FB2019_05, released Oct 15, 2019

Gene: Dmel\Shab

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General Information
Symbol
Dmel\Shab
Species
D. melanogaster
Name
Shaker cognate b
Annotation Symbol
CG43128
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262593
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
Shaker cognate b (Shab) encodes a member of the Sh family and the structural alpha subunit of a delayed rectifier K[+] channel (Kv2). The product of Shab channel functions to regulate excitability in neurons and muscles, and transmitter release. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
dShab, Kv2
Key Links
Genomic Location
Cytogenetic map
63A1-63A2
Sequence location
3L:2,895,017..2,959,579 [+]
Recombination map
3-5
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Shab sub-subfamily. (P17970)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
delayed rectifier potassium channel activity
Predictions / Assertions
voltage-gated potassium channel activity
Summaries
Gene Group (FlyBase)
VOLTAGE-GATED POTASSIUM CHANNEL - ALPHA SUBUNITS -
Voltage-gated potassium α subunits form homo- or heterotetrameric transmembrane channels specific for potassium which are activated by changes in membrane potential. Kv channel α subunits possess six or seven transmembrane domains. (Adapted from FBrf0224790).
Protein Function (UniProtKB)
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
(UniProt, P17970)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Shab: Shaker cognate b (J.C. Hall)
Expression in Xenopus oocytes reveals a delayed-rectifier type of potassium current expressed by Shab; the rate of current activation in Shab is somewhat faster than in Shaw.
Summary (Interactive Fly)
slow delayed rectifier K channel - upregulated by light stimulation - functions in light adaptation - regulates excitability in neurons and muscles, and transmitter release
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
9

Please see the GBrowse view of Dmel\Shab or the JBrowse view of Dmel\Shab for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 6.02
Contains low complexity sequences resulting in poly-glycine runs in the translation products.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Shab-RA
FBtr0305201
NM_167967
4598
985
Shab-RB
FBtr0305202
NM_079170
4586
1015
Shab-RC
FBtr0305203
NM_001043115
4756
1011
Shab-RH
FBtr0305205
NM_001202109
7439
1537
Shab-RI
FBtr0305206
NM_001202110
7461
1602
Shab-RJ
FBtr0305208
NM_001259655
4439
972
Shab-RK
FBtr0305207
NM_001104015
5231
799
Shab-RL
FBtr0305209
NM_001259656
4553
1010
Shab-RM
FBtr0333898
NM_001202108
7596
1607
Shab-RN
FBtr0333899
NM_001274416
7491
1602
Additional Transcript Data and Comments
Reported size (kB)
6.8, 4.3 (northern blot)
(Butler et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Shab-PA
FBpp0293731
106.6
985
6.28
NP_728783
AAG22233
Shab-PB
FBpp0293732
109.8
1015
6.57
NP_523894
AAG22232
Shab-PC
FBpp0293733
110.0
1011
6.41
NP_001036580
ABI31231
Shab-PH
FBpp0293735
164.6
1537
7.04
NP_001189038
ADV37475
Shab-PI
FBpp0293736
171.7
1602
6.57
NP_001189039
ADV37476
Shab-PJ
FBpp0293738
105.2
972
6.95
NP_001246584
AFH04255
Shab-PK
FBpp0293737
87.3
799
6.79
NP_001097485
ABW08445
Shab-PL
FBpp0293739
109.6
1010
6.69
NP_001246585
AFH04256
Shab-PM
FBpp0306030
171.8
1607
6.49
NP_001189037
ADV37474
Shab-PN
FBpp0306031
171.7
1602
6.57
NP_001261345
AGB94040
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1602 aa isoforms: Shab-PI, Shab-PN
Additional Polypeptide Data and Comments
Reported size (kDa)
955 (aa)
(Hegde et al., 1999)
924 (aa)
(Butler et al., 1990, Butler et al., 1989)
100 (kD predicted)
(Wei et al., 1990)
Comments
The sequence of Shab in Canton-S contains an inserted base relative to Oregon-R leading to a frameshift and a C-terminal extension of the protein.
(Hegde et al., 1999)
Co-injection experiments in Xenopus oocytes were used to test for formation of functional heterodimers between Sh subfamily members. In fact, no functional heterodimers (as shown by novel current kinetics) were detected when all pairwise combinations of the four different channel subfamilies (Sh, Shab, Shal, and Shaw) were tested. The independence of each channel system was retained even when all four were co-expressed.
(Covarrubias et al., 1991)
Shab protein was expressed in Xenopus oocytes and characterized with respect to kinetics (rate of macroscopic current activation and inactivation) and voltage sensitivity of steady-state inactivation. Those properties were compared among the Sh subfamily members and found to vary widely. Shab encodes the transient (A current)subtype of potassium channel and appears to function as a homomultimer.
(Wei et al., 1990)
External Data
Subunit Structure (UniProtKB)
Heterotetramer of potassium channel proteins.
(UniProt, P17970)
Domain
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
(UniProt, P17970)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shab using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
delayed rectifier potassium channel activity
inferred from direct assay
(Vahasoyrinki et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
voltage-gated potassium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000164970
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Littleton and Ganetzky, 2000)
Biological Process (9 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
action potential
inferred from mutant phenotype
(Ueda and Wu, 2006)
chemical synaptic transmission
inferred from mutant phenotype
(Yao and Wu, 2001)
larval locomotory behavior
inferred from mutant phenotype
(Ueda and Wu, 2006)
positive regulation of circadian sleep/wake cycle, sleep
inferred from mutant phenotype
(Pimentel et al., 2016)
regulation of heart contraction
inferred from mutant phenotype
(Frolov et al., 2008)
regulation of synaptic activity
inferred from mutant phenotype
(Ueda and Wu, 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
potassium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000164970
(assigned by GO_Central )
(Gaudet et al., 2011)
potassium ion transport
traceable author statement
(Littleton and Ganetzky, 2000)
protein homooligomerization
inferred from electronic annotation with InterPro:IPR003131
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000164970
(assigned by GO_Central )
(Gaudet et al., 2011)
plasma membrane
inferred from sequence or structural similarity
(Butler et al., 1990)
inferred from sequence or structural similarity with FLYBASE:Sh; FB:FBgn0003380
(Butler et al., 1989)
voltage-gated potassium channel complex
inferred from biological aspect of ancestor with PANTHER:PTN001355853
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Littleton and Ganetzky, 2000)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 17
organism
(Butler et al., 1989)
pupal stage
(Butler et al., 1989)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Shab in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Shab
Transgenic constructs containing regulatory region of Shab
Deletions and Duplications ( 10 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (28)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KCNB1
9 of 15
Yes
Yes
Hsap\KCNB2
8 of 15
No
Yes
Hsap\KCNF1
4 of 15
No
Yes
Hsap\KCNG1
4 of 15
No
Yes
Hsap\KCNG2
4 of 15
No
Yes
Hsap\KCNG3
4 of 15
No
Yes
Hsap\KCNG4
4 of 15
No
Yes
Hsap\KCNS1
4 of 15
No
Yes
Hsap\KCNS2
4 of 15
No
Yes
 
Hsap\KCNS3
4 of 15
No
Yes
 
Hsap\KCNV1
4 of 15
No
Yes
Hsap\KCNV2
4 of 15
No
Yes
Hsap\KCNC1
2 of 15
No
No
 
Hsap\KCNC2
2 of 15
No
No
Hsap\KCNC3
2 of 15
No
No
 
Hsap\KCNC4
2 of 15
No
No
Hsap\KCNA1
1 of 15
No
No
 
Hsap\KCNA2
1 of 15
No
No
 
Hsap\KCNA3
1 of 15
No
No
Hsap\KCNA4
1 of 15
No
No
Hsap\KCNA5
1 of 15
No
No
 
Hsap\KCNA6
1 of 15
No
No
 
Hsap\KCNA7
1 of 15
No
No
Hsap\KCNA10
1 of 15
No
No
 
Hsap\KCTD2
1 of 15
No
No
Hsap\KCTD9
1 of 15
No
No
Hsap\KCTD17
1 of 15
No
No
Hsap\TUBB
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kcnb1
9 of 15
Yes
Yes
Mmus\Kcnb2
8 of 15
No
Yes
Mmus\Kcnf1
4 of 15
No
Yes
Mmus\Kcng1
4 of 15
No
Yes
Mmus\Kcng2
4 of 15
No
Yes
Mmus\Kcng3
4 of 15
No
Yes
Mmus\Kcng4
4 of 15
No
Yes
Mmus\Kcns1
4 of 15
No
Yes
Mmus\Kcns2
4 of 15
No
Yes
Mmus\Kcns3
4 of 15
No
Yes
Mmus\Kcnv1
4 of 15
No
Yes
Mmus\Kcnv2
4 of 15
No
Yes
Mmus\Kcnc1
2 of 15
No
No
Mmus\Kcnc2
2 of 15
No
No
Mmus\Kcnc3
2 of 15
No
No
Mmus\Kcnc4
2 of 15
No
No
Mmus\Kcna1
1 of 15
No
No
Mmus\Kcna2
1 of 15
No
No
Mmus\Kcna3
1 of 15
No
No
Mmus\Kcna4
1 of 15
No
No
Mmus\Kcna5
1 of 15
No
No
Mmus\Kcna6
1 of 15
No
No
Mmus\Kcna7
1 of 15
No
No
Mmus\Kcna10
1 of 15
No
No
Mmus\Kctd5
1 of 15
No
No
Mmus\Kctd9
1 of 15
No
No
Mmus\Kctd17
1 of 15
No
No
Rattus norvegicus (Norway rat) (25)
Rnor\Kcnb1
6 of 13
Yes
Yes
Rnor\Kcnf1
4 of 13
No
Yes
Rnor\Kcng4
4 of 13
No
Yes
Rnor\Kcns1
4 of 13
No
Yes
Rnor\Kcns2
4 of 13
No
Yes
Rnor\Kcns3
4 of 13
No
Yes
Rnor\Kcnv1
4 of 13
No
Yes
Rnor\Kcnv2
4 of 13
No
Yes
Rnor\Kcnb2
3 of 13
No
Yes
Rnor\Kcng1
3 of 13
No
Yes
Rnor\Kcng2
3 of 13
No
Yes
Rnor\Kcng3
3 of 13
No
Yes
Rnor\Kcnc2
2 of 13
No
No
Rnor\Kcna1
1 of 13
No
No
Rnor\Kcna2
1 of 13
No
No
Rnor\Kcna4
1 of 13
No
No
Rnor\Kcna5
1 of 13
No
No
Rnor\Kcna6
1 of 13
No
No
Rnor\Kcna7
1 of 13
No
No
Rnor\Kcna10
1 of 13
No
No
Rnor\Kcnc1
1 of 13
No
No
Rnor\Kcnc4
1 of 13
No
No
Rnor\Kctd5
1 of 13
No
No
Rnor\Kctd9
1 of 13
No
No
Rnor\Kctd17
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\kcnb1
3 of 12
Yes
Yes
Xtro\kcnb2
3 of 12
Yes
Yes
Xtro\kcng1
3 of 12
Yes
Yes
Xtro\kcnf1
2 of 12
No
Yes
Xtro\kcng2
2 of 12
No
Yes
Xtro\kcng4
2 of 12
No
Yes
Xtro\kcns1
2 of 12
No
Yes
Xtro\kcns3
2 of 12
No
Yes
Xtro\kcnv1
2 of 12
No
Yes
Xtro\kcnv2
2 of 12
No
Yes
Xtro\kcna1
1 of 12
No
No
Xtro\kcna3
1 of 12
No
No
Xtro\kcna6
1 of 12
No
No
Xtro\kcnc1
1 of 12
No
No
Xtro\kcnc4
1 of 12
No
No
Danio rerio (Zebrafish) (34)
Drer\kcnb2
7 of 15
Yes
Yes
Drer\kcnb1
4 of 15
No
Yes
Drer\kcnf1a
4 of 15
No
Yes
Drer\kcnf1b
4 of 15
No
Yes
Drer\kcng2
4 of 15
No
Yes
Drer\kcng4a
4 of 15
No
Yes
Drer\kcng4b
4 of 15
No
Yes
Drer\kcns3a
4 of 15
No
Yes
Drer\kcns3b
4 of 15
No
Yes
Drer\kcnv2a
4 of 15
No
Yes
Drer\kcnv2b
4 of 15
No
Yes
Drer\si:dkey-43k4.5
4 of 15
No
Yes
Drer\si:dkey-192j17.1
4 of 15
No
Yes
Drer\si:rp71-39b20.4
4 of 15
No
Yes
Drer\kcng3
3 of 15
No
Yes
Drer\si:dkey-201i6.2
3 of 15
No
Yes
Drer\kcnc1a
2 of 15
No
No
Drer\kcnc1b
2 of 15
No
No
Drer\kcnc2
2 of 15
No
No
Drer\kcnc3a
2 of 15
No
No
Drer\kcnc4
2 of 15
No
No
Drer\kcng1
2 of 15
No
Yes
Drer\kcna1a
1 of 15
No
No
Drer\kcna2b
1 of 15
No
No
Drer\kcna3a
1 of 15
No
No
Drer\kcna4
1 of 15
No
No
Drer\kcna6a
1 of 15
No
No
Drer\kcnc3b
1 of 15
No
No
Drer\kctd2
1 of 15
No
No
Drer\kctd5a
1 of 15
No
No
Drer\kctd9a
1 of 15
No
No
Drer\kctd17
1 of 15
No
No
Drer\LOC100537815
1 of 15
No
No
Drer\rasgrp2
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\exp-2
5 of 15
Yes
Yes
Cele\C32C4.1
3 of 15
No
Yes
Cele\kvs-3
3 of 15
No
Yes
Cele\kvs-4
3 of 15
No
Yes
Cele\kvs-5
3 of 15
No
Yes
Cele\egl-36
2 of 15
No
No
Cele\kvs-1
2 of 15
No
Yes
Cele\shw-1
2 of 15
No
No
Cele\shw-3
2 of 15
No
No
Cele\C45B11.2
1 of 15
No
Yes
Cele\F17C11.11
1 of 15
No
Yes
Cele\F18A11.5
1 of 15
No
No
Cele\inso-1
1 of 15
No
No
Cele\shk-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\FIP2
1 of 9
Yes
No
Atha\KCO2
1 of 9
Yes
No
Atha\KCO3
1 of 9
Yes
Yes
Atha\KCO5
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919017A )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Shab
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004358
Drosophila simulans
Dsim\GD13713
Drosophila sechellia
Dsec\GM14516
Drosophila sechellia
Dsec\GM14517
Drosophila erecta
Dere\GG14890
Drosophila yakuba
Dyak\GE20344
Drosophila ananassae
Dana\GF24253
Drosophila pseudoobscura pseudoobscura
Dpse\GA28551
Drosophila persimilis
Dper\GL25503
Drosophila persimilis
Dper\GL11876
Drosophila willistoni
Dwil\GK16572
Drosophila virilis
Dvir\GJ13599
Drosophila mojavensis
Dmoj\GI11404
Drosophila grimshawi
Dgri\GH16991
Drosophila grimshawi
Dgri\GH16990
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915054K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014918
Glossina morsitans
Tsetse fly
Gmor\GMOY007816
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12211
Mayetiola destructor
Hessian fly
Mdes\Mdes000073
Mayetiola destructor
Hessian fly
Mdes\Mdes000071
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009619
Anopheles darlingi
American malaria mosquito
Adar\ADAC002463
Anopheles gambiae
Malaria mosquito
Agam\AGAP005925
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009252
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0A3H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011807
Danaus plexippus
Monarch butterfly
Dple\DPOGS213525-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013678
Apis florea
Little honeybee
Aflo\2481022692
Apis mellifera
Western honey bee
Amel\GB51370
Apis mellifera
Western honey bee
Amel\GB46981
Apis mellifera
Western honey bee
Amel\GB46982
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24684
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12996
Bombus terrestris
Buff-tailed bumblebee
Bter\15201935
Bombus terrestris
Buff-tailed bumblebee
Bter\15213684
Linepithema humile
Argentine ant
Lhum\LH19348
Linepithema humile
Argentine ant
Lhum\LH19351
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0002bf
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002d42
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003501
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003502
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03830
Tribolium castaneum
Red flour beetle
Tcas\TC034787
Pediculus humanus
Human body louse
Phum\PHUM520880
Rhodnius prolixus
Kissing bug
Rpro\RPRC003607
Cimex lectularius
Bed bug
Clec\CLEC012600
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008781
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12285
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09ZD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005391
Ixodes scapularis
Black-legged tick
Isca\ISCW000826
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56525.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g00210
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_438
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0FP3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kcns3
Ciona intestinalis
Vase tunicate
Cint\LOC100181616
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014509
Gallus gallus
Domestic chicken
Ggal\KCNF1
Gallus gallus
Domestic chicken
Ggal\KCNV2
Gallus gallus
Domestic chicken
Ggal\KCNB1
Gallus gallus
Domestic chicken
Ggal\KCNS3
Gallus gallus
Domestic chicken
Ggal\KCNB2
Gallus gallus
Domestic chicken
Ggal\KCNS1
Gallus gallus
Domestic chicken
Ggal\KCNS2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026161
Gallus gallus
Domestic chicken
Ggal\KCNV1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Shawl
3 of 10
Shaw
3 of 10
Sh
2 of 10
CG14647
1 of 10
KCNQ
1 of 10
Shal
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
KCNB1; potassium voltage-gated channel subfamily B member 1
9 of 15
600397
KCNB2; potassium voltage-gated channel subfamily B member 2
8 of 15
607738
      KCNF1; potassium voltage-gated channel modifier subfamily F member 1
      4 of 15
      603787
          KCNG1; potassium voltage-gated channel modifier subfamily G member 1
          4 of 15
          603788
              KCNG2; potassium voltage-gated channel modifier subfamily G member 2
              4 of 15
              605696
                  KCNG3; potassium voltage-gated channel modifier subfamily G member 3
                  4 of 15
                  606767
                      KCNG4; potassium voltage-gated channel modifier subfamily G member 4
                      4 of 15
                      607603
                          KCNS1; potassium voltage-gated channel modifier subfamily S member 1
                          4 of 15
                          602905
                              KCNS2; potassium voltage-gated channel modifier subfamily S member 2
                              4 of 15
                              602906
                                   
                                  KCNS3; potassium voltage-gated channel modifier subfamily S member 3
                                  4 of 15
                                  603888
                                       
                                      KCNV1; potassium voltage-gated channel modifier subfamily V member 1
                                      4 of 15
                                      608164
                                          KCNV2; potassium voltage-gated channel modifier subfamily V member 2
                                          4 of 15
                                          607604
                                          Functional Complementation Data
                                          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                          Interactions
                                          Summary of Physical Interactions
                                          esyN Network Diagram
                                          Interactions Browser
                                          Summary of Genetic Interactions
                                          esyN Network Diagram
                                          esyN Network Key:
                                          Suppression
                                          Enhancement
                                          View in Interactions Browser
                                          Please look at the allele data for full details of the genetic interactions
                                          Starting gene(s)
                                          Interaction type
                                          Interacting gene(s)
                                          Reference
                                          Shab
                                          suppressible
                                          Sh
                                          (Vahasoyrinki et al., 2006)
                                          Shab
                                          enhanceable
                                          Sh
                                          (Vahasoyrinki et al., 2006)
                                          Starting gene(s)
                                          Interaction type
                                          Interacting gene(s)
                                          Reference
                                          Sh
                                          enhanceable
                                          Shab
                                          (Vahasoyrinki et al., 2006)
                                          Sh
                                          suppressible
                                          Shab
                                          (Vahasoyrinki et al., 2006)
                                          External Data
                                          Subunit Structure (UniProtKB)
                                          Heterotetramer of potassium channel proteins.
                                          (UniProt, P17970 )
                                          Linkouts
                                          DroID - A comprehensive database of gene and protein interactions.
                                          MIST (genetic) - An integrated Molecular Interaction Database
                                          Pathways
                                          Gene Group - Pathway Membership (FlyBase)
                                          External Data
                                          Genomic Location and Detailed Mapping Data
                                          Chromosome (arm)
                                          3L
                                          Recombination map
                                          3-5
                                          Cytogenetic map
                                          63A1-63A2
                                          Sequence location
                                          3L:2,895,017..2,959,579 [+]
                                          FlyBase Computed Cytological Location
                                          Cytogenetic map
                                          Evidence for location
                                          63A1-63A2
                                          Limits computationally determined from genome sequence between P{PZ}Spn06911 and P{PZ}l(3)0680306803
                                          Experimentally Determined Cytological Location
                                          Cytogenetic map
                                          Notes
                                          References
                                          63A1-63B6
                                          (Hegde, 1998.8.14)
                                          63A-63A
                                          (determined by in situ hybridisation)
                                          (Butler et al., 1989)
                                          Experimentally Determined Recombination Data
                                          Location
                                          3-5
                                          (FlyBase, 2016)
                                          3-6.0
                                          (Comeron et al., 2012)
                                          3-14
                                          (Chopra et al., 2000)
                                          Left of (cM)
                                          (Chopra et al., 2000)
                                          Right of (cM)
                                          (Chopra et al., 2000)
                                          Notes
                                          Stocks and Reagents
                                          Stocks (16)
                                          Genomic Clones (38)
                                          cDNA Clones (37)
                                           

                                          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                          cDNA clones, fully sequences
                                          BDGP DGC clones
                                          Other clones
                                          Drosophila Genomics Resource Center cDNA clones

                                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                          cDNA Clones, End Sequenced (ESTs)
                                          BDGP DGC clones
                                          Other clones
                                          RNAi and Array Information
                                          Linkouts
                                          DRSC - Results frm RNAi screens
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          Antibody Information
                                          Laboratory Generated Antibodies
                                           
                                          Commercially Available Antibodies
                                           
                                          Other Information
                                          Relationship to Other Genes
                                          Source for database identify of
                                          Source for identity of: Shab CG1066
                                          (Evangelista, 1999.11)
                                          Source for database merge of
                                          Source for merge of: Shab CG9965
                                          (FlyBase Genome Annotators, 2010)
                                          Additional comments
                                          Annotations CG1066 and CG9965 merged as CG43128 in release 5.32 of the genome annotation.
                                          (FlyBase Genome Annotators, 2010)
                                          Other Comments
                                          The role of Shab channels in Drosophila photoreceptors is to dynamically attenuate the light-induced depolarisation and prevent response saturation in bright light.
                                          (Vahasoyrinki et al., 2006)
                                          A null mutation in Shab reduces the voltage-activated delayed sustained current (IK) but does not eliminate it. Observations suggest that IK consists of two components, which are genetically, pharmacalogically and physiologically distinct. These components are IKS (encoded by Shab) and IKF (which defines a new voltage-activated K+ current).
                                          (Singh and Singh, 1999)
                                          Shab, Shal and Shaw account for virtually all single channel currents.
                                          (Tsunoda and Salkoff, 1995)
                                          Shab may encode an 11 pS slowly inactivating K+ channel present in embryonic neurons.
                                          (Tsunoda and Salkoff, 1995)
                                          Shab encodes the major delayed rectifier component of the K+ current in both embryonic muscles and neurons.
                                          (Tsunoda and Salkoff, 1995)
                                          Yeast two-hybrid system studies demonstrate the association of the hydrophilic N-terminal domains of the genes encoding channel proteins plays an important role in determining the specificity of α subunit association to form heteromultimeric potassium channels.
                                          (Xu et al., 1995)
                                          Expression in Xenopus oocytes reveals a delayed-rectifier type of potassium current expressed by Shab; the rate of current activation in Shab is somewhat faster than in Shaw.
                                          (Lindsley and Zimm, 1992)
                                          Sh, Shal, Shab and Shaw encode independent channel systems that function independently in Xenopus oocytes.
                                          (Salkoff et al., 1992)
                                          Shab potassium channel and a mouse brain homolog potassium channel have similar kinetic, voltage sensitive and pharmacological properties. The greatest functional difference is recovery from inactivation.
                                          (Pak et al., 1991)
                                          Although Sh, Shal, Shab and Shaw proteins share a conserved structral organisation, their potassium channel currents (expressed in Xenopus oocytes) differ greatly in individual kinetic properties and voltage sensitivity.
                                          (Butler et al., 1990)
                                          Sh, Shal, Shab and Shaw encode voltage gated potassium channels with widely varying kinetics (rate of macroscopic current activation and inactivation) and voltage sensitivity of steady state inactivation.
                                          (Wei et al., 1990)
                                          Potassium channel diversity could result from an extended gene family as well as from alternate splicing of the Sh primary transcript.
                                          (Butler et al., 1989)
                                          Origin and Etymology
                                          Discoverer
                                          Etymology
                                          Identification
                                          External Crossreferences and Linkouts ( 76 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          modMine - A data warehouse for the modENCODE project
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          Linkouts
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                          MIST (genetic) - An integrated Molecular Interaction Database
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          Synonyms and Secondary IDs (11)
                                          Reported As
                                          Symbol Synonym
                                          CG1066
                                          (Neuert et al., 2017, Rieder et al., 2015, Tsubouchi et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Sepp et al., 2008)
                                          CG43128
                                          (Walcott et al., 2018, Hosono et al., 2015, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)
                                          CG9965
                                          (Keleman et al., 2009.8.5)
                                          Kv2
                                          (Ping et al., 2015)
                                          Kv2
                                          (Yang et al., 2008, McCormack, 2003)
                                          Shab
                                          (Kulik et al., 2019, Smith et al., 2018, Walcott et al., 2018, Wang et al., 2018, Kim et al., 2017, Neuert et al., 2017, Pimentel et al., 2016, Berger and Crook, 2015, Carrillo et al., 2015, Fogle et al., 2015, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Ashwal-Fluss et al., 2014, Frolov and Singh, 2014, Wolfram et al., 2014, Chow et al., 2013, Frolov et al., 2012, Rodriguez et al., 2012, Tsubouchi et al., 2012, Napoletano et al., 2011, Ping and Tsunoda, 2011, Diao et al., 2010, Diao et al., 2009, Frolov et al., 2008, Ryan et al., 2008, Joiner et al., 2007, Peng and Wu, 2007, Peng and Wu, 2007, Berke et al., 2006, Lee and Wu, 2006, Ueda and Wu, 2006, Vahasoyrinki et al., 2006, Bhalla et al., 2004, Wang et al., 2004, McCormack, 2003, Yao and Wu, 2001, Chopra et al., 2000)
                                          dShab
                                          (Carrillo et al., 2013, Hoopengardner et al., 2003)
                                          shab
                                          (Rieder et al., 2015, Bhogal et al., 2011, Jepson et al., 2011, Jepson and Reenan, 2009, Krause et al., 2008, Gasque et al., 2005, Draper et al., 2002, Young et al., 2002, Hansen et al., 1997)
                                          shb
                                          (Savva et al., 2012)
                                          Name Synonyms
                                          Shaker
                                          (Fogle et al., 2015)
                                          Shaker cognate b
                                          (Tsubouchi et al., 2012, Sepp et al., 2008, Wang et al., 2004)
                                          Secondary FlyBase IDs
                                          • FBgn0003383
                                          • FBgn0035381
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          References (142)