AP-2, dAP-2, l(3)1215, AP-2α
transcription factor that plays essential roles in leg and proboscis outgrowth - involved in development of the adult brain central complex
Please see the JBrowse view of Dmel\TfAP-2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
2.0 (longest cDNA)
None of the polypeptides share 100% sequence identity.
416 (aa); 50 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TfAP-2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
TfAP-2-protein co-localizes with ScerGAL4Tdc2.PC, a marker for octopaminergic neurons, in the adult gnathal ganglion and in parts of the optic lobe. In addition, TfAP-2-protein is detected in ScerGAL4Tdc2.PC-negative neurons throughout the brain.
TfAP-2 protein in expressed in three regions of the third instar male genital disc: in the A9 primordium in a medial domain on the ventral surface that encompasses the bnl-expressing cells; in the center of each half of the dorsal side of the A9 primordium; and in the center of each half of the A10 primordium.
Comment: when combined with TI{2A-GAL4(DBD)::Zip-}unc-4DBD
JBrowse - Visual display of RNA-Seq signals
View Dmel\TfAP-2 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
AP-2 is expressed in a spatio temporally restricted manner during embryogenesis with major sites of expression in the head and nervous system.
Source for merge of: AP-2 l(3)1215
Source for identity of: TfAP-2 AP-2
Renamed from 'AP-2' to 'Transcription factor AP-2' / 'TfAP-2' to avoid further confusion with the genes encoding subunits of the Adaptor Protein complex 2 (AP-2), specifically the 'Adaptor Protein complex 2, α subunit' / 'AP-2α' gene. The 'Transcription factor AP-2' / 'TfAP-2' name and symbol were used as these mirror the HGNC nomenclature for the orthologous human gene, and are clear and informative.