• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\mir-311

General Information
Symbol	Dmel\mir-311	Species	D. melanogaster
Name	mir-311 stem loop	Annotation symbol	CR42943
Feature type	miRNA_gene	FlyBase ID	FBgn0262402
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	Dme-miR-311
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57A6-57A6	Sequence location	2R:16,471,382..16,471,465 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mir-311 stem loop is referred to in FlyBase by the symbol Dmel\mir-311 (CR42943, FBgn0262402). It is a miRNA_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: dorsal closure; head involution. 7 alleles are reported. The phenotypes of these alleles are annotated with: 1st posterior cell; wing; wing vein. It has one annotated transcript. Gene sequence location is 2R:16471382..16471465.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57A6-57A6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mir-311 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt)   mir-311-RM FBtr0304311  NR_048171   84   mir-311-RA FBtr0304312  NR_048172   22
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences	miRBase - the home of microRNA data • MI0000423
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence   Name
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI mir-311Scer\UAS.cTa lethal | pharate adult stage, with Scer\GAL4Bx-MS1096 mir-311Scer\UAS.T:Ppyr\LUC partially lethal - majority die, with Scer\GAL4DJ715 mir-311Scer\UAS.cTa partially lethal - majority die, with Scer\GAL4NP5941 mir-311Scer\UAS.cTa viable, with Scer\GAL4Act5C.PU mir-311Scer\UAS.cSa Other Phenotypes Allele visible, with Scer\GAL4Bx-MS1096 mir-311Scer\UAS.T:Ppyr\LUC visible, with Scer\GAL4sd-SG29.1 mir-311Scer\UAS.T:Ppyr\LUC Phenotype manifest in Allele 1st posterior cell, with Scer\GAL4ptc-559.1 mir-311Scer\UAS.T:Ppyr\LUC wing, with Scer\GAL4Bx-MS1096 mir-311Scer\UAS.T:Ppyr\LUC wing, with Scer\GAL4sd-SG29.1 mir-311Scer\UAS.T:Ppyr\LUC wing vein, with Scer\GAL4Bx-MS1096 mir-311Scer\UAS.T:Ppyr\LUC
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of mir-311 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mir-311 Class Mutagen Stocks Known lesion mir-311Scer\UAS.cluster.T:Ppyr\LUC in vitro construct 1 Yes mir-311Scer\UAS.T:Ppyr\LUC in vitro construct 1 Yes mir-311Scer\UAS.cluster.T:Disc\RFP in vitro construct 0 Yes mir-311Scer\UAS.cluster in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mir-311Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes mir-311Scer\UAS.cTa in vitro construct - regulatory fusion 0 Yes mir-311UG.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Dm310s (Tang et al., 2010) Df(2R)KT40 (Tsurudome et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-mir-311.S} NA M{UAS-mir-311.UG} NA P{UAS-DsRed-mir-310+mir-311+mir-312+mir-313.L} NA P{UAS-LUC-mir-310.mir-311.mir-312.mir-313.T} NA P{UAS-LUC-mir-311.T} NA P{UAS-mir-310.cluster.DsRed} NA P{UAS-miR310s} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dorsal closure inferred from mutant phenotype (Leaman et al., 2005) head involution inferred from mutant phenotype (Leaman et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	miRNA_gene (Stark et al., 2003, Stark et al., 2003, FlyBase Genome Annotators, 2010) nuclear_gene (Stark et al., 2003, Stark et al., 2003, FlyBase Genome Annotators, 2010)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mir-311 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262402
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	41163 w1118; P{UAS-LUC-mir-311.T}attP2 41135 w1118; P{UAS-LUC-mir-310.mir-311.mir-312.mir-313.T}attP2/TM3, Sb1
Genomic Clones ( 2 )
	BACR03N16 BACR33D17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 12798127
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The annotation for mir-311 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR33615 to CR42943 to reflect this change. (FlyBase Genome Annotators, 2010)
Other Comments
	New annotation (CR33615) in release 4.1 of the genome annotation. (FlyBase Genome Annotators, 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NR_048171 NR_048172 Entrez Gene - A searchable database of RefSeq genes. • 12798127
Other Crossreferences
	miRBase - the home of microRNA data • MI0000423
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262402 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0262402 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 12798127 modMine - Data generated by the modENCODE project. • FBgn0262402
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	311 (Tsurudome et al., 2010) CR33615 (FlyBase Genome Annotators, 2005) CR42943 (FlyBase Genome Annotators, 2010, ) Dme-miR-311 (Zhou et al., 2009, Tang et al., 2010) mIR-310s (Lu et al., 2008) miR-311 (Liu et al., 2011, Leaman, 2005, Stark et al., 2003, Stark et al., 2003, Vagin et al., 2006, Vagin et al., 2006, Stark et al., 2005, Zhao et al., 2008, Leaman et al., 2005, Dubruille et al., 2009, Ruby et al., 2007, Silver et al., 2007, Behura et al., 2011, Thomsen et al., 2010, Ibáñez-Ventoso et al., 2008, Schertel et al., 2012, Fukunaga et al., 2012) mir-311 (FlyBase Genome Annotators, 2010, Neumuller et al., 2008, Stark et al., 2007, Burgler and Macdonald, 2005, Schertel et al., 2012, Bejarano et al., 2012) mIR-311 (Lu et al., 2008)
Name Synonym	mir-311   mir-311 stem loop
Secondary FlyBase IDs
	FBgn0067693 FBgn0262236
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 6 ) FlyBase analysis  ( 2 )
Recent research papers ( 6 )
	Fernandez-Costa et al., 2013, Hum. Mol. Genet. 22(4): 704--716 Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients. [FBrf0220611] Fukunaga et al., 2012, Cell 151(3): 533--546 Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals. [FBrf0219804] Marrone et al., 2012, BMC Cell Biol. 13: 26 Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile. [FBrf0220581] Schertel et al., 2012, Genetics 192(4): 1543--1552 Functional Characterization of Drosophila microRNAs by a Novel in Vivo Library. [FBrf0220194] Behura et al., 2011, PLoS ONE 6(7): e21504 Comparative Genomic Analysis of Drosophila melanogaster and Vector Mosquito Developmental Genes. [FBrf0214308] Liu et al., 2011, Curr. Biol. 21(22): 1888--1893 The Exoribonuclease Nibbler Controls 3' End Processing of MicroRNAs in Drosophila. [FBrf0216782] Show all research papers ...