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Gene Dmel\CG42796

General Information
Symbol	Dmel\CG42796	Species	D. melanogaster
Name		Annotation symbol	CG42796
Feature type	protein_coding_gene	FlyBase ID	FBgn0261929
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CG8007
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85A5-85A5	Sequence location	3R:4,403,927..4,452,743 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG42796 (FBgn0261929). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serotonin receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: serotonin receptor signaling pathway. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: GPCR, rhodopsin-like superfamily; GPCR, rhodopsin-like, 7TM. Gene sequence location is 3R:4403927..4452743.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA16362 HFA16360 BKN31548 BKN30711
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85A5-85A5   Limits computationally determined from genome sequence between P{EP}EP833 and P{lacW}l(3)L4740L4740
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG42796 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on RNA-Seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG42796-RD FBtr0303603  NM_141549   3358   904
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG42796-PD   FBpp0292636   99.5   904   9.49     NP_649806   AAN13390
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GPCR, rhodopsin-like, 7TM (IPR000276) GPCR, rhodopsin-like superfamily (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141456   AA141593   AA141655   AA141714   AA141885   AA142289   AE014297 AAN13390   AI386899   AI533463   AX254527   AX254528   AX254530   AX254531   BF489526   BG637093   BI142092   BI358319   BI367893   BI368978   BI566503   BI571671   BI571679   BI588633   BI589043   BI604852   BI638345   BI639929   BT029086   CO177549   CO178669   CO179410   CO179610   CO188508   CO196399   CO262294   CO263378   CO265804   CO266018   CO266528   CO267012   CO268279   CO268775   CO268945   CO269723   CO269956   CO270891   CO271243   CO271944   CO272166   CO272320   CO273402   CO273774   CO275886   CO278056   CO279733   CO280398   CO280947   CO281268   CO281528   CO281955   CO281956   CO284589   CO284981   CO285421   CO286248   CO286446   CO286890   CO288445   CO291601   CO291625   CO292457   CO293028   CO294536   CO294915   CO295160   CO295477   CO296503   CO299908   CO300458   CO300848   CO302228   CO302803   CO303448   CO304688   CO304728   CO308750   CO309979   CO311288   CO312884   CO314047   CO315692   CO316193   CO316223   CO320331   CO321061   CO321607   CO322659   CO325971   CO325983   CO326143   CO326309   CO326933   CO327053   CO328882   CO329578   CO331136   CO331743   CO331749   CO332242   CO336331   CO339030   CO339033   CO339323   CO339724   CO339761   CO340147   CO340901   CO341425   CO341811   CO342049   CO342388   CO343822   CO344057   CO344644   EC055697   EL881573   EL881574   EL881664   EL881748   EL881749   FE527339
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHP7 Q8INQ6 Q9VHP6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG42796GD678 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG42796 Class Mutagen Stocks Known lesion CG42796MB11858 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG42796 Class Mutagen Stocks Known lesion CG42796GD677 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG42796GD678 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG42796JF01913 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG42796KK111548 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6149 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG42796MB11858 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
serotonin receptor activity inferred from sequence or structural similarity with 5-HT2 (Brody and Cravchik, 2000)
Biological Process
CV term Evidence References
serotonin receptor signaling pathway inferred from sequence or structural similarity with 5-HT2 (Brody and Cravchik, 2000)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with 5-HT2 (Brody and Cravchik, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG42796 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261929 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41017
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18663 Dere\GG11177 Dere\GG11288 Dgri\GH17565 Dgri\GH17576 Dmoj\GI22528 Dper\GL23028 Dpse\GA20762 Dsec\GM23743 Dsec\GM23744 Dsim\GD18553 Dsim\GD18555 Dvir\GJ10131 Dwil\GK13210 Dwil\GK13212 Dyak\GE25886 Dyak\GE25887
Curated drosophilid orthologs	Dpse\GA20750   Dpse\GA20762
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10899 LH13266 FBgn0242937 FBgn0215221 FBgn0197419 FBgn0190077 FBgn0186815 FBgn0178609 FBgn0080752 FBgn0160618 FBgn0145256 FBgn0125035 FBgn0103478 FBgn0095681 CPIJ011881 ACYPI50707 GB30297 AGAP002229 GPR5HT9 GPR5HT8 GPR5HT6 PHUM440560 PHUM534440 GLEAN_13982
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	25874 y1 v1; P{TRiP.JF01913}attP2 29257 w1118; Mi{ET1}CG42796MB11858
VDRC	v102356 P{KK111548}VIE-260B v11461 w1118; P{GD678}v11461 v11462 w1118; P{GD678}v11462 v51385 w1118; P{GD677}v51385 v51427 w1118; P{GD677}v51427
Genomic Clones ( 3 )
	BACR01F13 BACR03F16 BACR48A14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 124 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP11261
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25571 GH17272 RE45055 RE53763 RE55048 RH06941 RH06949 RH30020 RH30716 RH36065 RH70341 SD05284 SD14952 SD16092 SD20610 SD22651
Other clones	CK01358 CK01771 CK02256 CK02584 CK02684 CK02693 DMG3-chr3R.8402.pred.a EC055697 EK004047 EK040554 EK053803 EK057316 EK059327 EK060011 EK062229 EK062839 EK064209 EK068527 EK084963 EK088356 EK090809 EK092643 EK093145 EK095703 EK097007 EK100937 EK102527 EK105244 EK106046 EK106728 EK110833 EK112136 EK119043 EK128624 EK135752 EK143704 EK144714 EK146664 EK148339 EK153953 EK155537 EK156329 EK157360 EK159162 EK159163 EK166349 EK167802 EK168941 EK176904 EK178232 EK179526 EK183708 EK184927 EK186020 EK188604 EK197806 EK197836 EK200229 EK201531 EK207145 EK207953 EK208757 EK209943 EK213836 EK220109 EK224049 EK230464 EK234764 EK241457 EK245728 EK245947 EK259242 EK262215 EK263921 EK264004 EK284052 EK290234 EK291606 EK293141 EK298525 EK301608 EK301618 EK302908 EN12324 EP00644 EP00647 EP01622 EP03007 EP03024 EP03318 EP03630 EP05010 EP05631 EP09350 EP10112 EP11538 EP12425 EP13216 EP13712 EP14817 EP18140 EP18609 EP19647 EP22363 IP11361 IP11461 IP11561
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261929 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41016 41017
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG7994 anon-WO0170980.94 anon-WO0170980.95 (FlyBase, 1996-) Source for merge of: CG7994 CG8007 (FlyBase Genome Annotators, 2010) Source for merge of: CG8007 anon-WO0170980.97 anon-WO0170980.98 (FlyBase, 1996-)
Additional comments	Annotations CG7994 and CG8007 merged as CG42796 in release 5.29 of the genome annotation. (FlyBase Genome Annotators, 2010) Source for merge of CG8007 anon-WO0170980.97 anon-WO0170980.98 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of CG7994 anon-WO0170980.94 anon-WO0170980.95 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141549 RefSeq (Proteins) • NP_649806 DDBJ / EMBL / GenBank • AAF54254 AAF54255 AAN13390 AX254527 AX254528 AX254530 AX254531 Entrez Gene - A searchable database of RefSeq genes. • 41016 41017 UniProtKB/TrEMBL • Q8INQ6 Q9VHP6 Q9VHP7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GPCR, rhodopsin-like, 7TM (IPR000276) GPCR, rhodopsin-like superfamily (IPR017452)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261929 DRSC - Results from RNAi screens. • FBgn0261929 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261929 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41016 41017 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41017 modMine - Data generated by the modENCODE project. • FBgn0261929 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10899 LH13266 FBgn0242937 FBgn0215221 FBgn0197419 FBgn0190077 FBgn0186815 FBgn0178609 FBgn0080752 FBgn0160618 FBgn0145256 FBgn0125035 FBgn0103478 FBgn0095681 CPIJ011881 ACYPI50707 GB30297 AGAP002229 GPR5HT9 GPR5HT8 GPR5HT6 PHUM440560 PHUM534440 GLEAN_13982
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	anon-WO0170980.94   anon-WO0170980.95   anon-WO0170980.97   anon-WO0170980.98   CG7994   CG8007 (Goldman and Arbeitman, 2007, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5) CG42796 (FlyBase Genome Annotators, 2010)
Name Synonym
Secondary FlyBase IDs
	FBgn0037599 FBgn0037600 FBgn0046494 FBgn0046495 FBgn0046496 FBgn0046497
References ( 15 )
Research paper	Goldman and Arbeitman, 2007, PLoS Genet. 3(11): e216 Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. [FBrf0202597] Brody and Cravchik, 2000, J. Cell Biol. 150(2): F83--F88 Drosophila melanogaster G Protein-coupled Receptors. [FBrf0129744]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2009.10.19, BDGP_2009_1020.GDP.xml BDGP_2009_1020.GDP.xml [FBrf0208884] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 1.15.2009, Initial TRiP stock collection. Initial TRiP stock collection. [FBrf0206489] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Genome Annotators, 2010, Changes affecting gene model number or type in release 5.29 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.29 of the annotated D.melanogaster genome. [FBrf0210863] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Curated genome annotation	Cravchik, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126659]
Patent	Cravchik, 2001.9.27, World Patent 0170980-A: Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets. [FBrf0141235]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]