FB2022_02, released March 29, 2022

Gene: Dmel\Rab8

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General Information
Symbol
Dmel\Rab8
Species
D. melanogaster
Name
Rab8
Annotation Symbol
CG8287
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262518
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes. [Date last reviewed: 2019-05-16] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)76BDu, DmRab8, dm-Rab8

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-46
RefSeq locus
NT_037436 REGION:19867488..19871078
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (24 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003579, InterPro:IPR005225
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables GTPase activity
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008-)
Biological Process (12 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in polarized secretion of basement membrane proteins in epithelium
inferred from mutant phenotype
(Devergne et al., 2017)
involved_in protein localization to membrane
inferred from mutant phenotype
(Mavor et al., 2016)
involved_in regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(West et al., 2015)
involved_in viral entry into host cell
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
involved_in cellular response to insulin stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000635544
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Golgi vesicle fusion to target membrane
inferred from biological aspect of ancestor with PANTHER:PTN000635544
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein localization to plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000635134
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein secretion
inferred from biological aspect of ancestor with PANTHER:PTN000635132
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008-)
involved_in regulation of exocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000635132
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle docking involved in exocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000635132
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008-)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Mavor et al., 2016)
located_in endosome
inferred from direct assay
(Devergne et al., 2017)
located_in Golgi apparatus
inferred from direct assay
(Devergne et al., 2017, Mavor et al., 2016)
located_in neuronal cell body
inferred from direct assay
(Jin et al., 2012)
located_in plasma membrane
inferred from direct assay
(Mavor et al., 2016)
located_in recycling endosome
inferred from direct assay
(Mavor et al., 2016, West et al., 2015)
inferred from high throughput direct assay
(Chan et al., 2011)
located_in synapse
inferred from high throughput direct assay
(Chan et al., 2011)
inferred from direct assay
(West et al., 2015, Jin et al., 2012)
located_in synaptic vesicle
inferred from high throughput direct assay
(Chan et al., 2011)
located_in vesicle
inferred from direct assay
(Mavor et al., 2016)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
is_active_in endosome
inferred from biological aspect of ancestor with PANTHER:PTN000635134
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000635134
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in synaptic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN001530779
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in trans-Golgi network transport vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000635544
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes. [Date last reviewed: 2019-05-16]
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Rab8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18338)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene
(Zhu et al., 2005)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab8-RA
FBtr0074921
NM_079448
2263
207
Rab8-RB
FBtr0308832
NM_001259907
1068
172
Rab8-RC
FBtr0308833
NM_001259908
2043
207
Additional Transcript Data and Comments
Reported size (kB)

2.2 (longest cDNA)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rab8-PA
FBpp0074690
23.7
207
8.77
NP_524172
AAF49101
Rab8-PB
FBpp0300989
19.7
172
8.67
NP_001246836
AFH04507
Rab8-PC
FBpp0300990
23.7
207
8.77
NP_001246837
AFH04508
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

207 aa isoforms: Rab8-PA, Rab8-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

207 (aa)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab8 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Mavor et al., 2016)
located_in endosome
inferred from direct assay
(Devergne et al., 2017)
located_in Golgi apparatus
inferred from direct assay
(Devergne et al., 2017, Mavor et al., 2016)
located_in neuronal cell body
inferred from direct assay
(Jin et al., 2012)
located_in plasma membrane
inferred from direct assay
(Mavor et al., 2016)
located_in recycling endosome
inferred from direct assay
(Mavor et al., 2016, West et al., 2015)
inferred from high throughput direct assay
(Chan et al., 2011)
located_in synapse
inferred from high throughput direct assay
(Chan et al., 2011)
inferred from direct assay
(West et al., 2015, Jin et al., 2012)
located_in synaptic vesicle
inferred from high throughput direct assay
(Chan et al., 2011)
located_in vesicle
inferred from direct assay
(Mavor et al., 2016)
Expression Deduced from Reporters
Reporter: PBac{I-SceI(FRT.Rab8-GAL4.ATG(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval ventral nerve cord
(West et al., 2015)
embryonic/larval motor neuron
(West et al., 2015)
neuron of embryonic/larval brain
(Chan et al., 2011)
glial cell | subset of embryonic/larval brain
(Chan et al., 2011)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron | subset of larval ventral nerve cord
(Chan et al., 2011)
wing disc | restricted
(Jin et al., 2012, Chan et al., 2011)
eye disc | restricted
(Jin et al., 2012, Chan et al., 2011)
ventral thoracic disc | restricted
(Jin et al., 2012, Chan et al., 2011)
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body
(Jin et al., 2012)
embryonic/larval optic stalk sheath cell
(Jin et al., 2012)
pupal stage P6 -- P7
neuron of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
mushroom body

Comment: 30-40h APF

(Chan et al., 2011)
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe | faint

Comment: 30-40h APF

(Jin et al., 2012)
mushroom body | intense

Comment: 30-40h APF

(Jin et al., 2012)
eye photoreceptor cell

Comment: 30-40h APF

(Jin et al., 2012)
adult stage
neuron of adult brain
(Chan et al., 2011)
adult mushroom body | intense
(Chan et al., 2011)
adult ensheathing glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell
(Jin et al., 2012)
neuron of adult optic lobe
(Jin et al., 2012)
adult mushroom body
(Jin et al., 2012)
adult antennal lobe
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis
(Jin et al., 2012)
neuron of lamina
(Jin et al., 2012)
ellipsoid body
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rab8 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab8
Transgenic constructs containing regulatory region of Rab8
Aberrations (Deficiencies and Duplications) ( 27 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of pupal stage
lethal - all die during immature adult stage (with Rab81)
lethal - all die during immature adult stage (with Rab82)
lethal - all die during immature adult stage (with Rab8B229)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4Act5C.PI
abnormal neuroanatomy | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4Mhc.PW
abnormal neuroanatomy | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4nSyb.PS
abnormal neuroanatomy | third instar larval stage (with Df(3L)ED228)
abnormal neuroanatomy | third instar larval stage (with Rab81)
abnormal neuroanatomy | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4Act5C.PI
abnormal neuroanatomy | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4Mhc.PW
abnormal neuroanatomy | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4nSyb.PS
abnormal neuroanatomy | third instar larval stage (with Rab82)
abnormal neuroanatomy | third instar larval stage (with Rab83)
abnormal neuroanatomy | third instar larval stage (with Rab8B229)
abnormal neuroanatomy | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4Act5C.PI
abnormal neuroanatomy | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4Mhc.PW
abnormal neuroanatomy | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4nSyb.PS
abnormal neuroanatomy | third instar larval stage (with Rab8Z3007)
abnormal neurophysiology | third instar larval stage (with Rab81)
abnormal neurophysiology | third instar larval stage (with Rab8B229)
some die during pupal stage
Phenotype manifest in
Allele
axoneme | spermatogenesis (with Df(3L)ED228)
embryo, with Avic\GFPdsRNA.shRNA.UAS.V20.1, Scer\GAL4VP16.mat.αTub67C
embryo, with Scer\GAL4VP16.mat.αTub67C, slmbUASp.cHa.vhhGFP4
embryonic/larval motor neuron | third instar larval stage (with Rab81)
embryonic/larval motor neuron | third instar larval stage (with Rab8B229)
embryonic/larval neuromuscular junction | third instar larval stage (with Df(3L)ED228)
embryonic/larval neuromuscular junction | third instar larval stage (with Rab81)
embryonic/larval neuromuscular junction | third instar larval stage (with Rab82)
embryonic/larval neuromuscular junction | third instar larval stage (with Rab83)
embryonic/larval neuromuscular junction | third instar larval stage (with Rab8B229)
embryonic/larval neuromuscular junction | third instar larval stage (with Rab8Z3007)
follicle cell, with Scer\GAL4GR1
follicle cell, with Scer\GAL4tj.PU
follicle cell | somatic clone
larval ventral nerve cord | third instar larval stage (with Rab81)
larval ventral nerve cord | third instar larval stage (with Rab8B229)
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4Act5C.PI
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4Mhc.PW
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4nSyb.PS
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab81)
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4Act5C.PI
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4Mhc.PW
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4nSyb.PS
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab8B229)
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4Act5C.PI
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4Mhc.PW
muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4nSyb.PS
muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with Rab81/Rab8B229, Scer\GAL4Mhc.PW
muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with Rab81)
muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with Rab81), with Rab8UAS.cWa, Scer\GAL4Mhc.PW
muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with Rab8B229)
muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with Rab8B229), with Rab8UAS.cWa, Scer\GAL4Mhc.PW
NMJ bouton | third instar larval stage (with Df(3L)ED228)
NMJ bouton | third instar larval stage (with Rab81)
NMJ bouton | third instar larval stage (with Rab82)
NMJ bouton | third instar larval stage (with Rab83)
NMJ bouton | third instar larval stage (with Rab8B229)
NMJ bouton | third instar larval stage (with Rab8Z3007)
ovarian basement membrane | oogenesis, with Scer\GAL4GR1
ovarian basement membrane | oogenesis, with Scer\GAL4tj.PU
ovarian basement membrane | oogenesis | somatic clone
recycling endosome (with Rab81)
recycling endosome (with Rab8B229)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RAB8A
13 of 15
Yes
Yes
1  
Hsap\RAB8B
12 of 15
No
Yes
Hsap\RAB10
5 of 15
No
No
Hsap\RAB13
5 of 15
No
Yes
Hsap\RAB3A
2 of 15
No
No
Hsap\RAB3B
2 of 15
No
No
Hsap\RAB12
2 of 15
No
No
Hsap\CRACR2A
1 of 15
No
Yes
Hsap\RAB1A
1 of 15
No
No
Hsap\RAB1B
1 of 15
No
No
Hsap\RAB3C
1 of 15
No
No
Hsap\RAB3D
1 of 15
No
No
Hsap\RAB15
1 of 15
No
No
Hsap\RAB28
1 of 15
No
Yes
Hsap\RAB40A
1 of 15
No
No
Hsap\RAB40AL
1 of 15
No
No
Hsap\RAB40B
1 of 15
No
No
Hsap\RAB40C
1 of 15
No
No
1  
Hsap\RAB44
1 of 15
No
Yes
Hsap\RASEF
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rab8a
13 of 15
Yes
Yes
Mmus\Rab8b
11 of 15
No
Yes
Mmus\Rab10
5 of 15
No
No
Mmus\Rab13
4 of 15
No
Yes
Mmus\Rab3a
2 of 15
No
No
Mmus\Rab3b
2 of 15
No
No
Mmus\Rab12
2 of 15
No
No
Mmus\Cracr2a
1 of 15
No
Yes
Mmus\Rab1a
1 of 15
No
No
1  
Mmus\Rab1b
1 of 15
No
No
Mmus\Rab3c
1 of 15
No
No
Mmus\Rab3d
1 of 15
No
No
Mmus\Rab15
1 of 15
No
No
Mmus\Rab28
1 of 15
No
Yes
Mmus\Rab35
1 of 15
No
No
Mmus\Rab40b
1 of 15
No
No
Mmus\Rab44
1 of 15
No
Yes
Mmus\Rasef
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (20)
Rnor\Rab8b
10 of 13
Yes
Yes
Rnor\Rab8a
9 of 13
No
Yes
Rnor\Rab10
3 of 13
No
No
Rnor\Rab13
3 of 13
No
Yes
Rnor\Rab3a
2 of 13
No
No
Rnor\Rab3b
2 of 13
No
No
Rnor\Rab12
2 of 13
No
No
Rnor\LOC100363782
1 of 13
No
No
Rnor\LOC102555167
1 of 13
No
No
Rnor\Rab1a
1 of 13
No
No
Rnor\Rab1b
1 of 13
No
No
Rnor\Rab3c
1 of 13
No
No
Rnor\Rab3d
1 of 13
No
No
Rnor\Rab15
1 of 13
No
No
Rnor\Rab28
1 of 13
No
Yes
Rnor\Rab35
1 of 13
No
No
Rnor\Rab40b
1 of 13
No
No
Rnor\Rab40c
1 of 13
No
No
Rnor\Rab44
1 of 13
No
Yes
Rnor\Rasef
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (20)
Xtro\rab8b
11 of 12
Yes
Yes
Xtro\rab8a
10 of 12
No
Yes
Xtro\rab13
4 of 12
No
Yes
Xtro\LOC100135070
3 of 12
No
No
Xtro\rab10
3 of 12
No
No
Xtro\rab3a
2 of 12
No
No
Xtro\rab3b
2 of 12
No
No
Xtro\rab12
2 of 12
No
No
Xtro\mgat4b
1 of 12
No
No
Xtro\rab1a
1 of 12
No
No
Xtro\rab3c
1 of 12
No
No
Xtro\rab3d
1 of 12
No
No
Xtro\rab15
1 of 12
No
No
Xtro\rab28
1 of 12
No
Yes
Xtro\rab35
1 of 12
No
No
Xtro\rab35
1 of 12
No
No
Xtro\rab40b
1 of 12
No
No
Xtro\rab44
1 of 12
No
Yes
Xtro\rasef
1 of 12
No
Yes
Xtro\rasef
1 of 12
No
Yes
Danio rerio (Zebrafish) (28)
Drer\rab8a
11 of 15
Yes
Yes
Drer\rab8b
11 of 15
Yes
Yes
Drer\rab10
5 of 15
No
No
Drer\rab13
5 of 15
No
Yes
Drer\LOC100535415
3 of 15
No
Yes
Drer\rab3ab
2 of 15
No
No
Drer\rab3b
2 of 15
No
No
Drer\rab12
2 of 15
No
No
Drer\cracr2aa
1 of 15
No
Yes
Drer\cracr2ab
1 of 15
No
Yes
Drer\rab1aa
1 of 15
No
No
Drer\rab1ab
1 of 15
No
No
Drer\rab1ba
1 of 15
No
No
Drer\rab1bb
1 of 15
No
No
Drer\rab3aa
1 of 15
No
No
Drer\rab3c
1 of 15
No
No
Drer\rab3da
1 of 15
No
No
Drer\rab3db
1 of 15
No
No
Drer\rab15
1 of 15
No
No
Drer\rab35a
1 of 15
No
No
Drer\rab35b
1 of 15
No
No
Drer\rab40b
1 of 15
No
No
Drer\rab40c
1 of 15
No
No
Drer\rab44
1 of 15
No
No
Drer\rasef
1 of 15
No
Yes
Drer\si:dkey-16l2.16
1 of 15
No
No
Drer\zgc:162879
1 of 15
No
Yes
Drer\zgc:171927
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\rab-8
14 of 15
Yes
Yes
Cele\rab-10
4 of 15
No
No
Cele\K02E10.1
2 of 15
No
No
Cele\4R79.2
1 of 15
No
Yes
Cele\rab-1
1 of 15
No
No
Cele\rab-3
1 of 15
No
No
Cele\rab-28
1 of 15
No
Yes
Cele\rab-35
1 of 15
No
No
Cele\rsef-1
1 of 15
No
Yes
Cele\Y71H2AM.12
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (6)
Atha\AT5G59840
9 of 9
Yes
Yes
Atha\RAB8
8 of 9
No
Yes
Atha\RABE1c
8 of 9
No
Yes
Atha\RAB8C
7 of 9
No
No
Atha\RABE1e
7 of 9
No
No
Atha\RABG1
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\SEC4
12 of 15
Yes
Yes
Scer\YPT1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\ypt2
11 of 12
Yes
Yes
Spom\ypt1
1 of 12
No
No
Spom\ypt4
1 of 12
No
No
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (34)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Rab10
8 of 10
Rab1
3 of 10
Rab3
3 of 10
Rab35
3 of 10
RabX4
3 of 10
CG4789
2 of 10
Rab2
2 of 10
Rab4
2 of 10
Rab5
2 of 10
Rab6
2 of 10
Rab7
2 of 10
Rab9Db
2 of 10
Rab9D
2 of 10
Rab9E
2 of 10
Rab9Fa
2 of 10
Rab9Fb
2 of 10
Rab9
2 of 10
Rab11
2 of 10
Rab14
2 of 10
Rab18
2 of 10
Rab19
2 of 10
Rab21
2 of 10
Rab23
2 of 10
Rab26
2 of 10
Rab27
2 of 10
Rab30
2 of 10
Rab32
2 of 10
Rab39
2 of 10
Rab40
2 of 10
RabX1
2 of 10
RabX2
2 of 10
RabX5
2 of 10
CG15399
1 of 10
RabX6
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 8 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAB8A; RAB8A, member RAS oncogene family
    13 of 15
    165040
         
        RAB8B; RAB8B, member RAS oncogene family
        12 of 15
        613532
            RAB10; RAB10, member RAS oncogene family
            5 of 15
            612672
                RAB13; RAB13, member RAS oncogene family
                5 of 15
                602672
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Rab8
                    suppressible
                    Hrs
                    (West et al., 2015)
                    Rab8
                    suppressible
                    kay
                    (West et al., 2015)
                    Rab8
                    suppressible
                    POSH
                    (West et al., 2015)
                    Rab8
                    suppressible
                    Tak1
                    (West et al., 2015)
                    Rab8
                    suppressible
                    tkv
                    (West et al., 2015)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Cby
                    enhanceable
                    Rab8
                    (Wu et al., 2020)
                    Fam92
                    enhanceable
                    Rab8
                    (Wu et al., 2020)
                    hh
                    suppressible
                    Rab8
                    (Gore et al., 2021)
                    para
                    suppressible
                    Rab8
                    (Kroll et al., 2015)
                    strat
                    suppressible
                    Rab8
                    (Bellec et al., 2018, Devergne et al., 2017)
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                    External Data
                    Linkouts
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3L
                    Recombination map
                    3-46
                    Cytogenetic map
                    76D2-76D3
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    76D2-76D3
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    3-46

                    (FlyBase, 2016)

                    3-43.2

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (18)
                    Genomic Clones (9)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (84)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of

                    Source for merge of: Rab8 l(3)76BDu

                    (Cooper et al., 2010)
                    Additional comments
                    Other Comments

                    dsRNA has been made from templates generated with primers directed against this gene.

                    (Kouranti et al., 2006)

                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                    (Kiger et al., 2003)

                    Isolated from a Drosophila head cDNA library.

                    (Satoh et al., 1997)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 54 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                    FlyMine - An integrated database for Drosophila genomics
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (13)
                    Reported As
                    Symbol Synonym
                    AAF49101
                    (Armstrong, 2000)
                    CG8287
                    (Meadows, 2017.9.14, Dunst et al., 2015, Krahmer et al., 2013, Christis and Munro, 2012, Li et al., 2010, Ni et al., 2010.12.1, Perkins et al., 2009, Sinka et al., 2008, Zhang et al., 2007, Colicelli, 2004, Verstreken and Bellen, 2000.9.4)
                    DRAB8
                    (Kohno et al., 1994)
                    DRab8
                    (Satoh et al., 1997)
                    Dm Rab8
                    (Jekely, 2003)
                    DmRab8
                    (Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
                    O18338
                    (Rojas et al., 2012)
                    Rab-r8
                    Rab8
                    (Gore et al., 2021, Ma and Brill, 2021, Sechi et al., 2021, Delfino et al., 2020, González-Méndez et al., 2020, Wu et al., 2020, Yu et al., 2020, Zhao et al., 2020, Han, 2019.5.8, Hodgson et al., 2019, Johnson and Andrew, 2019, Krämer et al., 2019, Bellec et al., 2018, Court et al., 2017, Coutinho-Budd et al., 2017, Devergne et al., 2017, Jewett et al., 2017, Liu et al., 2017, Sánchez-Sánchez et al., 2017, Caviglia et al., 2016, Mavor et al., 2016, Meehan et al., 2016, Vieillard et al., 2016, Kroll et al., 2015, West et al., 2015, White et al., 2015, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Thomas and Strutt, 2014, Yashiro et al., 2014, Yin et al., 2014, Zhang et al., 2014, Gradilla and Guerrero, 2013, Krahmer et al., 2013, Kwon et al., 2013, Lindsley et al., 2013, O'Sullivan et al., 2013, Puram and Bonni, 2013, Zhang et al., 2013, Giagtzoglou et al., 2012, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Callejo et al., 2011, Akimana et al., 2010, Cooper et al., 2010, Warner and Longmore, 2009, Cook, 2008.12.1, Liebl and Featherstone, 2008, Sinka et al., 2008, Haghnia et al., 2007, Stuart et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Cermelli et al., 2006, Kouranti et al., 2006, Wu et al., 2005)
                    dm-Rab8
                    (Fukuda, 2004, Fukuda et al., 2004)
                    l(3)76BDu
                    (Cooper et al., 2010)
                    rab8
                    (Wu et al., 2020, Das and Cagan, 2017, Lammers et al., 2017, Kanamori et al., 2015, Jin et al., 2012, Chan et al., 2011, Mudiganti et al., 2010, Fukuda, 2003.6.21, Ozaki, 1996.4.9)
                    Name Synonyms
                    Rab-protein 8
                    Rab8
                    l(3)76BDu
                    Secondary FlyBase IDs
                    • FBgn0015796
                    • FBgn0084975
                    Datasets (9)
                    Study focus (1)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    • bait_protein
                    Rab_Effectors_interaction_map
                    Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
                    Study result (8)
                    Result
                    Result Type
                    Title
                    scRNAseq_2020_Cattenoz_NI_seq_clustering
                    Clustering analysis of hemocytes from non-infested third instar larvae
                    scRNAseq_2020_Cattenoz_WI_seq_clustering
                    Clustering analysis of hemocytes from wasp-infested third instar larvae
                    scRNAseq_2020_Cho_NI72LG_seq_clustering
                    Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
                    scRNAseq_2020_Cho_NI96LG_seq_clustering
                    Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
                    scRNAseq_2020_Cho_NI120LG_seq_clustering
                    Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
                    scRNAseq_2020_Cho_WI96LG_seq_clustering
                    Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
                    scRNAseq_2020_Cho_NI96HL_seq_clustering
                    Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
                    scRNAseq_2020_Cho_NI120HL_seq_clustering
                    Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
                    References (131)