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Gene Dmel\mir-11

General Information
Symbol	Dmel\mir-11	Species	D. melanogaster
Name	mir-11 stem loop	Annotation symbol	CR42992
Feature type	miRNA_gene	FlyBase ID	FBgn0262434
Gene Model Status	Current	Stock availability	None publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93E9-93E9	Sequence location	3R:17,448,219..17,448,293 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mir-11 stem loop is referred to in FlyBase by the symbol Dmel\mir-11 (CR42992, FBgn0262434). It is a miRNA_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: cellular response to gamma radiation; negative regulation of apoptosis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript. Gene sequence location is 3R:17448219..17448293.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms cellular response to gamma radiation negative regulation of apoptosis References Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 Alleles mir-11[Delta1]
FB2012_01	Sequence features BKN40570
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93E9-93E9   Limits computationally determined from genome sequence between P{PZ}InR05545 and P{PZ}tsl00617
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mir-11 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt)   mir-11-RM FBtr0304412     75   mir-11-RA FBtr0304413     21
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences	miRBase - the home of microRNA data • MI0000131
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence   Name AJ421771
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Sempere et al., 2003)
Additional Descriptive Data
	Northern analysis of 24 microRNAs showed that a number of them were expressed constituitively throughout development. (Sempere et al., 2003)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mir-11Δ1 Other Phenotypes Allele radiation sensitive mir-11Δ1 radiation sensitive | somatic clone mir-11Δ1 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of mir-11 Class Mutagen Stocks Known lesion mir-11Δ1 amorphic allele - molecular evidence ends-in gene targeting FLPase SCEI endonuclease I-CreI endonuclease 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mir-11 Class Mutagen Stocks Known lesion mir-11Scer\UAS.T:Disc\RFP-DsRed2 in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-DsRed2-mir-11} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular response to gamma radiation inferred from mutant phenotype (Truscott et al., 2011) negative regulation of apoptosis inferred from genetic interaction with E2f (Truscott et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	miRNA_gene (Lagos-Quintana et al., 2001, FlyBase Genome Annotators, 2010) nuclear_gene (Lagos-Quintana et al., 2001, FlyBase Genome Annotators, 2010)
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mir-11 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262434
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\mir-11
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 2 )
	BACR16N15 BACR48I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 170873
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The annotation for mir-11 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR32929 to CR42992 to reflect this change. (FlyBase Genome Annotators, 2010) mir-998 and mir-11 are both located in the same intron of E2f. (Stark et al., 2007)
Other Comments
	mir-11 specifically modulates the proapoptotic function of E2f, but does not affect the ability of E2f to regulate cell proliferation. (Truscott et al., 2011) New annotation (CR32929) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AJ421771 Entrez Gene - A searchable database of RefSeq genes. • 3771987
Other Crossreferences
	miRBase - the home of microRNA data • MI0000131
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262434 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0262434 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 170873 modMine - Data generated by the modENCODE project. • FBgn0262434
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CR32929   CR42992 (FlyBase Genome Annotators, 2010, ) dme-mir-11 (Gesellchen and Boutros, 2004) miR-11 (Truscott et al., 2011, Leaman, 2005, Carthew, 2006, Miska, 2005, Brennecke et al., 2005, Boutla et al., 2003, Lai et al., 2003, Sempere et al., 2003, Lai, 2002, Lee et al., 2001, Lagos-Quintana et al., 2001, Stark et al., 2003, Stark et al., 2003, Stark et al., 2005, Rehwinkel et al., 2006, Czech et al., 2009, Behura et al., 2011) mir-11 (FlyBase Genome Annotators, 2010, Stark et al., 2007, Neumuller et al., 2008, Martin et al., 2009, Okamura et al., 2009, Ruby et al., 2007, Stark et al., 2007) MiR-11 (Yang et al., 2009)
Name Synonym	mir-11   mir-11 stem loop
Secondary FlyBase IDs
	FBgn0046832 FBgn0262285
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 4 ) Review  ( 4 ) FlyBase analysis  ( 2 )
Recent research papers ( 2 )
	Behura et al., 2011, PLoS ONE 6(7): e21504 Comparative Genomic Analysis of Drosophila melanogaster and Vector Mosquito Developmental Genes. [FBrf0214308] Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 mir-11 limits the proapoptotic function of its host gene, dE2f1. [FBrf0215211] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...