dMi-2, Pha, dMi2, PHD-containing ATPase, l(3)S000606
ATP dependent DNA helicase - Zinc finger, CHD family - associates with active chromatin and utilizes the energy of ATP hydrolysis to move nucleosomes along DNA - required for repression of cell type-specific genes and full activation of heat shock genes - regulates higher order chromatin structure of polytene chromosomes.
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
6.475 (compiled cDNA)
Interacts with the NuRD complex member HDAC1/Rpd3.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mi-2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mi-2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Mi-2 l(3)L1243
DNA-protein interactions: genome-wide binding profile assayed for Mi-2 protein in S2 cells; GEO accession number GSE32404.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Mi-2 results in reduced arborization of ddaD and ddaE neurons, defects in muscle and defects in dendrite morphogenesis.
ATPase activity, nucleosome binding and nucleosome mobilization activities are all modulated by phosphorylation of Mi-2.
The Mi-2 chromodomains are important for ATP-dependent nucleosome mobilisation.
Named 'Mi-2' after the human ortholog.