Meg
protein tyrosine phosphatase involved in neuronal circuit formation the central brain - regulates establishment and the stabilization of axonal projection patterns interacts with Eps-15 - negatively regulates border cell migration during oogenesis - inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis
Please see the JBrowse view of Dmel\Ptpmeg for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptpmeg using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as dorsal/lateral sensory complexes
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ptpmeg in JBrowse3-0.5
3-0.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The Ptpmeg product is required for the proper establishment of axon projections in the ellipsoid body and is required for stabilization of already-formed projection patterns in the mushroom body. The phosphatase activity of the protein is needed for these functions.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AA441636. This EST matches ESTs AA820540 and AA817484. Evidence of alternative splicing.
Source for merge of: Ptpmeg Meg
Source for merge of: Ptpmeg anon-WO0118547.211
Source for identity of Ptpmeg CG1228 was sequence comparison ( date:000327 ).
Source for merge of Ptpmeg anon-WO0118547.211 was sequence comparison ( date:051113 ).
Source for identity of: Ptpmeg CG1228