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Gene Dmel\Csk

General Information
Symbol	Dmel\Csk	Species	D. melanogaster
Name	C-terminal Src kinase	Annotation symbol	CG42317
Feature type	protein_coding_gene	FlyBase ID	FBgn0262081
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	dCsk, CG17309, l(3)j1D8
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E13-86E	Sequence location	3R:7,458,992..7,476,418 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene C-terminal Src kinase is referred to in FlyBase by the symbol Dmel\Csk (CG42317, FBgn0262081). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: negative regulation of growth; adherens junction maintenance; positive regulation of programmed cell death; establishment or maintenance of epithelial cell apical/basal polarity; epithelial structure maintenance; negative regulation of cell proliferation; germarium-derived egg chamber formation. 29 alleles are reported. The phenotypes of these alleles are annotated with: eye; wing disc; anterior crossvein; wing vein L4; wing; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 motif; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Gene sequence location is 3R:7458992..7476418.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN29731 BKN50796 BKN28405 BKN50245 HFA15223 HFA12861
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E13-86E   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886; Left limit from (method unavailable) (FBrf0126852) Right limit from (method unavailable) (FBrf0126852)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 86E-86E     (Stewart, 2000.3.3) 86E14-86E20   (determined by in situ hybridisation)   (Deak, 1999.12.22) 86E16-86E19   (determined by in situ hybridisation)   (Spradling et al., 1999) 86E14-86E20   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 86E14-86E20   (determined by in situ hybridisation)   (Deak et al., 1997) 86E16-86E19     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Csk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data Due to an oversight in the implementation of gene annotation merges, the symbols for some of the transcripts and polypeptides of this gene were changed to non-unique designations in r5.9. Although there were no conflicts within a given release, the same symbols were used for different isoforms in different releases. The affected gene product symbols have now been changed to symbols not used previously in the database; see individual transcript reports for details.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Csk-RF FBtr0299728  NM_176461   3946   723 Csk-RG FBtr0299729  NM_169418   5101   1052 Csk-RH FBtr0300546  NM_141840   4088   805 Csk-RI FBtr0300547  NM_169414   4514   723 Csk-RJ FBtr0300548  NM_169415   3952   723 Csk-RK FBtr0300549  NM_169416   4172   723
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Csk-PF   FBpp0289006   78.0   723   7.50     NP_788638   AAO41544 Csk-PG   FBpp0289007   113.7   1052   9.40     NP_731611   AAN13523 Csk-PH   FBpp0289773   87.2   805   7.52     NP_650097   AAF54668 Csk-PI   FBpp0289774   78.0   723   7.50     NP_731607   AAN13519 Csk-PJ   FBpp0289775   78.0   723   7.50     NP_731608   AAN13520 Csk-PK   FBpp0289776   78.0   723   7.50     NP_731609   AAN13521
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, active site (IPR008266) SH2 motif (IPR000980) Protein kinase, catalytic domain (IPR000719) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940695   AA979099   AE014297 AAF54668   AE014297 AAN13519   AE014297 AAN13520   AE014297 AAN13521   AE014297 AAN13523   AE014297 AAO41544   AC009740   AI063625   AI113796   AI113804   AI295167   AI296108   AI405147   AI456502   AQ034084   AW944121   BF491263   BF492157   BF493879   BF495190   BF497433   BF497457   BF498409   BF502612   BG632542   BG633349   BG639402   BG640796   BI161733   BI161734   BI167174   BI167256   BI167717   BI168833   BI169417   BI170165   BI173744   BI213019   BI214398   BI215759   BI234082   BI239225   BI242739   BI356504   BI361882   BI364873   BI368533   BI371255   BI372426   BI372900   BI375058   BI481997   BI482010   BI482049   BI483197   BI569060   BI580096   BI580267   BI580729   BI608344   BI608696   BI636532   BP552166   BP552167   BP557271   BP557272   BQ102795   BQ102800   BT011103   BT030413   CA805746   CO186590   CO188354   CO189725   CO190640   CO193747   CO263739   CO269556   CO271698   CO278036   CO280944   CO285145   CO294316   CO296789   CO297999   CO301162   CO303090   CO312028   CO313573   CO314820   CO319920   CO323234   CO326556   CO327571   CO330323   CO330613   CZ466346   CZ466729   CZ466730   CZ467835   CZ468609   CZ480955   CZ483923   DN154171   EC051979   EC053027   EC053030   EC053995   EC055377   EC059514   EC063185   EC067495   EC076653   EC076872   EC080245   EC080787   EC083018   EC085370   EC085662   EC199402   EC200394   EC212322   EC213133   EC216299   EC224449   EC226168   EC229938   EC231880   EC233124   EC235235   EC236617   EC236962   EC239113   EC248897   EC254541   EC262904   EL878206   EL878207   EL880274   EL880372   GH753766   GH844672   GH847335   GH888115   GH904110   GH911697   GH933039
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGK8 Q7KSQ2 Q8INJ8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage   salivary gland   (Lee et al., 2003)
Additional Descriptive Data
	The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue. (Lee et al., 2003)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CskS017909 lethal (with Df(3R)T-61) CskS017909 CskS030003 lethal | pharate adult stage | recessive CskS017909 CskS030003 lethal | pupal stage, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 CskGD9345 lethal | pupal stage, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS lethal | pupal stage (with Cskj1D8) CskS030003 lethal | pupal stage (with CskS030003) Cskj1D8 lethal | pupal stage | recessive Cskj1D8 lethal | recessive Cskj1D8 CskS017909 CskS030003 viable Cskc04256 viable, with Scer\GAL4pnr-MD237 CskGD15975 Sterility Allele fertile Cskc04256 Other Phenotypes Allele decreased cell death | pupal stage, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS increased cell death, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS increased cell death | recessive | third instar larval stage Cskj1D8 increased cell death | somatic clone CskS030003 increased cell number | somatic clone Cskj1D8 CskS030003 large body Cskj1D8 large body (with Cskj1D8) CskS030003 large body (with CskS030003) Cskj1D8 large body | pupal stage, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS mitotic cell cycle defective (with Cskj1D8) CskS030003 mitotic cell cycle defective (with CskS030003) Cskj1D8 mitotic cell cycle defective | somatic clone Cskj1D8 visible | somatic clone Cskc04256 Phenotype manifest in Allele anterior crossvein, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS egg chamber | germline clone CskD589N CskQ156Stop CskE481K eye, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS eye, with Scer\GAL4unspecified CskdsRNA.Scer\UAS eye | somatic clone Cskj1D8 CskS030003 Cskc04256 eye-antennal disc | somatic clone Cskj1D8 eye disc | somatic clone CskS030003 inter-ommatidial precursor cell | pupal stage, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS ommatidium, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS ommatidium | somatic clone Cskc04256 ommatidium | somatic clone | supernumerary Cskj1D8 CskS030003 secondary pigment cell | supernumerary, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS tertiary pigment cell | supernumerary, with Scer\GAL4GMR.PF CskdsRNA.Scer\UAS wing, with Scer\GAL4C-765 CskdsRNA.Scer\UAS wing, with Scer\GAL4sd-SG29.1 CskdsRNA.Scer\UAS wing disc Cskj1D8 wing disc, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS wing disc | somatic clone CskS030003 wing vein | ectopic, with Scer\GAL4C-765 CskdsRNA.Scer\UAS wing vein | ectopic, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS wing vein L4, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS zonula adherens & disc epithelium proper, with Scer\GAL4ptc-559.1 CskdsRNA.Scer\UAS
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of Csk Class Mutagen Stocks Known lesion Cskc04256 piggyBac transposase 2 -- Cskj1D8 loss of function allele P-element activity 2 Yes Cskc02285 piggyBac transposase 1 -- Cskc03290 1 -- Cskd09404 1 -- Cske03187 piggyBac transposase 1 -- Cskf01453 piggyBac transposase 1 -- CskNP3252 1 -- Csk50 0 -- Cskc00290 piggyBac transposase 0 -- Cskc00802 piggyBac transposase 0 -- Cskc03139 0 -- Cskc03332 piggyBac transposase 0 -- CskD589N ethyl methanesulfonate 0 Yes CskE481K ethyl methanesulfonate 0 Yes CskQ156Stop ethyl methanesulfonate 0 Yes CskS017909 loss of function allele Delta2-3 P-element activity 0 Yes CskS030003 loss of function allele Delta2-3 P-element activity 0 -- Cskunspecified 0 -- CskΔ13 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Csk Class Mutagen Stocks Known lesion CskGD15975 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CskGD9345 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CskGL00044 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CskKK109731 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CskdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Cskhs.PR in vitro construct - regulatory fusion 0 Yes Cskhs.PS in vitro construct - regulatory fusion 0 Yes CskKK108405 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CskScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)pros640 (Kusano et al., 2001) Df(3R)T-7 (Kusano et al., 2001) Df(3R)thoR1 (Kusano et al., 2001)
Disrupted in	Df(3R)BSC469 (Christensen et al., 2008.4.15) Df(3R)Exel6161 (Ryder, 2004.4.26) Df(3R)Exel6276 (Ryder, 2004.4.26) Df(3R)M-Kx1 (Spradling et al., 1999, Szeged Stock Center, 1998-, Stewart et al., 2003, BDGP Project Members, 1994-1999, Stewart, 2000.3.3) Df(3R)pros235 (Kusano et al., 2001) Df(3R)T-61 (Deak et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Csk.R} NA P{hs-Csk.S} NA UAS construct P{GD9345} NA P{KK108405} NA P{KK109731} NA P{TRiP.GL00044} NA P{UAS-Csk.P} NA P{UAS-Csk-IR} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions FB{}Cskj1D8 NA P{3'lacW}Cskj1D8 NA P{PT1}Csk50 NA PBac{PB}Cskc00290 NA PBac{PB}Cskc00802 NA PBac{PB}Cskc02285 NA PBac{PB}Cskc03139 NA PBac{PB}Cskc03290 NA PBac{PB}Cskc03332 NA PBac{PB}Cskc04256 NA PBac{RB}Cske03187 NA PBac{WH}Cskf01453 NA insertion of enhancer trap binary system P{GawB}CskNP3252 No insertion of mobile activating element P{XP}Cskd09404 NA insertion of enhancer trap P{lacW}CskS017909 No P{lacW}CskS030003 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
protein tyrosine kinase activity inferred from direct assay (Stewart et al., 2003, Pedraza et al., 2004)
Biological Process
CV term Evidence References
adherens junction maintenance inferred from mutant phenotype (Vidal et al., 2006) epithelial structure maintenance inferred from mutant phenotype (Vidal et al., 2006) establishment or maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Vidal et al., 2006) germarium-derived egg chamber formation inferred from mutant phenotype (O'Reilly et al., 2006) negative regulation of cell proliferation inferred from mutant phenotype (Read et al., 2004) negative regulation of growth inferred from genetic interaction with Src42A (Pedraza et al., 2004) inferred from genetic interaction with Src64B (Pedraza et al., 2004) inferred from mutant phenotype (Stewart et al., 2003) positive regulation of programmed cell death inferred from mutant phenotype (Vidal et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Stewart et al., 2000) protein tyrosine kinase activity inferred from sequence or structural similarity with UniProtKB:P32577 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
negative regulation of cell proliferation non-traceable author statement (Stewart et al., 2000) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) signal transduction non-traceable author statement (Stewart et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Csk allele Gene References Cskj1D8 Src42A (Pedraza et al., 2004) Src64B (Pedraza et al., 2004) wts (Stewart et al., 2003) CskScer\UAS.cPa Src42A (Pedraza et al., 2004) Src64B (Pedraza et al., 2004) unspecified bsk (Read et al., 2004) Btk29A (Read et al., 2004) os (Read et al., 2004) Ret (Read et al., 2005) rpr (Vidal et al., 2006) Src42A (Read et al., 2004) Src64B (O'Reilly et al., 2006, Read et al., 2004) Stat92E (Read et al., 2004)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262081 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41398
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19883 Dere\GG17207 Dgri\GH19323 Dmoj\GI23932 Dper\GL20506 Dpse\GA30184 Dvir\GJ10293 Dwil\GK18984 Dyak\GE10100
Curated drosophilid orthologs	Dpse\GA30184
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	11400 w1118; PBac{PB}Cskc04256 35174 y1 sc* v1; P{TRiP.GL00044}attP2
Harvard	- P{XP}Cskd09404 - PBac{PB}Cskc02285 - PBac{PB}Cskc03290 - PBac{PB}Cskc04256 - PBac{RB}Cske03187 - PBac{WH}Cskf01453
VDRC	v102313 P{KK109731}VIE-260B v32877 w1118; P{GD9345}v32877 v48282 w1118; P{GD15975}v48282 v48281 w1118; P{GD15975}v48281/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR11G22 BACR24C01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 125 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP09923
Other clones	IP10008
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02249 AT04051 AT11603 AT11630 AT12796 AT18403 AT27964 AT29045 GH03546 GH10255 LD22810 LD33364 LD36541 RE07502 RE07594 RE08166 RE09726 RE10585 RE11537 RE16836 RE18321 RE20185 RE22359 RE29719 RE35656 RE40154 RE42673 RE46275 RE50065 RE54520 RE58112 RE59379 RE60092 RE62778 RE64635 RE64650 RE64692 RE66050 RE74233 RE74431 RE74953 RH12755 RH13350 SD11945 SD18240
Other clones	17188 41833 53523 58004 60219 64263 65806 70027 76497 81475 99515 104247 107495 118685 120319 124568 176609 192161 192625 214313.44 524678 CK01.23C.D10 CK01.55B.H4 CK01.60D.F1 CK01.107A.G10 CK01.132A.E8 CK01.170A.G10 EC36729 EC051979 EC053027 EC053030 EC053995 EC055377 EK021347 EK039318 EK044962 EK048916 EK089457 EK094952 EK104357 EK128558 EK155533 EK168340 EK171064 EK180255 EK190017 EK193143 EK206544 EK215152 EK227726 EK233455 EK237856 EK239862 EK281422 EK294957 EK295727 EP04208 EP07546 ESG0119c.B21_B12 FGM217C01 FGM308D02 GH10267 GH25072 IP08094 IP10108 IP10208 LP08718 RE01155 RH01266 RP003078811 RP003175824 RP003189940 RP003496627 RP003539730 RP003589469 RP003642590 UUGC0182 UUGC0187
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0262081 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41398 318248 5658042
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Csk CG17309 (Read, 2003.2.10)
Source for database merge of	Source for merge of: Csk CG32852 (FlyBase Genome Annotators, 2008) Source for merge of: Csk flik (Stewart et al., 2003) Source for merge of: Csk flik l(3)j1D8 (Stewart et al., 2003) Source for merge of: Csk l(3)S017909 (Read et al., 2004)
Additional comments	Annotations CG17309 and CG32852 merged as CG42317 in release 5.9 of the genome annotation. (FlyBase Genome Annotators, 2008)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutants have increased body size and show over-proliferation of adult tissues. (Read et al., 2003) New annotation (CG32852) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) flik functions upstream of wts in a signaling pathway which negatively regulates cell proliferation during development. (Stewart et al., 2000) Homozygous flik animals display disc overproliferation and enlarged animal phenotypes. (Stewart et al., 2000) Lethal complementation group identified by insertion of a P{lacW} element in the 86E-87F region. (Deak et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141840 NM_169414 NM_169415 NM_169416 NM_169418 NM_176461 RefSeq (Proteins) • NP_650097 NP_731607 NP_731608 NP_731609 NP_731611 NP_788638 DDBJ / EMBL / GenBank • AAF54668 AAN13519 AAN13520 AAN13521 AAN13523 AAO41544 AC009740 AI296108 AQ034084 AW944121 CZ466346 CZ466729 CZ466730 CZ467835 CZ468609 CZ480955 CZ483923 Entrez Gene - A searchable database of RefSeq genes. • 41398 UniProtKB/TrEMBL • Q7KSQ2 Q8INJ8 Q9VGK8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, active site (IPR008266) SH2 motif (IPR000980) Protein kinase, catalytic domain (IPR000719) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262081 DRSC - Results from RNAi screens. • FBgn0262081 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0262081 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41398 318248 5658042 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41398 modMine - Data generated by the modENCODE project. • FBgn0262081
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG17309 (Giot et al., 2003, Keleman et al., 2009.8.5) CG32852 (Keleman et al., 2009.8.5) CG42317 (FlyBase Genome Annotators, 2008, Ni et al., 2011.7.19) Csk (Garcia-Lopez et al., 2008, Vidal et al., 2006, O'Reilly et al., 2006, Langton et al., 2007, Tountas and Fortini, 2007, Samakovlis, 2007.10.7, Larsen et al., 2006, Christensen et al., 2008.4.15, Karpova et al., 2006, Lee et al., 2009, Kim et al., 2005, Saja et al., 2010) csk (Pedraza et al., 2004, Edgar, 2006, Huang et al., 2008) CSK (Morrison et al., 2000) dCsk (Vidal et al., 2006, Read et al., 2005, Read et al., 2003, Vidal et al., 2006, Langton et al., 2007, Langton et al., 2009) DCsk (Pedraza et al., 2004) dcsk (Stewart et al., 2003, Saja et al., 2010) dCSK (Bates and Letsou, 2003) flik   l(3)j1D8 (Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(3)S017909 (Deak, 1999.12.22, ) unnamed (Deak et al., 1997)
Name Synonym	CG32852   CG42317 (FlyBase Genome Annotators, 2008) C-Src kinase (Edgar, 2006) C-terminal Src kinase (Read et al., 2003, Langton et al., 2009) C-terminal-Src kinase (O'Reilly et al., 2006) flik   lethal (3) j1D8   lethal (3) S017909
Secondary FlyBase IDs
	FBgn0023017 FBgn0024519 FBgn0037925 FBgn0041155 FBgn0052852 FBgn0086688 FBgn0086903 FBgn0259217
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 5 ) FlyBase analysis  ( 4 ) Computer file  ( 5 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Saja et al., 2010, Neurobiol. Disease 40(1): 135--145 Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. [FBrf0211567] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...