FB2019_05, released Oct 15, 2019

Gene: Dmel\pyd

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General Information
Symbol
Dmel\pyd
Species
D. melanogaster
Name
polychaetoid
Annotation Symbol
CG43140
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262614
Gene Model Status
Current
Stock Availability
43 publicly available
Gene Snapshot
polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
ZO-1, tamou, tam, Pyd/ZO-1
Key Links
Genomic Location
Cytogenetic map
85B3-85B7
Sequence location
3R:8,827,068..8,931,896 [-]
Recombination map
3-48
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
cell adhesion molecule binding
Predictions / Assertions
-
Summaries
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
pyd: polychaetoid
Extra bristles present in homozygote at or near almost all normal bristle locations but most frequently in dorsocentral and scutellar regions. Heterozygote in some stocks occasionally shows extra bristles, especially vibrissae. Character expressed better at low temperatures and in large flies. Combinations with h and Hw generally superadditive for bristle number. RK3.
Summary (Interactive Fly)
scaffolding protein, PDZ domain protein, MAGUK - involved in sensory organ development - mutations have a neurogenic effect - suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
10

Please see the GBrowse view of Dmel\pyd or the JBrowse view of Dmel\pyd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
pyd-RA
FBtr0305297
NM_169245
7195
2090
pyd-RB
FBtr0305295
NM_057349
5688
1371
pyd-RC
FBtr0305296
NM_169246
5024
1293
pyd-RF
FBtr0305294
NM_176426
4196
1149
pyd-RG
FBtr0305299
NM_001104241
5048
1301
pyd-RI
FBtr0305298
NM_001144556
5505
1386
pyd-RJ
FBtr0305301
NM_170646
6665
1735
pyd-RK
FBtr0305302
NM_001104242
5744
1446
pyd-RL
FBtr0305303
NM_001260071
5123
1285
pyd-RM
FBtr0305304
NM_001260072
6058
1301
pyd-RO
FBtr0310205
NM_001260069
8533
2395
Additional Transcript Data and Comments
Reported size (kB)
10.5, 9.5, 8.1, 6.7, 5.6 (northern blot)
(Takahisa et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
pyd-PA
FBpp0293840
230.2
2090
8.24
NP_731291
AAF54301
pyd-PB
FBpp0293838
148.8
1371
9.47
NP_476697
AAF54300
pyd-PC
FBpp0293839
140.5
1293
9.78
NP_731292
AAN13403
pyd-PF
FBpp0293837
125.6
1149
9.10
NP_788603
AAN13402
pyd-PG
FBpp0293842
142.1
1301
9.76
NP_001097711
ABW08622
pyd-PI
FBpp0293841
150.4
1386
9.43
NP_001138028
ACL83487
pyd-PJ
FBpp0293844
187.9
1735
8.91
NP_731293
AAF54303
pyd-PK
FBpp0293845
159.5
1446
9.15
NP_001097712
ABW08623
pyd-PL
FBpp0293846
141.0
1285
9.39
NP_001247000
AFH06318
pyd-PM
FBpp0293847
142.1
1301
9.76
NP_001247001
AFH06319
pyd-PO
FBpp0301889
263.8
2395
8.81
NP_001246998
AFH06316
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1301 aa isoforms: pyd-PG, pyd-PM
Additional Polypeptide Data and Comments
Reported size (kDa)
180 (kD observed)
(Wei and Ellis, 2001)
1367 (aa); 170, 160 (kD observed); 148 (kD predicted)
(Takahisa et al., 1996)
Comments
Antisera specific to the the larger pyd protein was prepared.
(Wei and Ellis, 2001)
Cortactin protein SH3 domain binds to a PXXP motif in the pyd protein proline-rich domain. This binding is abolished when the central 2 P residues in a motif consisting of 3 overlapping PXXP motifs are mutated to A. Cortactin and pyd proteins coimmunoprecipitate from Drosophila embryo lysates.
(Katsube et al., 1998)
tam protein contains three discs-large homologous regions, an SH3 domain, a guanylate kinase domain and a proline rich terminal region. It is a structural homolog of mammalian ZO-1.
(Takahisa et al., 1996)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pyd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (23 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cell adhesion molecule binding
inferred from physical interaction with FLYBASE:kirre; FB:FBgn0028369
(Weavers et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (15 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
branch fusion, open tracheal system
inferred from high throughput mutant phenotype
(Ghabrial et al., 2011)
inferred from mutant phenotype
(Jung et al., 2006)
cell-cell adhesion
inferred from mutant phenotype
(Jung et al., 2006)
chaeta development
inferred from mutant phenotype
(Djiane et al., 2011)
compound eye morphogenesis
inferred from mutant phenotype
(Seppa et al., 2008)
dorsal closure
inferred from mutant phenotype
(Choi et al., 2011)
fusion cell fate specification
inferred from mutant phenotype
(Jung et al., 2006)
head involution
inferred from mutant phenotype
(Choi et al., 2011)
negative regulation of endocytosis
inferred from mutant phenotype
(Shimizu et al., 2017)
negative regulation of Notch signaling pathway
inferred from mutant phenotype
(Djiane et al., 2011)
inferred from genetic interaction with FLYBASE:dx; FB:FBgn0000524
(Shimizu et al., 2017)
nephrocyte diaphragm assembly
inferred from mutant phenotype
(Zhuang et al., 2009)
open tracheal system development
inferred from mutant phenotype
(Choi et al., 2011)
positive regulation of Notch signaling pathway
inferred from mutant phenotype
(Djiane et al., 2011)
regulation of cell adhesion
inferred from mutant phenotype
(Seppa et al., 2008)
inferred from genetic interaction with FLYBASE:rst; FB:FBgn0003285
(Seppa et al., 2008)
inferred from genetic interaction with FLYBASE:shg; FB:FBgn0003391
(Seppa et al., 2008)
regulation of embryonic cell shape
inferred from mutant phenotype
(Choi et al., 2011)
wing disc development
inferred from mutant phenotype
(Djiane et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
adherens junction
inferred from direct assay
(Djiane et al., 2011, Seppa et al., 2008)
apical part of cell
inferred from direct assay
(Seppa et al., 2008)
axon
inferred from direct assay
(Seppa et al., 2008)
basolateral plasma membrane
inferred from direct assay
(Seppa et al., 2008)
cell-cell adherens junction
inferred from direct assay
(Jung et al., 2006)
nephrocyte diaphragm
inferred from direct assay
(Weavers et al., 2009)
plasma membrane
inferred from direct assay
(Weavers et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
dorsal ectoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 10 -- 11
embryonic/larval trachea
(Chung et al., 2011)
embryonic stage 11 -- 12
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
atrium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral apodeme
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
ventral midline
(Fisher et al., 2012)
third instar larval stage
wing disc
(Takahisa et al., 1996)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Takahisa et al., 1996)
larval stage & pupal stage
(Takahisa et al., 1996)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Wei and Ellis, 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Wei and Ellis, 2001)
larval stage
garland cell
(Tutor et al., 2014)
larval stage & pupal stage
wing disc
(Wei and Ellis, 2001)
third instar larval stage
wing disc
(Takahisa et al., 1996)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
The large form of pyd protein was assayed in embryos and wing discs and is present in both.
(Wei and Ellis, 2001, Takahisa et al., 1996)
The larger form of pyd protein is localized at the adherens junction.
(Wei and Ellis, 2001)
Cortactin protein colocalizes with pyd protein to intercellular junctions of imaginal disc epithelial cells.
(Katsube et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
adherens junction
inferred from direct assay
(Djiane et al., 2011, Seppa et al., 2008)
apical part of cell
inferred from direct assay
(Seppa et al., 2008)
axon
inferred from direct assay
(Seppa et al., 2008)
basolateral plasma membrane
inferred from direct assay
(Seppa et al., 2008)
cell-cell adherens junction
inferred from direct assay
(Jung et al., 2006)
nephrocyte diaphragm
inferred from direct assay
(Weavers et al., 2009)
plasma membrane
inferred from direct assay
(Weavers et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\pyd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 67 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pyd
Transgenic constructs containing regulatory region of pyd
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
partially lethal - majority die
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable | maternal effect
viable | maternal effect (with Df(3R)p-XT103)
Sterility
Allele
female fertile
fertile
male fertile
Other Phenotypes
Allele
behavior defective | recessive
cell migration defective | pupal stage, with Scer\GAL4GMR.PF
cell shape defective
increased cell number (with Df(3R)p-XT103)
increased cell number | pupal stage, with Scer\GAL4GMR.PF
learning defective | adult stage
majority die during embryonic stage (with pydB12)
majority die during embryonic stage (with pydex147)
some die during embryonic stage
some die during embryonic stage (with pydB12)
some die during embryonic stage (with pydex147)
some die during embryonic stage (with pydex180)
visible
visible, with Scer\GAL4pnr-MD237
visible (with Df(3R)p-XT103)
visible (with pydC5)
visible (with pydex147)
visible (with pydtam)
visible | adult stage, with Scer\GAL4GMR.PF
visible | recessive
wild-type
Phenotype manifest in
Allele
adult abdominal sensillum
adult thorax
adult thorax, with Scer\GAL4GMR.PF
cephalopharyngeal skeleton
chaeta
chaeta, with Scer\GAL4GMR.PF
chaeta, with Scer\GAL4pnr-MD237
cone cell
cone cell | pupal stage, with Scer\GAL4GMR.PF
denticle belt
dorsal branch primordium
dorsal branch primordium | somatic clone
dorsocentral bristle
dorsocentral bristle | supernumerary (with Df(3R)p-XT103)
dorsocentral bristle | supernumerary (with pydC5)
dorsocentral bristle | supernumerary (with pydtam)
embryo | dorsal closure stage
embryo | dorsal closure stage (with pydB12)
embryo | dorsal closure stage (with pydex147)
embryo | dorsal closure stage (with pydex180)
embryonic/first instar larval cuticle
embryonic/larval cuticle
embryonic/larval dorsal branch
embryonic/larval dorsal trunk
embryonic/larval garland cell, with Scer\GAL4sns.GCN
embryonic/larval lateral trunk
embryonic/larval tracheal system
embryonic dorsal branch & cell-cell adherens junction
embryonic dorsal branch & cell-cell adherens junction | somatic clone
embryonic ganglionic branch & cell-cell adherens junction
embryonic head
embryonic head (with pydB12)
embryonic head (with pydex147)
embryonic head (with pydex180)
embryonic leading edge cell
embryonic leading edge cell (with pydB12)
embryonic leading edge cell (with pydex147)
embryonic leading edge cell (with pydex180)
eye
eye, with Scer\GAL4GMR.PF
eye | adult stage, with Scer\GAL4GMR.PF
eye | somatic clone
female germline stem cell | supernumerary (with Df(3R)p-XT103)
ganglionic branch primordium
germarium cap cell | supernumerary
germarium cap cell | supernumerary (with Df(3R)p-XT103)
interocellar bristle
interommatidial precursor cell | pupal stage
interommatidial precursor cell | pupal stage | supernumerary
interommatidial precursor cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF
lateral trunk primordium
macrochaeta
macrochaeta & adult head | dorsal
macrochaeta & adult thorax | dorsal
mesothoracic metatarsus
mesothoracic tarsal bristle
ommatidium
orbital bristle
presumptive embryonic/larval tracheal system
presumptive embryonic/larval tracheal system (with Df(3R)p-XT103)
primary pigment cell
primary pigment cell | pupal stage, with Scer\GAL4GMR.PF
scutellar bristle
secondary pigment cell
sensory mother cell
sternopleural bristle
terminal tracheal cell
tertiary pigment cell | pupal stage | supernumerary
tertiary pigment cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF
tracheal fusion cell
tracheal fusion cell | somatic clone
trichogen cell, with Scer\GAL4pnr-MD237
ventral head epidermis
ventral head epidermis (with pydB12)
ventral head epidermis (with pydex147)
ventral head epidermis (with pydex180)
vertical bristle
wing (with Df(3R)p-XT103)
wing (with pydex147)
wing (with pydtam)
wing sensillum
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TJP1
10 of 15
Yes
Yes
Hsap\TJP2
10 of 15
Yes
Yes
Hsap\TJP3
7 of 15
No
Yes
Hsap\DLG1
1 of 15
No
No
Hsap\DLG2
1 of 15
No
No
Hsap\DLG3
1 of 15
No
No
Hsap\DLG4
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tjp1
9 of 15
Yes
Yes
Mmus\Tjp2
9 of 15
Yes
Yes
Mmus\Tjp3
8 of 15
No
Yes
Mmus\Dlg1
1 of 15
No
No
Mmus\Dlg2
1 of 15
No
No
Mmus\Dlg3
1 of 15
No
No
Mmus\Dlg4
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Tjp1
9 of 13
Yes
Yes
Rnor\Tjp3
6 of 13
No
Yes
Rnor\Tjp2
5 of 13
No
Yes
Rnor\Dlg1
1 of 13
No
No
Rnor\Dlg2
1 of 13
No
No
Rnor\Dlg3
1 of 13
No
No
Rnor\Dlg4
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\tjp1
4 of 12
Yes
Yes
Xtro\tjp2
2 of 12
No
Yes
Xtro\dlg1
1 of 12
No
No
Xtro\dlg2
1 of 12
No
No
Xtro\dlg4
1 of 12
No
No
Xtro\tjp3
1 of 12
No
Yes
Danio rerio (Zebrafish) (11)
Drer\tjp2a
9 of 15
Yes
Yes
Drer\tjp1a
6 of 15
No
Yes
Drer\tjp1b
4 of 15
No
Yes
Drer\tjp3
3 of 15
No
Yes
Drer\dlg1
1 of 15
No
No
Drer\dlg1l
1 of 15
No
No
Drer\dlg2
1 of 15
No
No
Drer\dlg3
1 of 15
No
No
Drer\dlg4
1 of 15
No
No
Drer\si:dkey-234i14.3
1 of 15
No
Yes
Drer\tjp2b
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\zoo-1
9 of 15
Yes
Yes
Cele\magu-4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\GUK1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\sid4
1 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919006K )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\pyd
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009498
Drosophila simulans
Dsim\GD20836
Drosophila sechellia
Dsec\GM26299
Drosophila erecta
Dere\GG17413
Drosophila yakuba
Dyak\GE24813
Drosophila ananassae
Dana\GF17278
Drosophila pseudoobscura pseudoobscura
Dpse\GA30196
Drosophila persimilis
Dper\GL22280
Drosophila persimilis
Dper\GL22283
Drosophila willistoni
Dwil\GK11118
Drosophila virilis
Dvir\GJ23434
Drosophila virilis
Dvir\GJ26529
Drosophila mojavensis
Dmoj\GI22708
Drosophila mojavensis
Dmoj\GI22704
Drosophila grimshawi
Dgri\GH22315
Drosophila grimshawi
Dgri\GH22524
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915003E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011612
Musca domestica
House fly
Mdoa\17026067
Glossina morsitans
Tsetse fly
Gmor\GMOY008067
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12728
Mayetiola destructor
Hessian fly
Mdes\Mdes001990
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018313
Anopheles darlingi
American malaria mosquito
Adar\ADAC004024
Anopheles gambiae
Malaria mosquito
Agam\AGAP003546
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007474
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00ME )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010279
Danaus plexippus
Monarch butterfly
Dple\DPOGS207354-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207353-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207352-PA
Apis florea
Little honeybee
Aflo\2856373092
Apis mellifera
Western honey bee
Amel\GB42401
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11949
Bombus terrestris
Buff-tailed bumblebee
Bter\15216871
Linepithema humile
Argentine ant
Lhum\LH11977
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001c7b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000464
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12771
Tribolium castaneum
Red flour beetle
Tcas\TC006063
Pediculus humanus
Human body louse
Phum\PHUM359090
Rhodnius prolixus
Kissing bug
Rpro\RPRC005715
Rhodnius prolixus
Kissing bug
Rpro\RPRC005706
Cimex lectularius
Bed bug
Clec\CLEC000909
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002448
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01360
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06VG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009888
Ixodes scapularis
Black-legged tick
Isca\ISCW019818
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74781.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71564.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur33g01420
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308707
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AJZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tjp1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008103
Ciona intestinalis
Vase tunicate
Cint\LOC100185856
Gallus gallus
Domestic chicken
Ggal\TJP1
Gallus gallus
Domestic chicken
Ggal\TJP2
Gallus gallus
Domestic chicken
Ggal\TJP3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CASK
1 of 10
CG11811
1 of 10
dlg1
1 of 10
Dlg5
1 of 10
inaD
1 of 10
metro
1 of 10
sdt
1 of 10
vari
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TJP1; tight junction protein 1
    10 of 15
    601009
        TJP2; tight junction protein 2
        10 of 15
        607709
        TJP3; tight junction protein 3
        7 of 15
        612689
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            pyd
            enhanceable
            Dl
            (Chen et al., 1996)
            pyd
            enhanceable
            emc
            (Chen et al., 1996)
            pyd
            enhanceable
            ena
            (Choi et al., 2011)
            pyd
            enhanceable
            ex
            (Djiane et al., 2011)
            pyd
            enhanceable
            h
            (Held, 1990)
            pyd
            enhanceable
            N
            (Djiane et al., 2011)
            pyd
            suppressible
            N
            (Djiane et al., 2011)
            pyd
            enhanceable
            rst
            (Seppa et al., 2008)
            pyd
            enhanceable
            shg
            (Seppa et al., 2008)
            pyd
            suppressible
            Su(dx)
            (Djiane et al., 2011)
            pyd
            enhanceable
            tkv
            (Seppa et al., 2008)
            pyd
            enhanceable
            α-Cat
            (Seppa et al., 2008)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            ena
            enhanceable
            pyd
            (Choi et al., 2011)
            h
            enhanceable
            pyd
            (Held, 1990)
            hep
            enhanceable
            pyd
            (Takahashi et al., 1998)
            N
            suppressible
            pyd
            (Chen et al., 1996)
            Su(dx)
            enhanceable
            pyd
            (Djiane et al., 2011)
            tkv
            enhanceable
            pyd
            (Seppa et al., 2008)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-48
            Cytogenetic map
            85B3-85B7
            Sequence location
            3R:8,827,068..8,931,896 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            85B3-85B7
            Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            85B1-85B6
            (Takahisa, 1996.2.7)
            Located in 85B1--85B6 by deficiency mapping (details unspecified).
            (Takahisa et al., 1996)
            85B1-85B6
            85B (determined by in situ hybridisation)
            (Takahisa et al., 1996)
            85B9-85B9
            (determined by in situ hybridisation)
            (Chen et al., 1996)
            Experimentally Determined Recombination Data
            Location
            3-48
            (FlyBase, 2016)
            3-45.5
            (Comeron et al., 2012)
            3-
            (Takahisa, 1996.2.7)
            3-48.1
            (Ellis et al., 1995)
            Left of (cM)
            Right of (cM)
            Notes
            Maps to 3R.
            (Ghabrial et al., 2011)
            Stocks and Reagents
            Stocks (43)
            Genomic Clones (45)
            cDNA Clones (129)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            polyclonal
            (Carrasco-Rando et al., 2019, Djiane et al., 2011, Seppa et al., 2008, Wei and Ellis, 2001, Takahisa et al., 1996)
            monoclonal
            (Choi et al., 2011)
            Commercially Available Antibodies
             
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of
            Source for merge of: pyd tam
            (Ellis, 1998.6.17)
            Source for merge of: pyd CG11782 CG11962 CG12409 CG9729
            (FlyBase Genome Annotators, 2002-2003)
            Source for merge of: pyd CG9731
            (FlyBase Genome Annotators, 2011)
            Additional comments
            Annotations CG31349 and CG9731 merged as CG43140 in release 5.33 of the genome annotation.
            (FlyBase Genome Annotators, 2011)
            Annotations CG9763, CG11782, CG11962, CG12409 and CG9729 merged as CG31349 in release 3 of the genome annotation.
            (FlyBase Genome Annotators, 2002-2003)
            Other Comments
            Most embryos lacking pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system.
            (Choi et al., 2011)
            Loss of maternal and zygotic pyd substantially compromises development.
            (Choi et al., 2011)
            ?? need to add more comments and GO terms
            (Choi et al., 2011)
            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
            (Kiger et al., 2003)
            Candidate gene for quantitative trait (QTL) locus determining bristle number.
            (Nuzhdin et al., 1999)
            cno protein binds directly to pyd protein.
            (Takahashi et al., 1998)
            The junction associated pyd protein is involved in the structural organisation or regulation of the putative components important for a signaling pathway to activate the emc expression.
            (Takahisa et al., 1996)
            "3-48.1" was stated as revision.
            (Ellis et al., 1995)
            In mutants of pyd inappropriate cell fate choices are made resulting in the presence of ectopic sensory organs. A decrease in pyd function results in defects in the process of cell to cell communication that normally restricts the sensory organ precursor to a single cell in each proneural cluster.
            (Ellis et al., 1995)
            Recessive P-element insert alleles have extra macrochaetae on head and thorax. Acts as a dominant enhancer of emc.
            Origin and Etymology
            Discoverer
            Spencer, 31st Aug. 1939.
            Etymology
            'tam' means 'hairy' in Japanese.
            (Takahisa et al., 1996)
            Identification
            External Crossreferences and Linkouts ( 112 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Linkouts
            ApoDroso - Functional genomic database for photoreceptor development, survival and function
            DroID - A comprehensive database of gene and protein interactions.
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (26)
            Reported As
            Symbol Synonym
            CG11782
            CG11962
            CG12409
            CG31349
            (Rosa-Ferreira et al., 2015, Christis and Munro, 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Deloger et al., 2009, Hazelett et al., 2009, Perkins et al., 2009, Sepp et al., 2008, Maisonhaute et al., 2007)
            CG43140
            (FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1)
            CG9729
            CG9731
            (Keleman et al., 2009.8.5)
            CG9763
            (Norga et al., 2003)
            CT36877
            (Ceriani et al., 2002)
            DZO-1
            (Katsube et al., 1998)
            Pch
            Pyd
            (Dlugos et al., 2019, Helmstädter and Simons, 2017, Chandra et al., 2015, Flores-Benitez and Knust, 2015, Sopko et al., 2014, Tutor et al., 2014, Guichard et al., 2013, Choi et al., 2011, Höhne et al., 2011, Ivarsson et al., 2011, Waldholm et al., 2011, Weavers et al., 2009, Gabut et al., 2007, Jennings et al., 2007, Wu et al., 2007, Wei and Ellis, 2001)
            Pyd/ZO-1
            (Jung et al., 2006, Müller and Bossinger, 2003, Tepass et al., 2001)
            Tamou
            (Caruana, 2002, Campuzano, 2001)
            ZO-1
            (Yu and Guan, 2013, Bulgakova et al., 2012, Bakal et al., 2008, Anderson et al., 2004, Martin and Parkhurst, 2004, Roper and Brown, 2003, Knox and Brown, 2002, Bilder, 2001, Peifer and Tepass, 2000, Noselli and Agnes, 1999, Stronach and Perrimon, 1999, Ueda et al., 1999, Takahashi et al., 1998)
            ZO1
            (Jacinto et al., 2002)
            dzo-1
            (Yeaman et al., 1999)
            polychaetoid
            (Staudt et al., 2005)
            pyd
            (Carrasco-Rando et al., 2019, Harbison et al., 2019, Mannix et al., 2019, Meltzer et al., 2019, Tegeder et al., 2019, Millet-Boureima et al., 2018, Hermle et al., 2017, Rohde et al., 2017, Shimizu et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Piegholdt et al., 2016, Aradska et al., 2015, Chaston et al., 2015, Gene Disruption Project members, 2015-, Kavi et al., 2015, Matthews et al., 2015, Na et al., 2015, Zaessinger et al., 2015, Ashwal-Fluss et al., 2014, Chaturvedi et al., 2014, Ciglar et al., 2014, Xu et al., 2014, Carter, 2013, Das et al., 2013, Zhang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Choi et al., 2011, Chung et al., 2011, Djiane et al., 2011, Friedman et al., 2011, Goossens et al., 2011, Cook et al., 2010.2.12, Kong et al., 2010, Magwire et al., 2010, Flaherty et al., 2009, Weavers et al., 2009, Zhuang et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Font-Burgada et al., 2008, Seppa et al., 2008, Akdemir et al., 2007, Araujo et al., 2007, Kankel et al., 2007, Maisonhaute et al., 2007, Weiler, 2007, Yi et al., 2007, Jung et al., 2006, Held, 1990)
            pyd(Z01)
            (Brumby et al., 2004)
            tam
            (Ponting et al., 1997, Ueda et al., 1997, Takahisa, 1996.2.7, Takahisa et al., 1996)
            xvt
            Name Synonyms
            Polychaetoid
            (Guichard et al., 2013, Choi et al., 2011, Rodrigues et al., 2011, Chang et al., 2008, Araujo et al., 2007, Gabut et al., 2007, Jennings et al., 2007)
            extra verticals
            failed fusions
            (Ghabrial et al., 2011)
            polychaetoid
            (Das et al., 2013, Eddison et al., 2012, Cammarato et al., 2011, FlyBase Genome Annotators, 2011, Ivarsson et al., 2011, Flaherty et al., 2009, Hazelett et al., 2009, Seppa et al., 2008, Sepp et al., 2008, Kankel et al., 2007, Jung et al., 2006, Burnette et al., 2005, Staudt et al., 2005)
            tamou
            (Dimitratos et al., 1999, Ponting et al., 1997, Ueda et al., 1997, Takahisa, 1996.2.7, Takahisa et al., 1996)
            Secondary FlyBase IDs
            • FBgn0003177
            • FBgn0010330
            • FBgn0037639
            • FBgn0037641
            • FBgn0037642
            • FBgn0040533
            • FBgn0051349
            • FBgn0037640
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (199)