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Gene Dmel\whd

General Information
Symbol	Dmel\whd	Species	D. melanogaster
Name	withered	Annotation symbol	CG12891
Feature type	protein_coding_gene	FlyBase ID	FBgn0261862
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	CPTI
Genomic Location
Chromosome (arm)	2R	Recombination map	2-61
Cytogenetic map	47A9-47A11	Sequence location	2R:6,356,978..6,366,072 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene withered is referred to in FlyBase by the symbol Dmel\whd (CG12891, FBgn0261862). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: carnitine O-palmitoyltransferase activity. There is experimental evidence that it is involved in the biological process: response to starvation; response to oxidative stress; response to metal ion. 36 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Acyltransferase ChoActase/COT/CPT. Gene sequence location is 2R:6356978..6366072.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	whd: withered Wings warped and waved or reduced to shrunken black pupal pads. Synthetic lethal in presence of su(r) (Strømen, 1974). RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47A9-47A11   Limits computationally determined from genome sequence between P{lacW}Hr46k10308 and P{PZ}lola00349&P{EP}lolaEP952
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-61
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\whd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) whd-RA FBtr0088307  NM_078961   2882   780 whd-RB FBtr0088308  NM_165777   2901   780 whd-RC FBtr0301281  NM_001169640   2888   782 whd-RD FBtr0301282  NM_001169641   2907   782
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein whd-PA   FBpp0087399   89.4   780   8.56     NP_523685   AAF58785 whd-PB   FBpp0087400   89.4   780   8.56     NP_724940   AAF58786 whd-PC   FBpp0290496   89.5   782   8.48     NP_001163111   ACZ94386 whd-PD   FBpp0290497   89.5   782   8.48     NP_001163112   ACZ94387
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Acyltransferase ChoActase/COT/CPT (IPR000542) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12891
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201857   AA202454   AA246272   AA264674   AA438947   AA440307   AA441641   AA536364   AA538628   AA541114   AA698204   AA698551   AA698606   AA698784   AA942279   AA942512   AA951286   AA951331   AE013599 AAF58785   AE013599 AAF58786   AE013599 ACZ94386   AE013599 ACZ94387   AI134998   AI135866   AI293914   AI402528   AI404807   AI404827   AI405915   AI455712   AI513065   AI517149   AI534607   AI546268   AJ010150 CAB52415   AW943099   BG637680   BG640778   BH759320   BH759321   BI162792   BI166096   BI166872   BI168782   BI170497   BI173497   BI227968   BI228497   BI230009   BI230050   BI230389   BI231287   BI232923   BI232996   BI235699   BI237011   BI238198   BI238860   BI239620   BI357391   BI358001   BI362897   BI363252   BI367008   BI368420   BI368616   BI371943   BI372593   BI373149   BI375141   BI376021   BI481752   BI482666   BI484260   BI485561   BI567780   BI570886   BI571160   BI571171   BI572254   BI572982   BI577203   BI580233   BI581448   BI581708   BI582215   BI588113   BI588907   BI590938   BI591884   BI592962   BI607079   BI607267   BI608626   BI608757   BI613247   BI614661   BI619294   BI620258   BI620779   BI630056   BI630863   BP547312   BP552298   BP559601   BT003548   BT010044 AAQ22513   BT120168   CA803299   CA803535   CK659070   CK659422   CO177136   CO181974   CO187902   CO190654   CO193361   CO282886   CO312614   CO313308   CO318613   CO324170   CO325376   CO327538   CO327989   CZ475477   CZ475795   CZ475796   CZ477226   CZ481992   EC069484   EC076200   EC080449   EC212035   EC213472   EC213840   EC223914   EC238852   EC241514   EC248675   EC251350   EC254535   EV586935   EV588009   EV590178   EV590794   EV590976   EV598184   GH739217   GH739633   GH740128   GH740516   GH742250   GH742567   GH742695   GH743411   GH743423   GH745635   GH746473   GH746876   GH761730   GH763536   GH763857   GH764422   GH764524   GH764637   GH764982   GH765566   GH766029   GH766894   GH767198   GH767623
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3K9 Q7JQH9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female    36 head, virgin 20-day female    60 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    48 head, mated 1-day male    42 head, mated 4-day male    25 head, mated 20-day male    43 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    60 digestive system, larvae L3 wandering    78 digestive system, 1-day adult    35 digestive system, 4-day adult    31 digestive system, 20-day adult    54 fat body, larvae L3 wandering    31 fat body, white prepupae    28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    30 carcass, 4-day adult    28 carcass, 20-day adult    37 ovary, virgin 4-day female    44 ovary, mated 4-day female    36 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female  (36) head, virgin 20-day female  (60) head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female  (48) head, mated 1-day male  (42) head, mated 4-day male    25 head, mated 20-day male  (43) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (60) digestive system, larvae L3 wandering  (78) digestive system, 1-day adult  (35) digestive system, 4-day adult  (31) digestive system, 20-day adult  (54) fat body, larvae L3 wandering  (31) fat body, white prepupae  (28) fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult  (30) carcass, 4-day adult  (28) carcass, 20-day adult  (37) ovary, virgin 4-day female  (44) ovary, mated 4-day female  (36) testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female    36 head, virgin 20-day female    60 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    48 head, mated 1-day male    42 head, mated 4-day male    25 head, mated 20-day male    43 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    60 digestive system, larvae L3 wandering    78 digestive system, 1-day adult    35 digestive system, 4-day adult    31 digestive system, 20-day adult    54 fat body, larvae L3 wandering    31 fat body, white prepupae    28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    30 carcass, 4-day adult    28 carcass, 20-day adult    37 ovary, virgin 4-day female    44 ovary, mated 4-day female    36 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female    36 head, virgin 20-day female    60 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    48 head, mated 1-day male    42 head, mated 4-day male    25 head, mated 20-day male    43 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    60 digestive system, larvae L3 wandering    78 digestive system, 1-day adult    35 digestive system, 4-day adult    31 digestive system, 20-day adult    54 fat body, larvae L3 wandering    31 fat body, white prepupae    28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    30 carcass, 4-day adult    28 carcass, 20-day adult    37 ovary, virgin 4-day female    44 ovary, mated 4-day female    36 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female    36 head, virgin 20-day female    60 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    48 head, mated 1-day male    42 head, mated 4-day male    25 head, mated 20-day male    43 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    60 digestive system, larvae L3 wandering    78 digestive system, 1-day adult    35 digestive system, 4-day adult    31 digestive system, 20-day adult    54 fat body, larvae L3 wandering    31 fat body, white prepupae    28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    30 carcass, 4-day adult    28 carcass, 20-day adult    37 ovary, virgin 4-day female    44 ovary, mated 4-day female    36 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female  (36) head, virgin 20-day female  (60) head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female  (48) head, mated 1-day male  (42) head, mated 4-day male    25 head, mated 20-day male  (43) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (60) digestive system, larvae L3 wandering  (78) digestive system, 1-day adult  (35) digestive system, 4-day adult  31 digestive system, 20-day adult  (54) fat body, larvae L3 wandering  31 fat body, white prepupae  28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult  30 carcass, 4-day adult  28 carcass, 20-day adult  (37) ovary, virgin 4-day female  (44) ovary, mated 4-day female  (36) testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female    36 head, virgin 20-day female    60 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    48 head, mated 1-day male    42 head, mated 4-day male    25 head, mated 20-day male    43 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    60 digestive system, larvae L3 wandering    78 digestive system, 1-day adult    35 digestive system, 4-day adult    31 digestive system, 20-day adult    54 fat body, larvae L3 wandering    31 fat body, white prepupae    28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    30 carcass, 4-day adult    28 carcass, 20-day adult    37 ovary, virgin 4-day female    44 ovary, mated 4-day female    36 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    8 central nervous system, pupae P8    14 head, virgin 1-day female    25 head, virgin 4-day female    36 head, virgin 20-day female    60 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    48 head, mated 1-day male    42 head, mated 4-day male    25 head, mated 20-day male    43 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    60 digestive system, larvae L3 wandering    78 digestive system, 1-day adult    35 digestive system, 4-day adult    31 digestive system, 20-day adult    54 fat body, larvae L3 wandering    31 fat body, white prepupae    28 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    30 carcass, 4-day adult    28 carcass, 20-day adult    37 ovary, virgin 4-day female    44 ovary, mated 4-day female    36 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    124 embryo 02-04hr    114 embryo 04-06hr    49 embryo 06-08hr    51 embryo 08-10hr    65 embryo 10-12hr    99 embryo 12-14hr    95 embryo 14-16hr    114 embryo 16-18hr    160 embryo 18-20hr    153 embryo 20-22hr    36 embryo 22-24hr    45 larva L1    27 larva L2    54 larva L3 12hr old    48 larva L3 puffstage 1-2    52 larva L3 puffstage 3-6    81 larva L3 puffstage 7-9    73 white prepupae new    111 white prepupae 12hr    30 white prepupae 24hr    36 pupae 2d postWPP    53 pupae 3d postWPP    47 pupae 4d postWPP    60 adult male 01day    71 adult male 05day    61 adult male 30day    53 adult female 01day    75 adult female 05day    78 adult female 30day    83 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (124) embryo 02-04hr  (114) embryo 04-06hr  (49) embryo 06-08hr  (51) embryo 08-10hr  (65) embryo 10-12hr  (99) embryo 12-14hr  (95) embryo 14-16hr  (114) embryo 16-18hr  (160) embryo 18-20hr  (153) embryo 20-22hr  (36) embryo 22-24hr  (45) larva L1  (27) larva L2  (54) larva L3 12hr old  (48) larva L3 puffstage 1-2  (52) larva L3 puffstage 3-6  (81) larva L3 puffstage 7-9  (73) white prepupae new  (111) white prepupae 12hr  (30) white prepupae 24hr  (36) pupae 2d postWPP  (53) pupae 3d postWPP  (47) pupae 4d postWPP  (60) adult male 01day  (71) adult male 05day  (61) adult male 30day  (53) adult female 01day  (75) adult female 05day  (78) adult female 30day  (83) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (124) embryo 02-04hr  (114) embryo 04-06hr    49 embryo 06-08hr    51 embryo 08-10hr    65 embryo 10-12hr    99 embryo 12-14hr    95 embryo 14-16hr  (114) embryo 16-18hr  (160) embryo 18-20hr  (153) embryo 20-22hr    36 embryo 22-24hr    45 larva L1    27 larva L2    54 larva L3 12hr old    48 larva L3 puffstage 1-2    52 larva L3 puffstage 3-6    81 larva L3 puffstage 7-9    73 white prepupae new  (111) white prepupae 12hr    30 white prepupae 24hr    36 pupae 2d postWPP    53 pupae 3d postWPP    47 pupae 4d postWPP    60 adult male 01day    71 adult male 05day    61 adult male 30day    53 adult female 01day    75 adult female 05day    78 adult female 30day    83 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    124 embryo 02-04hr    114 embryo 04-06hr    49 embryo 06-08hr    51 embryo 08-10hr    65 embryo 10-12hr    99 embryo 12-14hr    95 embryo 14-16hr    114 embryo 16-18hr    160 embryo 18-20hr    153 embryo 20-22hr    36 embryo 22-24hr    45 larva L1    27 larva L2    54 larva L3 12hr old    48 larva L3 puffstage 1-2    52 larva L3 puffstage 3-6    81 larva L3 puffstage 7-9    73 white prepupae new    111 white prepupae 12hr    30 white prepupae 24hr    36 pupae 2d postWPP    53 pupae 3d postWPP    47 pupae 4d postWPP    60 adult male 01day    71 adult male 05day    61 adult male 30day    53 adult female 01day    75 adult female 05day    78 adult female 30day    83 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    124 embryo 02-04hr    114 embryo 04-06hr    49 embryo 06-08hr    51 embryo 08-10hr    65 embryo 10-12hr    99 embryo 12-14hr    95 embryo 14-16hr    114 embryo 16-18hr    160 embryo 18-20hr    153 embryo 20-22hr    36 embryo 22-24hr    45 larva L1    27 larva L2    54 larva L3 12hr old    48 larva L3 puffstage 1-2    52 larva L3 puffstage 3-6    81 larva L3 puffstage 7-9    73 white prepupae new    111 white prepupae 12hr    30 white prepupae 24hr    36 pupae 2d postWPP    53 pupae 3d postWPP    47 pupae 4d postWPP    60 adult male 01day    71 adult male 05day    61 adult male 30day    53 adult female 01day    75 adult female 05day    78 adult female 30day    83 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (124) embryo 02-04hr  (114) embryo 04-06hr  (49) embryo 06-08hr  (51) embryo 08-10hr  (65) embryo 10-12hr  (99) embryo 12-14hr  (95) embryo 14-16hr  (114) embryo 16-18hr  (160) embryo 18-20hr  (153) embryo 20-22hr  (36) embryo 22-24hr  (45) larva L1  27 larva L2  (54) larva L3 12hr old  (48) larva L3 puffstage 1-2  (52) larva L3 puffstage 3-6  (81) larva L3 puffstage 7-9  (73) white prepupae new  (111) white prepupae 12hr  30 white prepupae 24hr  (36) pupae 2d postWPP  (53) pupae 3d postWPP  (47) pupae 4d postWPP  (60) adult male 01day  (71) adult male 05day  (61) adult male 30day  (53) adult female 01day  (75) adult female 05day  (78) adult female 30day  (83) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  124 embryo 02-04hr  114 embryo 04-06hr    49 embryo 06-08hr    51 embryo 08-10hr    65 embryo 10-12hr    99 embryo 12-14hr    95 embryo 14-16hr  114 embryo 16-18hr  (160) embryo 18-20hr  (153) embryo 20-22hr    36 embryo 22-24hr    45 larva L1    27 larva L2    54 larva L3 12hr old    48 larva L3 puffstage 1-2    52 larva L3 puffstage 3-6    81 larva L3 puffstage 7-9    73 white prepupae new  111 white prepupae 12hr    30 white prepupae 24hr    36 pupae 2d postWPP    53 pupae 3d postWPP    47 pupae 4d postWPP    60 adult male 01day    71 adult male 05day    61 adult male 30day    53 adult female 01day    75 adult female 05day    78 adult female 30day    83 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    124 embryo 02-04hr    114 embryo 04-06hr    49 embryo 06-08hr    51 embryo 08-10hr    65 embryo 10-12hr    99 embryo 12-14hr    95 embryo 14-16hr    114 embryo 16-18hr    160 embryo 18-20hr    153 embryo 20-22hr    36 embryo 22-24hr    45 larva L1    27 larva L2    54 larva L3 12hr old    48 larva L3 puffstage 1-2    52 larva L3 puffstage 3-6    81 larva L3 puffstage 7-9    73 white prepupae new    111 white prepupae 12hr    30 white prepupae 24hr    36 pupae 2d postWPP    53 pupae 3d postWPP    47 pupae 4d postWPP    60 adult male 01day    71 adult male 05day    61 adult male 30day    53 adult female 01day    75 adult female 05day    78 adult female 30day    83 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2  (32) ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2  32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    12 embryonic S1    5 embryonic S3    15 leg disc CME L1    1 wing disc CME-W2    10 wing disc ML-DmD8    3 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    4 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    32 ovary fGS/OSS    5 ovary OSC    2 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (56) Ethanol 5% 3 hrs, larvae L3  (34) Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (35) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (39) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (46) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (56) Ethanol 5% 3 hrs, larvae L3  (34) Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (35) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (39) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (46) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    20 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_09 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • MIP15836
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable whd1 whd2 whd3 whd4 whd5 whd6 whd7 whd8 whd9 whd10 whd11 whd12 whd13 whd14 viable, with Scer\GAL4pnr-MD237 whdGD1917 Other Phenotypes Allele chemical sensitive whd1 whd2 whd5 whd8 whd9 whd12 immune response defective | adult stage whd1 radiation sensitive whd1 stress response defective whd2 whd3 whd5 whd6 whd8 whd9 visible (with whd1) whd2 whd3 whd4 whd5 whd6 whd7 whd8 whd9 whd10 whd11 whd12 whd13 whd14 visible (with whd2) whd1 visible (with whd3) whd1 visible (with whd4) whd1 visible (with whd5) whd1 visible (with whd6) whd1 visible (with whd7) whd1 visible (with whd8) whd1 visible (with whd9) whd1 visible (with whd10) whd1 visible (with whd11) whd1 visible (with whd12) whd1 visible (with whd13) whd1 visible (with whd14) whd1 visible | recessive whd1 whd2 whd3 whd4 whd5 whd6 whd7 whd8 whd9 whd10 whd11 whd12 whd13 whd14 Phenotype manifest in Allele wing whd1 whd2 whd3 whd4 whd5 whd6 whd7 whd8 whd9 whd10 whd11 whd12 whd13 whd14 wing (with whd1) whd2 whd3 whd4 whd5 whd6 whd7 whd8 whd9 whd10 whd11 whd12 whd13 whd14 wing (with whd2) whd1 wing (with whd3) whd1 wing (with whd4) whd1 wing (with whd5) whd1 wing (with whd6) whd1 wing (with whd7) whd1 wing (with whd8) whd1 wing (with whd9) whd1 wing (with whd10) whd1 wing (with whd11) whd1 wing (with whd12) whd1 wing (with whd13) whd1 wing (with whd14) whd1
Classical Alleles ( 32 )
For All Classical Alleles Show
Allele of whd Class Mutagen Stocks Known lesion whd1 spontaneous 3 Yes whd5-HA-1287 1 -- whd5-HA-3096 1 -- whdCB-0496-3 1 -- whdCB-6742-3 1 -- whdd03587 1 -- whdd07538 P-element activity 1 -- whde04247 piggyBac transposase 1 -- whdEY07800 P-element activity 1 -- whdEY20655 P-element activity 1 -- whdKG01596 P-element activity 1 -- whdNP2610-3-1 1 -- whdNP3533 1 -- whdNP5262 1 -- whdNP7362 1 -- whdNP7382 1 -- whd10 ethyl methanesulfonate 0 Yes whd11 ethyl methanesulfonate 0 Yes whd12 ethyl methanesulfonate 0 Yes whd13 ethyl methanesulfonate 0 -- whd14 ethyl methanesulfonate 0 Yes whd2 X ray 0 Yes whd3 X ray 0 Yes whd4 X ray 0 Yes whd5 ethyl methanesulfonate 0 -- whd6 ethyl methanesulfonate 0 Yes whd76 ethyl methanesulfonate 0 -- whd7 ethyl methanesulfonate 0 -- whd8 ethyl methanesulfonate 0 Yes whd9 ethyl methanesulfonate 0 Yes whdd07001 P-element activity 0 -- whdd10342 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of whd Class Mutagen Stocks Known lesion whdGD1917 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes whdHMS00033 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes whdHMS00040 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes whdKK100935 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)E3363 (Strub et al., 2008) Df(2R)en-A (Chase and Baker, 1995) Df(2R)en-B (Chase and Baker, 1995) Df(2R)X1 (Strub et al., 2008)
Disrupted in	Df(2R)12 (Strub et al., 2008) Df(2R)stan1 (Strub et al., 2008) Df(2R)stan2 (Strub et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HMS00033} NA P{TRiP.HMS00040} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}whdEY07800 NA P{EPgy2}whdEY20655 NA P{XP}whdd03587 NA P{XP}whdd07001 NA P{XP}whdd07538 NA P{XP}whdd10342 NA miscellaneous insertions P{RS3}whdCB-0496-3 NA P{RS3}whdCB-6742-3 NA P{RS5}whd5-HA-1287 NA P{RS5}whd5-HA-3096 NA P{SUPor-P}whdKG01596 NA PBac{RB}whde04247 NA insertion of enhancer trap binary system P{GawB}whdNP2610-3-1 No P{GawB}whdNP3533 No P{GawB}whdNP5262 No P{GawB}whdNP7362 No P{GawB}whdNP7382 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to metal ion inferred from mutant phenotype (Strub et al., 2008) response to oxidative stress inferred from mutant phenotype (Strub et al., 2008) response to starvation inferred from mutant phenotype (Strub et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
carnitine O-palmitoyltransferase activity inferred from sequence or structural similarity with EMBL:U88294 (FlyBase, 1992-) non-traceable author statement (Price, 1998.8.7)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity with EMBL:U88294 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
whd - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) whd - CG32219 experimental knowledge based (Guruharsha et al., 2011) whd - CG3565 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) whd - Spn42Da anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions whd allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261862 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36109
Orthologs
OrthoDB Orthologs (58) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D7ZR4 Dipteran inclusive ortholog search EOG6T4D3H Insect inclusive ortholog search EOG6BG7QX Arthropod inclusive ortholog search EOG6G79D8 Metazoa inclusive ortholog search EOG6BS8CM
Orthologs in Drosophila Species (EOG6D7ZR4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\whd     Drosophila simulans   Dsim\GD25979 Y   Drosophila sechellia   Dsec\GM20519 Y   Drosophila erecta   Dere\GG22743 Y   Drosophila yakuba   Dyak\GE13102 Y   Drosophila ananassae   Dana\GF11106 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11884 Y   Drosophila persimilis   Dper\GL17200 Y   Drosophila willistoni   Dwil\GK10678 Y   Drosophila virilis   Dvir\GJ20140 Y   Drosophila mojavensis   Dmoj\GI20192 Y   Drosophila grimshawi   Dgri\GH20631 Y
Orthologs in non-Drosophila Dipterans (EOG6T4D3H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005458   Anopheles gambiae Malaria mosquito  Agam\AGAP010164   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005612
Orthologs in non-Dipteran Insects (EOG6BG7QX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54622   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007262   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21555   Atta cephalotes Leafcutter ant  Acep\ACEP25074   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22770   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16965   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16966   Linepithema humile Argentine ant  Lhum\LH10209   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15004   Solenopsis invicta Red fire ant  Sinv\SINV10663   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005329   Bombyx mori Silkmoth  Bmor\BGIBMGA013317   Pediculus humanus Human body louse  Phum\PHUM022280   Tribolium castaneum Red flour beetle  Tcas\TC002462
Orthologs in non-Insect Arthropods (EOG6G79D8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_57941   Ixodes scapularis Deer tick  Isca\ISCW018288
Orthologs in non-Arthropod Metazoa (EOG6BS8CM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cpt-4   Caenorhabditis elegans Nematode  Cele\W03F9.4   Caenorhabditis elegans Nematode  Cele\cpt-6   Caenorhabditis elegans Nematode  Cele\cpt-1   Caenorhabditis elegans Nematode  Cele\cpt-5   Caenorhabditis elegans Nematode  Cele\cpt-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015851gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025367gn   Danio rerio Zebrafish  Drer\si:ch211-236l14.3   Danio rerio Zebrafish  Drer\OTTDARG00000021773   Danio rerio Zebrafish  Drer\ENSDARG00000059770   Danio rerio Zebrafish  Drer\cpt1b   Danio rerio Zebrafish  Drer\CABZ01055343.2   Xenopus tropicalis Western clawed frog  Xtro\cpt1a   Xenopus tropicalis Western clawed frog  Xtro\cpt1b   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031557   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000020491   Gallus gallus Domestic chicken  Ggal\CPT1A   Mus musculus House mouse  Mmus\Cpt1a   Mus musculus House mouse  Mmus\Cpt1c   Mus musculus House mouse  Mmus\Cpt1b   Rattus norvegicus Norway rat  Rnor\Cpt1b   Rattus norvegicus Norway rat  Rnor\Cpt1c   Rattus norvegicus Norway rat  Rnor\Cpt1a   Homo sapiens Human  Hsap\ENSG00000110090   Homo sapiens Human  Hsap\CPT1B   Homo sapiens Human  Hsap\CPT1C
Human Orthologs (3)
Gene OMIM HGNC Hsap\ENSG00000110090     Hsap\CPT1B     Hsap\CPT1C
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25979 Drosophila sechellia Dsec\GM20519 Drosophila erecta Dere\GG22743 Drosophila yakuba Dyak\GE13102 Drosophila ananassae Dana\GF11106 Drosophila pseudoobscura pseudoobscura Dpse\GA11884 Drosophila persimilis Dper\GL17200 Drosophila willistoni Dwil\GK10678 Drosophila virilis Dvir\GJ20140 Drosophila mojavensis Dmoj\GI20192 Drosophila grimshawi Dgri\GH20631
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Bloomington	441 whd1
Harvard	- P{XP}whdd03587 - P{XP}whdd07538 - PBac{RB}whde04247
Kyoto	113330 w*; P{GawB}whdNP3533 123205 w1118; P{RS3}whdCB-0496-3 124202 w1118; P{RS3}whdCB-6742-3 125189 w1118; P{RS5}whd5-HA-1287 125798 w1118; P{RS5}whd5-HA-3096
VDRC	v105400 P{KK100935}VIE-260B v4046 w1118; P{GD1917}v4046 v4047 w1118; P{GD1917}v4047
	More stocks available...
Genomic Clones ( 2 )
	BACR16P22 BACR20O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 157 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD31742 RE02263
Other clones	MIP15836
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12607 GH13768 GH21765 GH24645 GH24665 GH26068 GH27794 HL03937 HL05323 HL05681 LD02181 LD03774 LD05141 LD08330 LD13347 LD15235 LD16640 LD16943 LD18204 LD20927 LD26387 LD26769 LD31672 LD35359 LD45287 LD47796 LP07173 LP16534 LP17172 RE02026 RE06123 RE07112 RE09646 RE10188 RE11970 RE16428 RE20735 RE25361 RE27925 RE27976 RE29073 RE29258 RE31615 RE33153 RE34592 RE36164 RE43862 RE44647 RE47578 RE48020 RE52670 RE54386 RE54619 RE58977 RE59592 RE60371 RE62878 RE63941 RE64353 RE65383 RE67334 RE68918 RE70855 RE74387 RH04633 RH05672 RH05984 RH05996 RH07692 RH07730 RH08559 RH10795 RH13206 RH13448 RH18902 RH19245 RH20172 RH29179 RH30365 RH38361 RH42359 RH44105 RH50304 RH51343 RH51993 RH59018 RH60201 RH74069 RH74290 SD07517 SD11925
Other clones	64581 69279 99661 101609 104990 109119 172799 214565.34 283569 CK01.32B.E1 CK01.60D.F6 CK01.66C.D11 Dmel_neb_005296_0422_3535 Dmel_neb_009749_0831_1191 Dmel_neb_010168_0340_0621 Dmel_neb_011800_0179_0833 Dmel_neb_013736_0096_0534 Dmel_neb_015572_0445_2576 EC18058 EC35658 EK034739 EK048942 EK052614 EK161705 EK192864 EK196343 EK229518 EK232105 EK273215 EP07444 EP08402 ESG011c.E7_A07 ESG011c.E21_A07 FGH115F06 FGM218A01 FGM321H01 HL04913 RE26055 RE41954 RP001009191 RP001010861 RP001011237 RP001011612 RP001012080 RP001012813 RP001015689 RP001016410 RP001016445 RP001016859 RP001018234 RP001021875 RP001023156 RP001028091 RP001031421 RP001031999 RP001036247 RP001040514 RP001043671 RP001046688 RP001046865 RP001048669 RP001050583 RP001053832
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261862 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36109
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CPTI BEST:GH27794 (FlyBase, 1996-) Source for merge of: whd CPTI (Strub et al., 2008)
Additional comments
Other Comments
	Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene. (Hansen et al., 2009) Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences. (Junger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078961 NM_165777 NM_001169640 NM_001169641 RefSeq (Proteins) • NP_523685 NP_724940 NP_001163111 NP_001163112 DDBJ / EMBL / GenBank • AA441641 AA951331 AAF58785 AAF58786 AAQ22513 ACZ94386 ACZ94387 AI517149 AJ010150 AW943099 BH759320 BH759321 BT010044 CAB52415 CZ475477 CZ475795 CZ475796 CZ477226 CZ481992 Entrez Gene - A searchable database of RefSeq genes. • 36109 UniProtKB/TrEMBL • Q7JQH9 Q9V3K9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Acyltransferase ChoActase/COT/CPT (IPR000542) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12891 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • MIP15836
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261862 DRSC - Results from RNAi screens. • FBgn0261862 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261862 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36109 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36109 modMine - Data generated by the modENCODE project. • FBgn0261862
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BEST:GH27794   CG12891 (Musselman et al., 2011, Strub et al., 2008, Hansen et al., 2009, Teleman et al., 2008, Keleman et al., 2009.8.5, Philipps et al., 2004, Ni et al., 2010.12.1, Ni et al., 2011.7.19, Cammarato et al., 2011) CPT1 (Price et al., 2010) CPTI (Wang et al., 2011, Strub et al., 2008, Claussen et al., 2006, Palanker et al., 2009, Hansen et al., 2009, Teleman et al., 2008, Liu and Lehmann, 2008, Philipps et al., 2004, Maynard et al., 2010) gh27794 (Zou et al., 2000) whd (Strub et al., 2008, )
Name Synonym	carnitine-O-palmitoyltransferase (Gronke et al., 2005) carnitine palmitoyltransferase 1 (Price et al., 2010) mitochondrial carnitine palamitoyltransferase I (Maynard et al., 2010) mitochondrial carnitine palmitoyltransferase I (Cammarato et al., 2011) withered (Von Ohlen et al., 2012, Strub et al., 2008)
Secondary FlyBase IDs
	FBgn0004012 FBgn0027842 FBgn0043803
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Book  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Von Ohlen et al., 2012, Infect. Immun. 80(10): 3576--3586 Identification of Critical Host Mitochondrion-Associated Genes during Ehrlichia chaffeensis Infections. [FBrf0219421] Musselman et al., 2011, Dis. Model Mech. 4(6): 842--849 A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. [FBrf0216626] Wang et al., 2011, Cell 145(4): 596--606 A hormone-dependent module regulating energy balance. [FBrf0213699] Show all research papers ...