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General Information
Symbol
Dmel\mir-ban
Species
D. melanogaster
Name
bantam
Annotation Symbol
CR43018
Feature Type
FlyBase ID
FBgn0262451
Gene Model Status
Stock Availability
Also Known As
ban, dme-bantam, EP3208
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:642,208..642,288 [+]
Recombination map
3-0.5
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Molecular Function (GO)
    [Detailed GO annotations]
    Experimental Evidence
    -
    Predictions / Assertions
    Summaries
    Pathway (FlyBase)
    Positive Regulators of Epidermal Growth Factor Receptor Signaling Pathway -
    Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.
    Negative Regulators of BMP Signaling Pathway -
    Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
    Summary (Interactive Fly)
    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    0

    Please see the GBrowse view of Dmel\mir-ban or the JBrowse view of Dmel\mir-ban for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).
    Conserved: found throughout the Drosophila genus (FBrf0230987).
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    FBtr0304469
    23
    FBtr0472739
    23
    FBtr0304468
    81
    Additional Transcript Data and Comments
    Reported size (kB)
    .021 (northern blot, sequence analysis)
    Comments
    External Data
    Crossreferences
    miRBase - A searchable database of published miRNA sequences and annotation.
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-ban using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Gene Ontology (25 terms)
    Molecular Function (1 term)
    Terms Based on Experimental Evidence (0 terms)
    Terms Based on Predictions or Assertions (1 term)
    CV Term
    Evidence
    References
    Biological Process (24 terms)
    Terms Based on Experimental Evidence (21 terms)
    CV Term
    Evidence
    References
    inferred from mutant phenotype
    inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
    inferred from mutant phenotype
    inferred from direct assay
    inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997 AND inferred from mutant phenotype
    inferred from mutant phenotype
    Terms Based on Predictions or Assertions (6 terms)
    CV Term
    Evidence
    References
    Cellular Component (0 terms)
    Terms Based on Experimental Evidence (0 terms)
    Terms Based on Predictions or Assertions (0 terms)
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    northern blot
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Additional Descriptive Data
    The ban microRNA is detected during all stages of development by northern analysis although level of expression varies with developmental stage. Expression is highest in 12-24 h embryos and 1st instar larvae. An assay employed a ubiquitously expressed GFP sensor protein whose transcript contained ban target sites and caused silencing of the reporter in the regions where ban microRNA is expressed. This assay indicates that ban microRNA is expressed throughout the wing disc but has the highest expression in areas of proliferation. A similar correlation between ban microRNA expression and cell proliferation was observed in the larval brain.
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    Reporter: P{ban-lacZ.5'F}
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\mir-ban in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 22 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 15 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of mir-ban
    Transgenic constructs containing regulatory region of mir-ban
    Deletions and Duplications ( 3 )
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Other Phenotypes
    Allele
    Phenotype manifest in
    Allele
    anterior fascicle & synapse, with Scer\GAL4elav-C155
    Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( None identified )
    No orthologies identified
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
    No non-Drosophilid orthologies identified
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v7.1)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    RNA-protein
    Physical Interaction
    Assay
    References
    RNA-RNA
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Positive Regulators of Epidermal Growth Factor Receptor Signaling Pathway -
    Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.
    Negative Regulators of BMP Signaling Pathway -
    Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-0.5
    Cytogenetic map
    Sequence location
    3L:642,208..642,288 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    61C7-61C7
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    61C7-61C8
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (20)
    cDNA Clones (0)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for identity of: ban EP3208
              Source for identity of: mir-ban ban
              Source for database merge of
              Additional comments
              The annotation for ban has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR33559 to CR43018 to reflect this change.
              Added 'mir-' prefix to be consistent with miRNA naming conventions in FlyBase, and thereby indicate the gene encodes a miRNA in its symbol.
              " BEST:RE64518 " does not encode "ban" function.
              Evidence suggests that the P{EP}EP3219EP3219 insertion is probably not an allele of "ban" but instead affects a genetically separable locus; the decrease in wing size seen in EP3219EP3219/Df(3L)banΔ1 flies is due primarily to a reduction in cell size rather than cell number, in contrast to banL1170a/Df(3L)banΔ1, banEP3622/Df(3L)banΔ1 or banEPg30491/Df(3L)banΔ1 flies, where the decrease in wing size is due to a reduction in the number of cells. In addition, EP3219EP3219 combined with banL1170a, banEPg30491 or banEP3622 has little or no effect on growth.
              Other Comments
              ban limits IR-induced apoptosis in larval imaginal discs.
              Upregulation of ban miRNA suppresses neurodegeneration.
              ban activity defines distinct targets that modulate neuro-degeneration.
              ban is a target of the hpo signalling pathway.
              ban suppresses W expression.
              ban mutant clones grow poorly due to a reduced rate of cell proliferation.
              ban acts downstream of yki in the hpo pathway.
              New annotation (CR33559) in release 4.1 of the genome annotation.
              ban microRNA simultaneously stimulates cell proliferating and prevent apoptosis.
              Origin and Etymology
              Discoverer
              Etymology
              The gene is named "bantam" after the mutant phenotype; mutant flies are smaller than normal.
              Identification
              External Crossreferences and Linkouts ( 27 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
              Other crossreferences
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              KEGG Genes - Molecular building blocks of life in the genomic space.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              miRBase - A searchable database of published miRNA sequences and annotation.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              ApoDroso - Functional genomic database for photoreceptor development, survival and function
              DroID - A comprehensive database of gene and protein interactions.
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Synonyms and Secondary IDs (16)
              Reported As
              Symbol Synonym
              ban
              (Ma et al., 2019, Misra and Irvine, 2019, Moreno et al., 2019, Sun et al., 2019, Texada et al., 2019, Azuma et al., 2018, Cho et al., 2018, Setiawan et al., 2018, Volin et al., 2018, Yu and Pan, 2018, Jordán-Álvarez et al., 2017, Li et al., 2017, Ma et al., 2017, Moeller et al., 2017, Perry et al., 2017, Tants et al., 2017, Wu et al., 2017, Zhang et al., 2017, Huang et al., 2016, Zhang et al., 2016, Dong et al., 2015, Panneton et al., 2015, Wang and Baker, 2015, Xing et al., 2015, Zhang et al., 2015, Bassett et al., 2014, Bilak et al., 2014, Huang et al., 2014, Robbins et al., 2014, Wang et al., 2014, Degoutin et al., 2013, Oh et al., 2013, Slattery et al., 2013, Smibert et al., 2013, Zhang and Lai, 2013, Djuranovic et al., 2012, Kagey et al., 2012, Matakatsu and Blair, 2012, Poon et al., 2012, Song et al., 2012, Tan et al., 2012, Genevet and Tapon, 2011, Muliyil et al., 2011, Oh and Irvine, 2011, Reddy and Irvine, 2011, Richter et al., 2011, Slattery et al., 2011, FlyBase Genome Annotators, 2010, Gehrke et al., 2010, Milton et al., 2010, Morrison and Halder, 2010, Neto-Silva et al., 2010, Robinson et al., 2010, Silicheva et al., 2010, Berry et al., 2009, Genevet et al., 2009, Parrish et al., 2009, Peng et al., 2009, Shen et al., 2009, Yang et al., 2009, Dutta and Baehrecke, 2008, Jaklevic et al., 2008, Okamura et al., 2008, Stofanko et al., 2008, Gibert et al., 2007, Kuzin et al., 2007, Shcherbata et al., 2007, Bilen et al., 2006, Bilen et al., 2006, Meyer et al., 2006, Thompson and Cohen, 2006, Leaman et al., 2005)
              mir-ban
              Name Synonyms
              bantam
              (Hanyu-Nakamura et al., 2019, Kobayashi et al., 2019, Liu et al., 2019, Liu et al., 2019, Banerjee and Roy, 2018, Osman and Pek, 2018, Xu et al., 2018, Banerjee and Roy, 2017, Banerjee and Roy, 2017, Li et al., 2017, Moeller et al., 2017, Shu et al., 2017, Song et al., 2017, Specchia et al., 2017, Barron and Moberg, 2016, Bonfini et al., 2016, Hu et al., 2016, Sharifkhodaei et al., 2016, Suijkerbuijk et al., 2016, Xiong et al., 2016, Fulga et al., 2015, Irvine and Harvey, 2015, Lerner et al., 2015, Pasco et al., 2015, Shen et al., 2015, Su, 2015, Suh et al., 2015, Tataroglu and Emery, 2015, Wen et al., 2015, Weng and Cohen, 2015, Barrio et al., 2014, Huang et al., 2014, Kozomara et al., 2014, Lam et al., 2014, Lee et al., 2014, Naqvi et al., 2014, Robbins et al., 2014, Wang et al., 2014, Carré et al., 2013, Coutinho-Budd and Freeman, 2013, Daneshvar et al., 2013, Degoutin et al., 2013, Doumpas et al., 2013, Huang et al., 2013, Hur et al., 2013, Jin et al., 2013, Lucas and Raikhel, 2013, McKay and Lieb, 2013, Nesler et al., 2013, Nishida et al., 2013, Slattery et al., 2013, Bejarano et al., 2012, Bejarano et al., 2012, Djuranovic et al., 2012, Helfer et al., 2012, Herranz et al., 2012, Herranz et al., 2012, Li and Padgett, 2012, Nagaraj et al., 2012, Schertel et al., 2012, Szuplewski et al., 2012, Tan et al., 2012, Vodala et al., 2012, Westholm et al., 2012, Becam et al., 2011, Enderle et al., 2011, Han et al., 2011, Hartig and Förstemann, 2011, Liu et al., 2011, Muliyil et al., 2011, Oh and Irvine, 2011, Qian et al., 2011, Reddy and Irvine, 2011, Sanders and Smith, 2011, Slattery et al., 2011, Smibert et al., 2011, Staiger and Koster, 2011, Ameres et al., 2010, Flynt et al., 2010, Gehrke et al., 2010, Ghildiyal et al., 2010, Herranz et al., 2010, Milton et al., 2010, Morrison and Halder, 2010, Nayak et al., 2010, Robinson et al., 2010, Schneiderman et al., 2010, Schneiderman et al., 2010, Cziko et al., 2009, Eulalio et al., 2009, Flynt et al., 2009, Genevet et al., 2009, Hamaratoglu et al., 2009, Kadener et al., 2009, Kadener et al., 2009, Lee et al., 2009, Martin et al., 2009, Miyoshi et al., 2009, Nahvi et al., 2009, Parrish et al., 2009, Pek et al., 2009, Peng et al., 2009, Sabin et al., 2009, Shen et al., 2009, Tanaka-Matakatsu et al., 2009, Yang et al., 2009, Yu et al., 2009, Zekri et al., 2009, Berdnik et al., 2008, Berdnik et al., 2008, Czech et al., 2008, Dutta and Baehrecke, 2008, Herranz et al., 2008, Ibáñez-Ventoso et al., 2008, Jaklevic et al., 2008, Kawamura et al., 2008, Neumuller et al., 2008, Okamura et al., 2008, Okamura et al., 2008, Reynolds et al., 2008, Semeshin et al., 2008, Shah and Förstemann, 2008, Shcherbata et al., 2008, Stofanko et al., 2008, Zhang et al., 2008, Easow et al., 2007, Förstemann et al., 2007, Garcia et al., 2007, Horwich et al., 2007, Kertesz et al., 2007, Liu et al., 2007, Neumüller et al., 2007, Nurminsky, 2007, Park et al., 2007, Reynolds, 2007, Ruby et al., 2007, Shcherbata et al., 2007, Shcherbata et al., 2007, Ye et al., 2007, Barbee et al., 2006, Bilen et al., 2006, Cho et al., 2006, Nolo et al., 2006, Orom et al., 2006, Rehwinkel et al., 2006, Thompson and Cohen, 2006, Vagin et al., 2006, Burgler and Macdonald, 2005, Stark et al., 2005, Trotta et al., 2005, Okamura et al., 2004, Rehmsmeier et al., 2004, Enright et al., 2003, Hipfner et al., 2002)
              mIR-bantam
              miR-bantam
              Secondary FlyBase IDs
              • FBgn0064191
              • FBgn0043352
              • FBgn0262311
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (334)