Gene Dmel\mtRNApol

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General Information

Symbol

Dmel\mtRNApol

Species

D. melanogaster

Name

mitochondrial RNA polymerase

Annotation symbol

CG4644

Feature type

protein_coding_gene

FlyBase ID

FBgn0261938

Gene Model Status

Current

Stock availability

1 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

21F1-21F1

Sequence location

2L:1,103,254..1,108,373 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene mitochondrial RNA polymerase is referred to in FlyBase by the symbol Dmel\mtRNApol (CG4644, FBgn0261938). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed RNA polymerase activity. Based on sequence similarity, it is predicted to be involved in the biological process: transcription, DNA-dependent. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA-directed RNA polymerase, helix hairpin domain; DNA-directed RNA polymerase, phage-type; Pentatricopeptide repeat. Gene sequence location is 2L:1103254..1108373.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21F1-21F1

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\mtRNApol for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

mtRNApol-RA

FBtr0077989

NM_134721

4489

1369

mtRNApol-RB

FBtr0332273

NM_001272924

4718

1369

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

mtRNApol-PA

FBpp0077654

156.8

1369

8.96

NP_608565

AAF51421

mtRNApol-PB

FBpp0304562

156.8

1369

8.96

NP_001259853

AGB92390

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

DNA-directed RNA polymerase, helix hairpin domain (IPR024075)

DNA-directed RNA polymerase, phage-type (IPR002092)

Pentatricopeptide repeat (IPR002885)

MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins

•

MTDROME04644

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		6
central nervous system, pupae P8		6
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		6
head, mated 1-day female		5
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		6
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		4
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		3
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		7
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		8
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		11
embryo 04-06hr		7
embryo 06-08hr		10
embryo 08-10hr		16
embryo 10-12hr		15
embryo 12-14hr		14
embryo 14-16hr		17
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		16
embryo 22-24hr		14
larva L1		18
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		13
pupae 4d postWPP		8
adult male 01day		11
adult male 05day		14
adult male 30day		13
adult female 01day		16
adult female 05day		15
adult female 30day		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		7
Schneider line 2 Sg4		6
embryonic 1182-4H		12
embryonic GM2		8
embryonic Kc167		12
embryonic S1		8
embryonic S3		7
leg disc CME L1		6
wing disc CME-W2		5
wing disc ML-DmD8		5
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		5
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		8
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		9
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		5
cold shock, 4-day adult		3
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		2
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		5
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		12
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		5
Paraquat 5 mM 48 hrs, 4-day adult		11
Paraquat 10 mM 48 hrs, 4-day adult		13
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_19

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Other Phenotypes

Allele

decreased cell number | conditional

mtRNApol^A4A7

size defective | adult stage | conditional

mtRNApol^B12-3

visible | adult stage | conditional

mtRNApol^B12-3

visible | conditional

mtRNApol^A4A7

Phenotype manifest in

Allele

eye | conditional

eye disc | conditional

mtRNApol^A4A7

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of mtRNApol	Class	Mutagen	Stocks	Known lesion
mtRNApol^A4A7		ethyl methanesulfonate	0	Yes
mtRNApol^B12-3		ethyl methanesulfonate	0	Yes

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mtRNApol	Mutagen	Stocks	Known lesion
mtRNApol^HMS01474	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
mtRNApol^GD4179	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
mtRNApol^KK101096	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
mtRNApol^NIG.4644R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)Exel6004

(Ryder, 2004.4.26)

Df(2L)Exel9037

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{KK101096}

P{NIG.4644R}

P{TRiP.HMS01474}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

DNA binding

inferred from electronic annotation with InterPro:IPR002092

(FlyBase Curators et al., 2004-)

DNA-directed RNA polymerase activity

inferred from sequence or structural similarity with UniProtKB:O00411

(Sardiello et al., 2003.6.11)

Biological Process

CV term

Evidence

References

transcription, DNA-dependent

inferred from sequence or structural similarity with UniProtKB:O00411

(Sardiello et al., 2003.6.11)

Cellular Component

CV term

Evidence

References

mitochondrion

inferred from sequence or structural similarity with UniProtKB:O00411

(Sardiello et al., 2003.6.11)

inferred from sequence or structural similarity with UniProtKB:P13433

(FlyBase, 1992-)

Sequence Ontology: Class of Gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

mtRNApol - CG3303

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

mtRNApol allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0261938

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

33285

Orthologs

OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6FJ8V5

Dipteran inclusive ortholog search

EOG6T78B7

Insect inclusive ortholog search

EOG6WM3PK

Arthropod inclusive ortholog search

EOG641NS8

Metazoa inclusive ortholog search

EOG6X6R23

Orthologs in Drosophila Species (EOG6FJ8V5)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18324

Drosophila persimilis

Dper\GL15084

Drosophila willistoni

Dwil\GK24692

Drosophila virilis

Dvir\GJ17831

Drosophila mojavensis

Dmoj\GI21974

Drosophila grimshawi

Dgri\GH13202

Orthologs in non-Drosophila Dipterans (EOG6T78B7)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001847

Anopheles gambiae

Malaria mosquito

Agam\AGAP007778

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000972

Orthologs in non-Dipteran Insects (EOG6WM3PK)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB51124

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025557

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH18387

Atta cephalotes

Leafcutter ant

Acep\ACEP14053

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO19900

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL21682

Linepithema humile

Argentine ant

Lhum\LH22641

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB14018

Solenopsis invicta

Red fire ant

Sinv\SINV17967

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006506

Bombyx mori

Silkmoth

Bmor\BGIBMGA008929

Pediculus humanus

Human body louse

Phum\PHUM190140

Tribolium castaneum

Red flour beetle

Tcas\TC006188

Orthologs in non-Insect Arthropods (EOG641NS8)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\CHS1

Daphnia pulex

Water flea

Dpux\JGI_V11_264936

Ixodes scapularis

Deer tick

Isca\ISCW007313

Orthologs in non-Arthropod Metazoa (EOG6X6R23)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\Y105E8A.23

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019062gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_011745gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020939gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003910gn

Danio rerio

Zebrafish

Drer\si:dkey-21e2.1

Xenopus tropicalis

Western clawed frog

Xtro\polrmt

Gallus gallus

Domestic chicken

Ggal\POLRMT

Mus musculus

House mouse

Mmus\Polrmt

Rattus norvegicus

Norway rat

Rnor\Polrmt

Homo sapiens

Human

Hsap\POLRMT

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\POLRMT

AAA Orthologs (10) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18324

Drosophila willistoni

Dwil\GK24692

Drosophila virilis

Dvir\GJ17831

Drosophila mojavensis

Dmoj\GI21974

Drosophila grimshawi

Dgri\GH13202

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

Bloomington

35732

y¹ sc^* v¹; P{TRiP.HMS01474}attP2

Genomic Clones ( 1 )

BACR35O22

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 10 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0261938

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

33285

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: mtRNApol CG4644

(Fernández-Moreno et al., 2009)

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

33285

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

DNA-directed RNA polymerase, helix hairpin domain (IPR024075)

DNA-directed RNA polymerase, phage-type (IPR002092)

Pentatricopeptide repeat (IPR002885)

MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins

•

MTDROME04644

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0261938

DRSC - Results from RNAi screens.

•

FBgn0261938

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0261938

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

33285

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

33285

modMine - Data generated by the modENCODE project.

•

FBgn0261938

Synonyms & Secondary IDs ( 6 )

Reported As

Symbol Synonym

CG4644

(Fernández-Moreno et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Japanese National Institute of Genetics, 2012.5.21)

mt RNA pol

(Sardiello et al., 2005)

mtRNApol

(Fernández-Moreno et al., 2009, Gerhold et al., 2011)

mtRNA-pol

(Barnes et al., 2010)

POLRMT

(Bruni et al., 2012)

Name Synonym

mitochondrial RNA polymerase

(Fernández-Moreno et al., 2009, Gerhold et al., 2011)

Secondary FlyBase IDs

FBgn0031300
FBgn0261273

References ( 19 )

Research paper

Bruni et al., 2012, Mitochondrion 12(5): 492--499: D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. [FBrf0219394]
Gerhold et al., 2011, Genetics 189(4): 1309--1326: Identification and characterization of genes required for compensatory growth in Drosophila. [FBrf0217000]
Barnes et al., 2010, BMC Biochem. 11: 26: Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function. [FBrf0211360]
Fernández-Moreno et al., 2009, Biochem. J. 418(2): 453--462: The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF. [FBrf0206941]

Supplementary material

The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]

Review

Sardiello et al., 2005, Trends Genet. 21(1): 12--15: Energy biogenesis: one key for coordinating two genomes. [FBrf0183426]

Personal communication to FlyBase

Ni et al., 2011.7.19, TRiP germline vector pVALIUM21.: TRiP germline vector pVALIUM21. [FBrf0214641]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project: DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion.: MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903]
Oliver, 2001.8.16, Genome Res.:: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Curated genome annotation

FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.]: [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]
Find Enzymes, 1999.11, [Automatic annotations performed at the Celera Jamboreee.]: [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126664]