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Gene Dmel\pyd

General Information
Symbol	Dmel\pyd	Species	D. melanogaster
Name	polychaetoid	Annotation symbol	CG43140
Feature type	protein_coding_gene	FlyBase ID	FBgn0262614
Gene Model Status	Current	Stock availability	35 publicly available
Also Known As	ZO-1, CG31349, tam, Pyd/ZO-1, Tamou, dzo-1
Genomic Location
Chromosome (arm)	3R	Recombination map	3-48.1
Cytogenetic map	85B3-85B7	Sequence location	3R:4,652,790..4,757,618 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene polychaetoid is referred to in FlyBase by the symbol Dmel\pyd (CG43140, FBgn0262614). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cell adhesion molecule binding. There is experimental evidence for 11 unique biological process terms, many of which group under: single-organism developmental process; system development; cellular process; multicellular organismal development; cellular component organization or biogenesis; sensory organ development; open tracheal system development; cell fate commitment; biological regulation; epithelial cell type specification, open tracheal system. 82 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; external compound sense organ; late extended germ band embryo; non-connected developing system; acellular anatomical structure; thoracic segment; tracheal branch primordium; tracheal system. It has 11 annotated transcripts and 11 annotated polypeptides. Protein features are: Guanylate kinase; Guanylate kinase/L-type calcium channel; PDZ domain; Src homology-3 domain; Variant SH3; ZU5. Gene sequence location is 3R:4652790..4757618.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	pyd: polychaetoid Extra bristles present in homozygote at or near almost all normal bristle locations but most frequently in dorsocentral and scutellar regions. Heterozygote in some stocks occasionally shows extra bristles, especially vibrissae. Character expressed better at low temperatures and in large flies. Combinations with h and Hw generally superadditive for bristle number. RK3.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms axon basolateral plasma membrane compound eye morphogenesis apical part of cell regulation of cell adhesion
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85B3-85B7   Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85B1-85B6   Located in 85B1--85B6 by deficiency mapping (details unspecified). 85B (determined by in situ hybridisation)   (Takahisa et al., 1996) 85B1-85B6     (Takahisa, 1996.2.7) 85B9-85B9   (determined by in situ hybridisation)   (Chen et al., 1996)
Experimentally Determined Recombination Data
Location	3- (Takahisa, 1996.2.7) 3-48.1 (Ellis et al., 1995, )
Left of (cM)
Right of (cM)
Notes	Maps to 3R. (Ghabrial et al., 2011)
Gene Model & Products
Please see the GBrowse view of Dmel\pyd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pyd-RA FBtr0305297  NM_169245   7195   2090 pyd-RB FBtr0305295  NM_057349   5688   1371 pyd-RC FBtr0305296  NM_169246   5024   1293 pyd-RF FBtr0305294  NM_176426   4196   1149 pyd-RG FBtr0305299  NM_001104241   5048   1301 pyd-RI FBtr0305298  NM_001144556   5505   1386 pyd-RJ FBtr0305301  NM_170646   6665   1735 pyd-RK FBtr0305302  NM_001104242   5744   1446 pyd-RL FBtr0305303  NM_001260071   5123   1285 pyd-RM FBtr0305304  NM_001260072   6058   1301 pyd-RO FBtr0310205  NM_001260069   8533   2395
Additional Transcript Data & Comments
Reported size (kB)	10.5, 9.5, 8.1, 6.7, 5.6 (northern blot) (Takahisa et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pyd-PA   FBpp0293840   230.2   2090   8.24     NP_731291   AAF54301 pyd-PB   FBpp0293838   148.8   1371   9.47     NP_476697   AAF54300 pyd-PC   FBpp0293839   140.5   1293   9.78     NP_731292   AAN13403 pyd-PF   FBpp0293837   125.6   1149   9.10     NP_788603   AAN13402 pyd-PG   FBpp0293842   142.1   1301   9.76     NP_001097711   ABW08622 pyd-PI   FBpp0293841   150.4   1386   9.43     NP_001138028   ACL83487 pyd-PJ   FBpp0293844   187.9   1735   8.91     NP_731293   AAF54303 pyd-PK   FBpp0293845   159.5   1446   9.15     NP_001097712   ABW08623 pyd-PL   FBpp0293846   141.0   1285   9.39     NP_001247000   AFH06318 pyd-PM   FBpp0293847   142.1   1301   9.76     NP_001247001   AFH06319 pyd-PO   FBpp0301889   263.8   2395   8.81     NP_001246998   AFH06316
Additional Polypeptide Data & Comments
Reported size (kDa)	1367 (aa); 170, 160 (kD observed); 148 (kD predicted) (Takahisa et al., 1996) 180 (kD observed) (Wei and Ellis, 2001)
Comments	Antisera specific to the the larger pyd protein was prepared. (Wei and Ellis, 2001) Cortactin protein SH3 domain binds to a PXXP motif in the pyd protein proline-rich domain. This binding is abolished when the central 2 P residues in a motif consisting of 3 overlapping PXXP motifs are mutated to A. Cortactin and pyd proteins coimmunoprecipitate from Drosophila embryo lysates. (Katsube et al., 1998) tam protein contains three discs-large homologous regions, an SH3 domain, a guanylate kinase domain and a proline rich terminal region. It is a structural homolog of mammalian ZO-1. (Takahisa et al., 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) ZU5 (IPR000906) PDZ domain (IPR001478) Guanylate kinase (IPR008144) Guanylate kinase/L-type calcium channel (IPR008145) Variant SH3 (IPR011511) Src homology-3 domain (IPR001452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141100   AA141418   AA142240   AA202159   AA392633   AA567411   AA698527   AE014297 AAF54300   AE014297 AAF54301   AE014297 AAF54303   AE014297 AAN13402   AE014297 AAN13403   AE014297 ABW08622   AE014297 ABW08623   AC008314   AE014297 ACL83487   AE014297 AFH06316   AE014297 AFH06318   AE014297 AFH06319   AI062583   AI257525   AI296365   AI404054   AI511679   AI512509   AI516377   AI532118   AI533276   AI534005   AI542053   AI542983   AI544389   AW941509   AW943645   AY051965 AAK93389   AY061056 AAL28604   AY128453 AAM75046   BE977248   BG633285   BG639133   BG639819   BG639995   BI172385   BI358329   BI482622   BI569592   BI570957   BI572102   BI574150   BI582482   BI583249   BI584805   BI588976   BI589335   BI589664   BI589856   BI591768   BI606015   BI608853   BI611607   BI618116   BI625205   BI630111   BI640576   BP546006   BP546854   BP552133   BP552134   BP556526   BP556527   BT126279   BT132671   CK086513   CK445197   CK660388   CK661399   CL527743   CO154287   CO178976   CO179234   CO181206   CO186480   CO189016   CO189878   CO190008   CO190417   CO195618   CO262730   CO262760   CO263946   CO266430   CO268089   CO269675   CO270150   CO271054   CO271276   CO271898   CO273688   CO274642   CO275422   CO275721   CO276045   CO277273   CO279049   CO280385   CO280998   CO282940   CO283348   CO288264   CO288323   CO289736   CO292577   CO293308   CO296624   CO297741   CO297796   CO298352   CO300198   CO301187   CO301388   CO301460   CO303544   CO306684   CO308223   CO310125   CO310339   CO311189   CO314666   CO316145   CO317378   CO317993   CO318953   CO319615   CO319877   CO321581   CO321721   CO321971   CO322732   CO322749   CO324330   CO324382   CO325791   CO326282   CO326577   CO326856   CO327226   CO327250   CO327645   CO327672   CO328360   CO329921   CO332423   CO341413   CO341636   CO345104   CO345371   CZ466262   CZ466263   CZ468334   CZ468335   CZ468661   CZ469252   CZ469253   CZ474884   CZ474885   CZ482816   CZ485084   CZ485423   CZ488019   CZ488486   CZ488487   CZ488525   D83477 BAA11923   EC054756   EC056963   EC057089   EC057090   EC058016   EC059749   EC062800   EC062983   EC064641   EC065712   EC066211   EC068862   EC069852   EC070617   EC070626   EC071351   EC071988   EC072106   EC074139   EC074759   EC077152   EC078187   EC078459   EC080805   EC081545   EC082349   EC082849   EC083615   EC083918   EC084486   EC085854   EC088762   EC089658   EC089879   EC090362   EC195390   EC197015   EC198396   EC199418   EC200348   EC200614   EC204888   EC206889   EC208052   EC208516   EC210248   EC216492   EC219467   EC221029   EC223763   EC224435   EC228026   EC231816   EC232619   EC233980   EC234096   EC234187   EC235783   EC238630   EC242216   EC245212   EC245321   EC245864   EC246020   EC246122   EC247160   EC247664   EC247937   EC248084   EC251142   EC252711   EC252878   EC253108   EC255105   EC256378   EC256933   EC257151   EC257244   EC259193   EC259823   EC260151   EC262805   EL887303   EL887335   EL887375   EL887412   EL887449   EL887475   EL887514   EL887550   EV594865   GH943382   GH944913   GH950915   GH953648   GH958538   GH961578   GH963139   GH963262   GH969860   GH970701   GH972425   GH974591   GH982497
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8INQ0 Q8MQQ3 Q9VHK1 Q9VHK3 Q9VHK4 A8JQV8 B7Z0U1 A8JQV7 Q7K4E2 Q94880 Q9VHK2 Q95RX8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal ectoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium tracheal primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic ventral apodeme   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) third instar larval stage   wing disc   (Takahisa et al., 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Takahisa et al., 1996) larval stage & pupal stage     (Takahisa et al., 1996) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Wei and Ellis, 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Wei and Ellis, 2001) larval stage & pupal stage   wing disc   (Wei and Ellis, 2001) third instar larval stage   wing disc   (Takahisa et al., 1996) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	The large form of pyd protein was assayed in embryos and wing discs and is present in both. (Takahisa et al., 1996, Wei and Ellis, 2001) The larger form of pyd protein is localized at the adherens junction. (Wei and Ellis, 2001) Cortactin protein colocalizes with pyd protein to intercellular junctions of imaginal disc epithelial cells. (Katsube et al., 1998)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
adherens junction inferred from direct assay (Djiane et al., 2011, Seppa et al., 2008) apical part of cell inferred from direct assay (Seppa et al., 2008) axon inferred from direct assay (Seppa et al., 2008) basolateral plasma membrane inferred from direct assay (Seppa et al., 2008) cell-cell adherens junction inferred from direct assay (Jung et al., 2006) nephrocyte diaphragm inferred from direct assay (Weavers et al., 2009) plasma membrane inferred from direct assay (Weavers et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    47 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    31 head, mated 4-day male    33 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (33) central nervous system, pupae P8  (47) head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male  (31) head, mated 4-day male  (33) head, mated 20-day male  (27) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    47 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    31 head, mated 4-day male    33 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    47 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    31 head, mated 4-day male    33 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    47 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    31 head, mated 4-day male    33 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (33) central nervous system, pupae P8  (47) head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male  31 head, mated 4-day male  (33) head, mated 20-day male  27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    47 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    31 head, mated 4-day male    33 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    47 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    17 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    31 head, mated 4-day male    33 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    6 fat body, pupae P8    24 carcass, larvae L3 wandering    21 carcass, 1-day adult    13 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    17 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    60 embryo 04-06hr    66 embryo 06-08hr    73 embryo 08-10hr    59 embryo 10-12hr    29 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    40 embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (29) embryo 02-04hr  (60) embryo 04-06hr  (66) embryo 06-08hr  (73) embryo 08-10hr  (59) embryo 10-12hr  (29) embryo 12-14hr  (36) embryo 14-16hr  (54) embryo 16-18hr  (40) embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr  (41) pupae 2d postWPP  (44) pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    60 embryo 04-06hr    66 embryo 06-08hr    73 embryo 08-10hr    59 embryo 10-12hr    29 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    40 embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    60 embryo 04-06hr    66 embryo 06-08hr    73 embryo 08-10hr    59 embryo 10-12hr    29 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    40 embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    60 embryo 04-06hr    66 embryo 06-08hr    73 embryo 08-10hr    59 embryo 10-12hr    29 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    40 embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  29 embryo 02-04hr  (60) embryo 04-06hr  (66) embryo 06-08hr  (73) embryo 08-10hr  (59) embryo 10-12hr  29 embryo 12-14hr  (36) embryo 14-16hr  (54) embryo 16-18hr  (40) embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr  (41) pupae 2d postWPP  (44) pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    60 embryo 04-06hr    66 embryo 06-08hr    73 embryo 08-10hr    59 embryo 10-12hr    29 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    40 embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    60 embryo 04-06hr    66 embryo 06-08hr    73 embryo 08-10hr    59 embryo 10-12hr    29 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    40 embryo 18-20hr    20 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    22 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS    31 ovary OSC    46 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS  (31) ovary OSC  (46) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS    31 ovary OSC    46 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS    31 ovary OSC    46 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS    31 ovary OSC    46 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS  31 ovary OSC  (46) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS    31 ovary OSC    46 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    9 embryonic 1182-4H    16 embryonic GM2    6 embryonic Kc167    5 embryonic S1    6 embryonic S3    20 leg disc CME L1    13 wing disc CME-W2    10 wing disc ML-DmD8    14 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    11 ovary fGS/OSS    31 ovary OSC    46 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts	BDGP expression data • LD02541 LP05923 LD43161
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive pydC5 partially lethal - majority die pydtex1 pydtex2 viable pydC5 pydex79 pydex147 pydex180 pydEY04259 pydG1 pydG7 pydG18 pydJ2 pydJ4 pydJ14 pydJ17 pydPL00355 pydtam viable, with Scer\GAL4pnr-MD237 pydGD8691 pydGD13813 Sterility Allele female fertile pydtam fertile pydex147 pydex180 pydEY04259 pydPL00355 male fertile pydtam Other Phenotypes Allele behavior defective | recessive pyd1 cell migration defective | pupal stage, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS increased cell number (with Df(3R)p-XT103) pydex79 pydex180 pydtam increased cell number | pupal stage, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS learning defective | adult stage pyd11.272 visible pydtex1 pydtex2 pydxvt visible, with Scer\GAL4pnr-MD237 pydGD13813 visible (with Df(3R)p-XT103) pydex79 pydex147 pydex180 pydtam visible (with pydC5) pydtam visible (with pydex147) pydtam visible (with pydtam) pydC5 pydex147 visible | adult stage, with Scer\GAL4GMR.PF pyd1.dsRNA.Scer\UAS pyd3.dsRNA.Scer\UAS visible | recessive pydunspecified wild-type pyd6-.hs pydhs.PT Phenotype manifest in Allele adult abdominal sensillum pyd66 adult thorax pydtex1 pydtex2 adult thorax, with Scer\GAL4GMR.PF pyd1.dsRNA.Scer\UAS cephalopharyngeal skeleton pydJ14 chaeta pydtex1 pydtex2 chaeta, with Scer\GAL4GMR.PF pyd1.dsRNA.Scer\UAS chaeta, with Scer\GAL4pnr-MD237 pydGD13813 cone cell pydJ14 cone cell | pupal stage, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS denticle belt pydJ14 dorsal branch primordium pydKG00264 pydBG02748 pydC5 pydKG02008 pydEY04259 dorsal branch primordium | somatic clone pydC5 dorsocentral bristle pyd66 dorsocentral bristle | supernumerary (with Df(3R)p-XT103) pydex79 pydex147 pydex180 pydtam dorsocentral bristle | supernumerary (with pydC5) pydtam dorsocentral bristle | supernumerary (with pydtam) pydC5 embryonic/first instar larval cuticle pydC5 embryonic/larval dorsal trunk pydPA14 pydAZ63 embryonic/larval garland cell, with Scer\GAL4sns.GCN pydGD8691 embryonic/larval lateral trunk pydPA14 pydAZ63 embryonic/larval tracheal system pydPA14 pydAZ63 embryonic dorsal branch & cell-cell adherens junction pydKG00264 pydBG02748 pydKG02008 pydEY04259 embryonic dorsal branch & cell-cell adherens junction | somatic clone pydC5 embryonic ganglionic branch & cell-cell adherens junction pydBG02748 eye pydtex1 pydtex2 pydJ14 eye, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS eye | adult stage, with Scer\GAL4GMR.PF pyd1.dsRNA.Scer\UAS eye | somatic clone pydPA14 pydAZ63 female germline stem cell | supernumerary (with Df(3R)p-XT103) pydex147 ganglionic branch primordium pydKG00264 pydBG02748 pydC5 pydKG02008 pydEY04259 germarium cap cell | supernumerary pydex147 pydtam germarium cap cell | supernumerary (with Df(3R)p-XT103) pydex147 interocellar bristle pyd66 inter-ommatidial precursor cell | pupal stage pydScer\UAS.T:Disc\RFP pydhs.PT inter-ommatidial precursor cell | pupal stage | supernumerary pydtex1 inter-ommatidial precursor cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS lateral trunk primordium pydKG00264 pydBG02748 pydC5 pydKG02008 pydEY04259 macrochaeta pydBG00007 pydG7 pyd1 pydJ14 pydL85C pydJ4 pydBG02735 pydJ17 pydC5 pydxvt pydJ2 pydG18 macrochaeta & adult head | dorsal pydtam macrochaeta & adult thorax | dorsal pydtam mesothoracic metatarsus pydunspecified mesothoracic tarsal bristle pydunspecified ommatidium pydtex1 pydJ14 orbital bristle pyd66 presumptive embryonic/larval tracheal system pydKG00264 pydBG02748 pydC5 pydKG02008 pydEY04259 presumptive embryonic/larval tracheal system (with Df(3R)p-XT103) pydBG02748 pydC5 primary pigment cell pydJ14 primary pigment cell | pupal stage, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS scutellar bristle pyd66 secondary pigment cell pydhs.PT sensory mother cell pydJ14 sternopleural bristle pyd66 terminal tracheal cell pydKG00264 pydBG02748 pydC5 pydKG02008 pydEY04259 pydPA14 pydAZ63 tertiary pigment cell | pupal stage | supernumerary pydtex1 pydhs.PT tertiary pigment cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF pyd3.dsRNA.Scer\UAS tracheal fusion cell pydKG00264 pydBG02748 pydC5 pydKG02008 pydEY04259 tracheal fusion cell | somatic clone pydC5 trichogen cell, with Scer\GAL4pnr-MD237 pydGD13813 vertical bristle pyd66 wing (with Df(3R)p-XT103) pydex79 pydex147 pydex180 wing (with pydex147) pydtam wing (with pydtam) pydex147 wing sensillum pydtam
Classical Alleles ( 55 )
For All Classical Alleles Show
Allele of pyd Class Mutagen Stocks Known lesion pydKG02008 P-element activity 2 -- pyd1 spontaneous 1 -- pydc00198 piggyBac transposase 1 -- pydc02928 piggyBac transposase 1 -- pydc03468 piggyBac transposase 1 -- pydc04440 piggyBac transposase 1 -- pydCB-5347-3 1 -- pydd06030 P-element activity 1 -- pydEY00825 1 -- pydEY01326 1 -- pydEY04259 P-element activity 1 -- pydf00349 piggyBac transposase 1 -- pydf02866 piggyBac transposase 1 -- pydf05868 piggyBac transposase 1 -- pydf05901 piggyBac transposase 1 -- pydf06812 1 -- pydG4460 P-element activity 1 -- pydJ4 gamma ray 1 -- pydKG00642 1 -- pydKG01738 1 -- pydMI01205 1 -- pydMI05252 1 -- pydNP4400 1 -- pydNP4414 1 -- pydNP4432 1 -- pydPL00355 P-element activity 1 -- pydtam hypomorphic allele - genetic evidence Delta2-3 1 Yes pyd11.272 0 Yes pyd1272 0 Yes pyd66 0 -- pydAZ63 ethyl methanesulfonate 0 -- pydBG00007 P-element activity 0 Yes pydBG02735 P-element activity 0 Yes pydBG02748 loss of function allele P-element activity 0 -- pydC5 loss of function allele Delta2-3 0 Yes pydEP3323 0 -- pydEP786 P-element activity 0 -- pydex147 P-element activity 0 Yes pydex180 P-element activity 0 Yes pydex79 P-element activity 0 Yes pydf02557 piggyBac transposase 0 -- pydf05443 piggyBac transposase 0 -- pydG18 ethyl methanesulfonate 0 -- pydG1 ethyl methanesulfonate 0 -- pydG7 ethyl methanesulfonate 0 -- pydJ14 gamma ray 0 -- pydJ17 gamma ray 0 -- pydJ2 gamma ray 0 Yes pydKG00264 P-element activity 0 -- pydL85C P-element activity 0 Yes pydPA14 ethyl methanesulfonate 0 -- pydtex1 Delta2-3 0 Yes pydtex2 Delta2-3 0 Yes pydunspecified 0 -- pydxvt spontaneous 0 --
Alleles Carried on Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pyd Class Mutagen Stocks Known lesion pydGD13813 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pydGD8691 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pydGL00109 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pydHM05131 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pydHMS00263 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pydKK105581 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pyd1.dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes pyd3.dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes pyd6-.hs in vitro construct - regulatory fusion 0 Yes pydC.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes pyddsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes pydexon6-.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes pydhs.PT in vitro construct - regulatory fusion 0 Yes pydN.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pydNIG.9763R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes pydScer\UAS.cJa in vitro construct - regulatory fusion 0 Yes pydScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pydScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pydScer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pydΔEx6.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔEx6ΔPro-Rich.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔGUK.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔPDZ1.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔPDZ2.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔPDZ3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔPro-Rich.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes pydΔSH3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC478 (Christensen et al., 2008.4.15) Df(3R)BSC506 (Christensen et al., 2008.4.15) Df(3R)Exel6150 (Ryder, 2004.4.26) Df(3R)p819 (Chen et al., 1996) Df(3R)p-XT103 (Chen et al., 1996, Jung et al., 2006) Df(3R)pydC2 (Chen et al., 1996)
Not disrupted in	Df(3R)p13 (Chen et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-pyd.6-} NA P{hs-pyd.T} NA UAS construct P{GD8691} NA P{NIG.9763R} NA P{TRiP.GL00109} NA P{TRiP.HM05131} NA P{TRiP.HMS00263} NA P{UAS-pyd.C.RFP} NA P{UAS-pyd.EGFP} NA P{UAS-pyd.exon6-.RFP} NA P{UAS-pyd.FL} NA P{UAS-pyd.J} NA P{UAS-pyd.N.RFP} NA P{UAS-pyd.RFP} NA P{UAS-pyd.RNAi.1} NA P{UAS-pyd.RNAi.3} NA P{UAS-pyd.RNAi} NA P{UAS-pyd.ΔEx6} NA P{UAS-pyd.ΔEx6ΔPro-Rich} NA P{UAS-pyd.ΔGUK} NA P{UAS-pyd.ΔPDZ1} NA P{UAS-pyd.ΔPDZ2} NA P{UAS-pyd.ΔPDZ3} NA P{UAS-pyd.ΔPro-Rich} NA P{UAS-pyd.ΔSH3} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP3243 NA P{EP}pydEP786 NA P{EP}pydEP3323 NA P{EP}pydG4460 NA P{EPgy2}pydEY00825 NA P{EPgy2}pydEY01326 NA P{EPgy2}pydEY04259 NA P{XP}pydd06030 NA miscellaneous insertions Mi{MIC}pydMI01205 NA Mi{MIC}pydMI05252 NA P{BmΔ-w}pydtam NA P{GT1}BG00008BG00008 NA P{GT1}BG00028BG00028 NA P{GT1}BG02748 NA P{GT1}pydBG00007 NA P{GT1}pydBG02735 NA P{GT1}pydBG02748 NA P{RS3}pydCB-5347-3 NA P{SUPor-P}pydKG00264 NA P{SUPor-P}pydKG00642 NA P{SUPor-P}pydKG01738 NA P{SUPor-P}pydKG02008 NA PBac{PB}pydc00198 NA PBac{PB}pydc02928 NA PBac{PB}pydc03468 NA PBac{PB}pydc04440 NA PBac{WH}pydf00349 NA PBac{WH}pydf02557 NA PBac{WH}pydf02866 NA PBac{WH}pydf05443 NA PBac{WH}pydf05868 NA PBac{WH}pydf05901 NA PBac{WH}pydf06812 NA insertion of enhancer trap binary system P{GawB}pyd11.272 No P{GawB}pydNP4400 No P{GawB}pydNP4414 No P{GawB}pydNP4432 No PBac{GAL4D,EYFP}pydPL00355 No insertion of enhancer trap P{lacZ-un1}pydC5 No P{lArB}pydL85C No
Gene Ontology: Function, Process & Cellular Component ( 24 unique terms )
Terms Based on Experimental Evidence ( 19 terms )
Molecular Function
CV term Evidence References
cell adhesion molecule binding inferred from physical interaction with kirre (Weavers et al., 2009)
Biological Process
CV term Evidence References
branch fusion, open tracheal system inferred from mutant phenotype (Jung et al., 2006) cell-cell adhesion inferred from mutant phenotype (Jung et al., 2006) chaeta development inferred from mutant phenotype (Djiane et al., 2011) compound eye morphogenesis inferred from mutant phenotype (Seppa et al., 2008) fusion cell fate specification inferred from mutant phenotype (Jung et al., 2006) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) nephrocyte diaphragm assembly inferred from mutant phenotype (Zhuang et al., 2009) neuron projection morphogenesis inferred from mutant phenotype (Sepp et al., 2008) regulation of cell adhesion inferred from genetic interaction with rst (Seppa et al., 2008) inferred from genetic interaction with shg (Seppa et al., 2008) inferred from mutant phenotype (Seppa et al., 2008) trachea morphogenesis inferred from mutant phenotype (Ghabrial et al., 2011) wing disc development inferred from mutant phenotype (Djiane et al., 2011)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Djiane et al., 2011, Seppa et al., 2008) apical part of cell inferred from direct assay (Seppa et al., 2008) axon inferred from direct assay (Seppa et al., 2008) basolateral plasma membrane inferred from direct assay (Seppa et al., 2008) cell-cell adherens junction inferred from direct assay (Jung et al., 2006) nephrocyte diaphragm inferred from direct assay (Weavers et al., 2009) plasma membrane inferred from direct assay (Weavers et al., 2009)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
guanylate kinase activity inferred from sequence or structural similarity with human TJP1 AND inferred from sequence or structural similarity with Saccharomyces GUK1 (Takahisa et al., 1996) non-traceable author statement (Takahisa, 1996.2.7)
Biological Process
CV term Evidence References
dorsal closure non-traceable author statement (Harden, 2002) traceable author statement (Noselli and Agnes, 1999) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) JNK cascade non-traceable author statement (Noselli and Agnes, 1999) regulation of JNK cascade non-traceable author statement (Harden, 2002)
Cellular Component
CV term Evidence References
adherens junction non-traceable author statement (Harden, 2002) traceable author statement (Noselli and Agnes, 1999, Liu and Lengyel, 2000)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
pyd - CG14995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - CG43759 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - CG43897 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - CG5190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - CG6686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - CG7686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - E(spl)mδ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - RnrS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - drk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - lack anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pyd - wee anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pyd allele Gene References pydJ4 emc (Chen et al., 1996) pydJ14 Dl (Chen et al., 1996) emc (Chen et al., 1996) N (Chen et al., 1996) pydtam cno (Takahashi et al., 1998) hep (Takahashi et al., 1998) pydunspecified h (Held, 1990) unspecified emc (Takahisa et al., 1996)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262614 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A8JQV8
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W3T69 Dipteran inclusive ortholog search EOG68SH20 Insect inclusive ortholog search EOG6ZPCQB Arthropod inclusive ortholog search EOG6PK0PZ Metazoa inclusive ortholog search EOG686N54
Orthologs in Drosophila Species (EOG6W3T69)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\pyd     Drosophila simulans   Dsim\GD20836 Y   Drosophila sechellia   Dsec\GM26299 Y   Drosophila erecta   Dere\GG17413 Y   Drosophila yakuba   Dyak\GE24813 Y   Drosophila ananassae   Dana\GF17278 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30196 Y   Drosophila persimilis   Dper\GL22282     Drosophila persimilis   Dper\GL22283     Drosophila willistoni   Dwil\GK11118 Y   Drosophila virilis   Dvir\GJ23434 Y   Drosophila mojavensis   Dmoj\GI22708 Y   Drosophila grimshawi   Dgri\GH22524 Y
Orthologs in non-Drosophila Dipterans (EOG68SH20)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000446   Anopheles gambiae Malaria mosquito  Agam\AGAP003546   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007474
Orthologs in non-Dipteran Insects (EOG6ZPCQB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42401   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000464   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12858   Atta cephalotes Leafcutter ant  Acep\ACEP21986   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23466   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16234   Linepithema humile Argentine ant  Lhum\LH11977   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16416   Solenopsis invicta Red fire ant  Sinv\SINV12185   Solenopsis invicta Red fire ant  Sinv\SINV12191   Solenopsis invicta Red fire ant  Sinv\SINV12188   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002448   Bombyx mori Silkmoth  Bmor\BGIBMGA010279   Pediculus humanus Human body louse  Phum\PHUM359090   Tribolium castaneum Red flour beetle  Tcas\TC006063
Orthologs in non-Insect Arthropods (EOG6PK0PZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\DPOL   Ixodes scapularis Deer tick  Isca\ISCW019818
Orthologs in non-Arthropod Metazoa (EOG686N54)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\zoo-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026907gn   Danio rerio Zebrafish  Drer\tjp2b   Danio rerio Zebrafish  Drer\tjp3   Danio rerio Zebrafish  Drer\OTTDARG00000029763   Danio rerio Zebrafish  Drer\si:dkey-33l14.1   Danio rerio Zebrafish  Drer\tjp2a   Xenopus tropicalis Western clawed frog  Xtro\tjp1   Xenopus tropicalis Western clawed frog  Xtro\tjp2   Xenopus tropicalis Western clawed frog  Xtro\tjp3   Gallus gallus Domestic chicken  Ggal\TJP1   Gallus gallus Domestic chicken  Ggal\TJP2   Gallus gallus Domestic chicken  Ggal\TJP3   Mus musculus House mouse  Mmus\Tjp1   Mus musculus House mouse  Mmus\Tjp2   Mus musculus House mouse  Mmus\Tjp3   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000015030   Rattus norvegicus Norway rat  Rnor\Tjp1   Rattus norvegicus Norway rat  Rnor\Tjp3   Homo sapiens Human  Hsap\ENSG00000105289   Homo sapiens Human  Hsap\TJP1   Homo sapiens Human  Hsap\TJP2
Human Orthologs (3)
Gene OMIM HGNC Hsap\ENSG00000105289     Hsap\TJP1     Hsap\TJP2
AAA Orthologs (16) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20835 Drosophila simulans Dsim\GD20836 Drosophila sechellia Dsec\GM26299 Drosophila erecta Dere\GG17411 Drosophila erecta Dere\GG17413 Drosophila yakuba Dyak\GE24813 Drosophila ananassae Dana\GF17278 Drosophila ananassae Dana\GF19907 Drosophila pseudoobscura pseudoobscura Dpse\GA30196 Drosophila persimilis Dper\GL22281 Drosophila willistoni Dwil\GK11118 Drosophila virilis Dvir\GJ23434 Drosophila mojavensis Dmoj\GI22707 Drosophila mojavensis Dmoj\GI22708 Drosophila grimshawi Dgri\GH22458 Drosophila grimshawi Dgri\GH22524
Stocks & Reagents
Stocks Listed in FlyBase ( 35 )
Bloomington	562 pyd1
Harvard	- P{XP}pydd06030 - PBac{PB}pydc00198 - PBac{PB}pydc02928 - PBac{PB}pydc03468 - PBac{PB}pydc04440 - PBac{WH}pydf00349 - PBac{WH}pydf02866 - PBac{WH}pydf05868 - PBac{WH}pydf05901 - PBac{WH}pydf06812
VDRC	v104159 P{KK105581}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR02B21 BACR02G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 158 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02541 LD43161 LP05923
Other clones	MIP18367 MIP30509
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01826 HL01146 HL04861 LD12866 LD42230 LP10232 LP14314 LP18927 LP20883 RE14851 RE45070 RE65336 RH01691 RH02931 RH03135 RH03348 RH05763 RH06746 RH07445 RH13562 RH17963 RH20644 RH21690 RH21793 RH24087 RH30607 RH31748 RH48665 RH59083 RH65485 RH72085 SD03490 SD05037 SD06425 SD07043 SD08114 SD09522 SD09966 SD10931 SD23492
Other clones	13026 13378 45760 54745 bs61e03 CK01.18D.G9 CK00016 CK01219 CK01711 Dmel_neb_012524_0654_0694 EC13780 EC40677 EC054756 EK020205 EK042758 EK045456 EK045950 EK048115 EK058106 EK058825 EK068112 EK068233 EK071931 EK086213 EK086310 EK090130 EK095523 EK097714 EK101810 EK102742 EK105063 EK111921 EK114811 EK117543 EK118417 EK119525 EK123710 EK133352 EK136942 EK146415 EK153932 EK155705 EK161819 EK162918 EK170439 EK170552 EK172825 EK177563 EK180363 EK180849 EK181105 EK185951 EK186243 EK186913 EK188747 EK188806 EK193237 EK193429 EK197450 EK200508 EK202535 EK214455 EK220545 EK221252 EK223720 EK237406 EK242048 EK251904 EK257032 EK263758 EK267850 EK269954 EK275547 EK279348 EK281301 EK294151 EK303411 EN03844 EP03556 EP04239 EP04748 EP06507 EP06537 EP07807 EP07837 EP09052 EP12413 EP12842 EP21323 EP21921 FGH101H01 FGH110G10 FGM217A06 FGM304A09 GH23642 IP18414 IP18514 IP18614 IP18714 LD44404 RP004030523 RP004126591 RP004163819 RP004220276 RP004236972 RP004251373 RP004360349 RP004398786 RP004422632 RP004435363 RP004516128 RP004518027 RP004533205
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41062
Antibody Information
	monoclonal (Choi et al., 2011) polyclonal (Djiane et al., 2011, Wei and Ellis, 2001, Seppa et al., 2008, Takahisa et al., 1996)
Other Information
Discoverer
	Spencer, 31st Aug. 1939.
Etymology
	'tam' means 'hairy' in Japanese. (Takahisa et al., 1996)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: pyd CG9731 (FlyBase Genome Annotators, 2011) Source for merge of: pyd CG11782 CG11962 CG12409 CG9729 (FlyBase Genome Annotators, 2002-2003) Source for merge of: pyd tam (Ellis, 1998.6.17)
Additional comments	Annotations CG31349 and CG9731 merged as CG43140 in release 5.33 of the genome annotation. (FlyBase Genome Annotators, 2011) Annotations CG9763, CG11782, CG11962, CG12409 and CG9729 merged as CG31349 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Candidate gene for quantitative trait (QTL) locus determining bristle number. (Nuzhdin et al., 1999) cno protein binds directly to pyd protein. (Takahashi et al., 1998) The junction associated pyd protein is involved in the structural organisation or regulation of the putative components important for a signaling pathway to activate the emc expression. (Takahisa et al., 1996) "3-48.1" was stated as revision. (Ellis et al., 1995) In mutants of pyd inappropriate cell fate choices are made resulting in the presence of ectopic sensory organs. A decrease in pyd function results in defects in the process of cell to cell communication that normally restricts the sensory organ precursor to a single cell in each proneural cluster. (Ellis et al., 1995) Recessive P-element insert alleles have extra macrochaetae on head and thorax. Acts as a dominant enhancer of emc.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057349 NM_169245 NM_169246 NM_170646 NM_176426 NM_001104241 NM_001104242 NM_001144556 NM_001260069 NM_001260071 NM_001260072 RefSeq (Proteins) • NP_476697 NP_731291 NP_731292 NP_731293 NP_788603 NP_001097711 NP_001097712 NP_001138028 NP_001246998 NP_001247000 NP_001247001 DDBJ / EMBL / GenBank • AA202159 AAF54300 AAF54300.3 AAF54301 AAF54301.3 AAF54302 AAF54303 AAF54303.3 AAK93389 AAL28604 AAM75046 AAN13402 AAN13402.2 AAN13403 AAN13403.2 ABW08622 ABW08623 AC008314 ACL83487 AFH06316 AFH06317 AFH06318 AFH06319 AI257525 AI511679 AW941509 AW943645 AY051965 AY061056 AY128453 BAA11923 CL527743 CZ466262 CZ466263 CZ468334 CZ468335 CZ468661 CZ469252 CZ469253 CZ474884 CZ474885 CZ482816 CZ485084 CZ485423 CZ488019 CZ488486 CZ488487 CZ488525 D83477 Entrez Gene - A searchable database of RefSeq genes. • 41062 41063 UniProtKB/TrEMBL • A8JQV7 A8JQV8 B7Z0U1 Q7K4E2 Q8INQ0 Q8MQQ3 Q9VHK1 Q9VHK2 Q9VHK3 Q9VHK4 Q95RX8 Q94880
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) ZU5 (IPR000906) PDZ domain (IPR001478) Guanylate kinase (IPR008144) Guanylate kinase/L-type calcium channel (IPR008145) Variant SH3 (IPR011511) Src homology-3 domain (IPR001452) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD02541 LD43161 LP05923
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262614 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41062 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A8JQV8
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	CG9729   CG9731 (Keleman et al., 2009.8.5) CG9763 (Norga et al., 2003, ) CG11782   CG11962   CG12409   CG31349 (Maisonhaute et al., 2007, Deloger et al., 2009, Perkins et al., 2009, Hazelett et al., 2009, Ni et al., 2011.7.19, Cammarato et al., 2011, Sepp et al., 2008) CG43140 (FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1) CT36877 (Ceriani et al., 2002) dzo-1 (Yeaman et al., 1999) DZO-1 (Katsube et al., 1998) Pch   polychaetoid (Staudt et al., 2005) pyd (Choi et al., 2011, Goossens et al., 2011, Held, 1990, Jung et al., 2006, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Maisonhaute et al., 2007, Akdemir et al., 2007, Weiler, 2007, Kankel et al., 2007, Araujo et al., 2007, Yi et al., 2007, Seppa et al., 2008, Font-Burgada et al., 2008, Weavers et al., 2009, Zhuang et al., 2009, Flaherty et al., 2009, Cook et al., 2010.2.12, Djiane et al., 2011, Magwire et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Pyd (Höhne et al., 2011, Waldholm et al., 2011, Wei and Ellis, 2001, Wu et al., 2007, Gabut et al., 2007, Weavers et al., 2009, Ivarsson et al., 2011) Pyd/ZO-1 (Mueller and Bossinger, 2003, Tepass et al., 2001, Jung et al., 2006) pyd(Z01) (Brumby et al., 2004) tam (Takahisa, 1996.2.7, Ponting et al., 1997, Ueda et al., 1997, Takahisa et al., 1996, ) Tamou (Campuzano, 2001, Caruana, 2002) xvt   ZO-1 (Roper and Brown, 2003, Martin and Parkhurst, 2004, Anderson et al., 2004, Knox and Brown, 2002, Bilder, 2001, Peifer and Tepass, 2000, Stronach and Perrimon, 1999, Noselli and Agnes, 1999, Ueda et al., 1999, Takahashi et al., 1998, Bakal et al., 2008) ZO1 (Jacinto et al., 2002)
Name Synonym	extra verticals   failed fusions (Ghabrial et al., 2011) Polychaetoid (Choi et al., 2011, Gabut et al., 2007, Araujo et al., 2007) polychaetoid (Jung et al., 2006, Staudt et al., 2005, Kankel et al., 2007, Seppa et al., 2008, Flaherty et al., 2009, FlyBase Genome Annotators, 2011, Hazelett et al., 2009, Cammarato et al., 2011, Ivarsson et al., 2011, Eddison et al., 2012, Sepp et al., 2008) tamou (Dimitratos et al., 1999, Takahisa, 1996.2.7, Ponting et al., 1997, Ueda et al., 1997, Takahisa et al., 1996, )
Secondary FlyBase IDs
	FBgn0003177 FBgn0010330 FBgn0037639 FBgn0037640 FBgn0037641 FBgn0037642 FBgn0040533 FBgn0051349
References ( 126 )
Generate a list of	All references relating to this gene ( 126 )
List References by type	Research paper  ( 56 ) Supplementary material  ( 7 ) Review  ( 22 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 12 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Eddison et al., 2012, PLoS ONE 7(12): e51684 A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. [FBrf0220425] Choi et al., 2011, Mol. Biol. Cell 22(12): 2010--2030 The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled. [FBrf0213894] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Goossens et al., 2011, Development 138(8): 1595--1605 The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. [FBrf0213316] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Höhne et al., 2011, Mol. Cell. Biol. 31(16): 3241--3251 The BAR Domain Protein PICK1 Regulates Cell Recognition and Morphogenesis by Interacting with Neph Proteins. [FBrf0214537] Ivarsson et al., 2011, J. Biol. Chem. 286(52): 44669--44678 Cooperative Phosphoinositide and Peptide Binding by PSD-95/Discs Large/ZO-1 (PDZ) Domain of Polychaetoid, Drosophila Zonulin. [FBrf0217021] Waldholm et al., 2011, BMC Mol. Biol. 12: 46 SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. [FBrf0216757] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...