Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\srw using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\srw in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene.
Mutants are isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis: mutants exhibit dorsal/ventral polarity pattern defects.
Genetic and phenotypic data reveals that srw is involved in post-transcriptional regulation of dpp activity by elevating dpp activity dorsally. Mutations in srw disrupt amnioserosa formation. Injection of dpp RNA into the ventral side results in an asymmetric response, lateral expansion of the preexisting dorsal amnioserosa rather than formation of a second amnioserosa at the site of injection.
srw alleles display relative phenotypic strengths, this may be correlated to the progressive loss of dorsal pattern elements in the ventralised mutants.
srw is required for the normal ontogeny of the zen pattern and fating of the amnioserosa.