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Gene Dmel\ver

General Information
Symbol	Dmel\ver	Species	D. melanogaster
Name	verrocchio	Annotation symbol	CG14121
Feature type	protein_coding_gene	FlyBase ID	FBgn0262524
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69C4-69C4	Sequence location	3L:12,517,087..12,518,250 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene verrocchio is referred to in FlyBase by the symbol Dmel\ver (CG14121, FBgn0262524). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: telomere capping; neurogenesis. 9 alleles are reported. The phenotype of these alleles is annotated with: chromosome, telomeric region. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleic acid-binding, OB-fold. Gene sequence location is 3L:12517087..12518250.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN23838 HFA10125
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69C4-69C4   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References 69F3-69F7   (determined by in situ hybridisation)   (Deak et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ver for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ver-RA FBtr0075960  NM_140330   808   214
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ver-PA   FBpp0075692   24.4   214   6.51     NP_648587   AAF49903
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nucleic acid-binding, OB-fold (IPR012340)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49903   AX260124   AX260125   AX260127   BP549285   BT082062   CO308763   EC077703
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VTZ2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 verGD8233 lethal | pupal stage | recessive verS147910 lethal | recessive ver1 viable, with Scer\GAL4pnr-MD237 verGD8233 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 verGD8233 Phenotype manifest in Allele chromosome, telomeric region ver1 chromosome, telomeric region (with Df(3L)sex204) ver1 chromosome, telomeric region (with ver1) verS147910 chromosome, telomeric region (with verS147910) ver1 ganglion mother cell | larval stage, with Scer\GAL41407 verGD8233
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of ver Class Mutagen Stocks Known lesion verS147910 amorphic allele - genetic evidence Delta2-3 0 Yes ver1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes verunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ver Class Mutagen Stocks Known lesion verGD8233 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ver1.T:Avic\GFP in vitro construct - coding region fusion 0 Yes verKK103646 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes verm4.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes vert4.7 in vitro construct - genomic fragment 0 Yes verTub.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)iro-2 (Carre et al., 2005) Df(3L)sex204 (Raffa et al., 2010)
Partially disrupted in	Df(3L)sex204 (Carre et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK103646} NA characterization construct P{tub-ver.GFP} NA P{ver1-GFP} NA P{verm4-GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}verS147910 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) telomere capping inferred from mutant phenotype (Raffa et al., 2010)
Cellular Component
CV term Evidence References
polytene chromosome, telomeric region inferred from direct assay (Raffa et al., 2010)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ver allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262524
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA12773
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v17404 w1118; P{GD8233}v17404
Genomic Clones ( 1 )
	BACR48G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP07673
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	155879 EK259260 FGM004F10
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0262524 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39432 247795
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "verrocchio", as the name of this artist is the name of an Italian train, after the mutant phenotype (chromosomes of mutant mitotic brain cells show frequent telomeric associations, some of which generate multicentric chromosomes that resemble little "trains" of chromosomes). (Raffa et al., 2010)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG14121 anon-WO0172774.86 anon-WO0172774.87 (FlyBase, 1996-) Source for merge of: l(3)S147910 CG14121 (Carre et al., 2005) Source for merge of: ver l(3)S147910 (Raffa et al., 2010)
Additional comments	Source for merge of CG14121 anon-WO0172774.86 anon-WO0172774.87 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Identification: identified in a screen to detect mutations affecting telomere behaviour in somatic cells. (Siriaco et al., 1999) Mutants show elevated frequencies of telomeric fusions compared to wild type. (Siriaco et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140330 RefSeq (Proteins) • NP_648587 DDBJ / EMBL / GenBank • AAF49903 AX260124 AX260125 AX260127 Entrez Gene - A searchable database of RefSeq genes. • 39432 UniProtKB/TrEMBL • Q9VTZ2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nucleic acid-binding, OB-fold (IPR012340)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262524 DRSC - Results from RNAi screens. • FBgn0262524 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0262524 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39432 247795 modMine - Data generated by the modENCODE project. • FBgn0262524
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	1479/10 (Deak et al., 1997) anon-WO0172774.86   anon-WO0172774.87   anon-WO0172774.89   CG14121 (Raffa et al., 2010, Carre et al., 2005, Giot et al., 2003, Keleman et al., 2009.8.5) l(3)S147910   ver (Raffa et al., 2010, )
Name Synonym	lethal (3) S147910   verrocchio (Raffa et al., 2010, Siriaco et al., 1999, )
Secondary FlyBase IDs
	FBgn0027937 FBgn0036297 FBgn0046345 FBgn0046346 FBgn0046347 FBgn0060312 FBgn0086699
References ( 12 )
Research paper	Raffa et al., 2010, Genes Dev. 24(15): 1596--1601 Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. [FBrf0211409] Carre et al., 2005, Molec. Cell. Biol. 25(18): 8228--8238 The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis. [FBrf0188098] Deak et al., 1997, Genetics 147(4): 1697--1722 P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. [FBrf0099762]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Abstract	Siriaco et al., 1999, Europ. Dros. Res. Conf. 16: 203 Mutations affecting telomere behaviour in Drosophila melanogaster. [FBrf0110815]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Patent	Deak et al., 2001.10.4, World Patent 0172774-A: Cell cycle progression proteins. [FBrf0141233]