Gene model reviewed during 5.50
Gene model reviewed during 5.55
One of a couple of products generated by alternative splicing.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\f using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\f in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: f CG12996
Annotations CG5424 and CG12996 merged as CG42864 in release 5.30 of the genome annotation.
Descriptions of phenotypes are such as to make classification highly subjective. Bridges (1938; see also Bridges and Brehme, 1942) lists 14 lost alleles of diverse origin not included here, and Belgovsky (1940) lists 35 "fB" alleles induced by X rays in In(1)sc8 or In(1)BM2, of which 33 are lost and not included here. RK1.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Definitive denticle belt phenotypes (abnormal hairs and/or bristles) are foreshadowed by abnormal organisation of the actin cytoskeleton in embryonic epidermal cells.
The Mutator Strain (MS) is characterised by a high frequency of spontaneous mutations and their reversions. Spontaneous reversions of ct and f gypsy mutations are shown to be due to precise excisions of the element.
Alterations in the ratios among the f proteins and other components of the bristle fiber, result in abnormal assembly of the fibrillar cytoplasmic structures necessary for bristle morphogenesis.
Recessive mutations at su(f) increase the fraction of wild type f transcripts suggesting that the wild type su(f) gene product either stimulates premature termination at the gypsy LTR or inhibits normal splicing.
Macrochaetae, microchaetae and trichomes affected to various degrees depending on allele -- short, gnarled and bent with ends split or sharply bent. Treatment with methylurea causes normal bristle formation (De Marinis).
Some mutations in f are due to insertion of a Stalker element.
Mutant alleles are useful as markers in clonal analysis.
Developmental studies show nature of pupal bristle secretion is affected.
Green (Green, 1955; Green, 1956) showed the forked mutants can be assigned to either of two pseudoallelic series, f is a member of the right series. Back mutations to f+ occur spontaneously and their incidence is not increased by X rays (Green, 1959; Lefevre and Green, 1959).
Bridges, 19th Nov. 1912.