FB2022_03, released June 9, 2022

Gene: Dmel\whd

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General Information
Symbol
Dmel\whd
Species
D. melanogaster
Name
withered
Annotation Symbol
CG12891
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261862
Gene Model Status
Current
Stock Availability
24 publicly available
Enzyme Name (EC)
Carnitine O-palmitoyltransferase (2.3.1.21)
Gene Summary
withered (whd) encodes a carnitine O-palmitoyltransferase involved in oxidative stress. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

CPTI, CPT1, mitochondrial carnitine palmitoyltransferase I

Key Links
Genomic Location
Cytogenetic map
47A9-47A11
Sequence location
Recombination map
2-62
RefSeq locus
NT_033778 REGION:10469473..10478567
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables carnitine O-palmitoyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN001097100
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in response to metal ion
inferred from mutant phenotype
(Strub et al., 2008)
involved_in response to oxidative stress
inferred from mutant phenotype
(Strub et al., 2008)
involved_in response to starvation
inferred from mutant phenotype
(Strub et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in carnitine metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001097100
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001097100
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN001097100
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine (2.3.1.21)
Summaries
Gene Snapshot
withered (whd) encodes a carnitine O-palmitoyltransferase involved in oxidative stress. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
PALMITOYLTRANSFERASES -
Palmitoyltransferases catalyze the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. (Adapted from FBrf0210485).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
whd: withered
Wings warped and waved or reduced to shrunken black pupal pads. Synthetic lethal in presence of su(r) (Strømen, 1974). RK2.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\whd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V3K9)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
whd-RA
FBtr0088307
NM_078961
2882
780
whd-RB
FBtr0088308
NM_165777
2901
780
whd-RC
FBtr0301281
NM_001169640
2888
782
whd-RD
FBtr0301282
NM_001169641
2907
782
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
whd-PA
FBpp0087399
89.4
780
8.56
Q7JQH9
NP_523685
AAF58785
whd-PB
FBpp0087400
89.4
780
8.56
Q7JQH9
NP_724940
AAF58786
whd-PC
FBpp0290496
89.5
782
8.48
Q9V3K9
NP_001163111
ACZ94386
whd-PD
FBpp0290497
89.5
782
8.48
Q9V3K9
NP_001163112
ACZ94387
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

780 aa isoforms: whd-PA, whd-PB
782 aa isoforms: whd-PC, whd-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\whd using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval brain
(Price et al., 2010)
embryonic/larval fat body
(Price et al., 2010)
embryonic/larval gut
(Price et al., 2010)
adult stage
adult muscle system
(Price et al., 2010)
flight muscle cell
(Price et al., 2010)
adult fat body
(Price et al., 2010)
Additional Descriptive Data

Two different isoforms of whd protein are produced through the use of alternative exons 6A and 6B. Transcripts for both isoforms are detected in all larval and adult tissues tested by RT-PCR. Transcripts containing alternative exon 6B are present at similar levels in the tissues tested. By contrast, transcripts containing alternative exon 6A are significantly more prevalent in flight muscle than fat body.

(Price et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\whd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of whd
Transgenic constructs containing regulatory region of whd
Aberrations (Deficiencies and Duplications) ( 7 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal | chemical conditional
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell number | larval stage
abnormal cell number | larval stage, with Scer\GAL4dome-PG14
abnormal cell number | larval stage, with Scer\GAL4dome-PG14, Spyo\Cas9UAS.cUa
abnormal cell number | larval stage, with Scer\GAL4NP7379
abnormal developmental rate | chemical conditional
abnormal immune response | adult stage
abnormal mitotic cell cycle | larval stage, with Scer\GAL4dome-PG14
abnormal size | larval stage
abnormal size | larval stage, with Scer\GAL4dome-PG14
abnormal size | larval stage, with Scer\GAL4dome-PG14, Spyo\Cas9UAS.cUa
abnormal size | larval stage, with Scer\GAL4NP7379
abnormal stress response
chemical sensitive
decreased memory | adult stage | calorie restriction conditional, with Scer\GAL4GMR54H02
decreased occurrence of cell division | larval stage, with Scer\GAL4dome-PG14
increased occurrence of cell division | larval stage
radiation sensitive
visible (with whd1)
visible (with whd2)
visible (with whd3)
visible (with whd4)
visible (with whd5)
visible (with whd6)
visible (with whd7)
visible (with whd8)
visible (with whd9)
visible (with whd10)
visible (with whd11)
visible (with whd12)
visible (with whd13)
visible (with whd14)
visible | recessive
Phenotype manifest in
Allele
adult brain
adult brain | calorie restriction conditional, with Scer\GAL4GMR54H02
cortical zone of lymph gland primary lobe | larval stage
cortical zone of lymph gland primary lobe | larval stage, with Scer\GAL4dome-PG14
cortical zone of lymph gland primary lobe | larval stage, with Scer\GAL4dome-PG14, Spyo\Cas9UAS.cUa
cortical zone of lymph gland primary lobe | larval stage, with Scer\GAL4NP7379
embryonic/larval crystal cell | decreased number | larval stage
embryonic/larval plasmatocyte | decreased number | larval stage
flight muscle cell
lipid droplet
lipid droplet | adult stage | calorie restriction conditional, with Scer\GAL4GMR54H02
primary lobe of embryonic/larval lymph gland | larval stage
primary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4dome-PG14
secondary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4dome-PG14
wing
wing (with whd1)
wing (with whd2)
wing (with whd3)
wing (with whd4)
wing (with whd5)
wing (with whd6)
wing (with whd7)
wing (with whd8)
wing (with whd9)
wing (with whd10)
wing (with whd11)
wing (with whd12)
wing (with whd13)
wing (with whd14)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CPT1A
13 of 15
Yes
Yes
Hsap\CPT1B
12 of 15
No
Yes
Hsap\CPT1C
11 of 15
No
Yes
1  
Hsap\CHKB
2 of 15
No
No
Hsap\CHAT
1 of 15
No
No
Hsap\CHKB-CPT1B
1 of 15
No
No
Hsap\CPT2
1 of 15
No
No
Hsap\CROT
1 of 15
No
No
1  
Hsap\LTF
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cpt1a
13 of 15
Yes
Yes
Mmus\Cpt1b
13 of 15
Yes
Yes
Mmus\Cpt1c
11 of 15
No
Yes
Mmus\Chat
1 of 15
No
No
Mmus\Cpt2
1 of 15
No
No
Mmus\Crot
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Cpt1a
12 of 13
Yes
Yes
Rnor\Cpt1b
12 of 13
Yes
Yes
Rnor\Cpt1c
11 of 13
No
Yes
Rnor\Chat
1 of 13
No
No
Rnor\Cpt2
1 of 13
No
No
Rnor\Crat
1 of 13
No
No
Rnor\Crot
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (13)
Xtro\cpt1b
12 of 12
Yes
Yes
Xtro\cpt1a
9 of 12
No
Yes
Xtro\LOC100490391
2 of 12
No
Yes
Xtro\chat
1 of 12
No
No
Xtro\cpt1a
1 of 12
No
Yes
Xtro\cpt2
1 of 12
No
No
Xtro\crata
1 of 12
No
No
Xtro\crat
1 of 12
No
No
Xtro\crot
1 of 12
No
No
Xtro\LOC100492695
1 of 12
No
Yes
Xtro\LOC101730365
1 of 12
No
Yes
Xtro\LOC108647324
1 of 12
No
Yes
Xtro\ppt2
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\cpt1aa
12 of 15
Yes
Yes
Drer\cpt1ab
12 of 15
Yes
Yes
Drer\cpt1b
12 of 15
Yes
Yes
Drer\cpt1cb
9 of 15
No
Yes
Drer\LOC100333227
8 of 15
No
Yes
Drer\chata
1 of 15
No
No
Drer\chatb
1 of 15
No
No
Drer\cpt2
1 of 15
No
No
Drer\crata
1 of 15
No
No
Drer\cratb
1 of 15
No
No
Drer\crot
1 of 15
No
No
Drer\LOC101884918
1 of 15
No
No
Drer\zgc:154046
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\cpt-1
13 of 15
Yes
Yes
Cele\cpt-3
4 of 15
No
Yes
Cele\cpt-4
4 of 15
No
Yes
Cele\cpt-6
4 of 15
No
Yes
Cele\W03F9.4
4 of 15
No
Yes
Cele\cpt-5
2 of 15
No
Yes
Cele\B0395.3
1 of 15
No
No
Cele\cha-1
1 of 15
No
No
Cele\cpt-2
1 of 15
No
No
Cele\F41E7.6
1 of 15
No
No
Cele\T20B3.1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\DRP4A
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\CAT2
3 of 15
Yes
No
Scer\YAT1
2 of 15
No
No
Scer\YAT2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG5122
3 of 10
CG5265
3 of 10
CPT2
3 of 10
CRAT
3 of 10
CROT
3 of 10
ChAT
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CPT1A; carnitine palmitoyltransferase 1A
    13 of 15
    600528
    CPT1B; carnitine palmitoyltransferase 1B
    12 of 15
    601987
        CPT1C; carnitine palmitoyltransferase 1C
        11 of 15
        608846
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        whd - CG32219
        experimental knowledge based
        (Guruharsha et al., 2011)
        whd - CG3565
        experimental knowledge based
        (Guruharsha et al., 2011)
        whd - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        whd
        suppressible
        Glut1
        (Tiwari et al., 2020)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        bsk
        suppressible
        whd
        (Tiwari et al., 2020)
        foxo
        suppressible
        whd
        (Tiwari et al., 2020)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-62
        Cytogenetic map
        47A9-47A11
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        47A9-47A11
        Limits computationally determined from genome sequence between P{lacW}Hr46k10308 and P{PZ}lola00349&P{EP}lolaEP952
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-62

        (FlyBase, 2016)

        2-61.1

        (Comeron et al., 2012)

        2-61

        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (24)
        Genomic Clones (12)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (142)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: CPTI BEST:GH27794

        (FlyBase, 1996-)

        Source for merge of: whd CPTI

        (Strub et al., 2008)
        Additional comments
        Other Comments

        Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

        (Hansen et al., 2009)

        Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.

        (Junger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 58 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (16)
        Reported As
        Symbol Synonym
        BEST:GH27794
        CG12891
        (Kim et al., 2021, Buescher et al., 2013, Chambers et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Musselman et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Hansen et al., 2009, Keleman et al., 2009.8.5, Strub et al., 2008, Teleman et al., 2008, Philipps et al., 2004)
        CPT1
        (Jouandin et al., 2022, Nagle et al., 2022, Silva et al., 2022, Carillo et al., 2020, Xu et al., 2019, Manzo et al., 2018, van der Hoek et al., 2018, Buescher et al., 2013, Price et al., 2010)
        CPTI
        (Mukherjee et al., 2020, Kanda et al., 2011, Wang et al., 2011, Kong et al., 2010, Maynard et al., 2010, Hansen et al., 2009, Palanker et al., 2009, Tan et al., 2009, Liu and Lehmann, 2008, Strub et al., 2008, Teleman et al., 2008, Claussen et al., 2006, Philipps et al., 2004)
        Cpt1
        (Liguori et al., 2021, Buescher et al., 2013)
        cpt1
        (Wang et al., 2016)
        dCPT1
        (Schulz et al., 2015)
        gh27794
        (Zou et al., 2000)
        whd
        (Jouandin et al., 2022, Zipper et al., 2022, Marr and Potter, 2021, Xu et al., 2021, Carillo et al., 2020, Sênos Demarco et al., 2020, Brunet Avalos et al., 2019, Chen et al., 2019, Kong et al., 2019, Gene Disruption Project members, 2018-, Levis, 2018.8.30, Manzo et al., 2018, Transgenic RNAi Project members, 2017-, Kockel et al., 2016, Logan-Garbisch et al., 2014, Friedman et al., 2011, Strub et al., 2008)
        Name Synonyms
        Carnitine PalmitoylTransferase 1
        (Carillo et al., 2020)
        carnitin-palmitoyl transferase-I
        (Kanda et al., 2011)
        carnitine palmitoyltransferase 1
        (Price et al., 2010)
        carnitine-O-palmitoyltransferase
        (Gronke et al., 2005)
        mitochondrial carnitine palamitoyltransferase I
        (Maynard et al., 2010)
        mitochondrial carnitine palmitoyltransferase I
        (Jaspers et al., 2012, Cammarato et al., 2011)
        withered
        (Logan-Garbisch et al., 2014, Von Ohlen et al., 2012, Strub et al., 2008)
        Secondary FlyBase IDs
        • FBgn0004012
        • FBgn0027842
        • FBgn0043803
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        References (97)