dme-mir-124
post-transcriptional regulation, gene silencing by miRNA, negative regulation of synaptic transmission; dendrite morphogenesis, neuroblast proliferation
Please see the JBrowse view of Dmel\mir-124 for information on other features
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Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).
Conserved: found throughout the Drosophila genus (FBrf0230987).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-124 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: expression starts at 2 hr AEL
mir-124 was found to be highly brain-specific in 10-day adult females by small RNA sequencing of brain, thorax, gut, and fat body tissue.
Mature mir-124-RNA is detected via northern blot analysis commencing at embryonic stage 9 to adult stage. Expression is very faint in second instar larvae but strong expression is detected in embryonic stages 11 to 17 and in the adult head. Analysis via in situ hybridization detects primary mir-124-transcripts weakly in nuclei of embryonic neuroblasts at stage 8. The expression increases towards stage 13 when it is strongly detected in the embryonic/larval central nervous system.
Expression peaks in 12-24 hour embryos, and has a second lower peak in adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\mir-124 in JBrowse2-53
2-52.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutant males show increased male-male courtship and reduced reproductive success with females, due to altered pheromone production.
New annotation (CR33573) in release 4.1 of the genome annotation.
The annotation for mir-124 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR33573 to CR42937 to reflect this change.
