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Gene Dmel\sdt

General Information
Symbol	Dmel\sdt	Species	D. melanogaster
Name	stardust	Annotation symbol	CG32717
Feature type	protein_coding_gene	FlyBase ID	FBgn0261873
Gene Model Status	Current	Stock availability	26 publicly available
Also Known As	Std, CG12657, PALS1
Genomic Location
Chromosome (arm)	X	Recombination map	1-23
Cytogenetic map	7D17-7D22	Sequence location	X:8,072,582..8,133,474 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene stardust is referred to in FlyBase by the symbol Dmel\sdt (CG32717, FBgn0261873). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: chitin-based cuticle development; lateral inhibition; zonula adherens assembly; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of epithelial cell apical/basal polarity. 62 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; anatomical structure; acellular anatomical structure; adherens junction; portion of tissue; embryonic/larval hemocoel; embryonic/larval integumentary system; external compound sense organ; plasma membrane part; late extended germ band embryo. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Guanylate kinase; Guanylate kinase, conserved site; Guanylate kinase/L-type calcium channel; L27; L27, C-terminal; PDZ/DHR/GLGF; Src homology-3 domain; Variant SH3. Gene sequence location is X:8072582..8133474.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sdt: stardust Embryonic lethal. Hypoderm almost totally absent; only small remains of cuticle found. sdt+ function not required in female germline (Wieschaus and Noell, 1986, Roux's Arch. Dev. Biol. 195: 63-73).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN50417 HFA17861 HFA18022 HFA18108 HFA18027 HFA18026 HFA17556 BKN50621 HFA17555 HFA17860 HFA18025 BKN27407
FB2011_10	Transgenic Constructs P{UAS-sdt.exon3.SV40.eGFP} P{UAS-sdt.B} P{UAS-sdt.A.SV40} P{UAS-sdt.A}
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D17-7D22   Limits computationally determined from genome sequence between P{EP}CG1583EP1516&P{EP}CG1583EP325 and P{EP}sdtEP1143
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-23 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sdt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Atypical cDNA: retained intron, early termination ( RH69430). DGC clone RH69430 appears problematic: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sdt-RB FBtr0089978  NM_132235   5746   1292 sdt-RD FBtr0089975  NM_206652   3838   879 sdt-RE FBtr0089974  NM_206653   5443   1367 sdt-RF FBtr0100375  NM_001038747   4480   859 sdt-RG FBtr0100376  NM_001038746   8462   2020 sdt-RH FBtr0111034  NM_001042798   4017   934 sdt-RI FBtr0308217     5228   1269 sdt-RJ FBtr0308218     6406   1527 sdt-RK FBtr0308219     3790   879 sdt-RL FBtr0308220     7745   1941
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sdt-PB   FBpp0088916   139.4   1292   7.04     NP_572463   AAF46351 sdt-PD   FBpp0088913   95.3   879   7.06     NP_996375   AAF46350 sdt-PE   FBpp0088912   148.3   1367   7.06     NP_996376   AAS65284 sdt-PF   FBpp0099784   93.9   859   7.20     NP_001033836   ABC67177 sdt-PG   FBpp0111740   217.8   2020   6.79     NP_001033835   ABC67176 sdt-PH   FBpp0110333   102.9   934   7.20     NP_001036263   ABI30970 sdt-PI   FBpp0300537   136.9   1269   7.08       sdt-PJ   FBpp0300538   165.4   1527   6.99       sdt-PK   FBpp0300539   95.3   879   7.06       sdt-PL   FBpp0300540   208.7   1941   6.83
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • L27, C-terminal (IPR014775) Variant SH3 (IPR011511) Guanylate kinase/L-type calcium channel (IPR008145) Guanylate kinase (IPR008144) L27 (IPR004172) PDZ/DHR/GLGF (IPR001478) Src homology-3 domain (IPR001452) Guanylate kinase, conserved site (IPR020590)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA433261   AE014298 AAF46350   AE014298 AAF46351   AE014298 AAS65284   AE014298 ABC67176   AE014298 ABC67177   AE014298 ABI30970   AF414117 AAL40935   AF414118 AAL40936   BI165388   BI230660   BI369478   BI486582   BI577142   BI611578   BI614594   BI622835   BT010281 AAQ23599   BT011047   BT011088   BT014921   BT025956   BT033055   BT072988   BT099747   BT120192   CO178321   CO264232   CO264836   CO267735   CO272079   CO272097   CO272098   CO275221   CO282095   CO283993   CO284029   CO292293   CO299059   CO300104   CO300209   CO304152   CO304785   CO305861   CO306385   CO307878   CO311826   CO311882   CO321594   CO322866   CO326487   CO326506   CO327110   CO330838   CO331481   CO339544   CO339906   CX309577   CX309578   CZ471437   CZ474550   DQ450340   DQ450341   DQ450342   DQ450343   DQ450344   DQ450345   DQ450346   DQ450347   DQ450348   DQ450349   DQ450350   DQ450351   DQ450352   DQ450353   DQ450354   DQ450355   EC058308   EC058914   EC061457   EC065080   EC071802   EC073469   EC076391   EC077172   EC077424   EC198958   EC199547   EC201096   EC203685   EC207446   EC210581   EC210835   EC211006   EC211506   EC227932   EC228070   EC232318   EC232323   EC236954   EC241521   EC246032   EC248195   EC248315   EC249176   EC250514   EC254321   EC256742   EC256994   EC257960   EC259882   EC260106   EL879437   EL879438   EL884450   EL884451   GH945066   GH948415   GH948477   GH954254   GH956116   GH963796   GH965887   GH966464   GH977396   GH978424   GH978573   GH983534   GH983603   GH984593
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3H8 Q9W3H7 Q9W3H6 Q8WRS3 Q8WRS2 Q7KVT3 Q6NR03 Q0KHU9 E2QD98
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference pupal stage   eye photoreceptor cell stalk | apical   (Nam and Choi, 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage sdtP10 sdtXP lethal | embryonic stage | recessive sdt1 sdt7D sdtEH681 sdtXN sdtXP lethal | pupal stage, with Scer\GAL4pnr-MD237 sdtGD8984 lethal | recessive sdtA23 sdtI118 sdtO159 sdtP10 sdtSc159 sdtU60 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 sdtGD8985 viable, with Scer\GAL4pnr-MD237 sdtGD9163 sdtGD15292 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 sdtGD8985 Phenotype manifest in Allele amnioserosa sdt7D sdt78D22 sdtEH681 chaeta | supernumerary, with Scer\GAL4pnr-MD237 sdtGD8985 embryo sdtP10 embryo | germline clone sdtXP embryonic/first instar larval cuticle sdt7D sdtdsRNA.MAGUK sdt1 embryonic/larval cuticle sdtXP sdtEH681 sdtP10 embryonic/larval salivary gland | embryonic stage sdt78D22 sdtEH681 embryonic epidermis sdt7D sdt78D22 sdtXP sdt1 sdtXN sdtEH681 sdtO159 eye photoreceptor cell stalk sdtXP eye photoreceptor cell stalk | somatic clone sdtK70 sdtK85 sdtXN sdtE195 macrophage sdtEH681 photoreceptor cell & actin filament & pupa | somatic clone sdtXP photoreceptor cell & adherens junction & pupa | somatic clone sdtXP rhabdomere | somatic clone sdt7D sdtXP salivary gland sdtunspecified sdtO159 spot adherens junction sdt78D22 sdtEH681 trachea sdt78D22 sdtEH681 zonula adherens sdt7D sdt78D22 sdtXP sdtXN sdtEH681 zonula adherens & photoreceptor cell & pupa sdtXP
Classical Alleles ( 44 )
For All Classical Alleles Show
Allele of sdt Class Mutagen Stocks Known lesion sdtXN hypomorphic allele - genetic evidence ethyl methanesulfonate 2 Yes sdt5-SZ-3206 1 -- sdtBG01114 P-element activity 1 -- sdtc04685 1 -- sdtCB-5259-3 1 -- sdtd00160 1 -- sdtd00185 P-element activity 1 -- sdtEP1143 P-element activity 1 -- sdtf03672 1 -- sdtG1472 P-element activity 1 -- sdtKG01390 1 -- sdtKG01701 1 -- sdtNP0160 1 -- sdtNP0977 1 -- sdtNP2290 1 -- sdtNP4094 1 -- sdt2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- sdt3 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- sdt7D amorphic allele - genetic evidence ethyl methanesulfonate 0 -- sdtEH681 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes sdtK8 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- sdt1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- sdt78D22 0 -- sdtA23 ethyl methanesulfonate 0 -- sdtd04460 0 -- sdtd05058 0 -- sdtd05475 P-element activity 0 -- sdtE195 0 Yes sdtf01364 0 -- sdtGG01001 0 -- sdtGG01055 0 -- sdtGG01258 0 -- sdtGX73w- 0 Yes sdtI118 ethyl methanesulfonate 0 -- sdtK70 0 -- sdtK85 0 Yes sdtM120 0 Yes sdtO159 ethyl methanesulfonate 0 -- sdtP10 P-element activity Delta2-3 0 -- sdtSc159 ethyl methanesulfonate 0 -- sdtU60 ethyl methanesulfonate 0 -- sdtunspecified 0 -- sdtXH21 0 -- sdtXP 0 Yes
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sdt Class Mutagen Stocks Known lesion sdtGD15292 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes sdtGD8984 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtGD8985 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtGD9163 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtGL00193 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtHMS00851 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtHMS00953 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtKK107407 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdtA.Scer\UAS.SV40 in vitro construct - regulatory fusion 0 Yes sdtA.Scer\UAS in vitro construct - regulatory fusion 0 Yes sdtB.Scer\UAS in vitro construct - regulatory fusion 0 Yes sdtdsRNA.MAGUK in vitro construct - RNAi 0 Yes sdtdsRNA.N-term in vitro construct - RNAi 0 Yes sdtdsRNA.SH3 in vitro construct - RNAi 0 Yes sdtexon3.Scer\UAS.SV40.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sdtGD8982 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes sdtScer\UAS.GUK in vitro construct - regulatory fusion 0 Yes sdtScer\UAS.MAGUK in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC187 (Popodi et al., 2010-) Tp(1;2)sn+72d (Berger et al., 2007)
Disrupted in	Df(1)RA2 (Tearle and Nusslein-Volhard, 1987, Harbecke and Lengyel, 1995) Df(1)sn+72d (Wieschaus et al., 1984) Ts(1Lt;YLt)B17 (Muller et al., 1999) Ts(1Rt;YLt)B139 (Muller et al., 1999) Ts(1Rt;YLt)W23 (Muller et al., 1999)
Not disrupted in	Df(1)KA14 (Tearle and Nusslein-Volhard, 1987) Tp(1;2)sn+72d (Wieschaus et al., 1984)
Not duplicated in	Dp(1;2)w+64b (Eberl and Hilliker, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8982} NA P{GD8984} NA P{GD8985} NA P{GD9163} NA P{GD15292} NA P{KK107407} NA P{TRiP.GL00193} NA P{TRiP.HMS00851} NA P{TRiP.HMS00953} NA P{UAS-sdt.A.SV40} NA P{UAS-sdt.A} NA P{UAS-sdt.B} NA P{UAS-sdt.exon3.SV40.eGFP} NA P{UAS-sdt.GUK} NA P{UAS-sdt.MAGUK} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}sdtEP1143 NA P{EP}sdtG1472 NA P{Mae-UAS.6.11}sdtGG01001 NA P{Mae-UAS.6.11}sdtGG01055 NA P{Mae-UAS.6.11}sdtGG01258 NA P{XP}sdtd00160 NA P{XP}sdtd00185 NA P{XP}sdtd04460 NA P{XP}sdtd05058 NA P{XP}sdtd05475 NA miscellaneous insertions P{}sdtP10 NA P{GT1}sdtBG01114 NA P{RS3}sdtCB-5259-3 NA P{RS5}sdt5-SZ-3206 NA P{SUPor-P}sdtKG01390 NA P{SUPor-P}sdtKG01701 NA PBac{PB}sdtc04685 NA PBac{WH}sdtf01364 NA PBac{WH}sdtf03672 NA insertion of enhancer trap binary system P{GawB}sdtNP0160 No P{GawB}sdtNP0977 No P{GawB}sdtNP2290 No P{GawB}sdtNP4094 No insertion of enhancer trap P{lacW}l(1)G0463G0463 No
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with par-6 (Wang et al., 2004)
Biological Process
CV term Evidence References
chitin-based cuticle development inferred from mutant phenotype (Horne-Badovinac and Bilder, 2008) establishment or maintenance of epithelial cell apical/basal polarity inferred from expression pattern (Hong et al., 2001, Bachmann et al., 2001) inferred from mutant phenotype (Hong et al., 2001, Bachmann et al., 2001) inferred from physical interaction with crb (Hong et al., 2001, Bachmann et al., 2001) NOT establishment or maintenance of neuroblast polarity inferred from expression pattern (Bachmann et al., 2001) inferred from mutant phenotype (Hong et al., 2001, Bachmann et al., 2001) establishment or maintenance of polarity of embryonic epithelium inferred from mutant phenotype (Hong et al., 2001) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) zonula adherens assembly inferred from mutant phenotype (Nam and Choi, 2003, Bachmann et al., 2001)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Hong et al., 2001) apical cortex inferred from direct assay (Hong et al., 2001) apical plasma membrane inferred from direct assay (Hong et al., 2001) apicolateral plasma membrane inferred from direct assay (Bachmann et al., 2001) plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
guanylate kinase activity inferred from sequence or structural similarity with EMBL:AF079366 (FlyBase, 1992-) inferred from sequence or structural similarity with mouse Mpp5 (Hong et al., 2001, Bachmann et al., 2001) non-traceable author statement (Bachmann, 2001.8.23)
Biological Process
CV term Evidence References
cell-cell junction assembly non-traceable author statement (Bilder et al., 2002, Wedlich, 2002) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) morphogenesis of an epithelium non-traceable author statement (Cereijido et al., 2003) traceable author statement (Tepass et al., 2001) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) zonula adherens assembly traceable author statement (Tepass et al., 2001)
Cellular Component
CV term Evidence References
apical plasma membrane non-traceable author statement (Wedlich, 2002) traceable author statement (Tepass et al., 2001) cell-cell adherens junction non-traceable author statement (Bilder et al., 2002) membrane inferred from sequence or structural similarity with EMBL:AF079366 (FlyBase, 1992-) non-traceable author statement (Bachmann, 2001.8.23) plasma membrane inferred from sequence or structural similarity with EMBL:AF079366 (FlyBase, 1992-) septate junction traceable author statement (Wedlich, 2002) subapical complex traceable author statement (Medina et al., 2002)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sdt allele Gene References sdtEH681 arm (Greaves et al., 1999) l(2)gl (Tanentzapf and Tepass, 2003) scrib (Tanentzapf and Tepass, 2003) sdtN5 Ras85D (Pagliarini and Xu, 2003) unspecified baz (Hong et al., 2001) crb (Hong et al., 2001) shg (Greaves et al., 1999)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261873 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44861
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA17100
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12091 LH21887 ISCW017172 FBgn0233336 FBgn0227144 FBgn0206555 FBgn0166184 JGI_V11_192312 FBgn0077114 FBgn0157963 FBgn0137125 FBgn0131559 FBgn0111510 FBgn0097370 CPIJ002874 BGIBMGA008411 ACYPI000348 GB18930 AGAP002711 AAEL014012 PB21938 PB21942 PHUM287330 GLEAN_07820
Stocks & Reagents
Stocks Listed in FlyBase ( 26 )
Bloomington	2181 y1 sdtXN/FM7c 33545 w* P{EP}sdtG1472
Harvard	- P{XP}sdtd00160 - P{XP}sdtd00185 - PBac{PB}sdtc04685 - PBac{WH}sdtf03672
Kyoto	106731 y1 sdtXN/FM7c
VDRC	v100685 P{KK107407}VIE-260B v19428 w1118; P{GD8985}v19428 v23822 w1118; P{GD9163}v23822 v43660 w1118; P{GD8984}v43660 v29844 w1118; P{GD15292}v29844
	More stocks available...
Genomic Clones ( 1 )
	BACR39F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 97 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10588 IP15645 RE05272 RE21473 RE70031 RH69430
Other clones	IP15845 MIP10078 MIP15553
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE14379 RE55671 RE70785 RH17925 RH44007 RH54761
Other clones	7988 8020 8082 33945 34016 38441 43380 43428 44178 46259 57203 57270 71395 102414 103892 103914 104167 105315 123247 144681 146913 150071 178474 193049 214217.10 214281.7 214311.20 214351.21 214477.19 214533.22 272943 CK01.66D.A4 CK01.71A.D1 CK01.80A.D6 CK01.96A.D3 EK056413 EK105811 EK105833 EK105835 EK116807 EK138208 EK140437 EK151634 EK159522 EK165001 EK165056 EK174424 EK177411 EK177620 EK186005 EK189108 EK199740 EK226763 EK227128 EK244001 EK246213 EK249562 EK250923 EK255921 EK296262 EK299920 EP02225 EP04011 EP04030 EP05821 EP09616 IP09414 IP15745 RP004085271 RP004117206 RP004196927 RP004197845 RP004199298 RP004207766 RP004208047 RP004233670 RP004259113 RP004260444 RP004292477 RP004478893 RP004487008 RP004510334
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261873 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31757 44861 326236
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sdt CG1617 CG15341 (FlyBase, 1996-)
Source for database merge of	Source for merge of: CG12658 sdt (Bachmann et al., 2001) Source for merge of: sdt anon-EST:fe2E6 (FlyBase, 1996-) Source for merge of: sdt BP1063 (FlyBase, 1996-) Source for merge of: sdt CG12657 (FlyBase Genome Annotators, 2007) Source for merge of: sdt CG15340 (FlyBase Genome Annotators, 2002-2003)
Additional comments	The release 5.2 annotation CG32717 (which corresponds to sdt) contains sequences corresponding to the release 2 annotation CG12657 (the transcript containing these sequences that was deleted in release 5.1 due to lack of evidence has been reinstated in release 5.2 due to new supporting evidence). (FlyBase Genome Annotators, 2007) The release 3.2 CG32717 annotation was made as a result of merging sequences corresponding to the release 3.1 annotations CG32717, CG15342 and CG32716 and the release 2 annotation CG12657. However, two CG32717 transcripts have been deleted due to lack of evidence in release 5.1, which means that the release 5.1 CG32717 annotation (which corresponds to sdt) no longer contains sequences corresponding to the annotations CG32716 and CG12657. Thus, sequences corresponding to CG32716 and CG12657 are no longer annotated on the genome in release 5.1. (FlyBase Genome Annotators, 2006) Annotations CG32717, CG15342, CG32716 and CG12657 merged as a single annotation (CG32717, which corresponds to sdt) in release 3.2 of the genome annotation. (FlyBase Genome Annotators, 2004) Annotations CG12658, CG15340 and CG1617 merged as CG32717 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) "l(1)G0463" may affect "sdt". (Peter et al., 2002) Source for identity of sdt CG1617 CG15341 was sequence comparison (date:011219). (FlyBase, 1996-)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) sdt is required for the regionalization of apical membrane into stalk membranes and rhabdomeres. (Hong et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) sdt provides an essential component of the Subapical complex. (Bachmann et al., 2001) sdt is a partner of crb in the control of epithelial cell polarity in the developing embryo. (Bachmann et al., 2001) sdt interacts with crb to control polarity of epithelia but not neuroblasts. (Hong et al., 2001) Loss of cell polarity in the epidermal primordium of sdt mutant embryos is associated with a failure to establish the zonulae adherentes. These junctions fail to develop when an altered polarity is induced by the overexpression of crb. crb and sdt have different functions during the formation of the zonula adherens. (Grawe et al., 1996) Embryos mutant for arm and sdt baz double mutant embryos have very similar early phenotypes with respect to zonula adherens formation. Results suggest that early stages in the assembly of the zonula adherens are critical for the stability of the polarised blastoderm epithelium. (Muller and Wieschaus, 1996) crb and sdt are required for the third step in zonula adherens formation. The marginal zone of the apical membrane may contain a crb- and sdt-dependent retention mechanism for adherens junction material that facilitates zonula adherens formation. (Tepass, 1996) crb and sdt encode critical components of a pathway that acts at the apical pole of epithelial cells to control their cytoarchitecture. Mosaic experiments suggest that sdt though not crb is required cell autonomously. Double mutant analysis suggests that sdt acts downstream of and is activated by crb. (Tepass and Knust, 1993) Zygotically active locus involved in the terminal developmental program in the embryo. (Strecker et al., 1991) A screen for X-linked genes that affect embryo morphology revealed sdt. (Eberl and Hilliker, 1988) sdt mutants display almost total absence of hypoderm, small patches of cuticle remain. (Wieschaus et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132235 NM_206652 NM_206653 NM_001038746 NM_001038747 NM_001042798 RefSeq (Proteins) • NP_572463 NP_996375 NP_996376 NP_001033835 NP_001033836 NP_001036263 DDBJ / EMBL / GenBank • AA433261 AAF46349 AAF46349.2 AAF46350 AAF46350.2 AAF46351 AAF46351.2 AAL40935 AAL40936 AAQ23599 AAS65283.1 AAS65284 AAS65284.1 ABC67176 ABC67177 ABI30970 AF414117 AF414118 BI165388 BI486582 BI622835 BT010281 CX309577 CX309578 CZ471437 CZ474550 DQ450340 DQ450341 DQ450342 DQ450343 DQ450344 DQ450345 DQ450346 DQ450347 DQ450348 DQ450349 DQ450350 DQ450351 DQ450352 DQ450353 DQ450354 DQ450355 Entrez Gene - A searchable database of RefSeq genes. • 44861 UniProtKB/TrEMBL • E2QD98 Q0KHU9 Q6NR03 Q7KVT3 Q8WRS2 Q8WRS3 Q9W3H6 Q9W3H7 Q9W3H8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • L27, C-terminal (IPR014775) Variant SH3 (IPR011511) Guanylate kinase/L-type calcium channel (IPR008145) Guanylate kinase (IPR008144) L27 (IPR004172) PDZ/DHR/GLGF (IPR001478) Src homology-3 domain (IPR001452) Guanylate kinase, conserved site (IPR020590)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261873 DRSC - Results from RNAi screens. • FBgn0261873 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261873 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31757 44861 326236 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44861 modMine - Data generated by the modENCODE project. • FBgn0261873 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12091 LH21887 ISCW017172 FBgn0233336 FBgn0227144 FBgn0206555 FBgn0166184 JGI_V11_192312 FBgn0077114 FBgn0157963 FBgn0137125 FBgn0131559 FBgn0111510 FBgn0097370 CPIJ002874 BGIBMGA008411 ACYPI000348 GB18930 AGAP002711 AAEL014012 PB21938 PB21942 PHUM287330 GLEAN_07820
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	anon-EST:fe2E6   BP1063   CG1617   CG12657 (Ringrose et al., 2003, Stronach and Perrimon, 2002, ) CG12658   CG15339 (Luschnig, 2003.12.17) CG15340   CG15341 (Boutros et al., 2004, ) CG15342   CG32717 (Keleman et al., 2009.8.5, Khanna et al., 2010, Ni et al., 2010.12.1, Ni et al., 2011.7.19) l(1)7Ef   pal1 (Wiggin et al., 2005) PALS1 (Peterson et al., 2004) Pals1 (Suzuki and Ohno, 2006) Sdt (Pocha et al., 2011, Le Bivic, 2005, Kolsch et al., 2007, Wu et al., 2007, Wang et al., 2004, Suzuki and Ohno, 2006, Grzeschik et al., 2007, Xu et al., 2008, Chen et al., 2010, Bachmann et al., 2008, Ling et al., 2010, Letizia et al., 2011, Richard et al., 2009) sdt (Richardson and Pichaud, 2010, Popodi et al., 2010-, Djiane et al., 2005, Nam and Choi, 2006, Berger et al., 2007, Horne-Badovinac and Bilder, 2008, Li et al., 2008, Wang and Riechmann, 2007, Gilchrist et al., 2008, Leandro et al., 2007, Bulgakova et al., 2008, Herranz et al., 2006, Courbard et al., 2009, Morais-de-Sá et al., 2010, Franz and Riechmann, 2010, Walther and Pichaud, 2010, Fichelson et al., 2010, Krahn et al., 2010, Ohsawa et al., 2011, Wasbrough et al., 2010) Std (Bachmann et al., 2004, Wu and Beitel, 2004) std (Lammel and Saumweber, 2000, Yu et al., 1999) unnamed (Yandell et al., 2005)
Name Synonym	anon-fast-evolving-2E6   BP1063   CG12657   Stardust (Pocha et al., 2011, Humbert et al., 2006, Bulgakova and Knust, 2007, Tountas and Fortini, 2007, Wang et al., 2004, Margolis and Borg, 2005, Suzuki and Ohno, 2006, Nam and Choi, 2006, Li et al., 2008, Wang and Riechmann, 2007, Xu et al., 2008, Morais-de-Sá et al., 2010, Khanna et al., 2010, Franz and Riechmann, 2010, Walther and Pichaud, 2010, Chen et al., 2010, Ling et al., 2010, Kempkens et al., 2006) stardust (Berger et al., 2007, Horne-Badovinac and Bilder, 2008, Huang et al., 2009, Herranz et al., 2006, Fichelson et al., 2010)
Secondary FlyBase IDs
	FBgn0001465 FBgn0003349 FBgn0025216 FBgn0030019 FBgn0030020 FBgn0030021 FBgn0030022 FBgn0030023 FBgn0030024 FBgn0040927 FBgn0052716 FBgn0052717 FBgn0082843 FBgn0243505
References ( 163 )
Generate a list of	All references relating to this gene ( 163 )
List References by type	Research paper  ( 67 ) Supplementary material  ( 9 ) Review  ( 45 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 15 ) FlyBase analysis  ( 7 ) Conference report  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Spoof  ( 1 ) Interview  ( 1 )
Recent research papers ( 11 )
	Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Pocha et al., 2011, Curr. Biol. 21(13): 1111--1117 Retromer controls epithelial cell polarity by trafficking the apical determinant crumbs. [FBrf0214250] Chen et al., 2010, PLoS ONE 5(3): e9480 Role of Spastin in Apical Domain Control along the Rhabdomere Elongation in Drosophila Photoreceptor. [FBrf0210148] Fichelson et al., 2010, Development 137(5): 815--824 lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. [FBrf0209930] Franz and Riechmann, 2010, Dev. Biol. 338(2): 136--147 Stepwise polarisation of the Drosophila follicular epithelium. [FBrf0209855] Krahn et al., 2010, J. Cell Biol. 190(5): 751--760 Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. [FBrf0211675] Ling et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10532--10537 The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. [FBrf0211036] Morais-de-Sá et al., 2010, Cell 141(3): 509--523 aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. [FBrf0210663] Richardson and Pichaud, 2010, Development 137(4): 641--650 Crumbs is required to achieve proper organ size control during Drosophila head development. [FBrf0209872] Walther and Pichaud, 2010, Curr. Biol. 20(12): 1065--1074 Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling. [FBrf0211169] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...