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Gene Dmel\l(2)gd1

General Information
Symbol	Dmel\l(2)gd1	Species	D. melanogaster
Name	lethal (2) giant discs 1	Annotation symbol	CG4713
Feature type	protein_coding_gene	FlyBase ID	FBgn0261983
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(2)gd, lgd, gd
Genomic Location
Chromosome (arm)	2L	Recombination map	2-[41]
Cytogenetic map	32D3-32D4	Sequence location	2L:11,106,912..11,110,851 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) giant discs 1 is referred to in FlyBase by the symbol Dmel\l(2)gd1 (CG4713, FBgn0261983). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phospholipid binding. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; wing disc morphogenesis; sensory organ development; compound eye development; regulation of endocytosis; regulation of Notch signaling pathway; imaginal disc-derived wing vein morphogenesis; sensory organ precursor cell division; intracellular protein transport; endosome transport. 33 alleles are reported. The phenotypes of these alleles are annotated with: imaginal precursor; multicellular structure; thoracic segment; adult segment; organ system subdivision; organ system; larval head segment; sense organ; cytoplasmic part; embryonic/larval imaginal precursor; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Domain of unknown function DM14. Gene sequence location is 2L:11106912..11110851.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)gd1: lethal (2) giant discs Pupariation delayed, up to nine days in crowded cultures; pupariation is but one day in uncrowded cultures. Discs continue to grow, becoming very large with long delays. Mutant discs transplanted into normal larval hosts metamorphose; cuticular patterns normal but bristles and to a greater degree sensillae and bracts missing; unguis missing from tarsal claws; tarsi two jointed. Mutant discs yield low incidence of trans-determination.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Dubatolova et al., 2010, Genetika, Moscow 46(2): 187--193 Sequence features BKN22176 HFA02773
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32D3-32D4   Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32D3-32D4     (Oh et al., 2003)
Experimentally Determined Recombination Data
Location	2-42.7 +/- 0.5 (Bryant and Schubiger, 1971) 2-[41]
Left of (cM)	amos Bl (Bryant and Schubiger, 1971)
Right of (cM)	wg J (Bryant and Schubiger, 1971)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)gd1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)gd1-RA FBtr0080197  NM_135644   3020   816 l(2)gd1-RB FBtr0306138     3074   834
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)gd1-PA   FBpp0079786   89.0   816   5.01     NP_609488   AAF53069 l(2)gd1-PB   FBpp0297275   91.0   834   5.11
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium/lipid-binding domain, CaLB (IPR008973) Domain of unknown function DM14 (IPR006608) C2 calcium-dependent membrane targeting (IPR000008) C2 membrane targeting protein (IPR018029)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439448   AA698450   AA940811   AE014134 AAF53069   AB082090   AI404590   AI530761   AI533142   AW942661   AY058523 AAL13752   BG639487   BI167525   BI236109   BI358348   BI363033   BI367264   BI370386   BI587164   BI616964   BI623644   BI638774   CL527761   CO189396   CO261996   CO262547   CO263691   CO268298   CO270388   CO270603   CO274106   CO283730   CO289753   CO290010   CO306892   CO328574   CO342195   CO344500   EC057831   EC059327   EC070449   EC070988   EC078676   EC082474   EC088775   EC204262   EC206186   EC208275   EC208410   EC208437   EC219163   EC219903   EC230748   EC231533   EC238400   EC252467   EC256021   EV575616   GH757747   GH760195   GH761121   GH772393   GH781070   GH782575   GH796575   GH797315   GH797932   GH798497   GH798859   GH801030   GH801898   GH802642   GH803759   GH805079   GH806280   GH806710   GH812399   GH813038   GH818284   GH821102   GH821688   GH827165   GH839325   GH855828   GH856972   GH859973   GH867256   GH867410   GH868186   GH872336   GH873296   GH876412   GH877222   GH878542   GH879261   GH880790   GH885207   GH885734   GH888327   GH890383   GH895099   GH918107   GH927214   GH930085   GH933915   GH933973   GH937578   GH938262   GH938299   GH940400
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VKJ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone l(2)gd1d7 lethal | larval stage | recessive l(2)gd14 lethal | pharate adult stage l(2)gd1SH0495 lethal | pharate adult stage (with Df(2L)FCK-20) l(2)gd1SH0495 lethal | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 lethal | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 lethal | pharate adult stage | recessive l(2)gd11 l(2)gd1d3 lethal | pupal stage l(2)gd11 lethal | pupal stage, with Scer\GAL4pnr-MD237 l(2)gd1GD11405 lethal | pupal stage | recessive l(2)gd11 lethal | recessive l(2)gd11 l(2)gd13 l(2)gd1d3 l(2)gd1SH0495 Other Phenotypes Allele hyperplasia l(2)gd1d3 hyperplasia | recessive l(2)gd11 l(2)gd14 l(2)gd1d3 l(2)gd1d7 increased cell death | somatic clone l(2)gd1d7 tumorigenic | somatic clone l(2)gd1d7 visible l(2)gd108 l(2)gd124 visible, with Scer\GAL4neur-P72 l(2)gd1Scer\UAS.cGa l(2)gd1ΔC2.C.Scer\UAS visible, with Scer\GAL4sca-109-68 l(2)gd1Scer\UAS.cGa visible | recessive l(2)gd11 visible | somatic clone l(2)gd108 l(2)gd124 l(2)gd1d10 Phenotype manifest in Allele antenna | pharate adult stage l(2)gd13 anterior crossvein, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa cephalopharyngeal skeleton l(2)gd1d3 l(2)gd11 denticle belt | ventral l(2)gd1d3 l(2)gd11 dorsal appendage l(2)gd1d3 l(2)gd11 dorsal appendage | germline clone l(2)gd1d3 dorsal organ l(2)gd1d3 l(2)gd11 early endosome, with Scer\GAL4neur-P72 l(2)gd1Scer\UAS.cGa early endosome | somatic clone l(2)gd108 egg l(2)gd1d3 l(2)gd11 embryonic/larval brain l(2)gd11 endosome | somatic clone l(2)gd1d7 external sensory organ l(2)gd124 l(2)gd108 external sensory organ, with Scer\GAL4neur-P72 l(2)gd1Scer\UAS.cGa l(2)gd1ΔC2.C.Scer\UAS external sensory organ, with Scer\GAL4sca-109-68 l(2)gd1Scer\UAS.cGa external sensory organ | somatic clone l(2)gd108 l(2)gd1d10 external sensory organ precursor cell, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa external sensory organ precursor cell | somatic clone l(2)gd108 eye-antennal disc l(2)gd11 genital disc l(2)gd11 haltere disc l(2)gd11 head l(2)gd124 l(2)gd108 head | somatic clone l(2)gd1d10 imaginal disc l(2)gd11 l(2)gd14 l(2)gd1d7 imaginal ring l(2)gd11 joint | ectopic | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 joint | ectopic | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 Keilin's organ l(2)gd1d3 l(2)gd11 labial disc l(2)gd11 larval head l(2)gd1d3 l(2)gd11 late endosome, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa late endosome | somatic clone l(2)gd1d7 leg | pharate adult stage l(2)gd1SH0495 macrochaeta l(2)gd11 macrochaeta | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 macrochaeta | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 macrochaeta | supernumerary, with Scer\GAL4sd-SG29.1 l(2)gd1Scer\UAS.cJa mesothoracic tarsal segment | pharate adult stage l(2)gd13 mesothoracic tergum | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 mesothoracic tergum | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 mesothoracic tergum | somatic clone l(2)gd1d7 metathoracic leg disc l(2)gd11 l(2)gd1d7 metathoracic tarsal segment | pharate adult stage l(2)gd13 microchaeta | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 microchaeta | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 postorbital bristle | somatic clone l(2)gd124 l(2)gd1d10 prothoracic tarsal segment | pharate adult stage l(2)gd13 salivary gland imaginal ring l(2)gd11 scutellar bristle, with Scer\GAL4ptc-559.1 l(2)gd1Scer\UAS.cJa sensory mother cell | somatic clone l(2)gd1d7 socket l(2)gd11 tarsal segment | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 tarsal segment | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 terminal organ l(2)gd1d3 l(2)gd11 tormogen cell | pharate adult stage | supernumerary (with l(2)gd1d7) l(2)gd1SH0495 tormogen cell | pharate adult stage | supernumerary (with l(2)gd1SH0495) l(2)gd1d7 ventral thoracic disc l(2)gd11 wing | anterior/posterior compartment boundary l(2)gd11 wing | pharate adult stage l(2)gd13 l(2)gd11 l(2)gd1SH0495 wing disc l(2)gd1d10 l(2)gd11 wing margin, with Scer\GAL4sd-SG29.1 l(2)gd1Scer\UAS.cJa wing vein, with Scer\GAL4sd-SG29.1 l(2)gd1Scer\UAS.cJa wing vein | somatic clone l(2)gd1d7 wing vein L2 | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 wing vein L2 | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 wing vein L4 | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 wing vein L4 | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7 wing vein L5 | pharate adult stage (with l(2)gd1d7) l(2)gd1SH0495 wing vein L5 | pharate adult stage (with l(2)gd1SH0495) l(2)gd1d7
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of l(2)gd1 Class Mutagen Stocks Known lesion l(2)gd1EY04750 P-element activity 2 -- l(2)gd1d7 PM hybrid dysgenesis 1 Yes l(2)gd1J12 ethyl methanesulfonate 1 Yes l(2)gd108 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes l(2)gd11 spontaneous 0 Yes l(2)gd124 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes l(2)gd13 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- l(2)gd14 hypomorphic allele - genetic evidence X ray 0 Yes l(2)gd1d10 0 Yes l(2)gd1d3 P-element activity 0 -- l(2)gd1rsk73a P-element activity 0 Yes l(2)gd1rsk83a P-element activity 0 Yes l(2)gd1SH0495 P-element activity 0 Yes l(2)gd1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)gd1 Class Mutagen Stocks Known lesion l(2)gd1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes l(2)gd1GD11405 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)gd1JF02619 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)gd1+tCa in vitro construct - genomic fragment 0 Yes l(2)gd1NIG.4713R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.cGa in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.cJa in vitro construct - regulatory fusion 0 Yes l(2)gd1Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes l(2)gd1Scer\UAS.T:Ivir\HA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.C.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.N.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.N.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔC2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes l(2)gd1ΔN.C.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.C.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.N.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.N.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes l(2)gd1ΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)J77 (Salas and Lengyel, 1984) Df(2L)J106 (Salas and Lengyel, 1984) Df(2L)J233 (Salas and Lengyel, 1984) T(Y;2)Jrv99 (Salas and Lengyel, 1984)
Disrupted in	Df(2L)Exel6027 (Ryder, 2004.4.26) Df(2L)FCK-20 (Jaekel and Klein, 2006, Gallagher and Knoblich, 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.JF02619} NA P{UAS-l(2)gd1.2xmyc} NA P{UAS-l(2)gd1.G} NA P{UAS-l(2)gd1.ΔC2.C.3xFlag} NA P{UAS-l(2)gd1.ΔC2.C.GFP} NA P{UAS-l(2)gd1.ΔC2.N.3xFlag} NA P{UAS-l(2)gd1.ΔC2.N.GFP} NA P{UAS-l(2)gd1.ΔC2} NA P{UAS-l(2)gd1.ΔN.C.3xFlag} NA P{UAS-l(2)gd1.ΔN.C.GFP} NA P{UAS-l(2)gd1.ΔN.N.3xFlag} NA P{UAS-l(2)gd1.ΔN.N.GFP} NA P{UAS-l(2)gd1.ΔN} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}l(2)gd1EY04750 NA insertion of enhancer trap P{lacW}l(2)gd1SH0495 No miscellaneous insertions P{?lacW}l(2)gd1rsk73a NA P{?lacW}l(2)gd1rsk83a NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
phospholipid binding inferred from direct assay (Gallagher and Knoblich, 2006)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Klein, 2003) endosome transport inferred from mutant phenotype (Jaekel and Klein, 2006) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Klein, 2003) intracellular protein transport inferred from mutant phenotype (Childress et al., 2006) negative regulation of Notch signaling pathway inferred from mutant phenotype (Childress et al., 2006, Jaekel and Klein, 2006) regulation of endocytosis inferred from mutant phenotype (Gallagher and Knoblich, 2006) regulation of Notch signaling pathway inferred from mutant phenotype (Gallagher and Knoblich, 2006) sensory organ development inferred from mutant phenotype (Klein, 2003) sensory organ precursor cell division inferred from mutant phenotype (Gallagher and Knoblich, 2006) wing disc morphogenesis inferred from mutant phenotype (Klein, 2003)
Cellular Component
CV term Evidence References
apical plasma membrane inferred from direct assay (Jaekel and Klein, 2006) cytoplasm inferred from direct assay (Jaekel and Klein, 2006, Childress et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)gd1 allele Gene References l(2)gd11 cg (Buratovich and Bryant, 1997) dpp (Buratovich and Bryant, 1995) ds (Buratovich and Bryant, 1997) ft (Buratovich and Bryant, 1997) vg (Agrawal et al., 1995) wg (Buratovich and Bryant, 1995) l(2)gd13 vg (Agrawal et al., 1995) l(2)gd1d7 N (Klein, 2003) obk (Atallah et al., 2004) Psn (Klein, 2003) Ser (Klein, 2003) unspecified Hrs (Childress et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261983 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34543
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15641 Dere\GG23706 Dgri\GH10307 Dmoj\GI17069 Dper\GL19542 Dpse\GA18377 Dsec\GM18896 Dsim\GD23762 Dvir\GJ10553 Dwil\GK18364 Dyak\GE18513
Curated drosophilid orthologs	Dpse\GA18377
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	25086 l(2)gd1J12/CyO 25088 w*; P{UAS-lgd.HA}2 25089 w*; P{UAS-lgd.HA}3 27311 y1 v1; P{TRiP.JF02619}attP2 25087 w*; P{neoFRT}40A l(2)gd1d7/CyO 16614 y1 w67c23; P{EPgy2}l(2)gd1EY04750/CyO
Kyoto	114432 yd2 w1118 P{ey-FLP.N}2; P{EPgy2}l(2)gd1EY04750 P{neoFRT}40A/CyO y+
VDRC	v21928 w1118 P{GD11405}v21928
Genomic Clones ( 2 )
	BACR09F02 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23056
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24357 HL04707 LD14025 RE07924 RE32112 RE45092 RE47734 RE52984 RE56884 RH27645 RH47150 RH55958 SD04867 SD21147
Other clones	145374 159461 165688 179711 CK01.20D.F2 CK01.54B.H6 CK01.92A.F4 CK01.93B.C8 CK01.101C.C8 CK01.106D.H8 CK01.109B.H11 CK01.110A.G9 CK01.110B.C11 CK01.110B.D11 CK01.119A.F6 Dmel_dig_001260_0612_3685 EC252467 EC256021 EK044163 EK071954 EK072844 EK083416 EK085731 EK089264 EK090855 EK098732 EK099425 EK113203 EK164204 EK252721 EK290915 EP14133 EP19404 RP003030931 RP003036709 RP003070633 RP003088410 RP003101292 RP003115884 RP003139756 RP003141046 RP003206404 RP003228512 RP003230893 RP003234083 RP003236826 RP003240472 RP003270484 RP003277432 RP003291619 RP003296970 RP003304673 RP003311163 RP003329685 RP003339150 RP003351101 RP003371249 RP003371923 RP003393154 RP003399239 RP003413093 RP003429153 RP003449003 RP003494845 RP003502594 RP003503427 RP003507214 RP003510483 RP003517096 RP003539704 RP003567425 RP003571862 RP003573931 RP003577276 RP003578597 RP003588544 RP003594375 RP003601956 RP003612819 RP003638857 RP003642339 RP003654797 RP003656792 RP003666491 RP003682944 SD01334
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261983 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34543 48503
Antibody Information
	polyclonal (Gallagher and Knoblich, 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)gd1 CG4713 (Childress et al., 2006) Source for merge of: l(2)gd1 l(2)SH0495 (Jaekel and Klein, 2006)
Additional comments
Other Comments
	The l(2)gd1 product regulates N signaling in a manner that is independent of the N ligands, Dl and Ser. The genetic interaction between l(2)gd1 and Hrs, and the accumulation of N protein in subcellular puncta suggests that l(2)gd1 has a role in N protein trafficking. (Childress et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Childress et al., 2006) l(2)gd1 is required to restrict N activity to the dorsal ventral boundary during wing development. (Klein, 2003) l(2)gd1 has a role in wing vein, eye and bristle formation. (Klein, 2003) 1 allele of l(2)SH0495 recovered in a P-insertion screen. (Oh et al., 2003) Tumor suppressor genes act in combination to control cell proliferation. Tissue hyperplasia can be associated with ectopic expression of genes involved in pattern formation. The enhancement of leg disc duplication in l(2)gd1 mutants by ft is mediated by dpp. (Buratovich and Bryant, 1997) The third leg disc duplication depends on the expression of wg and dpp. (Buratovich and Bryant, 1995) Mutants display hyperplastic phenotype, with imaginal disc overgrowth. (Mechler, 1994) Endocrine mechanisms responsible for the prolongation of larval life in l(2)gd1 mutants were investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system. (Sehnal and Bryant, 1993) Mutants at l(2)gd1 exhibit hyperplastic overgrowth. (Jursnich et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135644 RefSeq (Proteins) • NP_609488 DDBJ / EMBL / GenBank • AA940811 AAF53069 AAL13752 AB082090 AW942661 AY058523 CL527761 Entrez Gene - A searchable database of RefSeq genes. • 34543 UniProtKB/TrEMBL • Q9VKJ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium/lipid-binding domain, CaLB (IPR008973) Domain of unknown function DM14 (IPR006608) C2 calcium-dependent membrane targeting (IPR000008) C2 membrane targeting protein (IPR018029)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261983 DRSC - Results from RNAi screens. • FBgn0261983 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261983 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34543 48503 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34543 modMine - Data generated by the modENCODE project. • FBgn0261983
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG4713 (Childress et al., 2006, Childress et al., 2006, Gallagher and Knoblich, 2006, Jaekel and Klein, 2006, Kim et al., 2005) gd (Szabad, 1998, Mechler, 1994) l(2)gd (Jaiswal et al., 2005, Atallah et al., 2004, Nedelcheva et al., 2001, Santaren et al., 1998, Buratovich and Bryant, 1997, Mukherjee et al., 1995, Mechler, 1994, Malva et al., 1994, Gateff, 1994, Buratovich and Bryant, 1995, Gigliotti et al., 1993, Bryant, 1969, Schmidt, 1989, Gateff and Mechler, 1989, Bryant and Levinson, 1985, Salas and Lengyel, 1984, Gateff, 1978, Hernandez et al., 2004, Dubatolova et al., 2010, Dubatolova et al., 2010) l(2)gd1 (Saj et al., 2010, Perkins et al., 2009.8.10) l(2)giant disc (Potter et al., 2000) l(2)SH2 0495 (Oh et al., 2002.3.22) l(2)SH0495   l2gd (Ryerse and Nagel, 1984) lgd (Childress et al., 2006, Agrawal et al., 1995, Watson et al., 1994, Sehnal and Bryant, 1993, Skaer, 1993, Szabad et al., 1991, Bryant and Schmidt, 1990, Jursnich et al., 1990, Tyler et al., 2007, Childress et al., 2007, Gallagher and Knoblich, 2006, Jaekel and Klein, 2006, Bowman et al., 2008, Kanwar and Fortini, 2008) SH495 (Jaekel and Klein, 2006)
Name Synonym	CG4713   lethal (2) giant discs (Gallagher and Knoblich, 2006, Jaekel and Klein, 2006) lethal(2) giant discs (Kanwar and Fortini, 2008) lethal (2) giant discs 1   lethal (2) SH0495   lethal giant discs (Childress et al., 2007, Childress et al., 2006)
Secondary FlyBase IDs
	FBgn0002119 FBgn0032342 FBgn0065753 FBgn0250747
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 4 ) Review  ( 14 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Book  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Dubatolova et al., 2010, Russ. J. Genet. 46(2): 164--169 Effect of mutations in Drosophila melanogaster tumor suppressor Merlin on proliferation and differentiation of wing cells. [FBrf0215198] Dubatolova et al., 2010, Genetika, Moscow 46(2): 187--193 [Effect of mutations in Drosophila melanogaster tumor suppressor Merlin on proliferation and differentiation of wing cells] [FBrf0210296] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...