FB2022_02, released March 29, 2022

Gene: Dmel\Mdh2

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General Information
Symbol
Dmel\Mdh2
Species
D. melanogaster
Name
Malate dehydrogenase 2
Annotation Symbol
CG7998
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262559
Gene Model Status
Current
Stock Availability
10 publicly available
Enzyme Name (EC)
Malate dehydrogenase (1.1.1.37)
Gene Summary
Malate dehydrogenase 2 (Mdh2) encodes one of the enzymes in the tricarboxylic acid cycle in mitochondria. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)psg7, Malate dehydrogenase, psg7

Key Links
Genomic Location
Cytogenetic map
90E2-91A2
Sequence location
Recombination map
3-62
RefSeq locus
NT_033777 REGION:18226396..18228718
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables malate dehydrogenase activity
inferred from direct assay
(Wang et al., 2010, Lee et al., 1979)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables L-malate dehydrogenase activity
inferred from biological aspect of ancestor with PANTHER:PTN000166149
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in larval midgut cell programmed cell death
inferred from mutant phenotype
(Ihry and Bashirullah, 2014)
involved_in positive regulation of programmed cell death
inferred from mutant phenotype
(Wang et al., 2010)
involved_in pupal development
inferred from mutant phenotype
(Wang et al., 2010)
involved_in regulation of programmed cell death
inferred from mutant phenotype
(Wang et al., 2008)
involved_in salivary gland cell autophagic cell death
inferred from mutant phenotype
(Ihry and Bashirullah, 2014)
involved_in salivary gland histolysis
inferred from mutant phenotype
(Wang et al., 2010)
involved_in tricarboxylic acid cycle
inferred from direct assay
(Wang et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in carboxylic acid metabolic process
inferred from electronic annotation with InterPro:IPR001557
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in tricarboxylic acid cycle
inferred from biological aspect of ancestor with PANTHER:PTN000899458
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Wang et al., 2010)
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009, Alonso et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000166149
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000899458
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
(S)-malate + NAD(+) = oxaloacetate + NADH (1.1.1.37)
Summaries
Gene Snapshot
Malate dehydrogenase 2 (Mdh2) encodes one of the enzymes in the tricarboxylic acid cycle in mitochondria. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
L-MALATE DEHYDROGENASES -
L-malate dehydrogenases are NAD/NADH-dependent oxidoreductases that catalyze interconversion of the substrates malate and oxaloacetate. This reaction plays key role in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle within the mitochondrial matrix. (Adapted from PMID:12537350).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Mdh2
Structural gene for the mitochondrial NAD-dependent malate dehydrogenase = (S)-Malate: NAD+ oxidoreductase [MDH2 (EC 1.1.1.37)].
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Mdh2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VEB1)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mdh2-RA
FBtr0083563
NM_142439
1335
336
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mdh2-PA
FBpp0082985
35.3
336
9.65
NP_650696
AAF55516
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdh2 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
dissected tissue
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval salivary gland

Comment: from -12 hr APF

(Ihry and Bashirullah, 2014)
prepupal stage P1 -- P4
embryonic/larval salivary gland
(Ihry and Bashirullah, 2014)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
pole plasm

Comment: maternally deposited

(Fisher et al., 2012)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
germline cell
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage -- pupal stage P5
organism
(Wang et al., 2010)
Additional Descriptive Data

Mdh2 levels remain relatively flat in salivary glands as in whole animals throughout the period from -12 hr APF to +12 hr APF.

(Ihry and Bashirullah, 2014)

Mdh2 transcript is expressed more strongly at late larval stages than at early pupal stages.

(Wang et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Wang et al., 2010)
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009, Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mdh2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mdh2
Transgenic constructs containing regulatory region of Mdh2
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MDH2
14 of 15
Yes
Yes
Hsap\LDHA
1 of 15
No
No
1  
Hsap\LDHAL6A
1 of 15
No
No
Hsap\LDHAL6B
1 of 15
No
No
Hsap\LDHB
1 of 15
No
No
1  
Hsap\LDHC
1 of 15
No
No
Hsap\MDH1B
1 of 15
No
No
Hsap\MDH1
1 of 15
No
No
Hsap\UEVLD
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mdh2
13 of 15
Yes
Yes
Mmus\Ldhal6b
1 of 15
No
No
Mmus\Ldha
1 of 15
No
No
Mmus\Ldhb
1 of 15
No
No
Mmus\Ldhc
1 of 15
No
No
Mmus\Mdh1b
1 of 15
No
No
Mmus\Mdh1
1 of 15
No
No
Mmus\Uevld
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Mdh2
13 of 13
Yes
Yes
Rnor\Ldha
1 of 13
No
No
Rnor\Ldhb
1 of 13
No
No
Rnor\Ldhc
1 of 13
No
No
Rnor\Mdh1b
1 of 13
No
No
Rnor\Mdh1
1 of 13
No
No
Rnor\Uevld
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\mdh2
13 of 12
Yes
Yes
Xtro\ldha
1 of 12
No
No
Xtro\ldhb
1 of 12
No
No
Xtro\mdh1
1 of 12
No
No
Xtro\uevld
1 of 12
No
No
Danio rerio (Zebrafish) (7)
Drer\mdh2
14 of 15
Yes
Yes
Drer\ldha
1 of 15
No
No
Drer\ldhba
1 of 15
No
No
Drer\ldhbb
1 of 15
No
No
Drer\mdh1aa
1 of 15
No
No
Drer\mdh1b
1 of 15
No
No
Drer\uevld
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\mdh-2
13 of 15
Yes
Yes
Cele\ldh-1
1 of 15
No
No
Cele\mdh-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\mMDH1
8 of 9
Yes
Yes
Atha\mMDH2
8 of 9
Yes
Yes
Atha\PMDH1
7 of 9
No
Yes
Atha\PMDH2
7 of 9
No
Yes
Atha\MDH
5 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\MDH1
11 of 15
Yes
Yes
Scer\MDH2
5 of 15
No
No
Scer\MDH3
4 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPCC306.08c
10 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG10748
6 of 10
CG10749
6 of 10
CG13334
2 of 10
Ldh
2 of 10
Mdh1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    MDH2; malate dehydrogenase 2
    model of  developmental and epileptic encephalopathy 51
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MDH2; malate dehydrogenase 2
    14 of 15
    154100
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Mdh2 - ATPsynCF6
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - ATPsynβ
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Actn
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Adh
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Akap200
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Akr1B
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Ald1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - AnxB10
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Argk1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Bacc
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG10638
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG10863
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG11267
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG14715
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG1910
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG2852
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG32219
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG3226
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG4598
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG5174
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG8036
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - CG8993
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - COX7AL2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Calr
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Chd64
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Clic
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Df31
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Eb1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - EndoGI
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Eno
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Fkbp12
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Fkbp14
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Fum1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Gapdh1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Gdi
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Gpdh1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - GstE6
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - GstO3
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - GstS1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - HINT1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - HisRS
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - HmgD
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Idh
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Inos
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Mf
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Mhc
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Mlc1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Mlc2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Moe
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Nacα
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Nlp
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - PCNA
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - PHGPx
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Pdi
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Pgd
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Pgk
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Pglym78
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Phb2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Prosα1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Prosβ5
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Prx2540-2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Rab11
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - RhoGDI
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - RpS15Ab
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Scp1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Sh3β
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Stip1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Sumo
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - TER94
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Tm2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Trx-2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Trxr-1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - Uch
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - awd
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - capt
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - cib
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - eEF1δ
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - eEF2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - eEF5
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - fabp
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - kdn
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - mAcon1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - regucalcin
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - scu
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - up
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - wupA
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - yip2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Mdh2 - βTub85D
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-62
    Cytogenetic map
    90E2-91A2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    90E2-91A2
    Left limit from recombination mapping relative to sr (FBrf0032750) Right limit from recombination mapping relative to gl (FBrf0032750)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-62

    (FlyBase, 2016)

    3-61.9

    (Comeron et al., 2012)

    3-66

    (Wang et al., 2008)

    3-

    (Choudhary et al., 1992)

    3-62.6

    Left of (cM)
    (Voelker et al., 1979)
    Right of (cM)
    (Voelker et al., 1979)
    Notes

    Based on 21 recombinants between sr and gl.

    (Voelker et al., 1979)
    Stocks and Reagents
    Stocks (10)
    Genomic Clones (20)
    cDNA Clones (147)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: l(3)psg7 CG7998

      (Wang et al., 2008)
      Source for database merge of

      Source for merge of: Mdh2 l(3)psg7

      (Wang et al., 2010)
      Additional comments

      "Mdh2" is likely to correspond to "CG7998" based on map position and relevant GO annotations.

      (Gelbart, 2009.2.13)

      "CG7998" is likely to correspond to "Mdh2" based on map position and relevant GO annotations.

      (Gelbart, 2009.2.13)
      Other Comments

      No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.

      (Stoltenberg et al., 1992)

      The effect of dietary sucrose and ethanol on Mdh2 activity in the third larval instar has been studied.

      (Geer et al., 1983)

      Structural gene for the mitochondrial NAD-dependent malate dehydrogenase = (S)-Malate: NAD+ oxidoreductase (MDH2).

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 42 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (19)
      Datasets (8)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (8)
      Result
      Result Type
      Title
      scRNAseq_2020_Cattenoz_NI_seq_clustering
      Clustering analysis of hemocytes from non-infested third instar larvae
      scRNAseq_2020_Cattenoz_WI_seq_clustering
      Clustering analysis of hemocytes from wasp-infested third instar larvae
      scRNAseq_2020_Cho_NI72LG_seq_clustering
      Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
      scRNAseq_2020_Cho_NI96LG_seq_clustering
      Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
      scRNAseq_2020_Cho_NI120LG_seq_clustering
      Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
      scRNAseq_2020_Cho_WI96LG_seq_clustering
      Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
      scRNAseq_2020_Cho_NI96HL_seq_clustering
      Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
      scRNAseq_2020_Cho_NI120HL_seq_clustering
      Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
      References (81)