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Gene Dmel\l(2)gd1

General Information
Symbol	Dmel\l(2)gd1	Species	D. melanogaster
Name	lethal (2) giant discs 1	Annotation symbol	CG4713
Feature type	protein_coding_gene	FlyBase ID	FBgn0261983
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(2)gd, lgd, gd
Genomic Location
Chromosome (arm)	2L	Recombination map	2-[41]
Cytogenetic map	32D3-32D4	Sequence location	2L:11,106,912..11,110,851 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) giant discs 1 is referred to in FlyBase by the symbol Dmel\l(2)gd1 (CG4713, FBgn0261983). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phospholipid binding. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; wing disc morphogenesis; sensory organ development; compound eye development; regulation of endocytosis; regulation of Notch signaling pathway; imaginal disc-derived wing vein morphogenesis; sensory organ precursor cell division; intracellular protein transport; endosomal transport. 54 alleles are reported. The phenotypes of these alleles are annotated with: imaginal precursor; multicellular structure; thoracic segment; organ system subdivision; adult segment; organ system; sense organ; larval head segment; cytoplasmic part; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Domain of unknown function DM14. Gene sequence location is 2L:11106912..11110851.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)gd1: lethal (2) giant discs Pupariation delayed, up to nine days in crowded cultures; pupariation is but one day in uncrowded cultures. Discs continue to grow, becoming very large with long delays. Mutant discs transplanted into normal larval hosts metamorphose; cuticular patterns normal but bristles and to a greater degree sensillae and bracts missing; unguis missing from tarsal claws; tarsi two jointed. Mutant discs yield low incidence of trans-determination.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32D3-32D4   Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32D3-32D4     (Oh et al., 2003)
Experimentally Determined Recombination Data
Location	2-42.7 +/- 0.5 (Bryant and Schubiger, 1971) 2-[41]
Left of (cM)	amos Bl (Bryant and Schubiger, 1971)
Right of (cM)	wg J (Bryant and Schubiger, 1971)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)gd1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)gd1-RA FBtr0080197  NM_135644   3020   816 l(2)gd1-RB FBtr0306138  NM_001259047   3074   834
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)gd1-PA   FBpp0079786   89.0   816   5.01     NP_609488   AAF53069 l(2)gd1-PB   FBpp0297275   91.0   834   5.11     NP_001245976   AFH03650
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium/lipid-binding domain, CaLB (IPR008973) Domain of unknown function DM14 (IPR006608) C2 calcium-dependent membrane targeting (IPR000008) C2 membrane targeting protein (IPR018029)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439448   AA698450   AA940811   AE014134 AAF53069   AB082090   AE014134 AFH03650   AI404590   AI530761   AI533142   AW942661   AY058523 AAL13752   BG639487   BI167525   BI236109   BI358348   BI363033   BI367264   BI370386   BI587164   BI616964   BI623644   BI638774   CL527761   CO189396   CO261996   CO262547   CO263691   CO268298   CO270388   CO270603   CO274106   CO283730   CO289753   CO290010   CO306892   CO328574   CO342195   CO344500   EC057831   EC059327   EC070449   EC070988   EC078676   EC082474   EC088775   EC204262   EC206186   EC208275   EC208410   EC208437   EC219163   EC219903   EC230748   EC231533   EC238400   EC252467   EC256021   EV575616   GH757747   GH760195   GH761121   GH772393   GH781070   GH782575   GH796575   GH797315   GH797932   GH798497   GH798859   GH801030   GH801898   GH802642   GH803759   GH805079   GH806280   GH806710   GH812399   GH813038   GH818284   GH821102   GH821688   GH827165   GH839325   GH855828   GH856972   GH859973   GH867256   GH867410   GH868186   GH872336   GH873296   GH876412   GH877222   GH878542   GH879261   GH880790   GH885207   GH885734   GH888327   GH890383   GH895099   GH918107   GH927214   GH930085   GH933915   GH933973   GH937578   GH938262   GH938299   GH940400
UniProtKB/Swiss-Prot	Q9VKJ9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical plasma membrane inferred from direct assay (Jaekel and Klein, 2006) cytoplasm inferred from direct assay (Jaekel and Klein, 2006, Childress et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    11 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    20 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new    28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new  (28) white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new    28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new    28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new    28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new  28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new    28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    24 white prepupae new    28 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1    45 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1  (45) embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1    45 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1    45 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1    45 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1  (45) embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1    45 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    8 embryonic 1182-4H    21 embryonic GM2    21 embryonic Kc167    12 embryonic S1    45 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    18 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    8 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    15 ovary fGS/OSS    19 ovary OSC    8 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • LD23056
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone l(2)gd1d7 lethal | larval stage | recessive l(2)gd14 lethal | pharate adult stage l(2)gd1SH0495 lethal | pharate adult stage (with Df(2L)FCK-20) l(2)gd1SH0495 lethal | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 lethal | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 lethal | pharate adult stage | recessive l(2)gd11 l(2)gd1d3 lethal | pupal stage l(2)gd11 lethal | pupal stage, with Scer\GAL4pnr-MD237 l(2)gd1GD11405 lethal | pupal stage | recessive l(2)gd11 lethal | recessive l(2)gd11 l(2)gd13 l(2)gd1d3 l(2)gd1SH0495 Other Phenotypes Allele hyperplasia l(2)gd1d3 hyperplasia | recessive l(2)gd11 l(2)gd14 l(2)gd1d3 l(2)gd1d7 increased cell death | somatic clone l(2)gd1d7 tumorigenic | somatic clone l(2)gd1d7 visible l(2)gd108 l(2)gd124 visible, with Scer\GAL4C5 l(2)gd1Scer\UAS.cJa visible, with Scer\GAL4neur-P72 l(2)gd1Scer\UAS.cGa l(2)gd1ΔC2.C.Scer\UAS visible, with Scer\GAL4sca-109-68 l(2)gd1Scer\UAS.cGa visible | recessive l(2)gd11 visible | somatic clone l(2)gd108 l(2)gd124 l(2)gd1d10 Phenotype manifest in Allele antenna | pharate adult stage l(2)gd13 anterior crossvein, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa cephalopharyngeal skeleton l(2)gd1d3 l(2)gd11 denticle belt | ventral l(2)gd1d3 l(2)gd11 dorsal appendage l(2)gd1d3 l(2)gd11 dorsal appendage | germline clone l(2)gd1d3 dorsal organ l(2)gd1d3 l(2)gd11 early endosome, with Scer\GAL4neur-P72 l(2)gd1Scer\UAS.cGa early endosome | somatic clone l(2)gd108 egg l(2)gd1d3 l(2)gd11 embryonic/larval brain l(2)gd11 endosome | somatic clone l(2)gd1d7 external sensory organ l(2)gd124 l(2)gd108 external sensory organ, with Scer\GAL4neur-P72 l(2)gd1Scer\UAS.cGa l(2)gd1ΔC2.C.Scer\UAS external sensory organ, with Scer\GAL4sca-109-68 l(2)gd1Scer\UAS.cGa external sensory organ | somatic clone l(2)gd108 l(2)gd1d10 external sensory organ precursor cell, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa external sensory organ precursor cell | somatic clone l(2)gd108 eye-antennal disc l(2)gd11 genital disc l(2)gd11 haltere disc l(2)gd11 head l(2)gd124 l(2)gd108 head | somatic clone l(2)gd1d10 imaginal disc l(2)gd11 l(2)gd14 l(2)gd1d7 imaginal ring l(2)gd11 joint | ectopic | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 joint | ectopic | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 Keilin's organ l(2)gd1d3 l(2)gd11 labial disc l(2)gd11 larval head l(2)gd1d3 l(2)gd11 late endosome, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa late endosome | somatic clone l(2)gd1d7 leg | pharate adult stage l(2)gd1SH0495 macrochaeta l(2)gd11 macrochaeta | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 macrochaeta | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 macrochaeta | supernumerary, with Scer\GAL4sd-SG29.1 l(2)gd1Scer\UAS.cJa mesothoracic tarsal segment | pharate adult stage l(2)gd13 mesothoracic tergum | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 mesothoracic tergum | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 mesothoracic tergum | somatic clone l(2)gd1d7 metathoracic leg disc l(2)gd11 l(2)gd1d7 metathoracic tarsal segment | pharate adult stage l(2)gd13 microchaeta | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 microchaeta | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 postorbital bristle | somatic clone l(2)gd124 l(2)gd1d10 prothoracic tarsal segment | pharate adult stage l(2)gd13 salivary gland imaginal ring l(2)gd11 scutellar bristle, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa sensory mother cell | somatic clone l(2)gd1d7 socket l(2)gd11 tarsal segment | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 tarsal segment | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 terminal organ l(2)gd1d3 l(2)gd11 tormogen cell | pharate adult stage | supernumerary (with l(2)gd1d7) l(2)gd1SH0495 tormogen cell | pharate adult stage | supernumerary (with l(2)gd1SH0495) l(2)gd1d7 ventral thoracic disc l(2)gd11 wing | anterior/posterior compartment boundary l(2)gd11 wing | pharate adult stage l(2)gd13 l(2)gd11 l(2)gd1SH0495 wing disc l(2)gd1d10 l(2)gd11 wing margin, with Scer\GAL4sd-SG29.1 l(2)gd1Scer\UAS.cJa wing vein, with Scer\GAL4C5 l(2)gd1Scer\UAS.cJa wing vein, with Scer\GAL4sd-SG29.1 l(2)gd1Scer\UAS.cJa wing vein | somatic clone l(2)gd1d7 wing vein L2 | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 wing vein L2 | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 wing vein L4 | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 wing vein L4 | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 wing vein L5 | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 wing vein L5 | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of l(2)gd1 Class Mutagen Stocks Known lesion l(2)gd1EY04750 P-element activity 2 -- l(2)gd1d7 PM hybrid dysgenesis 1 Yes l(2)gd1J12 ethyl methanesulfonate 1 Yes l(2)gd108 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes l(2)gd11 spontaneous 0 Yes l(2)gd124 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes l(2)gd13 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- l(2)gd14 hypomorphic allele - genetic evidence X ray 0 Yes l(2)gd1d10 0 Yes l(2)gd1d3 P-element activity 0 -- l(2)gd1rsk73a P-element activity 0 Yes l(2)gd1rsk83a P-element activity 0 Yes l(2)gd1SH0495 P-element activity 0 Yes l(2)gd1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 40 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)gd1 Class Mutagen Stocks Known lesion l(2)gd1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes l(2)gd1GD11405 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)gd1JF02619 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)gd1+tCa in vitro construct - genomic fragment 0 Yes l(2)gd1C2.Scer\UAS.T:Disc\RFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes l(2)gd1NIG.4713R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.cGa in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.cJa.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes l(2)gd1Scer\UAS.cJa in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.T:Disc\RFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes l(2)gd1T:Avic\GFP in vitro construct - coding region fusion 0 Yes l(2)gd1T:Disc\RFP in vitro construct - coding region fusion 0 Yes l(2)gd1T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes l(2)gd1Δ2-135.Scer\UAS.T:Ivir\HA1 0 Yes l(2)gd1ΔC2.C.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.N.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.N.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes l(2)gd1ΔC2.Scer\UAS.T:Uuuu\nes,T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes l(2)gd1ΔC2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes l(2)gd1ΔC2.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔC2.T:Uuuu\nes,T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-1+2.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-1+3.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-1+4.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-1.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-2+3.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-3+4.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-4.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14-4.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔDM14ΔC2.T:Uuuu\nes,T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes l(2)gd1ΔN.C.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.C.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.N.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.N.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)J77 (Salas and Lengyel, 1984) Df(2L)J106 (Salas and Lengyel, 1984) Df(2L)J233 (Salas and Lengyel, 1984) T(Y;2)Jrv99 (Salas and Lengyel, 1984)
Disrupted in	Df(2L)Exel6027 (Ryder, 2004.4.26) Df(2L)FCK-20 (Jaekel and Klein, 2006, Gallagher and Knoblich, 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.JF02619} NA P{UAS-l(2)gd1.2xmyc} NA P{UAS-l(2)gd1.G} NA P{UAS-l(2)gd1.ΔC2.C.3xFlag} NA P{UAS-l(2)gd1.ΔC2.C.GFP} NA P{UAS-l(2)gd1.ΔC2.N.3xFlag} NA P{UAS-l(2)gd1.ΔC2.N.GFP} NA P{UAS-l(2)gd1.ΔC2} NA P{UAS-l(2)gd1.ΔN.C.3xFlag} NA P{UAS-l(2)gd1.ΔN.C.GFP} NA P{UAS-l(2)gd1.ΔN.N.3xFlag} NA P{UAS-l(2)gd1.ΔN.N.GFP} NA P{UAS-l(2)gd1.ΔN} NA P{UAS-lgd.C2.RFP} NA P{UAS-lgd.HA.Δ2-135} NA P{UAS-lgd.HA.ΔC2} NA P{UAS-lgd.HA.ΔDM14-4} NA P{UAS-lgd.HA.ΔDM14} NA P{UAS-lgd.RFP} NA P{UAS-NES-lgd.HA.ΔC2} NA characterization construct P{GFP-lgd} NA P{lgd-HA.ΔC2} NA P{lgd-HA.ΔDM14-1} NA P{lgd-HA.ΔDM14-1+2} NA P{lgd-HA.ΔDM14-1+3} NA P{lgd-HA.ΔDM14-1+4} NA P{lgd-HA.ΔDM14-2+3} NA P{lgd-HA.ΔDM14-3+4} NA P{lgd-HA.ΔDM14-4} NA P{lgd-HA.ΔDM14} NA P{lgd-HA} NA P{lgd-RFP} NA P{NES-lgd-HA.ΔC2} NA P{NES-lgd-HA.ΔDM14ΔC2} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}l(2)gd1EY04750 NA insertion of enhancer trap P{lacW}l(2)gd1SH0495 No miscellaneous insertions P{?lacW}l(2)gd1rsk73a NA P{?lacW}l(2)gd1rsk83a NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
phospholipid binding inferred from direct assay (Gallagher and Knoblich, 2006)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Klein, 2003) endosomal transport inferred from mutant phenotype (Jaekel and Klein, 2006) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Klein, 2003) intracellular protein transport inferred from mutant phenotype (Childress et al., 2006) negative regulation of Notch signaling pathway inferred from mutant phenotype (Childress et al., 2006, Jaekel and Klein, 2006) regulation of endocytosis inferred from mutant phenotype (Gallagher and Knoblich, 2006) regulation of Notch signaling pathway inferred from mutant phenotype (Gallagher and Knoblich, 2006) sensory organ development inferred from mutant phenotype (Klein, 2003) sensory organ precursor cell division inferred from mutant phenotype (Gallagher and Knoblich, 2006) wing disc morphogenesis inferred from mutant phenotype (Klein, 2003)
Cellular Component
CV term Evidence References
apical plasma membrane inferred from direct assay (Jaekel and Klein, 2006) cytoplasm inferred from direct assay (Jaekel and Klein, 2006, Childress et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
l(2)gd1 - shrb anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot (Troost et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)gd1 allele Gene References l(2)gd11 cg (Buratovich and Bryant, 1997) dpp (Buratovich and Bryant, 1995) ds (Buratovich and Bryant, 1997) ft (Buratovich and Bryant, 1997) vg (Agrawal et al., 1995) wg (Buratovich and Bryant, 1995) l(2)gd13 vg (Agrawal et al., 1995) l(2)gd1d7 N (Klein, 2003) obk (Atallah et al., 2004) Psn (Klein, 2003) Ser (Klein, 2003) unspecified Hrs (Childress et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261983 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34543
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D53HP Dipteran inclusive ortholog search EOG6CC492 Insect inclusive ortholog search EOG6NCK8F Arthropod inclusive ortholog search EOG6G79F0 Metazoa inclusive ortholog search EOG6DG2G9
Orthologs in Drosophila Species (EOG6D53HP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\l(2)gd1     Drosophila simulans   Dsim\GD23762 Y   Drosophila sechellia   Dsec\GM18896 Y   Drosophila erecta   Dere\GG23706 Y   Drosophila yakuba   Dyak\GE18513 Y   Drosophila ananassae   Dana\GF15641 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18377 Y   Drosophila persimilis   Dper\GL19542 Y   Drosophila willistoni   Dwil\GK18364 Y   Drosophila virilis   Dvir\GJ10553 Y   Drosophila mojavensis   Dmoj\GI17069 Y   Drosophila grimshawi   Dgri\GH10307 Y
Orthologs in non-Drosophila Dipterans (EOG6CC492)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004802   Anopheles gambiae Malaria mosquito  Agam\AGAP010539   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011659
Orthologs in non-Dipteran Insects (EOG6NCK8F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45436   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010411   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14639   Atta cephalotes Leafcutter ant  Acep\ACEP24033   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21856   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19633   Linepithema humile Argentine ant  Lhum\LH11468   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18441   Solenopsis invicta Red fire ant  Sinv\SINV10378   Solenopsis invicta Red fire ant  Sinv\SINV10379   Bombyx mori Silkmoth  Bmor\BGIBMGA006026   Pediculus humanus Human body louse  Phum\PHUM496550   Pediculus humanus Human body louse  Phum\PHUM593130   Tribolium castaneum Red flour beetle  Tcas\TC013686
Orthologs in non-Insect Arthropods (EOG6G79F0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rho   Ixodes scapularis Deer tick  Isca\ISCW018139
Orthologs in non-Arthropod Metazoa (EOG6DG2G9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y37H9A.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027279gn   Danio rerio Zebrafish  Drer\si:ch211-57g18.1   Danio rerio Zebrafish  Drer\ENSDARG00000036281   Xenopus tropicalis Western clawed frog  Xtro\cc2d1b   Xenopus tropicalis Western clawed frog  Xtro\cc2d1a   Gallus gallus Domestic chicken  Ggal\CC2D1B   Mus musculus House mouse  Mmus\Cc2d1a   Mus musculus House mouse  Mmus\Cc2d1b   Rattus norvegicus Norway rat  Rnor\Cc2d1a   Rattus norvegicus Norway rat  Rnor\Cc2d1b   Homo sapiens Human  Hsap\CC2D1B   Homo sapiens Human  Hsap\CC2D1A
Human Orthologs (2)
Gene OMIM HGNC Hsap\CC2D1B     Hsap\CC2D1A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23762 Drosophila sechellia Dsec\GM18896 Drosophila erecta Dere\GG23706 Drosophila yakuba Dyak\GE18513 Drosophila ananassae Dana\GF15641 Drosophila pseudoobscura pseudoobscura Dpse\GA18377 Drosophila persimilis Dper\GL19542 Drosophila willistoni Dwil\GK18364 Drosophila virilis Dvir\GJ10553 Drosophila mojavensis Dmoj\GI17069 Drosophila grimshawi Dgri\GH10307
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	25086 l(2)gd1J12/CyO 25088 w*; P{UAS-lgd.HA}2 25089 w*; P{UAS-lgd.HA}3 27311 y1 v1; P{TRiP.JF02619}attP2 25087 w*; P{neoFRT}40A l(2)gd1d7/CyO 16614 y1 w67c23; P{EPgy2}l(2)gd1EY04750/CyO
Kyoto	114432 yd2 w1118 P{ey-FLP.N}2; P{EPgy2}l(2)gd1EY04750 P{neoFRT}40A/CyO y+
VDRC	v21928 w1118 P{GD11405}v21928
Genomic Clones ( 2 )
	BACR09F02 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23056
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24357 HL04707 LD14025 RE07924 RE32112 RE45092 RE47734 RE52984 RE56884 RH27645 RH47150 RH55958 SD04867 SD21147
Other clones	145374 159461 165688 179711 CK01.20D.F2 CK01.54B.H6 CK01.92A.F4 CK01.93B.C8 CK01.101C.C8 CK01.106D.H8 CK01.109B.H11 CK01.110A.G9 CK01.110B.C11 CK01.110B.D11 CK01.119A.F6 Dmel_dig_001260_0612_3685 EC252467 EC256021 EK044163 EK071954 EK072844 EK083416 EK085731 EK089264 EK090855 EK098732 EK099425 EK113203 EK164204 EK252721 EK290915 EP14133 EP19404 RP003030931 RP003036709 RP003070633 RP003088410 RP003101292 RP003115884 RP003139756 RP003141046 RP003206404 RP003228512 RP003230893 RP003234083 RP003236826 RP003240472 RP003270484 RP003277432 RP003291619 RP003296970 RP003304673 RP003311163 RP003329685 RP003339150 RP003351101 RP003371249 RP003371923 RP003393154 RP003399239 RP003413093 RP003429153 RP003449003 RP003494845 RP003502594 RP003503427 RP003507214 RP003510483 RP003517096 RP003539704 RP003567425 RP003571862 RP003573931 RP003577276 RP003578597 RP003588544 RP003594375 RP003601956 RP003612819 RP003638857 RP003642339 RP003654797 RP003656792 RP003666491 RP003682944 SD01334
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261983 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34543
Antibody Information
	polyclonal (Gallagher and Knoblich, 2006, Troost et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)gd1 CG4713 (Childress et al., 2006) Source for merge of: l(2)gd1 l(2)SH0495 (Jaekel and Klein, 2006)
Additional comments
Other Comments
	The l(2)gd1 product regulates N signaling in a manner that is independent of the N ligands, Dl and Ser. The genetic interaction between l(2)gd1 and Hrs, and the accumulation of N protein in subcellular puncta suggests that l(2)gd1 has a role in N protein trafficking. (Childress et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Childress et al., 2006) l(2)gd1 is required to restrict N activity to the dorsal ventral boundary during wing development. (Klein, 2003) l(2)gd1 has a role in wing vein, eye and bristle formation. (Klein, 2003) 1 allele of l(2)SH0495 recovered in a P-insertion screen. (Oh et al., 2003) Tumor suppressor genes act in combination to control cell proliferation. Tissue hyperplasia can be associated with ectopic expression of genes involved in pattern formation. The enhancement of leg disc duplication in l(2)gd1 mutants by ft is mediated by dpp. (Buratovich and Bryant, 1997) The third leg disc duplication depends on the expression of wg and dpp. (Buratovich and Bryant, 1995) Mutants display hyperplastic phenotype, with imaginal disc overgrowth. (Mechler, 1994) Endocrine mechanisms responsible for the prolongation of larval life in l(2)gd1 mutants were investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system. (Sehnal and Bryant, 1993) Mutants at l(2)gd1 exhibit hyperplastic overgrowth. (Jursnich et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135644 NM_001259047 RefSeq (Proteins) • NP_609488 NP_001245976 DDBJ / EMBL / GenBank • AA940811 AAF53069 AAL13752 AB082090 AFH03650 AW942661 AY058523 CL527761 Entrez Gene - A searchable database of RefSeq genes. • 34543 UniProtKB/Swiss-Prot • Q9VKJ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium/lipid-binding domain, CaLB (IPR008973) Domain of unknown function DM14 (IPR006608) C2 calcium-dependent membrane targeting (IPR000008) C2 membrane targeting protein (IPR018029) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD23056
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261983 DRSC - Results from RNAi screens. • FBgn0261983 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261983 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34543 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34543 modMine - Data generated by the modENCODE project. • FBgn0261983
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG4713 (Childress et al., 2006, Childress et al., 2006, Gallagher and Knoblich, 2006, Jaekel and Klein, 2006, Kim et al., 2005) gd (Szabad, 1998, Mechler, 1994) l(2)gd (Jaiswal et al., 2005, Atallah et al., 2004, Nedelcheva et al., 2001, Santaren et al., 1998, Buratovich and Bryant, 1997, Mukherjee et al., 1995, Mechler, 1994, Malva et al., 1994, Gateff, 1994, Buratovich and Bryant, 1995, Gigliotti et al., 1993, Bryant, 1969, Schmidt, 1989, Gateff and Mechler, 1989, Bryant and Levinson, 1985, Salas and Lengyel, 1984, Gateff, 1978, Hernandez et al., 2004, Dubatolova et al., 2010, Dubatolova et al., 2010) l(2)gd1 (Coumailleau et al., 2009, Saj et al., 2010, Perkins et al., 2009.8.10, Popkova et al., 2012) l(2)giant disc (Potter et al., 2000) l(2)SH2 0495 (Oh et al., 2002.3.22) l(2)SH0495   l2gd (Ryerse and Nagel, 1984) lgd (Coumailleau et al., 2009, Troost et al., 2012, Childress et al., 2006, Agrawal et al., 1995, Watson et al., 1994, Sehnal and Bryant, 1993, Skaer, 1993, Szabad et al., 1991, Bryant and Schmidt, 1990, Jursnich et al., 1990, Tyler et al., 2007, Childress et al., 2007, Gallagher and Knoblich, 2006, Jaekel and Klein, 2006, Bowman et al., 2008, Kanwar and Fortini, 2008) SH495 (Jaekel and Klein, 2006)
Name Synonym	CG4713   lethal (2) giant discs (Gallagher and Knoblich, 2006, Jaekel and Klein, 2006) lethal(2) giant discs (Kanwar and Fortini, 2008) lethal (2) giant discs 1   lethal (2) SH0495   lethal giant discs (Coumailleau et al., 2009, Childress et al., 2007, Childress et al., 2006)
Secondary FlyBase IDs
	FBgn0002119 FBgn0032342 FBgn0065753 FBgn0250747
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 5 ) Review  ( 14 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Adamson and Lajeunesse, 2012, ScientificWorldJournal 2012: 347597 A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. [FBrf0218446] Popkova et al., 2012, PLoS Genet. 8(12): e1003159 Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515] Troost et al., 2012, J. Cell Sci. 125(3): 763--776 The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4. [FBrf0217584] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...