FlyBase Gene Report: Dmel\Sec23

General Information

Symbol

Dmel\Sec23

Species

D. melanogaster

Name

Secretory 23

Annotation Symbol

CG1250

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262125

Gene Model Status

Stock Availability

8 publicly available

Gene Summary

Secretory 23 (Sec23) encodes a COPII vesicle-coating component that functions in vesicle transport from the ER to the Golgi apparatus. It is involved in cell polarity maintenance and extracellular matrix secretion. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

dSec23p, dSec23, haunted, hau, COPII

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:5,649,065..5,652,629 [+]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5649065..5652629

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (27 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTPase activator activity

inferred from sequence or structural similarity with SGD:S000006385

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000124617

(assigned by GO_Central )

(Gaudet et al., 2011)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR006895, InterPro:IPR036174

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (20 terms)

Terms Based on Experimental Evidence (16 terms)

CV Term

Evidence

References

involved_in basement membrane organization

inferred from mutant phenotype

(Norum et al., 2010)

involved_in chitin-based cuticle development

inferred from mutant phenotype

(Norum et al., 2010)

involved_in chitin-based larval cuticle pattern formation

inferred from mutant phenotype

(Abrams and Andrew, 2005)

involved_in endoplasmic reticulum organization

inferred from mutant phenotype

(Norum et al., 2010)

involved_in Golgi organization

inferred from genetic interaction with FLYBASE:ecd; FB:FBgn0000543

(Kondylis et al., 2001)

inferred from mutant phenotype

(Norum et al., 2010)

involved_in larval chitin-based cuticle development

inferred from mutant phenotype

(Abrams and Andrew, 2005)

involved_in lumen formation, open tracheal system

inferred from mutant phenotype

(Norum et al., 2010)

involved_in maintenance of cell polarity

inferred from mutant phenotype

(Norum et al., 2010)

involved_in muscle attachment

inferred from mutant phenotype

(Norum et al., 2010)

involved_in positive regulation of cell-cell adhesion

inferred from mutant phenotype

(Norum et al., 2010)

involved_in positive regulation of cuticle pigmentation

inferred from mutant phenotype

(Norum et al., 2010)

involved_in positive regulation of dendrite morphogenesis

inferred from mutant phenotype

(Ye et al., 2007)

involved_in positive regulation of extracellular matrix constituent secretion

inferred from mutant phenotype

(Norum et al., 2010)

involved_in protein localization to cell surface

inferred from mutant phenotype

(Norum et al., 2010)

involved_in protein localization to plasma membrane

inferred from mutant phenotype

(Kumichel et al., 2015)

involved_in regulation of cell shape

inferred from mutant phenotype

(Norum et al., 2010)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in COPII-coated vesicle cargo loading

inferred from biological aspect of ancestor with PANTHER:PTN000124617

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR006895, InterPro:IPR006896, InterPro:IPR006900

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in positive regulation of GTPase activity

inferred from sequence or structural similarity with SGD:S000006385

(FlyBase Curators, 2008--)

involved_in regulation of COPII vesicle coating

inferred from sequence or structural similarity with SGD:S000006385

(FlyBase Curators, 2008--)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in endoplasmic reticulum exit site

inferred from direct assay

(Ivan et al., 2008, Herpers and Rabouille, 2004)

located_in endoplasmic reticulum

inferred from direct assay

(Kondylis et al., 2001)

located_in Golgi stack

inferred from direct assay

(Kondylis et al., 2001)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of COPII vesicle coat

inferred from sequence or structural similarity with SGD:S000006385

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000124617

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in COPII-coated ER to Golgi transport vesicle

traceable author statement

(Kondylis et al., 2001)

is_active_in endoplasmic reticulum exit site

inferred from biological aspect of ancestor with PANTHER:PTN000124617

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

COAT PROTEIN COMPLEX II

ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Secretory 23 (Sec23) encodes a COPII vesicle-coating component that functions in vesicle transport from the ER to the Golgi apparatus. It is involved in cell polarity maintenance and extracellular matrix secretion. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

COAT PROTEIN COMPLEX II -: The Coat Protein Complex II (COPII) mediates protein transport from the ER to Golgi (anterograde transport). COPII recruitment is initiated by the activation of the small GTPase Sar1. Sar1 recruits a heterodimeric complex comprising of Sec23/24, which interacts with cargo and the outer cage - a heterotetramer composed of Sec13/31. (Adapted from PMID:18060556).
ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS -: ArfGAPs are GTPase activating proteins for ARF family GTPases. ARFGAPs contain a characteristic 130 amino acid module, the ArfGAP domain, originally defined as the minimal fragment possessing ArfGAP activity. (Adapted from FBrf0158741, PMID:15731001 and PMID:18809720).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

hau: haunted

Homozygous lethal; only head skeleton visible in homozygous embryo; no differentiation of cuticle.

Gene Model and Products

Number of Transcripts

7

Number of Unique Polypeptides

3

Please see the JBrowse view of Dmel\Sec23 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.40

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0078711

2706

773

FBtr0078710

2798

773

FBtr0304794

2819

780

FBtr0309091

2701

781

FBtr0310266

2698

780

FBtr0330314

2590

773

FBtr0339320

2677

773

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0078360

86.8

773

6.78

FBpp0078359

86.8

773

6.78

FBpp0293334

87.5

780

6.78

FBpp0301099

87.6

781

6.78

FBpp0301949

87.5

780

6.78

FBpp0303346

86.8

773

6.78

FBpp0308424

86.8

773

6.78

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

780 aa isoforms: Sec23-PD, Sec23-PF

773 aa isoforms: Sec23-PA, Sec23-PB, Sec23-PG, Sec23-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sec23 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sec23_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

foregut primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum exit site

inferred from direct assay

(Ivan et al., 2008, Herpers and Rabouille, 2004)

located_in endoplasmic reticulum

inferred from direct assay

(Kondylis et al., 2001)

located_in Golgi stack

inferred from direct assay

(Kondylis et al., 2001)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sec23 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sec23

View exonic expression by tissue for Dmel\Sec23

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262125

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40694/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262125

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0262125

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262125

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1250

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sec23

Transgenic constructs containing regulatory region of Sec23

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

(Giesen, 2001.1.24)

(Norum et al., 2010)

(Ryder, 2004.4.26)

Gene not disrupted in

(Giesen, 2001.1.24)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sec23^GD7746

lethal, with Scer\GAL4^pnr-MD237

Sec23^GD7746

lethal - all die before end of first instar larval stage

lethal - all die before end of first instar larval stage (with Df(3R)ED5187)

lethal - all die before end of first instar larval stage (with Sec23^9G)

Sec23^CK

lethal - all die before end of first instar larval stage (with Sec23^CK)

Sec23^9G

lethal - all die during embryonic stage | recessive

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

Sec23^GD7746

Sec23^EY06757

viable (with Df(3R)ED5187)

Sec23^j13C8

viable (with Sec23^9G)

Sec23^j13C8

viable (with Sec23^j13C8)

Sec23^9G

Sterility

Allele

Sec23^EY06757

Other Phenotypes

Allele

abnormal cell adhesion | first instar larval stage

Sec23^9G

abnormal cell polarity | late embryonic stage

Sec23^9G

abnormal cell shape | first instar larval stage

Sec23^9G

abnormal neuroanatomy

Sec23^8-2-55

some die during embryonic stage | recessive

some die during first instar larval stage

some die during first instar larval stage (with Df(3R)ED5187)

some die during first instar larval stage (with Sec23^9G)

Sec23^CK

some die during first instar larval stage (with Sec23^CK)

Sec23^9G

Phenotype manifest in

Allele

adherens junction

Sec23^9G

basement membrane

Sec23^9G

cephalopharyngeal skeleton

cephalopharyngeal skeleton (with Df(3R)ED5187)

cephalopharyngeal skeleton (with Sec23^9G)

Sec23^CK

cephalopharyngeal skeleton (with Sec23^CK)

Sec23^9G

dendrite & dendritic arborising neuron

Sec23^8-2-55

denticle (with Df(3R)ED5187)

denticle (with Sec23^9G)

Sec23^CK

denticle (with Sec23^CK)

Sec23^9G

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle (with Df(3R)ED5187)

embryonic/first instar larval cuticle (with Sec23^9G)

Sec23^CK

embryonic/first instar larval cuticle (with Sec23^CK)

Sec23^9G

embryonic/larval apodeme

Sec23^9G

embryonic/larval dorsal trunk | embryonic stage 17

Sec23^9G

embryonic/larval epidermis

Sec23^9G

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Sec23^HMS00356

embryonic/larval trachea

embryonic/larval trachea (with Df(3R)ED5187)

embryonic/larval trachea (with Sec23^9G)

Sec23^CK

embryonic/larval trachea (with Sec23^CK)

Sec23^9G

embryonic/larval trachea | first instar larval stage

Sec23^9G

endoplasmic reticulum | late embryonic stage

Sec23^9G

Sec23^9G

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Sec23^HMS00356

Golgi apparatus | embryonic stage 16

Sec23^9G

Sec23^9G

septate junction

Sec23^9G

taenidial fold | first instar larval stage

Sec23^9G

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

13 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

12 of 15

No

Yes

Rattus norvegicus (Norway rat) (2)

13 of 13

Yes

Yes

8 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (2)

9 of 12

Yes

Yes

8 of 12

No

Yes

Danio rerio (Zebrafish) (2)

14 of 15

Yes

Yes

13 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

13 of 15

Yes

Yes

Arabidopsis thaliana (thale-cress) (6)

9 of 9

Yes

Yes

8 of 9

No

Yes

8 of 9

No

Yes

8 of 9

No

Yes

4 of 9

No

Yes

1 of 9

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

13 of 15

Yes

Yes

2 of 15

No

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

11 of 12

Yes

Yes

6 of 12

No

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902OZ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00010900

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501FH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY009071

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11805

Mayetiola destructor

Hessian fly

Mdes\Mdes014278

Mayetiola destructor

Hessian fly

Mdes\Mdes014279

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007484

Anopheles darlingi

American malaria mosquito

Adar\ADAC003830

Anopheles gambiae

Malaria mosquito

Agam\AGAP001759

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005333

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W018F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004852

Danaus plexippus

Monarch butterfly

Dple\DPOGS214955-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015596

Apis florea

Little honeybee

Aflo\2150470404

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0027b6

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003578

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM514700

Rhodnius prolixus

Kissing bug

Rpro\RPRC008500

Rhodnius prolixus

Kissing bug

Rpro\RPRC008502

Cimex lectularius

Bed bug

Clec\CLEC008561

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007972

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10425

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14975

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04217

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01JV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003764

Ixodes scapularis

Black-legged tick

Isca\ISCW016963

Ixodes scapularis

Black-legged tick

Isca\ISCW009326

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67211.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur25g00020

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_190968

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G063R )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024983

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

SEC23A; SEC23 homolog A, COPII coat complex component

model of craniolenticulosutural dysplasia

IEA

(FlyBase, 2019-)

SEC23B; SEC23 homolog B, COPII coat complex component

model of congenital dyserythropoietic anemia type II

IEA

(FlyBase, 2019-)

model of Cowden syndrome 7

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SEC23A; SEC23 homolog A, COPII coat complex component

14 of 15

CRANIOLENTICULOSUTURAL DYSPLASIA; CLSD

craniolenticulosutural dysplasia

SEC23B; SEC23 homolog B, COPII coat complex component

13 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Kunduri et al., 2014)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262125

MIST (protein-protein) - An integrated Molecular Interaction Database

Sec23

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Protein processing in endoplasmic reticulum

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-47.5

Cytogenetic map

Sequence location

3R:5,649,065..5,652,629 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83B7-83B8

Limits computationally determined from genome sequence between P{lacW}Atu^s1938 and P{lacW}cas^j1C2

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

86B3-86B7

(Rabouille, 2000.3.15)

83B6-83B7

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

3-48

(Tearle and Nusslein-Volhard, 1987)

3-48.4

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

19921

y¹ w^67c23; P{EPgy2}Sec23^EY06757

79400

y¹ sc^* v¹ sev²¹; P{TKO.GS00801}attP40

32365

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00356}attP2

78874

y¹ w^*; TI{CRIMIC.GT36}Sec23^CR00083/TM3, Sb¹ Ser¹

10218

w¹¹¹⁸; P{lacW}Sec23^j13C8, l(3)j13C8^j13C8/TM3, P{ftz-lacC}SC1, ry^RK Sb¹ Ser¹

3094

ru¹ h¹ Diap1¹ st¹ Sec23^9G cu¹ sr¹ e^s ca¹/TM3, Sb¹ Ser¹

v110568

P{KK100659}VIE-260B

v24552

w¹¹¹⁸; P{GD7746}v24552/TM3

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (202)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262125

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0262125

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40694

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: sec23 CG1250

(FlyBase, 1996-)

Source for identity of: Sec23 sec23

(FlyBase, 2009-)

Source for database merge of

Source for merge of: sec23 hau

(Norum et al., 2010)

Additional comments

FlyBase Curator comment: Although the "hau" symbol has precedence over the "sec23" symbol, "sec23" has been retained as the approved FlyBase symbol for this gene because of its currency in the literature.

(Norum et al., 2010)

Source for identity of sec23 CG1250 was sequence comparison ( date:000327 ).

(FlyBase, 1996-)

Other Comments

S2 cells treated with dsRNA directed against sec23 show a marked abnormality in actin polymerization and a total absence of bacterial binding in a phagocytosis assay.

(Stuart et al., 2007)

Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.

(Ye et al., 2007)

hau mutants display only a visible head skeleton, no differentiation of cuticle.

(Jurgens et al., 1984)

Origin and Etymology

Discoverer

Etymology

Named "Sec23" after the S. cerevisiae ortholog.

(FlyBase, 2009-)

Identification

In a screen for mutations affecting dendritic and/or axonal development in the class IV dendritic arborization (da) neurons. 1 allele has been isolated.

(Ye et al., 2007)

External Crossreferences and Linkouts ( 74 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40694

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262125

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262125

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40694/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262125

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sec23_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0262125

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262125

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1250

FlyMine - An integrated database for Drosophila genomics

FBgn0262125

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40694

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009191

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1250

MARRVEL_MODEL - MARRVEL (model organism gene)

40694

modMine - A data warehouse for the modENCODE project

FBgn0262125

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262125

DRSC - Results frm RNAi screens

FBgn0262125

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Protein processing in endoplasmic reticulum

MIST (protein-protein) - An integrated Molecular Interaction Database

Sec23

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG1250

(Hosono et al., 2015, Christis and Munro, 2012, Glatter et al., 2011, Ni et al., 2010.12.1, Norum et al., 2010, Keleman et al., 2009.8.5, Sepp et al., 2008, Dorer et al., 2006, Dunne et al., 2002, Levis, 2002.12.19, Kondylis et al., 2001, Rabouille, 2000.5.2)

COPII

(Feng et al., 2020, Kunduri et al., 2014, Aikin et al., 2012)

Hau

(Moussian, 2013)

SEC23

(Dorer et al., 2006)

Sec23A

(Rabouille, 2000.5.2)

Sec23p

(Sone et al., 2009)

dSec23

(Kondylis et al., 2011, Sinka et al., 2008, Friggi-Grelin et al., 2006, Dunne et al., 2002, Dunne and Rabouille, 2001)

dSec23p

(Castro et al., 2007, Kondylis et al., 2007, Kondylis et al., 2005, Kondylis and Rabouille, 2003, Kondylis et al., 2001)

dar2

(Ye et al., 2007)

dsec23

(Dunne et al., 2002)

dsec23p

(Herpers and Rabouille, 2004)

hau

(Kumichel et al., 2015, Norum et al., 2010)

Name Synonyms

Haunted

(Moussian, 2013, Norum et al., 2010)

Sec23 ortholog

Secretory 23

coat protein II

(Kunduri et al., 2014)

dendritic arbor reduction 2

(Ye et al., 2007)

haunted

(Wieschaus and Nüsslein-Volhard, 2016, Kumichel et al., 2015, Norum et al., 2010)

sec23

(Sepp et al., 2008)

Secondary FlyBase IDs

FBgn0001178
FBgn0037357
FBgn0011441

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (125)

Report Sections