FB2020_06, released Dec 22, 2020

Gene: Dmel\mir-184

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General Information
Symbol
Dmel\mir-184
Species
D. melanogaster
Name
mir-184 stem loop
Annotation Symbol
CR42925
Feature Type
miRNA_gene
FlyBase ID
FBgn0262391
Gene Model Status
Current
Stock Availability
4 publicly available
Other Summaries
Also Known As

dme-mir-184, mir-184S, miR-184*, miR-184-3p

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:13,329,402..13,329,501 [-]
Recombination map

2-68

RefSeq locus
NT_033778 REGION:13329402..13329501
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in anterior/posterior axis specification, embryo
inferred from mutant phenotype
(Iovino et al., 2009)
involved_in oocyte dorsal/ventral axis specification
inferred from mutant phenotype
(Iovino et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Summary (Interactive Fly)

    a highly conserved microRNA that is expressed in the female germline and has assumed control over multiple steps in oogenesis and early embryogenesis

    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    0

    Please see the JBrowse view of Dmel\mir-184 for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).

    Conserved: found throughout the Drosophila genus (FBrf0230987).

    Sequence Ontology: Class of Gene
    miRNA_gene
    (FlyBase Genome Annotators, 2010, Stark et al., 2003, Stark et al., 2003)
    nuclear_gene
    (FlyBase Genome Annotators, 2010, Stark et al., 2003, Stark et al., 2003)
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    mir-184-RA
    FBtr0304273
    NR_048102
    21
    mir-184-RB
    FBtr0304274
    NR_048101
    22
    mir-184-RM
    FBtr0304272
    NR_048100
    100
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    miRBase - A searchable database of published miRNA sequences and annotation.
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-184 using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      in situ
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 8 -- 11
      mesoderm
      (Aboobaker et al., 2005)
      anterior endoderm
      (Aboobaker et al., 2005)
      posterior endoderm
      (Aboobaker et al., 2005)
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Dmel\mir-184 in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Bulk Downloads
      RNA-Seq RPKM values for all genes
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, and Transgenic Constructs
      Classical and Insertion Alleles ( 3 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 10 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of mir-184
      Transgenic constructs containing regulatory region of mir-184
      Deletions and Duplications ( 0 )
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      lethal, with Scer\GAL4Act5C.PU
      lethal, with Scer\GAL4Bx-MS1096
      lethal, with Scer\GAL4da.G32
      lethal | pharate adult stage, with Scer\GAL4sd-SG29.1
      lethal | pupal stage, with Scer\GAL4sd-SG29.1
      lethal - all die before end of embryonic stage, with Scer\GAL4Act.PU
      lethal - all die before end of embryonic stage, with Scer\GAL4da.PU
      lethal - all die before end of embryonic stage | maternal effect | recessive
      lethal - all die before end of larval stage, with Scer\GAL4ptc-559.1
      partially lethal - majority die, with Scer\GAL4Bx-MS1096
      viable
      viable, with Scer\GAL4Tub.PU
      Sterility
      Allele
      female fertile (with Df(2R)BSC273)
      female sterile, with Scer\GAL4GR1
      male fertile
      male fertile (with Df(2R)BSC273)
      Other Phenotypes
      Allele
      decreased fecundity | female
      locomotor behavior defective | adult stage
      neuroanatomy defective | embryonic stage
      neuroanatomy defective | third instar larval stage
      short lived | female | RU486 conditional, with Scer\GAL4Tub.Switch.PU
      short lived | male (with Df(2R)BSC273)
      short lived | male | recessive
      short lived | male | RU486 conditional, with Scer\GAL4Tub.Switch.PU
      some die during embryonic stage | recessive | maternal effect | recessive
      some die during larval stage, with Scer\GAL4ptc-559.1
      visible, with Scer\GAL4Bx-MS1096
      Phenotype manifest in
      Allele
      dorsal appendage | maternal effect
      egg | maternal effect
      eye, with Scer\GAL4ey.PU
      NMJ bouton | third instar larval stage
      ovariole
      ovary
      wing, with Scer\GAL4Bx-MS1096
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Download All OrthoDB Orthologs
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      Isobase
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      RoundUp
      TreeFam
      ZFIN
      Alignment
      Complementation?
      Transgene?
      Hsap\MIR184
      1 of 15
      Yes
      Yes
      Model Organism Orthologs (via DIOPT v8.0)
      Mus musculus (laboratory mouse) (0)
      No records found.
      Rattus norvegicus (Norway rat) (1)
      Rnor\Mir184
      1 of 13
      Yes
      Yes
      Xenopus tropicalis (Western clawed frog) (0)
      No records found.
      Danio rerio (Zebrafish) (2)
      Drer\mir184-2
      1 of 15
      Yes
      Yes
      Drer\mir184
      1 of 15
      Yes
      Yes
      Caenorhabditis elegans (Nematode, roundworm) (0)
      No records found.
      Arabidopsis thaliana (thale-cress) (0)
      No records found.
      Saccharomyces cerevisiae (Brewer's yeast) (0)
      No records found.
      Schizosaccharomyces pombe (Fission yeast) (0)
      No records found.
      Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( None identified )
      No orthologies identified
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
      No non-Drosophilid orthologies identified
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
      No non-Dipteran orthologies identified
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
      No non-Insect Arthropod orthologies identified
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
      No non-Arthropod Metazoa orthologies identified
      Paralogs
      Downloads
      Download All DIOPT Paralogs
      Paralogs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Allele
        Disease
        Interaction
        References
        mir-184UAS.cGa
        ameliorates  Parkinson's disease
        modeled by LrrkI1915T.UAS
        (Gehrke et al., 2010)
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        RNA-RNA
        Physical Interaction
        Assay
        References
        mir-184 - CG12880
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - CG5704
        luminiscence technology, necessary binding region
        (Easow et al., 2007)
        mir-184 - Cont
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - Dg
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - Dok
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - E2f1
        western blot, luminiscence technology, necessary binding region
        (Gehrke et al., 2010)
        mir-184 - Gli
        luminiscence technology, immunohistochemistry
        (Sharifkhodaei et al., 2016, Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - Hr39
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - Itgbn
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - Kif3C
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - Mcr
        immunohistochemistry, luminiscence technology, phenotype-based detection assay
        (Lim et al., 2018, Sharifkhodaei et al., 2016)
        mir-184 - Nrx-IV
        immunohistochemistry, luminiscence technology
        (Sharifkhodaei et al., 2016, Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - Rab10
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - Rab32
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - Socs36E
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - cad
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - cora
        luminiscence technology, immunohistochemistry
        (Sharifkhodaei et al., 2016, Kertesz et al., 2007)
        mir-184 - cpo
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - fs(1)K10
        luminiscence technology, necessary binding region, immunohistochemistry
        (Iovino et al., 2009)
        mir-184 - kek2
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - nec
        luminiscence technology, necessary binding region
        (Easow et al., 2007)
        mir-184 - pck
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - rn
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - santa-maria
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - sax
        immunohistochemistry, luminiscence technology, necessary binding region
        (Iovino et al., 2009)
        mir-184 - sinu
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - stau
        luminiscence technology
        (Iovino et al., 2009)
        mir-184 - trio
        luminiscence technology
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - ttk
        western blot, luminiscence technology, necessary binding region
        (Iovino et al., 2009, Kertesz et al., 2007)
        mir-184 - vvl
        luminiscence technology
        (Kertesz et al., 2007)
        RNA-protein
        Physical Interaction
        Assay
        References
        mir-184 - AGO1
        anti tag coimmunoprecipitation, quantitative reverse transcription pcr, anti bait coimmunoprecipitation, northern blot
        (Hong et al., 2009, Okamura et al., 2008)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mir-184
        suppressible
        sax
        (Iovino et al., 2009)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Gli
        suppressible
        mir-184
        (Sharifkhodaei et al., 2016)
        Gli
        enhanceable
        mir-184
        (Sharifkhodaei et al., 2016)
        Lrrk
        suppressible
        mir-184
        (Gehrke et al., 2010)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-68

        Cytogenetic map
        50A1-50A1
        Sequence location
        2R:13,329,402..13,329,501 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        50A1-50A1
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-68

        (FlyBase, 2016)

        2-72.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (31)
        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of

                  Source for merge of: mir-184 mir-184S

                  (FlyBase Genome Annotators, 2010)
                  Additional comments

                  The annotation for mir-184 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. Thus the separate annotations (CR33576 and CR33577) which previously each represented one of the two mature miRNAs made from the mir-184 stem loop precursor have been converted into a single annotation (CR42925).

                  (FlyBase Genome Annotators, 2010)
                  Other Comments

                  New annotation (CR33576) in release 4.1 of the genome annotation.

                  (FlyBase Genome Annotators, 2005)

                  New annotation (CR33577) in release 4.1 of the genome annotation.

                  (FlyBase Genome Annotators, 2005)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 15 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
                  Other crossreferences
                  FlyMine - An integrated database for Drosophila genomics
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  miRBase - A searchable database of published miRNA sequences and annotation.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (genetic) - An integrated Molecular Interaction Database
                  Synonyms and Secondary IDs (17)
                  Reported As
                  Symbol Synonym
                  184
                  (Han et al., 2011)
                  CR33576
                  (FlyBase Genome Annotators, 2005)
                  CR33577
                  (FlyBase Genome Annotators, 2005)
                  CR42925
                  (FlyBase Genome Annotators, 2010)
                  MIR-184
                  (Ylla et al., 2016)
                  dme-miR-184
                  (Volin et al., 2018, Chandra et al., 2017, Lucas et al., 2015, Towler et al., 2015, Yang et al., 2008)
                  dme-miR-184-3p
                  (Chandra et al., 2015)
                  dme-mir-184
                  (miRBase, 2013, Reinhardt et al., 2012, Berezikov et al., 2011, Huang and Gu, 2007, Gesellchen and Boutros, 2004)
                  miR-
                  (Picao-Osorio et al., 2017)
                  miR-184
                  (Li et al., 2020, Eyk et al., 2019, Kobayashi et al., 2019, Liu et al., 2019, Mendes-Silva et al., 2019, Reichholf et al., 2019, Zhu et al., 2019, Cosacak et al., 2018, Goodwin et al., 2018, Kaschula et al., 2018, Atilano et al., 2017, Chandra et al., 2017, Gendron and Pletcher, 2017, Shu et al., 2017, Rainey et al., 2016, Sharifkhodaei et al., 2016, Yang et al., 2016, Fulga et al., 2015, Suh et al., 2015, Tattikota et al., 2015, Abe et al., 2014, Barrio et al., 2014, Bassett et al., 2014, Kong et al., 2014, Kozomara et al., 2014, Xia and Zhang, 2014, Esslinger et al., 2013, Lucas and Raikhel, 2013, Mezan et al., 2013, Nesler et al., 2013, Bejarano et al., 2012, Fukunaga et al., 2012, Liu et al., 2012, Eliazer and Buszczak, 2011, Li et al., 2011, Liu et al., 2011, Pane et al., 2011, Patraquim et al., 2011, Seitz et al., 2011, Büssing et al., 2010, Fernandez-Valverde et al., 2010, Czech et al., 2009, Hong et al., 2009, Kadener et al., 2009, Nahvi et al., 2009, Bushati et al., 2008, Haley et al., 2008, Ibáñez-Ventoso et al., 2008, Behura, 2007, Easow et al., 2007, Kertesz et al., 2007, Biemar et al., 2006, Nguyen and Frasch, 2006, Rehwinkel et al., 2006, Leaman, 2005, Stark et al., 2005, Nakahara and Carthew, 2004, Enright et al., 2003, Lai et al., 2003, Stark et al., 2003, Stark et al., 2003)
                  miR-184*
                  (Nesler et al., 2013, Gehrke et al., 2010)
                  miR-184-3p
                  (Lim et al., 2018, Seong et al., 2018)
                  miR-184S
                  (Stark et al., 2003, Stark et al., 2003)
                  mir-184
                  (Estacio-Gómez et al., 2020, Niu et al., 2019, Shcherbata, 2019, Mohammed and Lai, 2016.2.8, Cohen, 2015.4.15, Peng et al., 2015, Chen et al., 2014, Fricke et al., 2014, Wang et al., 2014, Bausek, 2013, Daneshvar et al., 2013, Bejarano et al., 2012, Schertel et al., 2012, Enderle et al., 2011, FlyBase Genome Annotators, 2010, Herranz et al., 2010, Iovino et al., 2009, Okamura et al., 2009, Neumuller et al., 2008, Okamura et al., 2008, Liu et al., 2007, Ruby et al., 2007, Burgler and Macdonald, 2005)
                  mir-184*
                  (Aravin et al., 2003)
                  mir-184S
                  Name Synonyms
                  miR-184
                  (Easow et al., 2007)
                  mir-184
                  (Salz et al., 2017)
                  mir-184 stem loop
                  mir-184S
                  Secondary FlyBase IDs
                  • FBgn0067726
                  • FBgn0067725
                  • FBgn0262218
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (117)