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Gene Dmel\cic

General Information
Symbol	Dmel\cic	Species	D. melanogaster
Name	capicua	Annotation symbol	CG43122
Feature type	protein_coding_gene	FlyBase ID	FBgn0262582
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	fet, CG5067, CG5060
Genomic Location
Chromosome (arm)	3R	Recombination map	3-72.4
Cytogenetic map	92D9-92E2	Sequence location	3R:16,078,492..16,128,194 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene capicua is referred to in FlyBase by the symbol Dmel\cic (CG43122, FBgn0262582). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding; repressing transcription factor binding. There is experimental evidence that it is involved in the biological process: terminal region determination; regulation of transcription, DNA-dependent; wing disc dorsal/ventral pattern formation; eye morphogenesis; imaginal disc-derived wing vein specification; negative regulation of transcription from RNA polymerase II promoter; dorsal appendage formation; negative regulation of cell growth. 51 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; adult segment; thoracic segment; cell part; external compound sense organ; spiracle; cell periphery; acellular anatomical structure. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Armadillo-like helical; High mobility group, HMG1/HMG2; High mobility group, superfamily. Gene sequence location is 3R:16078492..16128194.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Controlled Vocabulary Terms repressing transcription factor binding terminal region determination References Kazemian et al., 2010, PLoS Biol. 8(8): Majumdar et al., 2010, Fly 4(3): 204--212 Sequence features BKN32641 HFA16918 HFA14276 BKN33095 BKN46491 BKN46403 HFA21243 BKN20934 BKN33658 HFA15708
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92D9-92E2   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References 92D1-92D2   Mapped by standard recombination and deficiency tests (details unspecified).   (Jimenez et al., 2000) 92D-92D   (determined by in situ hybridisation)   (Goff et al., 2001)
Experimentally Determined Recombination Data
Location	3-72.4 (Klein and Campos-Ortega, 1992) 3-67.2--68.6 (Goff et al., 2001)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cic for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cic-RA FBtr0305026     5146   1403 cic-RB FBtr0305027     6433   1832 cic-RC FBtr0305028     5131   1427 cic-RD FBtr0305029     7164   2141 cic-RE FBtr0305030     6241   1403 cic-RF FBtr0305031     3509   787
Additional Transcript Data & Comments
Reported size (kB)	5.175 (sequence analysis) (Jimenez et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cic-PA   FBpp0293563   150.1   1403   9.05       cic-PB   FBpp0293564   195.7   1832   7.17       cic-PC   FBpp0293565   152.7   1427   9.05       cic-PD   FBpp0293566   230.6   2141   9.18       cic-PE   FBpp0293567   150.1   1403   9.05       cic-PF   FBpp0293568   85.1   787   8.41
Additional Polypeptide Data & Comments
Reported size (kDa)	1403 (aa) (Jimenez et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • High mobility group, HMG1/HMG2 (IPR000910) High mobility group, superfamily (IPR009071) Armadillo-like helical (IPR011989)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246505   AA536533   AA538911   AA698912   AI063512   AI114008   AI133843   AI295450   AI532562   AJ252268 CAB66144   AY061271   BG636535   BI605170   BI623871   BP545337   BP545338   BP547369   BP549099   BP549100   BT024235   BT044183   BT100233   CK662332   CO178981   CO178993   CO180882   CO192671   CO196550   CO264093   CO265736   CO267092   CO269457   CO273044   CO275598   CO278409   CO280625   CO283839   CO286040   CO287829   CO289322   CO289986   CO290072   CO294986   CO297713   CO297843   CO298852   CO300955   CO305386   CO308967   CO309046   CO312476   CO315062   CO320483   CO321016   CO323803   CO323946   CO325805   CO327474   CO332177   CO338302   CO340819   CO343553   CO344899   CO345154   CZ467888   CZ468000   CZ468155   CZ468156   CZ468953   CZ468954   CZ469384   CZ469998   CZ470023   CZ470247   CZ470296   CZ470644   CZ470645   CZ471050   CZ479062   CZ479063   CZ479079   CZ489464   EC057540   EC058425   EC062273   EC066324   EC070321   EC072630   EC079079   EC081189   EC081572   EC082755   EC083784   EC086246   EC087045   EC194485   EC194551   EC194650   EC195869   EC197947   EC198899   EC198962   EC206170   EC214716   EC216103   EC219062   EC220247   EC223079   EC223738   EC226657   EC227594   EC228709   EC231941   EC241975   EC245866   EC246665   EC253399   EC253750   EC260039   EC266213   EV576977   EV589136   EV591556   EW712798   EW712842
UniProtKB/Swiss-Prot	Q9U1H0
UniProtKB/TrEMBL	Q9VDP1 A8JR49
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Jimenez et al., 2000)
Additional Descriptive Data
	cic transcripts are present at high levels in early blastoderm embryos, consistent with maternal expression and decay rapidly thereafter. They are barely detectable by gastrulation. (Jimenez et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | 10-90% egg length   (Jimenez et al., 2000) Comment:5-95% egg length third instar larval stage   eye disc anterior to the morphogenetic furrow   • nucleus (Tseng et al., 2007) morphogenetic furrow   • nucleus (Tseng et al., 2007)
Additional Descriptive Data
	cic protein is detected in the eye imaginal disc. There is a stripe of increased expression just anterior to the furrow and less within the furrow. (Tseng et al., 2007) cic protein is present in blastoderm embryos in nuclei in the trunk region. It is absent from both poles. (Jimenez et al., 2000)
Marker for
Subcellular Localization
CV Term	nucleus (Jimenez et al., 2000)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal cicCC00526 cicQ219X cicQ474X cicQ677X cicR505W lethal | embryonic stage | germline clone | maternal effect | recessive cicfet-U6 lethal | embryonic stage | germline clone | maternal effect | recessive | terminal cicfet-E11 lethal | embryonic stage | maternal effect (with cicfet-E11) cicfet-U6 lethal | embryonic stage | maternal effect (with cicfet-U6) cicfet-E11 lethal | embryonic stage | maternal effect | partially | recessive | somatic clone cicfet-E11 cicfet-U6 lethal | embryonic stage | recessive cicD49 lethal | larval stage | recessive cicfet-U6 lethal | maternal effect cicΔC2.T:Ivir\HA1 lethal | non-rescuable maternal effect | recessive cic1 lethal | pharate adult stage | recessive cicfet-T6 lethal | recessive cicD49 lethal | terminal cic1 lethal | terminal (with cic1) cicD49 lethal | terminal (with cicD49) cic1 viable cic1 cicfet-E11 viable, with Scer\GAL4pnr-MD237 cicGD1404 viable (with cicfet-E11) cicfet-T6 cicfet-U6 viable (with cicfet-T6) cicfet-E11 viable (with cicfet-U6) cicfet-E11 Sterility Allele female sterile | recessive cic1 Other Phenotypes Allele increased cell number | somatic clone cicQ474X visible, with Scer\GAL4C5 cicScer\UAS.cLa visible (with cicfet-E11) cicfet-T6 cicfet-U6 visible (with cicfet-T6) cicfet-E11 visible (with cicfet-U6) cicfet-E11 visible | somatic clone cicQ219X cicQ474X cicQ677X cicR505W wild-type cic+tJa Phenotype manifest in Allele abdominal segment cic1 chorion (with cicfet-E11) cicfet-U6 cicfet-T6 chorion (with cicfet-T6) cicfet-E11 chorion (with cicfet-U6) cicfet-E11 chorion | maternal effect | somatic clone cicfet-U6 chorion | somatic clone cicfet-U6 denticle belt cic1 dorsal appendage cicΔC2.T:Ivir\HA1 dorsal appendage (with cicBA53) cicfet-U6 dorsal appendage (with cicfet-E11) cicfet-U6 dorsal appendage (with cicfet-T6) cicfet-U6 dorsal appendage (with cicfet-U6) cicBA53 cicfet-E11 cicfet-T6 egg (with cicBA53) cicfet-U6 egg (with cicfet-E11) cicfet-U6 egg (with cicfet-T6) cicfet-U6 egg (with cicfet-U6) cicBA53 cicfet-E11 cicfet-T6 embryo cicΔC2.T:Ivir\HA1 embryonic/first instar larval cuticle cic1 embryonic/first instar larval cuticle (with cic1) cicfet-U6 embryonic/first instar larval cuticle (with cicfet-E11) cicfet-T6 embryonic/first instar larval cuticle (with cicfet-T6) cicfet-E11 embryonic/first instar larval cuticle (with cicfet-U6) cic1 embryonic/first instar larval cuticle | somatic clone cicfet-U6 embryonic/larval posterior spiracle cicΔC2.T:Ivir\HA1 embryonic abdominal segment cic1 embryonic abdominal segment 8 cicΔC2.T:Ivir\HA1 embryonic epidermis (with cicfet-E11) cicfet-U6 embryonic epidermis (with cicfet-U6) cicfet-E11 eye | somatic clone cicR505W cicQ677X cicQ219X cicQ474X nervous system cicD49 ommatidium, with Scer\GAL4GMR.PF cicScer\UAS.cLa ommatidium | somatic clone cicR505W cicQ677X cicQ219X cicQ474X posterior crossvein, with Scer\GAL4C5 cicScer\UAS.cLa wing (with cicfet-E11) cicfet-U6 cicfet-T6 wing (with cicfet-T6) cicfet-E11 wing (with cicfet-U6) cicfet-E11 wing disc | somatic clone cicQ474X wing vein (with cicfet-E11) cicfet-U6 wing vein (with cicfet-U6) cicfet-E11 wing vein | cell non-autonomous | ectopic | somatic clone cicD49 wing vein | posterior, with Scer\GAL4C5 cicScer\UAS.cLa
Classical Alleles ( 32 )
For All Classical Alleles Show
Allele of cic Class Mutagen Stocks Known lesion cicc02708 piggyBac transposase 1 -- cicc04008 piggyBac transposase 1 -- cicc04631 piggyBac transposase 1 -- cicc05457 piggyBac transposase 1 -- cicc05774 piggyBac transposase 1 -- cicc06380 piggyBac transposase 1 -- cicc06875 piggyBac transposase 1 -- cicDG02303 1 -- cice01254 piggyBac transposase 1 -- cice01274 piggyBac transposase 1 -- cicf06735 piggyBac transposase 1 -- cicG9155 P-element activity 1 -- cicKG06726 1 -- cicMI00034 1 -- cicNP2682 1 -- cic1 hypomorphic allele - genetic evidence hobo activity 0 Yes cicBA53 0 Yes cicc02357 piggyBac transposase 0 -- cicc02514 piggyBac transposase 0 -- cicc05480 piggyBac transposase 0 -- cicc05845 piggyBac transposase 0 -- cicCC00526 P-element activity 0 Yes cicD49 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cicEP3-1005 0 -- cicfet-E11 PM hybrid dysgenesis 0 Yes cicfet-T6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cicfet-U6 loss of function allele ethyl methanesulfonate 0 Yes cicQ219X 0 Yes cicQ474X 0 Yes cicQ677X 0 Yes cicR505W 0 Yes cicΔ14 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cic Class Mutagen Stocks Known lesion cicGD1404 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cicJF02017 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cicKK100838 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cicKK112641 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cic+tJa in vitro construct - genomic fragment 0 Yes cic.mini.ΔC2.T:Ivir\HA1 in vitro construct - deletion 0 Yes cicdsRNA.cDa in vitro construct - RNAi 0 Yes cicdsRNA.cDb in vitro construct - RNAi 0 Yes cicGD11519 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cich.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes cicmini.T:Ivir\HA1 in vitro construct - deletion 0 Yes cicminiNLS.T:Ivir\HA1,T:SV40\nls2 in vitro construct - deletion 0 Yes cicScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes cicT1059A.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes cicT1059D.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes cicT:Ivir\HA1 in vitro construct - coding region fusion 0 Yes cicΔC1.T:Ivir\HA1 in vitro construct - deletion 0 Yes cicΔC2.T:Ivir\HA1 in vitro construct - deletion 0 Yes cicΔHMG.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)bwkΔ14 (Jimenez et al., 2000) Df(3R)Dl-BX12 (Goff et al., 2001) Df(3R)Exel6271 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1404} NA P{KK100838} NA P{TRiP.JF02017} NA P{UAS-cic.L} NA reporter construct P{UAS-lacZ.cic} No characterization construct P{cic:flu} NA P{cic.h.HA} NA P{cic.mini.HA} NA P{cic.mini.NLS.HA} NA P{cic.mini.ΔC2.HA} NA P{cic.T1059A.HA} NA P{cic.T1059D.HA} NA P{cic.ΔC1.HA} NA P{cic.ΔC2.HA} NA P{cic.ΔHMG.HA} NA P{cic+tJa} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions H{}cic1 NA Mi{MIC}cicMI00034 NA P{}cicfet-E11 NA P{PTT-GC}cicCC00526 NA P{SUPor-P}cicKG06726 NA P{wHy}cicDG02303 NA PBac{PB}cicc02357 NA PBac{PB}cicc02514 NA PBac{PB}cicc02708 NA PBac{PB}cicc04008 NA PBac{PB}cicc04631 NA PBac{PB}cicc05457 NA PBac{PB}cicc05480 NA PBac{PB}cicc05774 NA PBac{PB}cicc05845 NA PBac{PB}cicc06380 NA PBac{PB}cicc06875 NA PBac{RB}cice01254 NA PBac{RB}cice01274 NA PBac{WH}cicf06735 NA insertion of enhancer trap binary system P{GawB}cicNP2682 No insertion of mobile activating element P{EP}cicEP3-1005 NA P{EP}cicG9155 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
repressing transcription factor binding inferred from physical interaction with gro (Jimenez et al., 2000) sequence-specific DNA binding inferred from direct assay (Ajuria et al., 2011)
Biological Process
CV term Evidence References
dorsal appendage formation inferred from mutant phenotype (Atkey et al., 2006) eye morphogenesis inferred from mutant phenotype (Lam et al., 2006) imaginal disc-derived wing vein specification inferred from mutant phenotype (Lam et al., 2006) negative regulation of cell growth inferred from mutant phenotype (Tseng et al., 2007) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Ajuria et al., 2011) inferred from mutant phenotype (Jimenez et al., 2000) regulation of transcription, DNA-dependent inferred from mutant phenotype (Astigarraga et al., 2007) terminal region determination inferred from mutant phenotype (Jimenez et al., 2000) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Bx, ap (Bejarano et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Jimenez et al., 2000)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:AB014474 (FlyBase, 1992-) transcription cofactor activity non-traceable author statement (Jimenez, 2000.1.6)
Biological Process
CV term Evidence References
embryonic development via the syncytial blastoderm non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) negative regulation of transcription, DNA-dependent traceable author statement (Courey and Jia, 2001, Stathopoulos and Levine, 2002) regulation of transcription, DNA-dependent non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:AB014474 (FlyBase, 1992-) non-traceable author statement (Jimenez, 2000.1.6, Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	nuclear_gene (FlyBase Genome Annotators, 2010) protein_coding_gene (FlyBase Genome Annotators, 2010)
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cic allele Gene References cic1 bwk (Roch et al., 2002) cicD49 bwk (Roch et al., 2002) Dl (Klein and Campos-Ortega, 1992) cicfet-E11 spz (Goff et al., 2001)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262582
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17644 Dana\GF17645 Dere\GG23812 Dere\GG23823 Dgri\GH23544 Dgri\GH23608 Dmoj\GI22720 Dmoj\GI22721 Dper\GL12096 Dper\GL12097 Dpse\GA30228 Dsec\GM23103 Dsec\GM23104 Dsim\GD19344 Dsim\GD19345 Dvir\GJ23447 Dvir\GJ23448 Dwil\GK10918 Dwil\GK10919 Dyak\GE25658 Dyak\GE25659
Curated drosophilid orthologs	Dpse\GA30228
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Harvard	- PBac{PB}cicc02708 - PBac{PB}cicc04008 - PBac{PB}cicc04631 - PBac{PB}cicc05457 - PBac{PB}cicc05774 - PBac{PB}cicc06380 - PBac{PB}cicc06875 - PBac{RB}cice01254 - PBac{RB}cice01274 - PBac{WH}cicf06735
VDRC	v103245 P{KK112641}VIE-260B v103805 P{KK100838}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR09G02 BACR38H07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 100 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05430 LD17181 LD19629
Other clones	FI04109
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03376 GH10572 GH10633 HL05932 LD18573 LP09082 LP22451 RH56228 RH70710 SD04109 SD14271
Other clones	9683 17725 29349 33166 34001 50574 54760 56851 65105 65336 65753 78726 145846 156817 156898 179171 181816 194730 214225.3 214253.62 214535.75 571254 CK01.6C.D6 CK01.10C.G2 CK01.13C.G9 CK01.18D.A2 CK01.31C.F5 CK01.73D.A8 CK01.73D.D1 CK01.79B.B12 CK01.84A.E3 CK01.87A.G6 CK01.89D.E10 CK01.93A.G8 CK01.117A.C10 CK01.129D.A10 CK01.133C.F11 CK01.141D.E7 Dmel_dig_020941_0657_2170 Dmel_neb_010883_0385_1747 Dmel_neb_013724_0338_1897 EC13078 EC34259 EK005532 EK058113 EK058136 EK061540 EK066918 EK070749 EK072760 EK073005 EK094607 EK109341 EK118020 EK130011 EK137360 EK143516 EK148717 EK154509 EK164542 EK170407 EK170651 EK174001 EK179754 EK191528 EK192022 EK208116 EK228906 EK238907 EK248427 EK259812 EK259959 EK285649 EK290140 EK302707 EN16435 EP02548 EP07305 EP11414 EP17063 EP20302 EP21451 FGC030G04 FGH116C03 FGM003F07
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0262582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42406 53560
Antibody Information
	polyclonal (Jimenez et al., 2000, Tseng et al., 2007)
Other Information
Discoverer
Etymology
	"capicua" is Catalonian for "head-and-tail". (Jimenez and Casanova, 1999) The gene is named "capicua", Catalan for "head-and-tail", after the phenotype of embryos produced by homozygous females (they form head and tail structures but lack most of the segmented trunk). (Jimenez et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cic fet (Goff et al., 2001)
Source for database merge of	Source for merge of: cic CG5060 (FlyBase Genome Annotators, 2010) Source for merge of: cic CG5067 (Mumford, 2000.4.13) Source for merge of: E(Dl)D49 cic (Roch et al., 2002)
Additional comments	Annotations CG5067 and CG5060 merged as CG43122 in release 5.32 of the genome annotation. (FlyBase Genome Annotators, 2010) "hab" is allelic to "cic" and "bwk". This locus is genetically and molecularly complex, encoding distinct genetic functions and producing multiple isoforms. (Scherer and Duffy, 2003) Molecular analysis indicates that the "fet" and "cic" mutations are allelic (mutant lesions responsible for "fet" mutations are located in the open reading frame of the "cic" gene, and a "cic" rescue construct rescues the maternal and zygotic "fet" phenotypes). cic[1]/cic[fet-U6] females produce embryos with a tor gain-of-function phenotype, indicating that both alleles affect the same germline function. However, cic[1] complements the follicle cell defect of "fet" mutants, as eggs laid by transheterozygous females show apparently normal dorsoventral polarity of the eggshell and embryo. The relationship between "cic" (and therefore "fet") and "bwk" is unclear. "bwk" alleles complement the "fet" eggshell and wing defects, while the embryos laid by "fet"/"bwk" transheterozygotes are bicaudal (maternal effect "bwk" mutations result in bicaudal embryos). (Goff et al., 2001) The P{PZ} insertion in "bwk08482" maps approximately 300bp away from the hobo insertion in "cic1". However, "cic1" and "bwk08482" complement each other, produce different phenotypes and while the P{cic+tJa} construct rescues "cic1", it does not rescue "bwk08482", indicating that "bwk" and cic represent separate gene functions. (Jimenez et al., 2000)
Other Comments
	New annotation (CG43122) in release 5.32 of the genome annotation. (FlyBase Genome Annotators, 2010) cic represses appendage-producing follicle cell fate during development. (Atkey et al., 2006) cic acts as a repressor of terminal genes regulated by the tor pathway. cic also mediates repression along the dorsoventral axis, a process mediated by dl and gro. (Jimenez et al., 2000) cic acts downstream of the tor phosphorylation cascade. (Jimenez and Casanova, 1999) Mutant embryos form head and tail structures but lack most of the segmented trunk. (Jimenez and Casanova, 1999) Identification: fettucine was originally isolated by D. Morisato as a dominant suppressor of spzDom. (Berg, 1994) A screen that identified Dominant enhancers of the wing phenotype associated with Dl9P and DlFE32 identified this E(Dl) locus. (Klein and Campos-Ortega, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AA246505 AA536533 AA538911 AAF55749 AAF55751 ABW08707 ABW08708 AJ252268 CAB66144 CZ467888 CZ468000 CZ468155 CZ468156 CZ468953 CZ468954 CZ469384 CZ469998 CZ470023 CZ470247 CZ470296 CZ470644 CZ470645 CZ471050 CZ479062 CZ479063 CZ479079 CZ489464 Entrez Gene - A searchable database of RefSeq genes. • 42406 53560 UniProtKB/Swiss-Prot • Q9U1H0 UniProtKB/TrEMBL • A8JR49 Q9VDP1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • High mobility group, HMG1/HMG2 (IPR000910) High mobility group, superfamily (IPR009071) Armadillo-like helical (IPR011989)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262582 DRSC - Results from RNAi screens. • FBgn0262582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42406 53560 modMine - Data generated by the modENCODE project. • FBgn0262582
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG5060 (Dorner et al., 2006, Buszczak et al., 2007, Keleman et al., 2009.8.5, Blard et al., 2007) CG5067 (Berg, 2000.5.11, Mumford, 2000.4.13, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5) CG43122 (FlyBase Genome Annotators, 2010) cic (Lam et al., 2006, Coppey et al., 2007, Atkey et al., 2006, Charroux et al., 2006, Sessa and Bianchi, 2007, de las Heras and Casanova, 2006, Astigarraga et al., 2007, Tseng et al., 2007, Smith-Bolton et al., 2009, Vaccari et al., 2009, Lachance et al., 2009, Löhr et al., 2009, Kim et al., 2010, Blanco and Gehring, 2008, Beam and Moberg, 2010, Grillo et al., 2011, Ajuria et al., 2011, Helman et al., 2011, Kazemian et al., 2010) Cic (Yakoby et al., 2008, Cinnamon et al., 2008, Jennings et al., 2008, Jiang et al., 2011) E(Dl)D49 (Klein and Campos-Ortega, 1992, ) fet (Goff et al., 2001, Goff and Morisato, 2001, Goff and Morisato, 2000, Goff and Morisato, 1998, Astigarraga et al., 2007)
Name Synonym	capicua (Jimenez and Casanova, 1999, Coppey et al., 2007, de las Heras and Casanova, 2006, Bejarano et al., 2008, Tseng et al., 2007, Smith-Bolton et al., 2009, Vaccari et al., 2009, Lachance et al., 2009, Majumdar et al., 2010) Capicua (Atkey et al., 2006, Liu and Bonini, 2006, Kim et al., 2008, Astigarraga et al., 2007, Yakoby et al., 2008, Cinnamon et al., 2008, Jennings et al., 2008, Löhr et al., 2009, Classen et al., 2009, Kim et al., 2010, Beam and Moberg, 2010, Ajuria et al., 2011, Jiang et al., 2011, Helman et al., 2011, Majumdar et al., 2010) Enhancer of Delta D49   fettucine (Goff et al., 2001, Goff and Morisato, 2001, Goff and Morisato, 1998, Berg, 1994, Tseng et al., 2007, Astigarraga et al., 2007)
Secondary FlyBase IDs
	FBgn0010023 FBgn0028386 FBgn0038780 FBgn0038782
References ( 79 )
Generate a list of	All references relating to this gene ( 79 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 3 ) Review  ( 9 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 10 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 8 )
	Ajuria et al., 2011, Development 138(5): 915--924 Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila. [FBrf0212975] Grillo et al., 2011, Genetics 187(2): 513--521 Control of Germline torso Expression by the BTB/POZ Domain Protein Pipsqueak Is Required for Embryonic Terminal Patterning in Drosophila. [FBrf0213010] Helman et al., 2011, Curr. Biol. 21(13): 1102--1110 Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. [FBrf0214255] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Beam and Moberg, 2010, Fly 4(2): 104--116 The gang of four gene regulates growth and patterning of the developing Drosophila eye. [FBrf0211089] Kazemian et al., 2010, PLoS Biol. 8(8): Quantitative analysis of the Drosophila segmentation regulatory network using pattern generating potentials. [FBrf0211688] Kim et al., 2010, Curr. Biol. 20(5): 446--451 MAPK Substrate Competition Integrates Patterning Signals in the Drosophila Embryo. [FBrf0210220] Majumdar et al., 2010, Fly 4(3): 204--212 MAP Kinase phosphorylation is dispensable for cell division, but required for cell growth in Drosophila. [FBrf0216352] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...