FlyBase Gene Report: Dmel\FoxP

General Information

Symbol

Dmel\FoxP

Species

D. melanogaster

Name

Forkhead box P

Annotation Symbol

CG43067

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262477

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Forkhead box P (FoxP) encodes a transcription factor expressed in the nervous system. It is involved in locomotion, operant self-learning and courtship behavior. [Date last reviewed: 2019-05-16]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

fd85E, forkhead domain 85E

Key Links

Genomic Location

Cytogenetic map

85E5-85E5

Sequence location

3R:9,726,020..9,730,872 [-]

Recombination map

3-49

RefSeq locus

NT_033777 REGION:9726020..9730872

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein homodimerization activity

inferred from direct assay

(Castells-Nobau et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in locomotion

inferred from mutant phenotype

(Lawton et al., 2014)

involved_in male courtship behavior, veined wing generated song production

inferred from mutant phenotype

(Lawton et al., 2014)

involved_in operant conditioning

inferred from mutant phenotype

(Mendoza et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS -: The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).

Summary (Interactive Fly)

forkhead domain transcription factor - a highly conserved transcription factor known for its importance in human speech and language production - reduced expression in Drosophila leads to decreased levels of courtship behavior, altered pulse-song structure, and sex-specific motor impairments in walking and flight

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\FoxP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.44

Gene model reviewed during 5.41

Gene model reviewed during 5.39

Gene model reviewed during 5.56

Gene model reviewed during 6.05

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FoxP-RC

FBtr0304869

NM_001260082

3552

520

FoxP-RD

FBtr0329937

NM_001104256

2428

442

FoxP-RE

FBtr0433516

NM_001316572

2800

393

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FoxP-PC

FBpp0293409

59.5

520

6.84

NP_001247011

AFH06329

FoxP-PD

FBpp0302969

50.9

442

7.98

NP_001097726

AAF54432

FoxP-PE

FBpp0390648

45.3

393

7.43

NP_001303501

ALI30549

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FoxP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FoxP_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

embryonic stage 4 -- 13

organism

• yolk plasma

(Lee and Frasch, 2004)

embryonic stage 12 -- 17

embryonic/larval central nervous system

(Lee and Frasch, 2004)

Additional Descriptive Data

FoxP transcript is localized to the yolk cytoplasm from blastoderm stages through embryonic stage 13. FoxP is also expressed in the developing embryonic CNS beginning at embryonic stage 12.

(Lee and Frasch, 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult central nervous system | restricted

(Lawton et al., 2014)

third instar larval stage

embryonic/larval nervous system | restricted

(Lawton et al., 2014)

Additional Descriptive Data

Expression of FoxP protein overlaps with the expression of Scer\GAL4^FoxP.1.5 except for cells in the posterior region of the ventral nerve cord that are not detected by the antibody against FoxP.

(Lawton et al., 2014)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{FoxP-GAL4.1.5}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron | subset of protocerebral bridge

(Lawton et al., 2014)

adult central nervous system

(Lawton et al., 2014)

third instar larval stage

neuron | subset of embryonic/larval brain

(Lawton et al., 2014)

neuron | subset of ventral nerve cord

(Lawton et al., 2014)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\FoxP in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FoxP

View exonic expression by tissue for Dmel\FoxP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262477

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FoxP

Transgenic constructs containing regulatory region of FoxP

Deletions and Duplications ( 1 )

Disrupted in

Df(3R)ED5438

(Mendoza et al., 2014)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during pupal stage, with Scer\GAL4^Act5C.PI

FoxP^GD4320

partially lethal - majority die, with Scer\GAL4^Act5C.PI

FoxP^GD4320

partially lethal - majority die | recessive

FoxP^del

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

FoxP^GD4320

viable, with Scer\GAL4^pnr-MD237

FoxP^GD4320

viable, with Scer\GAL4^tin.CΔ4

FoxP^GD4320

Sterility

Allele

sterile

FoxP^del

Other Phenotypes

Allele

behavior defective | adult stage

FoxP^del

behavior defective | adult stage, with Scer\GAL4^elav.PLu

courtship behavior defective | male | heat sensitive, with Scer\GAL4^elav-C155

FoxP^GD4320

flight defective

flight defective, with Scer\GAL4^Act5C.PI

FoxP^GD4320

flight defective, with Scer\GAL4^elav.PLu

FoxP^GD4320

flight defective | male limited, with Scer\GAL4^elav-C155

FoxP^GD4320

flight defective | recessive

FoxP^del

jump response defective

FoxP^del

learning defective, with Scer\GAL4^elav.PU

FoxP^GD15847

learning defective (with Df(3R)ED5438)

FoxP^5-SZ-3955

learning defective | adult stage, with Scer\GAL4^elav.PLu

learning defective | adult stage (with FoxP^5-SZ-3955)

FoxP^del

learning defective | adult stage (with FoxP^del)

FoxP^5-SZ-3955

learning defective | recessive

FoxP^5-SZ-3955

locomotor behavior defective | adult stage

FoxP^del

locomotor behavior defective | adult stage, with Scer\GAL4^Act5C.PI

FoxP^GD4320

locomotor behavior defective | adult stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

locomotor behavior defective | adult stage, with Scer\GAL4^elav-C155

FoxP^GD4320

locomotor behavior defective | adult stage | dominant

FoxP^del

majority die during pupal stage, with Scer\GAL4^Act5C.PI

FoxP^GD4320

majority die during pupal stage | recessive

FoxP^del

neuroanatomy defective

FoxP^del

neuroanatomy defective, with Scer\GAL4^elav.PLu

FoxP^GD4320

neuroanatomy defective, with Scer\GAL4^Mef2.247

neuroanatomy defective | third instar larval stage

FoxP^del

neuroanatomy defective | third instar larval stage, with Scer\GAL4⁴⁷⁷

neuroanatomy defective | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

neurophysiology defective | adult stage

pain response defective | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

FoxP^GD4320

short lived, with Scer\GAL4^Act5C.PI

FoxP^GD4320

short lived | recessive

FoxP^del

size defective

FoxP^del

size defective, with Scer\GAL4^elav.PLu

FoxP^GD4320

size defective, with Scer\GAL4^Mef2.247

size defective | third instar larval stage

FoxP^del

size defective | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

song defective, with Scer\GAL4^elav-C155

FoxP^GD4320

visible | male limited, with Scer\GAL4^Bx-MS1096

FoxP^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

adult brain

FoxP^5-SZ-3955

adult mushroom body alpha-lobe

FoxP^del

adult mushroom body alpha-lobe, with Scer\GAL4^elav.PLu

FoxP^GD4320

adult mushroom body alpha-lobe, with Scer\GAL4^Mef2.247

alpha/beta Kenyon cell | adult stage

dendritic branch | third instar larval stage

FoxP^del

dendritic branch | third instar larval stage, with Scer\GAL4⁴⁷⁷

dendritic tree | third instar larval stage

FoxP^del

dendritic tree | third instar larval stage, with Scer\GAL4⁴⁷⁷

embryonic/larval neuromuscular junction | third instar larval stage

FoxP^del

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

end plate | third instar larval stage

FoxP^del

end plate | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

larval multidendritic class IV neuron | third instar larval stage

FoxP^del

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4⁴⁷⁷

mitochondrial crista | third instar larval stage

FoxP^del

mitochondrion | third instar larval stage

FoxP^del

neuropil

FoxP^5-SZ-3955

optic glomerulus

FoxP^5-SZ-3955

subsynaptic reticulum | third instar larval stage

FoxP^del

wing | male limited, with Scer\GAL4^Bx-MS1096

FoxP^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\FOXP1

8 of 15

Yes

Hsap\FOXP2

8 of 15

Yes

Hsap\FOXP4

8 of 15

Yes

Hsap\FOXP3

4 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Foxp1

8 of 15

Yes

Mmus\Foxp2

8 of 15

Yes

Mmus\Foxp4

8 of 15

Yes

Mmus\Foxp3

4 of 15

Yes

Rattus norvegicus (Norway rat) (4)

Rnor\Foxp1

7 of 13

Yes

Rnor\Foxp2

4 of 13

Yes

Rnor\Foxp3

4 of 13

Yes

Rnor\Foxp4

4 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\foxp2

5 of 12

Yes

Xtro\foxp4

5 of 12

Yes

Xtro\foxp1

3 of 12

Yes

Danio rerio (Zebrafish) (6)

Drer\foxp1b

8 of 15

Yes

Drer\foxp2

7 of 15

Yes

Drer\foxp4

7 of 15

Yes

Drer\foxp1a

6 of 15

Yes

Drer\foxp3a

3 of 15

Yes

Drer\foxp3b

3 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\fkh-7

9 of 15

Yes

Cele\fkh-8

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905SR )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA30170

Drosophila persimilis

Dper\GL21960

Drosophila willistoni

Dwil\GK13409

Drosophila virilis

Dvir\GJ23621

Drosophila mojavensis

Dmoj\GI23814

Drosophila grimshawi

Dgri\GH19587

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505PP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Glossina morsitans

Tsetse fly

Gmor\GMOY011303

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01475

Mayetiola destructor

Hessian fly

Mdes\Mdes015629

Mayetiola destructor

Hessian fly

Mdes\Mdes001315

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL000250

Anopheles darlingi

American malaria mosquito

Adar\ADAC002773

Anopheles gambiae

Malaria mosquito

Agam\AGAP000569

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009524

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009523

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009522

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06XW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004582

Danaus plexippus

Monarch butterfly

Dple\DPOGS213641-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004589

Apis florea

Little honeybee

Aflo\2147668051

Apis mellifera

Western honey bee

Amel\GB40150

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17535

Bombus terrestris

Buff-tailed bumblebee

Bter\15205133

Linepithema humile

Argentine ant

Lhum\LH11306

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002f82

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG022796

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06642

Tribolium castaneum

Red flour beetle

Tcas\TC031528

Pediculus humanus

Human body louse

Phum\PHUM527250

Rhodnius prolixus

Kissing bug

Rpro\RPRC000937

Cimex lectularius

Bed bug

Clec\CLEC011332

Cimex lectularius

Bed bug

Clec\CLEC011330

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15899

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06TE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR010863

Ixodes scapularis

Black-legged tick

Isca\ISCW023474

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76810.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76226.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g00270

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_335438

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08HY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-FoxP

Ciona intestinalis

Vase tunicate

Cint\foxp

Gallus gallus

Domestic chicken

Ggal\FOXP2

Gallus gallus

Domestic chicken

Ggal\FOXP4

Gallus gallus

Domestic chicken

Ggal\FOXP1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

bin

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

fkh

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

FoxP^5-SZ-3955

model of specific developmental disorder

CEA

(Mendoza et al., 2014)

FoxP^GD15847

model of specific developmental disorder

CEA

(Mendoza et al., 2014)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

FOXP2; forkhead box P2

model of speech-language disorder-1

IEA

(FlyBase, 2019-)

FOXP1; forkhead box P1

model of intellectual disability-severe speech delay-mild dysmorphism syndrome

IEA

(FlyBase, 2019-)

FOXP3; forkhead box P3

model of immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FOXP1; forkhead box P1

8 of 15

605515

MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES

intellectual disability-severe speech delay-mild dysmorphism syndrome

FOXP2; forkhead box P2

8 of 15

605317

SPEECH-LANGUAGE DISORDER 1; SPCH1

speech-language disorder-1

FOXP4; forkhead box P4

8 of 15

608924

FOXP3; forkhead box P3

4 of 15

300292

IMMUNODYSREGULATION, POLYENDOCRINOPATHY, AND ENTEROPATHY, X-LINKED; IPEX

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

FoxP

two hybrid

(Castells-Nobau et al., 2019)

FoxP - B-H2

two hybrid array

(Shokri et al., 2019)

FoxP - CG13887

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

FoxP - GATAe

two hybrid array

(Shokri et al., 2019)

FoxP - Unr

two hybrid array

(Shokri et al., 2019)

FoxP - org-1

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262477

MIST (protein-protein) - An integrated Molecular Interaction Database

FoxP

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-49

Cytogenetic map

85E5-85E5

Sequence location

3R:9,726,020..9,730,872 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85E5-85E5

Limits computationally determined from genome sequence between P{EP}Crc^EP3006 and P{lacW}s2681

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-49

(FlyBase, 2016)

3-46.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

85667

w¹¹¹⁸; PBac{WH}FoxP^f03746

62660

w¹¹¹⁸; PBac{IT.GAL4}FoxP^0136-G4

66407

y¹ w^*; P{FoxP-GFP.FPTB}attP40/CyO

26774

y¹ v¹; P{TRiP.JF02338}attP2/TM3, Sb¹

82809

y¹ sc^* v¹ sev²¹; P{TKO.GS04192}attP40

FlyORF

F004517

M{UAS-FoxP.ORF-CC}ZH-21F

F000078

M{UAS-FoxP.ORF.3xHA.GW}ZH-86Fb

Kyoto

126252

w¹¹¹⁸; P{RS5}FoxP^5-SZ-3955

VDRC

v15732

w¹¹¹⁸; P{GD4320}v15732

v15735

w¹¹¹⁸; P{GD4320}v15735

v50200

w¹¹¹⁸; P{GD15847}v50200

v318511

PBac{fTRG00251.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262477

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0262477

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41182

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lawton et al., 2014)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: fd85E CG16899

(Lee and Frasch, 2004)

Source for identity of: FoxP fd85E

(Santos et al., 2011)

Source for database merge of

Source for merge of: fd85E CG32937

(FlyBase Genome Annotators, 2010)

Additional comments

Annotations CG16899 and CG32937 merged as CG43067 in release 5.31 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Other Comments

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

New annotation (CG32937) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 30 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41182

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262477

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262477

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FoxP_1

FlyMine - An integrated database for Drosophila genomics

FBgn0262477

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41182

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43067

modMine - A data warehouse for the modENCODE project

FBgn0262477

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262477

DRSC - Results frm RNAi screens

FBgn0262477

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

FoxP

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG16899

(Sarov et al., 2016, Mendoza et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Santos et al., 2011, Schenck, 2010.9.8, Perkins et al., 2009.3.31, Hoskins et al., 2005, Lee and Frasch, 2004)

CG32937

(Mendoza et al., 2014, Santos et al., 2011, Schenck, 2010.9.8)

CG43067

(Mendoza et al., 2014, FlyBase Genome Annotators, 2010)

DmFoxP

(Santos et al., 2011)

Dmcg16899

(Mazet et al., 2003)

FoxP

(Castells-Nobau et al., 2019, Coll-Tané et al., 2019, Groschner and Miesenböck, 2019, Hall et al., 2019, Kottler et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Davie et al., 2018, Groschner et al., 2018, Schatton and Scharff, 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Schertel et al., 2015, DasGupta et al., 2014, Lawton et al., 2014, Mendoza et al., 2014, Brembs, 2011, Santos et al., 2011, Lee and Frasch, 2004)

dFoxP

(Mendoza et al., 2014)

fd85E

(Schenck, 2010.9.8, Lee and Frasch, 2004)

Name Synonyms

Forkhead box P

forkhead box P

(Groschner et al., 2018)

forkhead domain 85E

(Schenck, 2010.9.8)

Secondary FlyBase IDs

FBgn0037735
FBgn0052937

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

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