FlyBase Gene Report: Dmel\Ptpmeg

General Information

Symbol

Dmel\Ptpmeg

Species

D. melanogaster

Name

Protein tyrosine phosphatase Meg

Annotation Symbol

CG1228

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261985

Gene Model Status

Current

Stock Availability

30 publicly available

Enzyme Name (EC)

protein-tyrosine-phosphatase (3.1.3.48)

Gene Summary

Protein tyrosine phosphatase Meg (Ptpmeg) encodes a tyrosine phosphatase that interacts with the product of Eps-15. It negatively regulates border cell migration during oogenesis. It also inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Meg

Key Links

Genomic Location

Cytogenetic map

61C1-61C1

Sequence location

3L:328,097..356,050 [+]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:328097..356050

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables non-membrane spanning protein tyrosine phosphatase activity

inferred from direct assay

(Chen et al., 2012)

enables protein tyrosine phosphatase activity

inferred from direct assay

(Li et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cytoskeletal protein binding

inferred from electronic annotation with InterPro:IPR012151

(InterPro Project Members, 2004-)

enables protein tyrosine phosphatase activity

inferred from sequence or structural similarity with SGD:S000002389

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR000242

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000242, InterPro:IPR012151

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN005236628

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in axon extension involved in axon guidance

inferred from mutant phenotype

(Whited et al., 2007)

involved_in central complex development

inferred from mutant phenotype

(Whited et al., 2007)

involved_in mushroom body development

inferred from mutant phenotype

(Whited et al., 2007)

involved_in negative regulation of border follicle cell migration

inferred from mutant phenotype

(Li et al., 2015)

involved_in negative regulation of epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Li et al., 2015)

inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205

(Li et al., 2015)

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Li et al., 2015)

involved_in thermosensory behavior

inferred from mutant phenotype

(Hong et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with SGD:S000002389

(Gene Ontology Curators, 2002-)

located_in cytoskeleton

inferred from electronic annotation with InterPro:IPR000299

(InterPro Project Members, 2004-)

located_in mitochondrion

inferred from sequence or structural similarity with SGD:S000002389

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES

Negative Regulators of EGFR Signaling Pathway

Protein Family (UniProt)

Catalytic Activity (EC/Rhea)

protein tyrosine phosphatase activity

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (3.1.3.48)

RHEA 10684:

Summaries

Gene Snapshot

Gene Group (FlyBase)

CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES -: Cytosolic Protein Tyrosine Phosphatases are non-receptor tyrosine phosphatases. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).
Negative Regulators of EGFR Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.

Summary (Interactive Fly)

protein tyrosine phosphatase involved in neuronal circuit formation the central brain - regulates establishment and the stabilization of axonal projection patterns interacts with Eps-15 - negatively regulates border cell migration during oogenesis - inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ptpmeg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0R3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ptpmeg-RG

FBtr0306559

NM_138187

3608

974

Ptpmeg-RH

FBtr0306560

NM_167831

4116

974

Ptpmeg-RI

FBtr0306561

NM_001169838

3596

974

Ptpmeg-RJ

FBtr0306562

NM_001169839

4028

974

Ptpmeg-RK

FBtr0306563

NM_167830

4079

974

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ptpmeg-PG

FBpp0297514

109.7

974

7.22

FBpp0297515

109.7

974

7.22

FBpp0297516

109.7

974

7.22

FBpp0297517

109.7

974

7.22

FBpp0297518

109.7

974

7.22

Q9W0R3

NP_728522

AAF47380

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

974 aa isoforms: Ptpmeg-PG, Ptpmeg-PH, Ptpmeg-PI, Ptpmeg-PJ, Ptpmeg-PK

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptpmeg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.54

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

sensory nervous system primordium

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{544.SVS-1}Ptpmeg^CPTI100033

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ptpmeg in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ptpmeg

View exonic expression by tissue for Dmel\Ptpmeg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261985

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38059/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261985

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035133

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261985

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1228

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 42 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ptpmeg

Transgenic constructs containing regulatory region of Ptpmeg

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene partially disrupted in

Df(3L)mth^attP

(Rao and Deng, 2019.10.23)

Df(3L)mthl9^attP

(Rao and Deng, 2019.10.23)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ptpmeg^GD7557

viable, with Scer\GAL4^Mef2.PR

Ptpmeg^GD7557

viable, with Scer\GAL4^pnr-MD237

Ptpmeg^GD7557

viable, with Scer\GAL4^tin.CΔ4

Ptpmeg^GD7557

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

Other Phenotypes

Allele

abnormal behavior

Ptpmeg¹

abnormal cell migration, with Scer\GAL4^slbo.2.6

Ptpmeg^UAS.cLa

abnormal cell migration (with Df(3L)ED201)

Ptpmeg¹

abnormal cell migration | recessive

Ptpmeg¹

abnormal neuroanatomy (with Df(3L)ED201)

abnormal neuroanatomy | recessive

Ptpmeg¹

visible, with Scer\GAL4^en.PU

Ptpmeg^UAS.cLa

visible, with Scer\GAL4^GMR.PF

Ptpmeg^GS9137

Phenotype manifest in

Allele

adult mushroom body alpha-lobe

Ptpmeg¹

adult mushroom body alpha-lobe (with Df(3L)ED201)

adult mushroom body beta-lobe

Ptpmeg¹

axon & ellipsoid body

Ptpmeg¹

axon & ellipsoid body (with Df(3L)ED201)

Ptpmeg¹

axon & mushroom body | somatic clone | cell non-autonomous

Ptpmeg¹

border follicle cell

Ptpmeg¹

border follicle cell, with Scer\GAL4^slbo.2.6

Ptpmeg^UAS.cLa

border follicle cell (with Df(3L)ED201)

Ptpmeg¹

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

Ptpmeg^EP3542

eye, with Scer\GAL4^GMR.PF

Ptpmeg^GS9137

medial lobe of adult mushroom body

Ptpmeg¹

vertical lobe of adult mushroom body

Ptpmeg¹

wing vein, with Scer\GAL4^en.PU

Ptpmeg^UAS.cLa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (65)

Hsap\PTPN4

13 of 14

Yes

Hsap\PTPN3

11 of 14

Yes

Hsap\FRMPD2

2 of 14

Yes

Hsap\PTPN13

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (62)

Rnor\Ptpn4

13 of 14

Yes

Rnor\Ptpn3

11 of 14

Yes

Rnor\Ptpn13

2 of 14

Yes

Rnor\Ptpn14

2 of 14

Rnor\Arhgef7

1 of 14

Rnor\Ect2l

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (61)

Mmus\Ptpn4

12 of 14

Yes

Mmus\Ptpn3

11 of 14

Yes

Mmus\Ptpn13

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gopc

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (28)

Xtro\ptpn4

7 of 13

Yes

Xtro\ptpn3

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\frmd4b

1 of 13

Yes

Xtro\frmd6

1 of 13

Xtro\frmd7

1 of 13

Xtro\gopc

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (76)

Drer\ptpn4a

12 of 14

Yes

Drer\ptpn4b

12 of 14

Yes

Drer\ptpn3

11 of 14

Yes

Drer\frmpd2

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-178k16.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (49)

Cele\ptp-1

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F10G8.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\frm-5.2

1 of 14

Cele\frm-7

1 of 14

Cele\gopc-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (26)

Agam\AgaP_AGAP007130

12 of 12

Yes

Agam\AgaP_AGAP009975

2 of 12

Agam\AgaP_AGAP012185

2 of 12

Agam\AgaP_AGAP013042

2 of 12

Yes

Agam\AgaP_AGAP000209

1 of 12

Agam\AgaP_AGAP000292

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PTP1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pyp1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ptpmeg. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

Pez

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

Lar

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

csw

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Mer

1 of 13

Moe

1 of 13

Myo81F

1 of 13

pbl

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

yrt

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, invasive collective cell migration, border cell model

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PTPN4; protein tyrosine phosphatase non-receptor type 4

13 of 14

176878

PTPN3; protein tyrosine phosphatase non-receptor type 3

11 of 14

176877

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ptpmeg - Cortactin

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Li et al., 2015)

Ptpmeg - Eps-15

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Li et al., 2015)

Ptpmeg - Pvr

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Li et al., 2015)

Ptpmeg - TER94

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Li et al., 2015)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2015)

suppressible

(Li et al., 2015)

suppressible

(Li et al., 2015)

suppressible

(Whited et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pbl

enhanceable

Ptpmeg

(Gregory et al., 2007)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261985

MIST (protein-protein) - An integrated Molecular Interaction Database

38059

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of EGFR Signaling Pathway

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q86PA5

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

61C1-61C1

Sequence location

3L:328,097..356,050 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61C1-61C1

Limits computationally determined from genome sequence between P{PZ}trh¹⁰⁵¹² and P{EP}EP3104^EP3104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (30)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

9756

w^*; Ptpmeg¹/TM6B, Tb¹

63952

w¹¹¹⁸; PBac{IT.GAL4}Ptpmeg^1002-G4

9886

y¹ w^*; P{GawB}Ptpmeg^NP4498

32686

y¹ w^*; Mi{MIC}Ptpmeg^MI00492

42962

y¹ w^*; Mi{MIC}Ptpmeg^MI03892

44358

y¹ w^*; Mi{MIC}Ptpmeg^MI08056

9830

y¹ w^*; P{UAST-YFP.Rab40}Ptpmeg⁰³

17540

y¹ w^67c23; P{EPgy2}Ptpmeg^EY14306

Kyoto

125882

w¹¹¹⁸; P{RS5}Ptpmeg^5-SZ-3091

115080

w¹¹¹⁸; PBac{544.SVS-1}Ptpmeg^CPTI100033

VDRC

v103740

P{KK102294}VIE-260B

v38651

w¹¹¹⁸; P{GD7557}v38651

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (124)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP01515

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261985

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261985

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

FlyBase curator comment: although GenBank/EMBL/DDBJ: AF323978 refers to Ptpmeg as "split central complex", the ability of a scc allele to complement Ptpmeg phenotypes and to produce full-length Ptpmeg protein suggests that these genes are separate.

(Whited et al., 2007)

The Ptpmeg product is required for the proper establishment of axon projections in the ellipsoid body and is required for stabilization of already-formed projection patterns in the mushroom body. The phosphatase activity of the protein is needed for these functions.

(Whited et al., 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila EST AA441636. This EST matches ESTs AA820540 and AA817484. Evidence of alternative splicing.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: Ptpmeg Meg

(Edwards et al., 2001)

Source for merge of: Ptpmeg anon-WO0118547.211

(FlyBase, 1996-)

Additional comments

Source for identity of Ptpmeg CG1228 was sequence comparison ( date:000327 ).

(FlyBase, 1996-)

Source for merge of Ptpmeg anon-WO0118547.211 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Ptpmeg CG1228

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG1228

(Park et al., 2014, Yano et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Hong et al., 2008, Laviolette et al., 2005, Brody et al., 2002, Goldstein and Gunawardena, 2000, Morrison et al., 2000)

MEG1

(Morrison et al., 2000)

Meg

PTP-meg

(Gregory et al., 2007)

PTPMEG

(Andersen et al., 2004)

anon-WO0118547.211

dMEG1

(Wittwer et al., 2003)

dPtpmeg

(Chen et al., 2012)

dptpmeg

(Li et al., 2015)

ptmpeg

(Hong et al., 2008)

ptpmeg

(Mukherjee et al., 2020, Goossens et al., 2011, Maybeck and Röper, 2009, Hong et al., 2008, Hong et al., 2008, Whited et al., 2007, Whited et al., 2005)

scc

(Pascual, 2000.11.24)

Name Synonyms

Meg

Protein tyrosine phosphatase Meg

Ptpmeg

split central complex

(Pascual, 2000.11.24)

Secondary FlyBase IDs

FBgn0035133
FBgn0062170
FBgn0046703

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 109 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38059

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0R3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0R3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261985

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38059/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261985

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261985

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1228

MARRVEL_MODEL - MARRVEL (model organism gene)

38059

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261985

DroID - A comprehensive database of gene and protein interactions.

FBgn0261985

DRSC - Results frm RNAi screens

FBgn0261985

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035133

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261985

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1228

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261985

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005339

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

38059

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q86PA5

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

0.54

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