Gene Dmel\mir-7

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General Information

Symbol

Dmel\mir-7

Species

D. melanogaster

Name

mir-7 stem loop

Annotation symbol

CR42883

Feature type

miRNA_gene

FlyBase ID

FBgn0262370

Gene Model Status

Current

Stock availability

None publicly available

Also Known As

mir7, dme-mir-7

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

57A7-57A7

Sequence location

2R:16,493,572..16,493,659 [+]

Genomic Maps

Select View:

modENCODE GBrowse

Summary Information

Automatically generated summary

See sections below for more information

The gene mir-7 stem loop is referred to in FlyBase by the symbol Dmel\mir-7 (CR42883, FBgn0262370). It is a miRNA_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: compound eye photoreceptor cell differentiation; compound eye development; epidermal growth factor receptor signaling pathway. 7 alleles are reported. The phenotypes of these alleles are annotated with: 1st posterior cell; interommatidial bristle; wing; ommatidium. It has one annotated transcript. Gene sequence location is 2R:16493572..16493659.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2011_10

References

Sanders and Smith, 2011, PLoS ONE 6(8): e24151

FB2012_01

Sequence features

BKN40257

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57A7-57A7

Limits computationally determined from genome sequence between P{EP}l(2)05510^EP2587&P{lacW}rig^k07917 and P{lacW}l(2)k02206^k02206

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\mir-7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

mir-7-RM

FBtr0304180

mir-7-RA

FBtr0304181

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

miRBase - the home of microRNA data

•

MI0000127

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Name

AJ421767

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Sempere et al., 2003)

organism

(Aravin et al., 2003)

Additional Descriptive Data

Northern analysis of 24 microRNAs showed that a number of them were expressed constituitively throughout development.

(Sempere et al., 2003)

Expression peaks in 4-6 hour embryos. Expression is very faint in 0-2 hour embryos, and after the first larval instar.

(Aravin et al., 2003)

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Untitled Document detailed view

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Other Phenotypes

Allele

visible, with Scer\GAL4^dpp.blk1

visible, with Scer\GAL4^ptc-559.1

mir-7^{Scer\UAS.T:Disc\RFP-DsRed2}

Phenotype manifest in

Allele

1st posterior cell, with Scer\GAL4^dpp.blk1

mir-7^Scer\UAS.cLa

1st posterior cell, with Scer\GAL4^ptc-559.1

mir-7^{Scer\UAS.T:Disc\RFP-DsRed2}

interommatidial bristle, with Scer\GAL4^GMR.PF

ommatidium, with Scer\GAL4^GMR.PF

photoreceptor cell R7 | ectopic, with Scer\GAL4^GMR.PF

mir-7^Scer\UAS.cLb

scutellar bristle | ectopic, with Scer\GAL4^dpp.blk1

mir-7^{Scer\UAS.T:Disc\RFP-DsRed2}

sensory mother cell & antennal disc (with Df(2R)exu1)

mir-7^Δ1

spermatogonial cyst | supernumerary, with Scer\GAL4^nos.PG

sternopleural bristle | ectopic, with Scer\GAL4^dpp.blk1

mir-7^{Scer\UAS.T:Disc\RFP-DsRed2}

wing, with Scer\GAL4^dpp.blk1

wing, with Scer\GAL4^ptc-559.1

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of mir-7	Class	Mutagen	Stocks	Known lesion
mir-7^EP954			0	Yes
mir-7^Δ1			0	--

Alleles Carried on Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mir-7	Mutagen	Known lesion
mir-7^Scer\UAS.cLa	in vitro construct - regulatory fusion	Yes
mir-7^Scer\UAS.cLb	in vitro construct - regulatory fusion	Yes
mir-7^{Scer\UAS.P\T.cYa}	in vitro construct - regulatory fusion	Yes
mir-7^{Scer\UAS.T:Disc\RFP-DsRed2}	in vitro construct - regulatory fusion	Yes
mir-7^αTub84B.PS	in vitro construct - regulatory fusion	Yes

Aneuploid Aberrations

Disrupted in

Df(2R)mir-7-Δ1

(Li and Carthew, 2005)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}bl^EP954

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 3 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

compound eye development

inferred from mutant phenotype

(Li and Carthew, 2005)

compound eye photoreceptor cell differentiation

inferred from mutant phenotype

(Li and Carthew, 2005)

epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Li and Carthew, 2005)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

miRNA_gene

(Lagos-Quintana et al., 2001, FlyBase Genome Annotators, 2010)

nuclear_gene

(Lagos-Quintana et al., 2001, FlyBase Genome Annotators, 2010)

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

mir-7 allele

Gene

References

unspecified

aop

(Li and Carthew, 2005)

Egfr

(Li and Carthew, 2005)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0262370

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Dpse\mir-7

Linkouts

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 0 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

170857

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

The annotation for mir-7 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR33042 to CR42883 to reflect this change.

(FlyBase Genome Annotators, 2010)

Other Comments

mir-7 buffers specific gene expression and cell fates against environmental perturbation.

(Li et al., 2009)

There is reciprocal negative regulation between mir-7 and aop in retinal cells.

(Li and Carthew, 2005)

mir-7 transcription may be induced by Egfr through degradation of aop protein.

(Li and Carthew, 2005)

New annotation (CR33042) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

DDBJ / EMBL / GenBank

•

AJ421767

Entrez Gene - A searchable database of RefSeq genes.

•

3772237

Other Crossreferences

miRBase - the home of microRNA data

•

MI0000127

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0262370

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0262370

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

170857

modMine - Data generated by the modENCODE project.

•

FBgn0262370

Synonyms & Secondary IDs ( 10 )

Reported As

Symbol Synonym

CR33042

CR42883

(FlyBase Genome Annotators, 2010, )

dme-mir-7

(Gesellchen and Boutros, 2004, Huang and Gu, 2007)

mir-7

(Sanders and Smith, 2011, FlyBase Genome Annotators, 2010, Garcia et al., 2007, Liu et al., 2007, Okamura et al., 2009, Herranz et al., 2010, Ruby et al., 2007)

Mir-7

(Robins, 2005)

mir7

(Segal et al., 2008)

miR7

(Ochoa-Espinosa et al., 2009, Berdnik et al., 2008)

Name Synonym

microRNA-7

(Pek et al., 2009)

mir-7

miR-7

(Easow et al., 2007)

mir-7 stem loop

Secondary FlyBase IDs

FBgn0046816
FBgn0262176

References ( 55 )

Generate a list of

All references relating to this gene ( 55 )

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Recent research papers ( 3 )

Sanders and Smith, 2011, PLoS ONE 6(8): e24151: LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster. [FBrf0215206]
Ghildiyal et al., 2010, RNA 16(1): 43--56: Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. [FBrf0209572]
Herranz et al., 2010, EMBO J. 29(10): 1688--1698: The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. [FBrf0210816]

Show all research papers ...

Recent reviews ( 1 )

Graham et al., 2010, Development 137(14): 2265--2278: Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives. [FBrf0211114]

Show all reviews ...