eld, eyelid, l(3)00090, C819
transcription factor - Bright family - associates with the Brahma chromatin remodeling complex - antagonizes Wingless signaling during Drosophila development and affects patterning of the eye imaginal disc
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
10.601 (sequence analysis)
Component of the Brahma complex, which is composed of Brm, Osa, Mor, Snr1/Bap45, Bap111/Dalao, Bap55, Bap60 and Bap47. Interacts with Pnr and Chi via its EHD domain.
The ARID domains mediates the binding to DNA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\osa using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\osa in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: osa CG7467
D.melanogaster contains two distinct brahma (BRM) complexes: the BAP complex, defined by the presence of osa protein and the absence of both polybromo and Bap170 proteins, and the PBAP complex, which contains the polybromo and Bap170 proteins but lacks the osa protein.
Area matching Drosophila EST AA201670.
osa may be involved in signalling through N or wg pathways. osa protein is expressed ubiquitously in the early embryos and in imaginal discs and is localised to the nucleus where results suggests it counteracts the effects of wg on its target genes.
Mosaic analysis in eye discs suggests a function for osa in cell proliferation and/or survival and neuronal differentiation.
osa is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of AntpScx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not.
"osa" means "fate" in Norwegian.