpsu417) aPKCk06403 aPKCpsu69 aPKCpsu265 lethal (with Df(2R)Jp1) aPKCk06403 aPKCpsu69 aPKCpsu141 aPKCpsu265 aPKCpsu417 lethal | embryonic stage (with Df(2R)Jp1) aPKCk06403 lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive aPKCpsu69 aPKCpsu141 aPKCpsu265 aPKCpsu417 lethal | embryonic stage | recessive aPKCk06403 lethal | larval stage aPKCk06403 lethal | larval stage, with Scer\GAL4neur-GAL4-A101 aPKCΔN.Scer\UAS lethal | larval stage | recessive aPKCpsu417 lethal | pupal stage, with Scer\GAL4pnr-MD237 aPKCGD1366 lethal | recessive aPKCk06403 aPKCpsu265 aPKCpsu417 aPKCSG58 lethal | recessive | second instar larval stage aPKCk06403 aPKCpsu417 lethal | second instar larval stage aPKCk06403 lethal | second instar larval stage (with Df(2R)Jp1) aPKCk06403 semi-lethal (with aPKCk06403) aPKCpsu69 aPKCpsu141 semi-lethal (with aPKCpsu69) aPKCk06403 semi-lethal (with aPKCpsu141) aPKCk06403 aPKCpsu417 semi-lethal (with aPKCpsu417) aPKCpsu141 semi-lethal | recessive aPKCpsu69 aPKCpsu141 aPKCpsu265 viable aPKCEX48 aPKCExc55 aPKCpsu69 aPKCpsu141 aPKCpsu265 viable (with aPKCpsu69) aPKCpsu141 viable (with aPKCpsu141) aPKCpsu69 aPKCpsu265 viable (with aPKCpsu265) aPKCpsu141 Sterility Allele female sterile aPKCpsu69 aPKCpsu141 female sterile | recessive aPKCEX48 aPKCExc55 aPKCpsu69 aPKCpsu141 aPKCpsu265 sterile | recessive aPKCpsu69 aPKCpsu141 aPKCpsu265 Other Phenotypes Allele cell polarity defective aPKCk06403 aPKCunspecified cell polarity defective, with Scer\GAL4GMR.PF aPKCCAAXWT.Scer\UAS cell polarity defective | somatic clone aPKCk06403 decreased cell number | somatic clone aPKCk06403 locomotor behavior defective | larval stage aPKCk06403 locomotor behavior defective | larval stage (with Df(2R)Jp1) aPKCk06403 mitotic cell cycle defective aPKCk06403 neuroanatomy defective aPKCEX48 aPKCExc55 aPKCk06403 neuroanatomy defective, with Scer\GAL41407 aPKCCAAXWT.Scer\UAS neuroanatomy defective, with Scer\GAL4BG487 aPKCM.Scer\UAS neuroanatomy defective, with Scer\GAL4C380 aPKCM.Scer\UAS neuroanatomy defective, with Scer\GAL4wor.PA aPKCCAAXWT.Scer\UAS aPKCΔN.Scer\UAS neuroanatomy defective | somatic clone aPKCk06403 neurophysiology defective aPKCEX48 neurophysiology defective, with Scer\GAL4BG487 aPKCM.Scer\UAS neurophysiology defective (with aPKCExc55) aPKCk06403 neurophysiology defective (with aPKCk06403) aPKCExc55 neurophysiology defective | larval stage, with Scer\GAL4C57 aPKCdsRNA.cRa.Scer\UAS planar polarity defective aPKCk06403 planar polarity defective, with Scer\GAL4da.G32 aPKCS330A.T422A.Scer\UAS aPKCScer\UAS.cBa planar polarity defective, with Scer\GAL4sev.EP aPKCΔN.Scer\UAS Phenotype manifest in Allele adult Malpighian tubule | conditional | somatic clone, with Scer\GAL4Scer\FRT.Act5C, Scer\GAL80αTub84B.PL aPKCCAAXWT.Scer\UAS aPKCΔN.Scer\UAS bouton aPKCExc55 aPKCEX48 bouton, with Scer\GAL4BG487 aPKCM.Scer\UAS bouton, with Scer\GAL4C380 aPKCM.Scer\UAS bouton (with aPKCExc55) aPKCk06403 bouton (with aPKCk06403) aPKCExc55 denticle belt aPKCk06403 denticle belt, with Scer\GAL4da.G32 aPKCScer\UAS.cBa aPKCS330A.T422A.Scer\UAS egg chamber | germline clone aPKCk06403 embryonic/first instar larval cuticle aPKCk06403 embryonic/first instar larval cuticle (with Df(2R)Jp1) aPKCk06403 embryonic/first instar larval cuticle | germline clone | maternal effect aPKCpsu141 aPKCpsu69 aPKCpsu417 aPKCpsu265 embryonic/first instar larval cuticle | ventral aPKCk06403 embryonic/larval brain | larval stage, with Scer\GAL41407 aPKCCAAXWT.Scer\UAS embryonic/larval cuticle | germline clone | maternal effect aPKCpsu141 aPKCpsu69 aPKCpsu417 aPKCpsu265 aPKCk06403 embryonic/larval neuroblast aPKCk06403 embryonic/larval neuroblast, with Scer\GAL41407 aPKCCAAXWT.Scer\UAS embryonic head aPKCk06403 epithelial cell aPKCk06403 eye, with Scer\GAL4GMR.PF aPKCCAAXWT.Scer\UAS eye disc aPKCk06403 eye photoreceptor cell, with Scer\GAL4sev.EP aPKCΔN.Scer\UAS follicle cell aPKCpsu69 follicle cell | ectopic | somatic clone aPKCk06403 follicle cell | germline clone aPKCk06403 follicle cell | somatic clone aPKCpsu69 aPKCk06403 larval brain & neuroblast aPKCk06403 larval brain & neuroblast | supernumerary, with Scer\GAL4wor.PA aPKCCAAXWT.Scer\UAS aPKCΔN.Scer\UAS larval brain | posterior & neuroblast | supernumerary, with Scer\GAL41407 aPKCΔN.Scer\UAS microtubule & synapse aPKCEX48 microtubule & synapse, with Scer\GAL4BG487 aPKCM.Scer\UAS microtubule & synapse, with Scer\GAL4C380 aPKCM.Scer\UAS microtubule & synapse (with Df(2R)Jp1) aPKCEX48 microtubule | somatic clone aPKCk06403 mushroom body & neuron | somatic clone aPKCk06403 neurogenic region | germline clone | maternal effect aPKCpsu141 nurse cell | germline clone aPKCk06403 ommatidium, with Scer\GAL4sev.EP aPKCΔN.Scer\UAS oocyte | germline clone aPKCk06403 terminal tracheal cell | somatic clone aPKCpsu69 aPKCk06403 tormogen cell | somatic clone | supernumerary, with Scer\GAL4neur-GAL4-A101 aPKCΔN.Scer\UAS zonula adherens | germline clone | maternal effect aPKCpsu141 zonula adherens | somatic clone aPKCk06403
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of aPKC Class Mutagen Stocks Known lesion aPKCk06403 loss of function allele, amorphic allele - genetic evidence P-element activity 2 Yes aPKCe00408 1 -- aPKCEY22946 P-element activity 1 -- aPKCNP4234 1 -- aPKCe02056 piggyBac transposase 0 -- aPKCe04135 piggyBac transposase 0 -- aPKCEX48 P-element activity 0 Yes aPKCExc55 P-element activity 0 Yes aPKCKG06602 P-element activity 0 -- aPKCp622 0 -- aPKCpsu141 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes aPKCpsu265 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes aPKCpsu417 ethyl methanesulfonate 0 Yes aPKCpsu69 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes aPKCSG58 ethyl methanesulfonate 0 -- aPKCunspecified 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of aPKC Class Mutagen Stocks Known lesion aPKCGD1366 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aPKCGL00007 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aPKCHMS01320 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aPKCHMS01411 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aPKCJF01966 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aPKCKK100874 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aPKCCAAXDN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes aPKCCAAXWT.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes aPKCdsRNA.301-900 in vitro construct - RNAi 0 Yes aPKCdsRNA.cBa in vitro construct - RNAi 0 Yes aPKCdsRNA.cCa in vitro construct - RNAi 0 Yes aPKCdsRNA.cRa.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes aPKCGD14814 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes aPKCM.DN.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes aPKCM.Scer\UAS in vitro construct - regulatory fusion 0 -- aPKCS330A.T422A.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes aPKCScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes aPKCScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes aPKCScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aPKCΔN.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aPKCΔN.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)Jp4 (Sekelsky et al., 2000) Df(2R)XTE-18 (Sekelsky et al., 2000)
Disrupted in	Df(2R)BSC330 (Christensen et al., 2007.10.29) Df(2R)BSC651 (Christensen et al., 2008.10.20) Df(2R)EP2590-Δ1 (Dworak et al., 2001) Df(2R)EP2590-Δ11 (Dworak et al., 2001) Df(2R)EP2590-Δ12 (Dworak et al., 2001) Df(2R)EP2590-Δ14 (Dworak et al., 2001) Df(2R)Jp1 (Wodarz et al., 2000, Spradling et al., 1999, Sekelsky et al., 2000, Rolls et al., 2003, Sekelsky, 1999.9.21) Df(2R)knSA3 (Sekelsky, 1999.9.21, Sekelsky et al., 2000) Df(2R)knSA4 (Ma et al., 2009) Df(2R)XTE-58 (Ma et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1366} NA P{KK100874} NA P{TRiP.GL00007} NA P{TRiP.HMS01320} NA P{TRiP.HMS01411} NA P{TRiP.JF01966} NA P{UAS-aPKC.B} NA P{UAS-aPKC.CAAXWT} NA P{UAS-aPKC.Myc} NA P{UAS-aPKC.RNAi.R} NA P{UAS-aPKC.S330A.T422A} NA P{UAS-aPKC.S} NA P{UAS-aPKC.ΔN.Myc} NA P{UAS-aPKC.ΔN} NA P{UASp-aPKC.GFP} NA P{UASp-aPKC.ΔN.GFP} NA P{UAS-PKM.DN} NA P{UAS-PKM} NA characterization construct P{UZ.aPKC} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}aPKCNP4234 No miscellaneous insertions P{SUPor-P}aPKCKG06602 NA PBac{RB}aPKCe00408 NA PBac{RB}aPKCe02056 NA PBac{RB}aPKCe04135 NA insertion of enhancer trap P{lacW}aPKCk06403 No insertion of mobile activating element P{EPgy2}aPKCEY22946 NA
Gene Ontology: Function, Process & Cellular Component ( 35 unique terms )
Terms Based on Experimental Evidence ( 21 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with crb (Sotillos et al., 2004) inferred from physical interaction with Myo10A (Liu et al., 2008) inferred from physical interaction with Patj (Sotillos et al., 2004) protein serine/threonine kinase activity inferred from direct assay (Morais-de-Sá et al., 2010)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from genetic interaction with raps (Cai et al., 2003) asymmetric protein localization involved in cell fate determination inferred from physical interaction with par-6 (Betschinger et al., 2003) branching involved in open tracheal system development inferred from mutant phenotype (Jones and Metzstein, 2011) compound eye retinal cell programmed cell death inferred from direct assay (Ogawa et al., 2009) epithelial cell morphogenesis inferred from genetic interaction with sgg (Kaplan et al., 2011) inferred from mutant phenotype (Kaplan et al., 2011) establishment of epithelial cell planar polarity inferred from genetic interaction with sgg (Kaplan et al., 2011) inferred from mutant phenotype (Kaplan et al., 2011) establishment or maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Sotillos et al., 2004) establishment or maintenance of neuroblast polarity inferred from mutant phenotype (Kim et al., 2009) establishment or maintenance of polarity of embryonic epithelium inferred from mutant phenotype (Kim et al., 2009) establishment or maintenance of polarity of follicular epithelium inferred from mutant phenotype (Kim et al., 2009) germarium-derived oocyte fate determination inferred from mutant phenotype (Cox et al., 2001) maintenance of cell polarity inferred from mutant phenotype (Rolls et al., 2003) memory inferred from mutant phenotype (Drier et al., 2002) oocyte anterior/posterior axis specification inferred from genetic interaction with l(2)gl (Tian and Deng, 2008) positive regulation of neuroblast proliferation inferred from mutant phenotype (Chabu and Doe, 2008) sensory organ development inferred from mutant phenotype (Roegiers et al., 2005) synapse assembly inferred from mutant phenotype (Ruiz-Canada et al., 2004)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Chabu and Doe, 2008, Chabu and Doe, 2009, Morais-de-Sá et al., 2010) apicolateral plasma membrane inferred from direct assay (Sotillos et al., 2004)
Terms Based on Predictions or Assertions ( 19 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR012233, InterPro:IPR017441, InterPro:IPR017892 (FlyBase Curators et al., 2004-) protein kinase C activity non-traceable author statement (Wodarz, 2000.7.19) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR012233 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
apical protein localization non-traceable author statement (Schaefer and Knoblich, 2001) cell-cell junction assembly non-traceable author statement (Wedlich, 2002) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Bachmann et al., 2001) traceable author statement (Ahringer, 2003) establishment or maintenance of neuroblast polarity non-traceable author statement (Bachmann et al., 2001) establishment or maintenance of polarity of embryonic epithelium non-traceable author statement (Hong et al., 2001) intracellular signal transduction inferred from electronic annotation with InterPro:IPR002219 (FlyBase Curators et al., 2004-) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) oocyte axis specification traceable author statement (Ahringer, 2003) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR008271, InterPro:IPR017892 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) zonula adherens assembly non-traceable author statement (Tepass et al., 2001) traceable author statement (Gibson and Perrimon, 2003)
Cellular Component
CV term Evidence References
apical cortex non-traceable author statement (Hong et al., 2001) apical plasma membrane non-traceable author statement (Wedlich, 2002) traceable author statement (Gibson and Perrimon, 2003) cell cortex traceable author statement (Bardin et al., 2004) subapical complex traceable author statement (Medina et al., 2002, Gibson and Perrimon, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions aPKC allele Gene References aPKCk06403 peb (Wilk et al., 2004) unspecified aur (Wang et al., 2006) crb (Sotillos et al., 2004) l(2)gl (Rolls et al., 2003, Lee et al., 2006) orb (Hafer et al., 2002) Syx7 (Lu and Bilder, 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261854 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47594
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12632 Dere\GG22380 Dgri\GH20802 Dmoj\GI20886 Dpse\GA10200 Dsec\GM20164 Dsim\GD25642 Dvir\GJ20621 Dwil\GK21803 Dyak\GE12269
Curated drosophilid orthologs	Dpse\GA10200   Dpse\GA15867
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19268 NV14702 LH15010 ISCW023594 FBgn0230026 FBgn0223788 FBgn0207759 FBgn0196927 FBgn0175047 JGI_V11_319272 FBgn0070259 FBgn0149314 FBgn0143620 FBgn0128265 FBgn0114552 FBgn0089668 CPIJ013835 ACYPI001831 GB19525 AGAP011988 AAEL002885 PHUM529700 GLEAN_05980
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	25946 y1 v1; P{TRiP.JF01966}attP2 35140 y1 sc* v1; P{TRiP.GL00007}attP2 10622 y1 w67c23; P{lacW}aPKCk06403/CyO 34332 y1 sc* v1; P{TRiP.HMS01320}attP2 35001 y1 sc* v1; P{TRiP.HMS01411}attP2 23116 y1 w67c23; P{EPgy2}aPKCEY22946/CyO
Harvard	- PBac{RB}aPKCe00408
Kyoto	104640 y* w*; P{GawB}aPKCNP4234 / CyO, P{UAS-lacZ.UW14}UW14 111194 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}aPKCk06403 /CyO y+
VDRC	v105624 P{KK100874}VIE-260B v2907 w1118; P{GD1366}v2907/CyO
Genomic Clones ( 1 )
	BACR01L16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE60936
Other clones	FI03288 MIP16743
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL05754
Other clones	1821 8030 15438 17553 28994 30370 33543 38752 53577 55717 57847 58616 62362 62801 63585 64984 99050 108489 118424 147258 153595 190961 191194 277611 CK01.69B.C12 CK01.83B.E3 CK01.83B.G3 CK01.168C.C10 EC35787 EC36987 EC053045 EC053048 EC053533 EC053973 EC054974 EC055442 EC056307 EK038340 EK065433 EK066418 EK066426 EK069707 EK100404 EK101102 EK103441 EK106033 EK123164 EK125608 EK129818 EK131715 EK136723 EK139354 EK151849 EK170943 EK180605 EK181121 EK188541 EK190363 EK191432 EK227936 EK250419 EK256828 EK262404 EK293320 EK304751 EP15207 MB6-CG10261.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261854 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47594 246637
Antibody Information
	polyclonal (Wodarz et al., 2000, Chang et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: aPKC l(2)k06403 (FlyBase, 1996-)
Source for database merge of	Source for merge of: aPKC CG30475 (FlyBase Genome Annotators, 2010) Source for merge of: l(2)k06403 CG10261 (Wodarz, 2000.7.26)
Additional comments	Annotations CG10261 and CG30475 merged as CG42783 in release 5.28 of the genome annotation. (FlyBase Genome Annotators, 2010) Mutations in aPKC complement mutations in gsu. (Luschnig et al., 2004) Source for identity of aPKC l(2)k06403 was sequence comparison (date:000915). (FlyBase, 1996-)
Other Comments
	aPKC promotes neuroblast self-renewal. (Lee et al., 2006) In vivo overexpression experiments reveal the kinase activity of aPKC on crb to be required for epithelial polarity. (Sotillos et al., 2004) Phosphorylation of l(2)gl by aPKC at the apical neuroblast cortex restricts l(2)gl activity and mira localisation to the opposite, basal side of the cell in embryonic neuroblasts. (Betschinger et al., 2003) aPKC phosphorylates l(2)gl and thus directs asymmetric cell division. (Betschinger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG30475) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) A loss of function mutation in aPKC results in loss of apico-basal polarity and multilayering of epithelia in the embryo. (Wodarz et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080153 NM_001043076 NM_001043077 NM_001043078 NM_001043079 NM_001043080 NM_001202010 NM_001202011 NM_001202012 RefSeq (Proteins) • NP_524892 NP_001036541 NP_001036542 NP_001036543 NP_001036544 NP_001036545 NP_001188939 NP_001188940 NP_001188941 DDBJ / EMBL / GenBank • AA698822 AAF58177 AAG01528 AAM48431 AAM68540 ABI31090 ABI31091 ABI31092 ABI31093 ABI31094 ADV37185 ADV37186 ADV37187 AF288482 AQ025792 AY118402 BH840698 BI373600 CZ479878 CZ479879 CZ481886 Entrez Gene - A searchable database of RefSeq genes. • 47594 246637 UniProtKB/TrEMBL • A1Z9X0 A1Z9X1 Q0E971 Q0E972 Q0E973 Q0E974 Q8MT38 Q9GSZ3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phox/Bem1p (IPR000270) Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase C, zeta/iota (IPR012233) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, C-terminal (IPR017892) Diacylglycerol/phorbol-ester binding (IPR020454)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261854 DRSC - Results from RNAi screens. • FBgn0261854 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261854 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47594 246637 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47594 modMine - Data generated by the modENCODE project. • FBgn0261854 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19268 NV14702 LH15010 ISCW023594 FBgn0230026 FBgn0223788 FBgn0207759 FBgn0196927 FBgn0175047 JGI_V11_319272 FBgn0070259 FBgn0149314 FBgn0143620 FBgn0128265 FBgn0114552 FBgn0089668 CPIJ013835 ACYPI001831 GB19525 AGAP011988 AAEL002885 PHUM529700 GLEAN_05980
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	aPKC (Richter et al., 2011, Leong et al., 2009, Yu et al., 2008, Hutterer et al., 2004, Wang et al., 2009, Pocha et al., 2011, Jones and Metzstein, 2011, Campbell et al., 2010, Le Bivic, 2005, Wirtz-Peitz and Knoblich, 2006, Humbert et al., 2006, Liu et al., 2008, Djiane et al., 2005, Gotta, 2005, Tian and Deng, 2007, Andersen et al., 2007, Grifoni et al., 2007, Budde, 2005, Budde, 2005, Siegrist and Doe, 2005, Betschinger et al., 2006, Wiggin et al., 2005, Solecki et al., 2006, Lu and Bilder, 2005, Caussinus and Gonzalez, 2005, Chabu et al., 2007, Guthridge et al., 2007, Kim et al., 2007, Leibfried et al., 2007, Orihara-Ono et al., 2007, Wirtz-Peitz et al., 2007, Wang and Riechmann, 2007, Harris and Peifer, 2005, Wang et al., 2006, Christensen et al., 2007.10.29, Sasaki et al., 2007, Lee et al., 2006, Lee et al., 2007, Wang et al., 2007, Becam et al., 2005, Morrison and Kimble, 2006, Krahn and Wodarz, 2008, Chen et al., 2008, Harris and Tepass, 2008, Colosimo and Tolwinski, 2008, Roegiers et al., 2005, Rolls and Doe, 2004, Lecuit, 2004, Yamashita et al., 2005, Margolis and Borg, 2005, Hampoelz et al., 2005, Suzuki and Ohno, 2006, Lin, 2008, Chia et al., 2008, Christensen et al., 2008.10.20, Horne-Badovinac and Bilder, 2008, Menut et al., 2007, Pirraglia et al., 2006, Siegrist and Doe, 2006, Smith et al., 2007, Lee et al., 2006, Bowman et al., 2006, Harris and Peifer, 2007, Denef et al., 2008, Bowman et al., 2008, Choksi et al., 2006, Mirouse et al., 2007, Li et al., 2008, Rusan et al., 2008, Grzeschik et al., 2007, Wirtz-Peitz et al., 2008, Slack et al., 2007, Wang and Riechmann, 2007, Polesello and Tapon, 2007, Albertson et al., 2004, Sotillos et al., 2008, Leibfried et al., 2008, Spasić et al., 2008, Atwood et al., 2007, Romani et al., 2009, Harris and Tepass, 2008, Mirouse et al., 2009, Blankenship et al., 2007, Sousa-Nunes et al., 2009, Vincent et al., 2008, Chabu and Doe, 2008, Kurusu et al., 2009, McDonald et al., 2008, Morrison et al., 2008, Li et al., 2009, Grusche et al., 2009, Peng et al., 2009, Atwood and Prehoda, 2009, Chabu and Doe, 2009, Ramachandran et al., 2009, Hamaratoglu et al., 2009, Genevet et al., 2009, Laprise et al., 2009, Cabernard and Doe, 2009, Flaherty et al., 2009, Campbell et al., 2009, Yan et al., 2009, Warner and Longmore, 2009, Ogawa et al., 2009, Langton et al., 2009, Weng et al., 2010, Ma et al., 2009, Morais-de-Sá et al., 2010, Krahn et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Franz and Riechmann, 2010, Wirtz-Peitz et al., 2008, Shao et al., 2010, David et al., 2010, Duchi et al., 2010, Warner et al., 2010, Genevet et al., 2010, Froldi et al., 2010, Simone and DiNardo, 2010, Harumoto et al., 2010, Tikhmyanova et al., 2010, Fernandez-Minan et al., 2008, Djiane et al., 2011, Grifoni et al., 2007, Lee and Thomas, 2011, Orihara-Ono et al., 2011, Hazelett et al., 2009, Kaplan et al., 2011, Kaplan et al., 2009, Chang et al., 2010, Letizia et al., 2011, Shaik et al., 2011, Feng et al., 2011, Kim et al., 2009, Georgiou and Baum, 2010, Cabernard et al., 2010, Colosimo et al., 2010) apkc (Lee et al., 2004, Tian and Deng, 2008, Nam et al., 2007, Georgiou et al., 2008, Atwood and Prehoda, 2009) a-PKC (Dubnau et al., 2003) aPKC-zeta (Broadie and Pan, 2005, Zarnescu et al., 2005) aPKCζ (Margulies et al., 2005, Grifoni et al., 2007, Drier et al., 2002, Kaplan and Tolwinski, 2010, Orihara-Ono et al., 2011, Kaplan et al., 2009) CG10261 (Manning, 2001.10.8, Morrison et al., 2000, Wodarz, 2000.7.26, Wodarz, 2000.7.26, Liu et al., 2008, Perkins et al., 1.15.2009, Li et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CG30475   CG42783 (FlyBase Genome Annotators, 2010, Ni et al., 2011.7.19) DaPKC (Langevin et al., 2005, Sotillos et al., 2004, Izumi et al., 2004, Goto et al., 2003, Yu et al., 2003, Yu et al., 2003, Wu and Beitel, 2004, Fischer and Wodarz, 2005, von Stein et al., 2003, Bardin et al., 2004, Drier et al., 2004, Hidalgo and ffrench-Constant, 2003, Wodarz and Huttner, 2003, Mueller and Bossinger, 2003, Hong et al., 2003, Doerflinger et al., 2003, Humbert et al., 2003, Tuxworth and Chia, 2003, Abdelilah-Seyfried et al., 2003, Skeath and Thor, 2003, Muller, 2003, Chia and Yang, 2002, Adler, 2002, Schaefer and Knoblich, 2001, Wedlich, 2002, Pellettieri and Seydoux, 2002, Knust and Bossinger, 2002, Izumi et al., 2003, Sotillos et al., 2003, Radimerski et al., 2002, Wodarz et al., 2002, Tello et al., 2001, Cox et al., 2001, Mastushita-Sakai et al., 2010, Wodarz, 2001, Knust, 2001, Silverman and Maniatis, 2001, Knust, 2001, Bilder, 2001, Ohno, 2001, Bilder, 2001, Wodarz et al., 2001, Kramer, 2000, Wodarz, 2000.7.19, Wodarz et al., 2000, Letizia et al., 2007, Somers and Chia, 2005, Avila et al., 2002, Wang et al., 2005, Bonaccorsi et al., 2007, Blankenship et al., 2006, Speicher et al., 2008, Xu et al., 2008, Gilbert et al., 2009, Walther and Pichaud, 2010, Zeng et al., 2010, Kempkens et al., 2006) dapkc (Ruiz-Canada et al., 2004, Ramachandran et al., 2009) daPKC (Zarnescu et al., 2005) l(2)k06403 (Dworak et al., 2001, Artero et al., 2001, Wodarz, 2000.7.19, Wodarz, 2000.7.26, Sekelsky et al., 2000, Spradling et al., 1999, ) pkc-3 (Pellettieri and Seydoux, 2002) PKCl,i (Morrison et al., 2000) psu (Luschnig et al., 2004, Luschnig et al., 2004) αPKCζ (Horne-Badovinac and Bilder, 2008)
Name Synonym	Atypical PKC (Grifoni et al., 2007) atypical PKC (Dubnau et al., 2003, Chia et al., 2008, Yamashita and Fuller, 2008, Jaekel and Klein, 2006, Harris and Tepass, 2008, Djiane et al., 2011, Lee and Thomas, 2011) atypical protein kinase C (Wodarz, 2000.7.19, Liu et al., 2008, Ahringer, 2005, Harris and Peifer, 2005, Sasaki et al., 2007, Becam et al., 2005, Lecuit, 2004, Marques, 2005, Choksi et al., 2006, Wirtz-Peitz et al., 2008, Blankenship et al., 2007, Chabu and Doe, 2009, Ogawa et al., 2009, Kim et al., 2009, Krahn et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Warner et al., 2010, Kaplan et al., 2009, Shaik et al., 2011) atypical-Protein Kinase C (Duchi et al., 2007) atypical Protein kinase C (Pirraglia et al., 2006, Simone and DiNardo, 2010) atypical Protein Kinase C (Harris and Peifer, 2007, Polesello and Tapon, 2007, Mirouse et al., 2009, Vincent et al., 2008, Flaherty et al., 2009, Froldi et al., 2010) Atypical protein kinase C (Atwood and Prehoda, 2009, Chang et al., 2010) atypical protein kinase C ζ (Drier et al., 2002) pschur (Luschnig et al., 2004, Luschnig et al., 2004)
Secondary FlyBase IDs
	FBgn0022131 FBgn0033986 FBgn0050475 FBgn0260478
References ( 307 )
Generate a list of	All references relating to this gene ( 307 )
List References by type	Research paper  ( 164 ) Supplementary material  ( 8 ) Review  ( 68 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 39 ) FlyBase analysis  ( 6 ) DNA/RNA sequence record  ( 1 ) Meeting report  ( 1 ) Computer file  ( 4 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 34 )
	Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Doggett et al., 2011, BMC Dev. Biol. 11: 57 Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. [FBrf0216618] Feng et al., 2011, EMBO Rep. 12(2): 157--163 Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. [FBrf0214189] Jones and Metzstein, 2011, Genetics 189(1): 153--164 A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. [FBrf0215238] Kaplan et al., 2011, PLoS ONE 6(4): e18616 Complex Interactions between GSK3 and aPKC in Drosophila Embryonic Epithelial Morphogenesis. [FBrf0213424] Lee and Thomas, 2011, Mech. Dev. 128(1-2): 116--128 Rac1 modulation of the apical domain is negatively regulated by β(Heavy)-spectrin. [FBrf0213021] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Orihara-Ono et al., 2011, Dev. Biol. 351(1): 163--175 Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1. [FBrf0212978] Pocha et al., 2011, Curr. Biol. 21(13): 1111--1117 Retromer controls epithelial cell polarity by trafficking the apical determinant crumbs. [FBrf0214250] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Shaik et al., 2011, Glycobiology 21(6): 743--756 The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. [FBrf0214472] Cabernard et al., 2010, Nature 467(7311): 91--94 A spindle-independent cleavage furrow positioning pathway. [FBrf0211664] Campbell et al., 2010, Mech. Dev. 127(7-8): 345--357 Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours. [FBrf0211143] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] Colosimo et al., 2010, Dev. Dyn. 239(1): 115--125 GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels. [FBrf0215313] David et al., 2010, Development 137(10): 1645--1655 The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila. [FBrf0210666] Duchi et al., 2010, Development 137(9): 1493--1503 Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability. [FBrf0210606] Franz and Riechmann, 2010, Dev. Biol. 338(2): 136--147 Stepwise polarisation of the Drosophila follicular epithelium. [FBrf0209855] Froldi et al., 2010, BMC Biol. 8: 33 The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. [FBrf0210873] Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. [FBrf0214990] Grzeschik et al., 2010, Curr. Biol. 20(7): 573--581 Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. [FBrf0210559] Harumoto et al., 2010, Dev. Cell 19(3): 389--401 Atypical cadherins dachsous and fat control dynamics of noncentrosomal microtubules in planar cell polarity. [FBrf0211754] Kaplan and Tolwinski, 2010, J. Cell Sci. 123(18): 3157--3165 Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. [FBrf0211705] Krahn et al., 2010, Curr. Biol. 20(7): 636--642 Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids. [FBrf0210551] Mastushita-Sakai et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(26): 11987--11992 Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. [FBrf0211209] Morais-de-Sá et al., 2010, Cell 141(3): 509--523 aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. [FBrf0210663] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Shao et al., 2010, PLoS ONE 5(4): e9938 A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. [FBrf0210449] Simone and DiNardo, 2010, Development 137(8): 1385--1394 Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. [FBrf0210407] Tikhmyanova et al., 2010, PLoS ONE 5(8): e12369 Dcas supports cell polarization and cell-cell adhesion complexes in development. [FBrf0211678] Walther and Pichaud, 2010, Curr. Biol. 20(12): 1065--1074 Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling. [FBrf0211169] Warner et al., 2010, Curr. Biol. 20(8): 677--686 The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia. [FBrf0211164] Weng et al., 2010, Dev. Cell 18(1): 126--135 dFezf/Earmuff Maintains the Restricted Developmental Potential of Intermediate Neural Progenitors in Drosophila. [FBrf0209927] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...