FlyBase Gene Report: Dmel\Ptpmeg

General Information

Symbol

Dmel\Ptpmeg

Species

D. melanogaster

Name

Protein tyrosine phosphatase Meg

Annotation Symbol

CG1228

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261985

Gene Model Status

Current

Stock Availability

39 publicly available

Enzyme Name (EC)

Protein-tyrosine-phosphatase (3.1.3.48)

Gene Snapshot

Protein tyrosine phosphatase Meg is a tyrosine phosphatase that interacts with Eps-15. It negatively regulates border cell migration during oogenesis. It also inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis. [Date last reviewed: 2016-06-23]

Other Summaries

Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

61C1-61C1

Sequence location

3L:328,097..356,050 [+]

Recombination map

3-0.5

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI Genome Data Viewer

UCSC Genome Browser

Ensembl Genome Browser

PopFly Genome Browser

GO Summary Ribbons

[Detailed GO annotations]

Families, Domains and Molecular Function

Gene Group Membership (FlyBase)

CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES

Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway

Protein Family (UniProt, Sequence Similarities)

Molecular Function (see GO section for details)

Experimental Evidence

protein tyrosine phosphatase activity

Predictions / Assertions

cytoskeletal protein binding; protein tyrosine phosphatase activity

Catalytic Activity (EC)

Experimental Evidence

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)

Predictions / Assertions

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)

Summaries

Gene Group Membership

CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES -: Cytosolic Protein Tyrosine Phosphatases are non-receptor tyrosine phosphatases. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).
Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Ptpmeg or the JBrowse view of Dmel\Ptpmeg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ptpmeg-RG

FBtr0306559

NM_138187

3608

974

Ptpmeg-RH

FBtr0306560

NM_167831

4116

974

Ptpmeg-RI

FBtr0306561

NM_001169838

3596

974

Ptpmeg-RJ

FBtr0306562

NM_001169839

4028

974

Ptpmeg-RK

FBtr0306563

NM_167830

4079

974

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ptpmeg-PG

FBpp0297514

109.7

974

7.22

NP_612031

AAN11441

Ptpmeg-PH

FBpp0297515

109.7

974

7.22

NP_728523

AAN11442

Ptpmeg-PI

FBpp0297516

109.7

974

7.22

NP_001163309

ACZ94581

Ptpmeg-PJ

FBpp0297517

109.7

974

7.22

NP_001163310

ACZ94582

Ptpmeg-PK

FBpp0297518

109.7

974

7.22

NP_728522

AAF47380

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

974 aa isoforms: Ptpmeg-PG, Ptpmeg-PH, Ptpmeg-PI, Ptpmeg-PJ, Ptpmeg-PK

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptpmeg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (15 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

protein tyrosine phosphatase activity

inferred from direct assay

(Li et al., 2015, Chen et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

cytoskeletal protein binding

inferred from electronic annotation with InterPro:IPR012151

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(Goldstein and Gunawardena, 2000)

protein tyrosine phosphatase activity

non-traceable author statement

(Morrison et al., 2000)

inferred from sequence or structural similarity

(Edwards et al., 2001)

inferred from sequence or structural similarity with SGD:S000002389

(FlyBase Curators, 2008--)

Biological Process (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

axon extension involved in axon guidance

inferred from mutant phenotype

(Whited et al., 2007)

central complex development

inferred from mutant phenotype

(Whited et al., 2007)

mushroom body development

inferred from mutant phenotype

(Whited et al., 2007)

negative regulation of border follicle cell migration

inferred from mutant phenotype

(Li et al., 2015)

negative regulation of epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Li et al., 2015)

inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205

(Li et al., 2015)

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Li et al., 2015)

peptidyl-tyrosine dephosphorylation

inferred from direct assay

(Chen et al., 2012)

peptidyl-tyrosine phosphorylation

inferred from direct assay

(Chen et al., 2012)

thermosensory behavior

inferred from mutant phenotype

(Hong et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

protein dephosphorylation

non-traceable author statement

(Morrison et al., 2000)

inferred from sequence or structural similarity with SGD:S000002389

(FlyBase Curators, 2008--)

inferred from sequence or structural similarity

(Edwards et al., 2001)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

cytoplasm

inferred from sequence or structural similarity with SGD:S000002389

(FlyBase Curators, 2008--)

cytoskeleton

inferred from electronic annotation with InterPro:IPR000299

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

mitochondrion

inferred from sequence or structural similarity with SGD:S000002389

(FlyBase Curators, 2008--)

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

sensory nervous system primordium

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{544.SVS-1}Ptpmeg^CPTI100033

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ptpmeg in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ptpmeg

View exonic expression by tissue for Dmel\Ptpmeg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261985

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1228

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs and Phenotypes

Classical and Insertion Alleles ( 40 )

For All Classical and Insertion Alleles Show

Allele of Ptpmeg

Class

Mutagen

Associated Insertion

Stocks

Known lesion

Ptpmeg¹

Yes

Ptpmeg^f01047

piggyBac activity

PBac{WH}Ptpmeg^f01047

Yes

Ptpmeg^EP3542

P{EP}Ptpmeg^EP3542

Yes

Ptpmeg^EY12179

P-element activity

P{EPgy2}Ptpmeg^EY12179

Yes

Ptpmeg^{MI08056-GFSTF.0}

phiC31 integrase

Mi{PT-GFSTF.0}Ptpmeg^{MI08056-GFSTF.0}

Yes

Ptpmeg^DG23409

P-element activity

P{wHy}Ptpmeg^DG23409

Yes

Ptpmeg^NP4498

P{GawB}Ptpmeg^NP4498

Yes

Ptpmeg⁰³

P{UAST-YFP.Rab40}Ptpmeg⁰³

Yes

Ptpmeg^5-SZ-3091

P{RS5}Ptpmeg^5-SZ-3091

Yes

Ptpmeg^0370-G4

piggyBac activity

PBac{IT.GAL4}Ptpmeg^0370-G4

Yes

Ptpmeg^1002-G4

piggyBac activity

PBac{IT.GAL4}Ptpmeg^1002-G4

Yes

Ptpmeg^c06290

piggyBac activity

PBac{PB}Ptpmeg^c06290

Yes

Ptpmeg^c06293

piggyBac activity

PBac{PB}Ptpmeg^c06293

Yes

Ptpmeg^c06880

piggyBac activity

PBac{PB}Ptpmeg^c06880

Yes

Ptpmeg^CPTI100033

piggyBac activity

PBac{544.SVS-1}Ptpmeg^CPTI100033

Yes

Ptpmeg^d03310

P-element activity

P{XP}Ptpmeg^d03310

Yes

Ptpmeg^d05374

P-element activity

P{XP}Ptpmeg^d05374

Yes

Ptpmeg^e03119

piggyBac activity

PBac{RB}Ptpmeg^e03119

Yes

Ptpmeg^e04126

piggyBac activity

PBac{RB}Ptpmeg^e04126

Yes

Ptpmeg^EY13883

P-element activity

P{EPgy2}Ptpmeg^EY13883

Yes

Ptpmeg^EY14306

P-element activity

P{EPgy2}Ptpmeg^EY14306

Yes

Ptpmeg^EY23549

P-element activity

P{EPgy2}Ptpmeg^EY23549

Yes

Ptpmeg^f04972

piggyBac activity

PBac{WH}Ptpmeg^f04972

Yes

Ptpmeg^f06198

piggyBac activity

PBac{WH}Ptpmeg^f06198

Yes

Ptpmeg^G8954

P-element activity

Yes

Yes

Yes

Yes

Mi{MIC}Ptpmeg^MI00492

Yes

Ptpmeg^MI03892

Mi{MIC}Ptpmeg^MI03892

Yes

Ptpmeg^MI08056

Mi{MIC}Ptpmeg^MI08056

Yes

Ptpmeg^MI11948

Mi{MIC}Ptpmeg^MI11948

Yes

Ptpmeg^c02341

piggyBac activity

PBac{PB}Ptpmeg^c02341

Yes

Ptpmeg^c02785

piggyBac activity

PBac{PB}Ptpmeg^c02785

Yes

Ptpmeg^c05544

piggyBac activity

PBac{PB}Ptpmeg^c05544

Yes

Ptpmeg^c05591

piggyBac activity

PBac{PB}Ptpmeg^c05591

Yes

Ptpmeg^EY10853

P-element activity

P{EPgy2}Ptpmeg^EY10853

Yes

Ptpmeg^f05405

piggyBac activity

PBac{WH}Ptpmeg^f05405

Yes

Ptpmeg^f06210

piggyBac activity

PBac{WH}Ptpmeg^f06210

Yes

Ptpmeg^G16277

hypomorphic allele - molecular evidence

P-element activity

P{}Ptpmeg^G16277

Yes

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ptpmeg

Allele of Ptpmeg

Mutagen

Associated Transgenic Construct

Stocks

Ptpmeg^{dsRNA.UAS.cCa}

Ptpmeg^{G494A.F494A.UAS}

P{UAS-Ptpmeg.G494A.F494A}

Ptpmeg^R883M.UAS

P{UAS-Ptpmeg.R883M}

Ptpmeg^UAS.cLa

in vitro construct - regulatory fusion

P{UAS-Ptpmeg.L}

Ptpmeg^UAS.cWa

in vitro construct - regulatory fusion

P{UAS-Ptpmeg.W}

Ptpmeg^{Y650F.D787A.UAS}

P{UAS-Ptpmeg.Y650F.D787A}

Ptpmeg^ΔFERM.UAS

in vitro construct - coding region fusion

P{UAS-Ptpmeg.ΔFERM}

Transgenic constructs containing regulatory region of Ptpmeg

Deletions and Duplications ( 0 )

Summary of Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ptpmeg^GD7557

viable, with Scer\GAL4^Mef2.PR

Ptpmeg^GD7557

viable, with Scer\GAL4^pnr-MD237

Ptpmeg^GD7557

viable, with Scer\GAL4^tin.CΔ4

Ptpmeg^GD7557

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

Other Phenotypes

Allele

behavior defective

Ptpmeg¹

cell migration defective, with Scer\GAL4^slbo.2.6

Ptpmeg^UAS.cLa

cell migration defective (with Df(3L)ED201)

Ptpmeg¹

cell migration defective | recessive

Ptpmeg¹

neuroanatomy defective (with Df(3L)ED201)

neuroanatomy defective | recessive

Ptpmeg¹

visible, with Scer\GAL4^en.PU

Ptpmeg^UAS.cLa

visible, with Scer\GAL4^GMR.PF

Ptpmeg^GS9137

Phenotype manifest in

Allele

axon & ellipsoid body

Ptpmeg¹

axon & ellipsoid body (with Df(3L)ED201)

Ptpmeg¹

axon & mushroom body | somatic clone | cell non-autonomous

Ptpmeg¹

border follicle cell

Ptpmeg¹

border follicle cell, with Scer\GAL4^slbo.2.6

Ptpmeg^UAS.cLa

border follicle cell (with Df(3L)ED201)

Ptpmeg¹

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

Ptpmeg^EP3542

eye, with Scer\GAL4^GMR.PF

Ptpmeg^GS9137

medial lobe of adult mushroom body

Ptpmeg¹

mushroom body alpha-lobe

Ptpmeg¹

mushroom body alpha-lobe (with Df(3L)ED201)

mushroom body beta-lobe

Ptpmeg¹

vertical lobe of adult mushroom body

Ptpmeg¹

wing vein, with Scer\GAL4^en.PU

Ptpmeg^UAS.cLa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PTPN4

12 of 15

Yes

Hsap\PTPN3

9 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ptpn4

12 of 15

Yes

Mmus\Ptpn3

9 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Ptpn4

10 of 13

Yes

Rnor\Ptpn3

9 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\ptpn4

5 of 12

Yes

Xtro\ptpn3

4 of 12

Yes

Danio rerio (Zebrafish) (3)

Drer\ptpn4a

10 of 15

Yes

Drer\ptpn4b

10 of 15

Yes

Drer\ptpn3

7 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\ptp-1

12 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No orthologs reported.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No orthologs reported.

Schizosaccharomyces pombe (Fission yeast) (0)

No orthologs reported.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901U1 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Ptpmeg

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11530

Drosophila persimilis

Dper\GL16093

Drosophila willistoni

Dwil\GK13061

Drosophila virilis

Dvir\GJ12484

Drosophila mojavensis

Dmoj\GI16737

Drosophila grimshawi

Dgri\GH15457

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501B2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022816

Glossina morsitans

Tsetse fly

Gmor\GMOY002373

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01155

Mayetiola destructor

Hessian fly

Mdes\Mdes003716

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003108

Anopheles darlingi

American malaria mosquito

Adar\ADAC004382

Anopheles gambiae

Malaria mosquito

Agam\AGAP007130

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003699

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W013T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005255

Danaus plexippus

Monarch butterfly

Dple\DPOGS215123-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS214085-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002725

Apis florea

Little honeybee

Aflo\3012599876

Apis mellifera

Western honey bee

Amel\GB44779

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23042

Bombus terrestris

Buff-tailed bumblebee

Bter\15214143

Linepithema humile

Argentine ant

Lhum\LH20601

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00124a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002894

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06355

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06354

Tribolium castaneum

Red flour beetle

Tcas\TC005339

Pediculus humanus

Human body louse

Phum\PHUM004630

Pediculus humanus

Human body louse

Phum\PHUM004640

Rhodnius prolixus

Kissing bug

Rpro\RPRC007678

Cimex lectularius

Bed bug

Clec\CLEC000620

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008797

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10849

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0123 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009978

Ixodes scapularis

Black-legged tick

Isca\ISCW009425

Ixodes scapularis

Black-legged tick

Isca\ISCW009429

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70585.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80932.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g01090

Tetranychus urticae

Two-spotted spider mite

Turt\tetur09g03690

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_197788

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G016K )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ptpd_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ptpn3/4

Ciona intestinalis

Vase tunicate

Cint\ptp

Gallus gallus

Domestic chicken

Ggal\PTPN3

Gallus gallus

Domestic chicken

Ggal\PTPN4

Human Disease Model Data

FlyBase Human Disease Model Reports

Alleles Reported to Model Human Disease (Disease Ontology)

Download

Models ( 0 )

Allele

Disease

Evidence

References

Interactions ( 0 )

Allele

Disease

Interaction

References

Comments ( 0 )

Human Orthologs (via DIOPT v7.1)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

Complementation?

Transgene?

PTPN4; protein tyrosine phosphatase, non-receptor type 4

12 of 15

176878

PTPN3; protein tyrosine phosphatase, non-receptor type 3

9 of 15

176877

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please look at the Interaction Group reports for full details of the physical interactions

protein-protein

Interacting group

Assay

References

Ptpmeg - Cortactin

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Li et al., 2015)

Ptpmeg - Eps-15

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Li et al., 2015)

Ptpmeg - Pvr

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Li et al., 2015)

Ptpmeg - TER94

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Li et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2015)

suppressible

(Li et al., 2015)

suppressible

(Li et al., 2015)

suppressible

(Whited et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pbl

enhanceable

Ptpmeg

(Gregory et al., 2007)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261985

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38059

Pathways

Gene Group - Pathway Membership (FlyBase)

Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q86PA5

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

61C1-61C1

Sequence location

3L:328,097..356,050 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61C1-61C1

Limits computationally determined from genome sequence between P{PZ}trh¹⁰⁵¹² and P{EP}EP3104^EP3104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (39)

Harvard

d03310

P{XP}Ptpmeg^d03310

d05374

P{XP}Ptpmeg^d05374

c06293

PBac{PB}Ptpmeg^c06293

c06880

PBac{PB}Ptpmeg^c06880

e03119

PBac{RB}Ptpmeg^e03119

e04126

PBac{RB}Ptpmeg^e04126

f01047

PBac{WH}Ptpmeg^f01047

f04972

PBac{WH}Ptpmeg^f04972

f06198

PBac{WH}Ptpmeg^f06198

VDRC

v103740

P{KK102294}VIE-260B

v38651

w¹¹¹⁸; P{GD7557}v38651

v38652

w¹¹¹⁸; P{GD7557}v38652

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (131)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261985

cDNA Clones, End Sequenced (ESTs)

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261985

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38059

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ptpmeg CG1228

(FlyBase, 1996-)

Source for database merge of

Source for merge of: Ptpmeg Meg

(Edwards et al., 2001)

Source for merge of: Ptpmeg anon-WO0118547.211

(FlyBase, 1996-)

Additional comments

Source for identity of Ptpmeg CG1228 was sequence comparison ( date:000327 ).

(FlyBase, 1996-)

Source for merge of Ptpmeg anon-WO0118547.211 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

FlyBase curator comment: although GenBank/EMBL/DDBJ: AF323978 refers to Ptpmeg as "split central complex", the ability of a scc allele to complement Ptpmeg phenotypes and to produce full-length Ptpmeg protein suggests that these genes are separate.

(Whited et al., 2007)

The Ptpmeg product is required for the proper establishment of axon projections in the ellipsoid body and is required for stabilization of already-formed projection patterns in the mushroom body. The phosphatase activity of the protein is needed for these functions.

(Whited et al., 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila EST AA441636. This EST matches ESTs AA820540 and AA817484. Evidence of alternative splicing.

(Davies, 2001.3.15)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 100 )

Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38059

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261985

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones

FBgn0261985

DroID - A comprehensive database of gene and protein interactions.

FBgn0261985

DRSC - Results frm RNAi screens

FBgn0261985

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1228

FlyMine - An integrated database for Drosophila genomics

FBgn0261985

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38059

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005339

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38059

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1228

modMine - A data warehouse for the modENCODE project

FBgn0261985

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q86PA5

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG1228

(Park et al., 2014, Yano et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Hong et al., 2008, Laviolette et al., 2005, Brody et al., 2002, Goldstein and Gunawardena, 2000, Morrison et al., 2000)

MEG1

(Morrison et al., 2000)

Meg

PTP-meg

(Gregory et al., 2007)

PTPMEG

(Andersen et al., 2004)

Ptpmeg

(Lee et al., 2018, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Hatzihristidis et al., 2015, Park et al., 2014, Sopko et al., 2014, Pankotai et al., 2013, Sen et al., 2013, Yin et al., 2013, Garcia et al., 2012, Yano et al., 2012, Dworkin et al., 2009, Hoopfer et al., 2008, Gregory et al., 2007, Whited et al., 2007, Zhang et al., 2007, Kim et al., 2006, Laviolette et al., 2005, Nelson et al., 2005)

anon-WO0118547.211

dMEG1

(Wittwer et al., 2003)

dPtpmeg

(Chen et al., 2012)

dptpmeg

(Li et al., 2015)

ptmpeg

(Hong et al., 2008)

ptpmeg

(Goossens et al., 2011, Maybeck and Röper, 2009, Hong et al., 2008, Hong et al., 2008, Whited et al., 2007, Whited et al., 2005)

scc

(Pascual, 2000.11.24)

Name Synonyms

Meg

Protein tyrosine phosphatase Meg

Ptpmeg

split central complex

(Pascual, 2000.11.24)

Secondary FlyBase IDs

FBgn0035133
FBgn0062170
FBgn0046703

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (85)

The following external sites may use different assemblies or annotations than FlyBase.

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