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Gene Dmel\IntS3

General Information
Symbol	Dmel\IntS3	Species	D. melanogaster
Name	Integrator 3	Annotation symbol	CG17665
Feature type	protein_coding_gene	FlyBase ID	FBgn0262117
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	h44-h46	Sequence location	2R:123,284..130,439 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Integrator 3 is referred to in FlyBase by the symbol Dmel\IntS3 (CG17665, FBgn0262117). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: snRNA processing. 13 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Integrator complex subunit 3. Gene sequence location is 2R:123284..130439.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location h44-h46   Left limit from inclusion within Df(2R)M41A8 (FBrf0094580) Right limit from inclusion within Df(2R)M41A10 (FBrf0094580)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 41C-41C     (Drosophila Heterochromatin Genome Project, 2004)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\IntS3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) IntS3-RA FBtr0111268  NM_001042972   3382   1068
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein IntS3-PA   FBpp0110478   123.9   1068   7.11     NP_001036437   EAA46157
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Integrator complex subunit 3 (IPR019333)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202436   AA697845   AA951252   AABU01002711 EAA46157   AABU01002711 EAA46158   BG637751   BG638646   BI214354   BI214985   BI215746   BI228669   BI230692   BI231153   BI234140   BI358168   BI366921   BI369225   BI375488   BI375571   BI484848   BI485722   BT001469 AAN71224   BT016083 AAV36968   BT044308   CO177581   CO187461   CO187556   CO189828   CO270562   CO273169   CO277793   CO278573   CO279257   CO280577   CO282112   CO295545   CO296190   CO296445   CO303054   CO303624   CO304306   CO306640   CO307943   CO314394   CO320577   CO330145   CO344655   DN154238   DN154362   AE013599 EAA46157   EC059522   EC062053   EC064258   EC067439   EC072513   EC075240   EC082433   EC090106   EC194942   EC207101   EC210072   EC213158   EC217946   EC218244   EC225636   EC225991   EC225995   EC226527   EC233297   EC235965   EC237124   EC240971   EC248893   EC257485   EV582068   GH941252   GH948649   GH949825   GH950612   GH952362   GH953249   GH955877   GH957829   GH964202   GH964941   GH971095   GH973027   GH973209   GH975302   GH977172   GH977531   GH981300   GH981442   GH985084
UniProtKB/Swiss-Prot	Q7PLS8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Golgi apparatus inferred from direct assay (Wendler et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    52 ovary, mated 4-day female    30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (52) ovary, mated 4-day female  (30) testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    52 ovary, mated 4-day female    30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    52 ovary, mated 4-day female    30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    52 ovary, mated 4-day female    30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (52) ovary, mated 4-day female  30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    52 ovary, mated 4-day female    30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    17 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    18 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    52 ovary, mated 4-day female    30 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr    28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr  (28) embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr    28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr    28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr    28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr  28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr    28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    25 embryo 04-06hr    19 embryo 06-08hr    17 embryo 08-10hr    22 embryo 10-12hr    13 embryo 12-14hr    28 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    12 embryo 22-24hr    18 larva L1    5 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    23 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2    47 embryonic Kc167    21 embryonic S1    11 embryonic S3    33 leg disc CME L1    11 wing disc CME-W2    39 wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    26 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2  (47) embryonic Kc167    21 embryonic S1    11 embryonic S3  (33) leg disc CME L1    11 wing disc CME-W2  (39) wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3  (29) eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  26 ovary fGS/OSS    16 ovary OSC  26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2    47 embryonic Kc167    21 embryonic S1    11 embryonic S3    33 leg disc CME L1    11 wing disc CME-W2    39 wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    26 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2    47 embryonic Kc167    21 embryonic S1    11 embryonic S3    33 leg disc CME L1    11 wing disc CME-W2    39 wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    26 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2    47 embryonic Kc167    21 embryonic S1    11 embryonic S3    33 leg disc CME L1    11 wing disc CME-W2    39 wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    26 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2  (47) embryonic Kc167    21 embryonic S1    11 embryonic S3  (33) leg disc CME L1    11 wing disc CME-W2  (39) wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3  29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  26 ovary fGS/OSS    16 ovary OSC  26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2    47 embryonic Kc167    21 embryonic S1    11 embryonic S3    33 leg disc CME L1    11 wing disc CME-W2    39 wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    26 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    7 embryonic GM2    47 embryonic Kc167    21 embryonic S1    11 embryonic S3    33 leg disc CME L1    11 wing disc CME-W2    39 wing disc ML-DmD8    13 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    26 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal IntS3Lc lethal (with Df(2R)34-2) IntS345-34 IntS345-61 IntS345-71 IntS3IR23 IntS3Lc IntS3NC19 IntS3NC28 IntS3NC89 lethal (with Df(2R)247) IntS345-34 IntS345-61 IntS345-71 IntS3IR23 IntS3Lc IntS3NC19 IntS3NC28 IntS3NC89 lethal (with IntS345-34) IntS345-61 IntS345-71 IntS3IR23 IntS3Lc IntS3NC19 IntS3NC28 IntS3NC89 lethal (with IntS345-61) IntS345-34 IntS345-71 lethal (with IntS345-71) IntS345-34 IntS345-61 lethal (with IntS3IR23) IntS345-34 IntS3Lc IntS3NC28 IntS3NC89 lethal (with IntS3Lc) IntS345-34 IntS3IR23 IntS3NC19 IntS3NC89 lethal (with IntS3NC19) IntS345-34 IntS3Lc IntS3NC28 IntS3NC89 lethal (with IntS3NC28) IntS345-34 IntS3IR23 IntS3NC19 IntS3NC89 lethal (with IntS3NC89) IntS345-34 IntS3IR23 IntS3Lc IntS3NC19 IntS3NC28 lethal | recessive IntS345-34 IntS345-61 IntS345-71 IntS3IR23 IntS3NC19 IntS3NC28 IntS3NC86 partially lethal - majority die, with Scer\GAL4da.G32 IntS3GD9439 viable, with Scer\GAL4pnr-MD237 IntS3GD9439 viable (with IntS345-61) IntS3IR23 IntS3Lc IntS3NC19 IntS3NC28 IntS3NC89 viable (with IntS345-71) IntS3IR23 IntS3Lc IntS3NC19 IntS3NC28 IntS3NC89 viable (with IntS3IR23) IntS345-61 IntS345-71 IntS3NC19 viable (with IntS3Lc) IntS345-61 IntS345-71 IntS3NC28 viable (with IntS3NC19) IntS345-61 IntS345-71 IntS3IR23 viable (with IntS3NC28) IntS345-61 IntS345-71 IntS3Lc viable (with IntS3NC89) IntS345-61 IntS345-71 Other Phenotypes Allele visible, with Scer\GAL4Bx-MS1096 IntS3HM04039 visible, with Scer\GAL4pnr-MD237 IntS3GD9439 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 IntS3GD9439 wing, with Scer\GAL4Bx-MS1096 IntS3HM04039
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of IntS3 Class Mutagen Stocks Known lesion IntS3EY09264 P-element activity 1 -- IntS3IR23 IR-hybrid dysgenesis 1 -- IntS3MI03529 1 -- IntS3NC19 ethyl methanesulfonate 1 Yes IntS3NC28 ethyl methanesulfonate 1 Yes IntS3NC89 ethyl methanesulfonate 1 -- IntS345-34 ethyl methanesulfonate 0 Yes IntS345-61 ethyl methanesulfonate 0 Yes IntS345-71 ethyl methanesulfonate 0 Yes IntS3Lc ethyl methanesulfonate 0 -- IntS3NC86 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of IntS3 Class Mutagen Stocks Known lesion IntS3HM04039 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IntS3GD9439 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)34-2 (Coulthard et al., 2010, Coulthard et al., 2010) Df(2R)247 (Myster et al., 2004, Marygold et al., 2005, Myster and Peifer, 2003.9.11, Coulthard et al., 2010, Coulthard et al., 2010) Df(2R)M41A1 (Marygold et al., 2005) Df(2R)M41A2 (Marygold et al., 2005, Myster et al., 2004, Coulthard et al., 2010) Df(2R)M41A4 (Marygold et al., 2005) Df(2R)M41A8 (Marygold et al., 2005, Myster et al., 2004, Dimitri et al., 1997) Df(2R)M41A10 (Marygold et al., 2005, Myster et al., 2004, Dimitri et al., 1997) Df(2R)NC13 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)NC50 (Myster et al., 2004) Df(2R)NC68 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC125 (Myster et al., 2004) Df(2R)NC167 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC191 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC202 (Myster et al., 2004) Df(2R)NC218 (Myster et al., 2004) Df(2R)NC228 (Myster and Peifer, 2003.9.11, Myster et al., 2004)
Not disrupted in	Df(2R)244 (Myster et al., 2004) Df(2R)247 (Myster et al., 2004) Df(2R)Dark2 (Myster et al., 2004) Df(2R)M41A2 (Myster et al., 2004) Df(2R)nap1 (Myster et al., 2004) Df(2R)NC32 (Myster et al., 2004) Df(2R)NC73 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC207 (Myster et al., 2004) Df(2R)NC219 (Myster et al., 2004) Df(2R)NC1198 (Myster et al., 2004) Df(2R)Nipped-D (Myster et al., 2004)
Duplicated in	Dp(2;f)e97 (Dimitri et al., 1997)
Partially disrupted in	Df(2R)M41A2 (Coulthard et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}IntS3EY09264 NA miscellaneous insertions Mi{MIC}IntS3MI03529 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2012-02-09)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (Wendler et al., 2010)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
snRNA processing inferred from sequence or structural similarity with human INTS3 (Baillat et al., 2005)
Cellular Component
CV term Evidence References
integrator complex inferred from sequence or structural similarity with human INTS3 (Baillat et al., 2005)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions IntS3 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262117
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6V7020 Dipteran inclusive ortholog search EOG6QVCM1 Insect inclusive ortholog search EOG6X6B45 Arthropod inclusive ortholog search EOG6MKKX3 Metazoa inclusive ortholog search EOG6CCGSZ
Orthologs in Drosophila Species (EOG6V7020)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\IntS3     Drosophila sechellia   Dsec\GM26749     Drosophila erecta   Dere\GG23122     Drosophila yakuba   Dyak\GE11342     Drosophila ananassae   Dana\GF16127     Drosophila persimilis   Dper\GL21164     Drosophila willistoni   Dwil\GK23434     Drosophila virilis   Dvir\GJ17515     Drosophila mojavensis   Dmoj\GI18256     Drosophila grimshawi   Dgri\GH13349
Orthologs in non-Drosophila Dipterans (EOG6QVCM1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008068   Anopheles gambiae Malaria mosquito  Agam\INT3_ANOGA   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008133
Orthologs in non-Dipteran Insects (EOG6X6B45)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48524   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG028983   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG028515   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15427   Atta cephalotes Leafcutter ant  Acep\ACEP16768   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20219   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19628   Linepithema humile Argentine ant  Lhum\LH24261   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20124   Solenopsis invicta Red fire ant  Sinv\SINV16324   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008853   Bombyx mori Silkmoth  Bmor\BGIBMGA001430   Pediculus humanus Human body louse  Phum\PHUM244110   Tribolium castaneum Red flour beetle  Tcas\TC002074
Orthologs in non-Insect Arthropods (EOG6MKKX3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306579   Ixodes scapularis Deer tick  Isca\ISCW021591
Orthologs in non-Arthropod Metazoa (EOG6CCGSZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y92H12A.4   Caenorhabditis elegans Nematode  Cele\Y92H12A.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000924gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007970gn   Danio rerio Zebrafish  Drer\ints3   Xenopus tropicalis Western clawed frog  Xtro\ints3   Mus musculus House mouse  Mmus\Ints3   Rattus norvegicus Norway rat  Rnor\Ints3   Homo sapiens Human  Hsap\ENSG00000143624
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000143624
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	6973 IntS3IR23/CyO 31730 y1 v1; P{TRiP.HM04039}attP2 7161 IntS3NC89 cn1 bw1/SM1 7169 IntS3NC19 cn1 bw1/SM1 7170 IntS3NC28 cn1 bw1/SM1 37007 y1 w*; Mi{MIC}IntS3MI03529/SM6a 20082 y1 w67c23; P{EPgy2}IntS3EY09264/CyO
Genomic Clones ( 0 )
cDNA Clones ( 86 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02622 LD44383
Other clones	FI06801
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	15957 18671 20236 44206 73858 77276 80479 81911 106283 106768 120200 120271 152959 181820 191923 214249.36 CK01.27A.D9 CK01.34D.C4 CK01.35C.E2 CK01.56A.H12 CK01.66B.C6 CK01.110A.G1 Dmel_dig_002260_0696_3735 EK029542 EK030337 EK045248 EK053843 EK099325 EK109905 EK126427 EK130447 EK133912 EK154401 EK159546 EK203353 EK210653 EK213014 EK213654 EK225206 EK236019 EK239815 EK242243 EK244318 EK251642 EK256238 EK286330 EK294616 EP19659 HL03310 LD31627 RE14716 RE19357 RE20131 RE21161 RE22344 RE26288 RE29786 RE44856 RE52561 RE55345 RE63322 RE63421 RE68014 RE69058 RP004049264 RP004089233 RP004133032 RP004145807 RP004172663 RP004181160 RP004196635 RP004231829 RP004233148 RP004233480 RP004269627 RP004288221 RP004299926 RP004345630 RP004385495 RP004388572 RP004417846 RP004497489 RP004506983
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0262117 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355010
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: IntS3 CG17665 (Baillat et al., 2005)
Source for database merge of	Source for merge of: CG17665 l(2)NC19 l(2)NC28 l(2)IR23 (Coulthard et al., 2010)
Additional comments	The "l(2)41Ae" locus fails to complement mutations in 7 genes ("l(2)NC37", "l(2)NC38", "l(2)NC133", "l(2)NC110", "l(2)NC70", "l(2)IR3" and "l(2)IR23"). The "l(2)41Ae" locus has previously been shown to have complex complementation behaviour (FBrf0028786). This information suggests that the "l(2)41Ae""locus" may contain mutations in different genes. (Dimitri et al., 2005) May correspond to l(2)41Ae of FBrf0028786. (Myster and Peifer, 2003.9.11)
Other Comments
	Identification: During an EMS mutagenesis for lethal mutations uncovered by Df(2R)M41A8. (Myster et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001042972 RefSeq (Proteins) • NP_001036437 DDBJ / EMBL / GenBank • AA202436 AABU01002711 AAN71224 AAV36968 BG637751 BT001469 BT016083 EAA46157 EAA46158 Entrez Gene - A searchable database of RefSeq genes. • 3355010 UniProtKB/Swiss-Prot • Q7PLS8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Integrator complex subunit 3 (IPR019333)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262117 DRSC - Results from RNAi screens. • FBgn0262117 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0262117 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355010 modMine - Data generated by the modENCODE project. • FBgn0262117
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG17665 (Friedman et al., 2011, Wendler et al., 2010, Coulthard et al., 2010, Rossi et al., 2007, Ni et al., 2008) Int3 (Baillat et al., 2005) IntS3 (Ezzeddine et al., 2011, ) IR23 (Dimitri et al., 2005) l(2)IR23   l(2)NC19   l(2)NC28   l(2Rh)IR23 (Myster et al., 2004) NC19 (Dimitri et al., 2005) NC28 (Dimitri et al., 2005)
Name Synonym	Integrator 3 (Ezzeddine et al., 2011, ) lethal (2) IR23   lethal (2) NC19   lethal (2) NC28
Secondary FlyBase IDs
	FBan0017665 FBgn0022283 FBgn0039997 FBgn0067367 FBgn0067370
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 )
Recent research papers ( 2 )
	Ezzeddine et al., 2011, Mol. Cell. Biol. 31(2): 328--341 A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation. [FBrf0212592] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...