FlyBase Gene Report: Dmel\pyd

General Information

Symbol

Dmel\pyd

Species

D. melanogaster

Name

polychaetoid

Annotation Symbol

CG43140

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262614

Gene Model Status

Current

Stock Availability

38 publicly available

Gene Summary

polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Red Book
Interactive Fly

Also Known As

ZO-1, tamou, tam, Pyd/ZO-1

Key Links

Genomic Location

Cytogenetic map

85B2-85B7

Sequence location

3R:8,827,068..8,931,896 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8827068..8931896

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (25 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cell adhesion molecule binding

inferred from physical interaction with FLYBASE:kirre; FB:FBgn0028369

(Weavers et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cell adhesion molecule binding

inferred from biological aspect of ancestor with PANTHER:PTN001015414

(GO Reference Genome Project, 2011-)

Biological Process (17 terms)

Terms Based on Experimental Evidence (15 terms)

CV Term

Evidence

References

involved_in branch fusion, open tracheal system

inferred from mutant phenotype

(Jung et al., 2006)

inferred from high throughput mutant phenotype

(Ghabrial et al., 2011)

involved_in cell-cell adhesion

inferred from mutant phenotype

(Jung et al., 2006)

involved_in chaeta development

inferred from mutant phenotype

(Djiane et al., 2011)

involved_in compound eye morphogenesis

inferred from mutant phenotype

(Seppa et al., 2008)

involved_in dorsal closure

inferred from mutant phenotype

(Choi et al., 2011)

involved_in fusion cell fate specification

inferred from mutant phenotype

(Jung et al., 2006)

involved_in head involution

inferred from mutant phenotype

(Choi et al., 2011)

involved_in negative regulation of endocytosis

inferred from mutant phenotype

(Shimizu et al., 2017)

involved_in nephrocyte diaphragm assembly

inferred from mutant phenotype

(Carrasco-Rando et al., 2019, Zhuang et al., 2009)

inferred from genetic interaction with FLYBASE:scramb1; FB:FBgn0052056

(Castillo-Mancho et al., 2024)

involved_in open tracheal system development

inferred from mutant phenotype

(Choi et al., 2011)

involved_in positive regulation of hippo signaling

inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970

(Sang et al., 2021)

involved_in R8 cell development

inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739,FLYBASE:kibra; FB:FBgn0262127

(Sang et al., 2021)

involved_in regulation of cell adhesion

inferred from mutant phenotype

(Seppa et al., 2008)

inferred from genetic interaction with FLYBASE:rst; FB:FBgn0003285

(Seppa et al., 2008)

inferred from genetic interaction with FLYBASE:shg; FB:FBgn0003391

(Seppa et al., 2008)

involved_in regulation of embryonic cell shape

inferred from mutant phenotype

(Choi et al., 2011)

involved_in wing disc development

inferred from mutant phenotype

(Djiane et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell-cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN001015414

(GO Reference Genome Project, 2011-)

involved_in cell-cell junction organization

inferred from biological aspect of ancestor with PANTHER:PTN001015414

(GO Reference Genome Project, 2011-)

involved_in protein localization to cell-cell junction

inferred from biological aspect of ancestor with PANTHER:PTN001015414

(GO Reference Genome Project, 2011-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Djiane et al., 2011, Seppa et al., 2008, Jung et al., 2006)

located_in apical part of cell

inferred from direct assay

(Seppa et al., 2008)

located_in axon

inferred from direct assay

(Seppa et al., 2008)

located_in basolateral plasma membrane

inferred from direct assay

(Seppa et al., 2008)

located_in nephrocyte diaphragm

inferred from direct assay

(Carrasco-Rando et al., 2019, Weavers et al., 2009)

located_in plasma membrane

inferred from direct assay

(Weavers et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in bicellular tight junction

inferred from biological aspect of ancestor with PANTHER:PTN001015414

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001015414

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Positive Regulators of Hippo Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

Positive Regulators of Hippo Signaling Pathway -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

pyd: polychaetoid

Extra bristles present in homozygote at or near almost all normal bristle locations but most frequently in dorsocentral and scutellar regions. Heterozygote in some stocks occasionally shows extra bristles, especially vibrissae. Character expressed better at low temperatures and in large flies. Combinations with h and Hw generally superadditive for bristle number. RK3.

Summary (Interactive Fly)

scaffolding protein, PDZ domain protein, MAGUK - involved in sensory organ development - mutations have a neurogenic effect - suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\pyd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K6Y7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.31

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

pyd-RA

FBtr0305297

NM_169245

7195

2090

pyd-RB

FBtr0305295

NM_057349

5688

1371

pyd-RC

FBtr0305296

NM_169246

5024

1293

pyd-RF

FBtr0305294

NM_176426

4196

1149

pyd-RG

FBtr0305299

NM_001104241

5048

1301

pyd-RI

FBtr0305298

NM_001144556

5505

1386

pyd-RJ

FBtr0305301

NM_170646

6665

1735

pyd-RK

FBtr0305302

NM_001104242

5744

1446

pyd-RL

FBtr0305303

NM_001260071

5123

1285

pyd-RM

FBtr0305304

NM_001260072

6058

1301

pyd-RO

FBtr0310205

NM_001260069

8533

2395

pyd-RP

FBtr0479647

NM_001382097

5408

1390

Additional Transcript Data and Comments

Reported size (kB)

10.5, 9.5, 8.1, 6.7, 5.6 (northern blot)

(Takahisa et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

pyd-PA

FBpp0293840

230.2

2090

8.24

FBpp0293838

148.8

1371

9.47

FBpp0293839

140.5

1293

9.78

FBpp0293837

125.6

1149

9.10

FBpp0293842

142.1

1301

9.76

FBpp0293841

150.4

1386

9.43

FBpp0293844

187.9

1735

8.91

FBpp0293845

159.5

1446

9.15

FBpp0293846

141.0

1285

9.39

FBpp0293847

142.1

1301

9.76

FBpp0301889

263.8

2395

8.81

FBpp0424324

153.0

1390

9.82

AFH06317

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1301 aa isoforms: pyd-PG, pyd-PM

Additional Polypeptide Data and Comments

Reported size (kDa)

180 (kD observed)

(Wei and Ellis, 2001)

1367 (aa); 170, 160 (kD observed); 148 (kD predicted)

(Takahisa et al., 1996)

Comments

Antisera specific to the the larger pyd protein was prepared.

(Wei and Ellis, 2001)

Cortactin protein SH3 domain binds to a PXXP motif in the pyd protein proline-rich domain. This binding is abolished when the central 2 P residues in a motif consisting of 3 overlapping PXXP motifs are mutated to A. Cortactin and pyd proteins coimmunoprecipitate from Drosophila embryo lysates.

(Katsube et al., 1998)

tam protein contains three discs-large homologous regions, an SH3 domain, a guanylate kinase domain and a proline rich terminal region. It is a structural homolog of mammalian ZO-1.

(Takahisa et al., 1996)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pyd using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.24

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 10 -- 11

embryonic/larval tracheal section

(Chung et al., 2011)

embryonic stage 11 -- 12

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

third instar larval stage

wing disc

(Takahisa et al., 1996)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Takahisa et al., 1996)

larval stage & pupal stage

(Takahisa et al., 1996)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Wei and Ellis, 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Wei and Ellis, 2001)

embryonic stage 12 -- 17

nephrocyte

(Carrasco-Rando et al., 2019)

larval stage

garland cell

(Tutor et al., 2014)

nephrocyte

(Carrasco-Rando et al., 2019)

larval stage & pupal stage

wing disc

(Wei and Ellis, 2001)

third instar larval stage

wing disc

(Takahisa et al., 1996)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

tam protein is localized at cell-cell junctions in a position slightly basal to shg.

(Carrasco-Rando et al., 2019, Takahisa et al., 1996)

The large form of pyd protein was assayed in embryos and wing discs and is present in both.

(Wei and Ellis, 2001, Katsube et al., 1998)

The larger form of pyd protein is localized at the adherens junction.

(Wei and Ellis, 2001)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Djiane et al., 2011, Seppa et al., 2008, Jung et al., 2006)

located_in apical part of cell

inferred from direct assay

(Seppa et al., 2008)

located_in axon

inferred from direct assay

(Seppa et al., 2008)

located_in basolateral plasma membrane

inferred from direct assay

(Seppa et al., 2008)

located_in nephrocyte diaphragm

inferred from direct assay

(Carrasco-Rando et al., 2019, Weavers et al., 2009)

located_in plasma membrane

inferred from direct assay

(Weavers et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\pyd in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\pyd

View exonic expression by tissue for Dmel\pyd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262614

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41062/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262614

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262614

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31349

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 71 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 35 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of pyd

Transgenic constructs containing regulatory region of pyd

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(3R)BSC478

(Christensen et al., 2008.4.15)

Df(3R)BSC506

(Christensen et al., 2008.4.15)

Df(3R)Exel6150

(Ryder, 2004.4.26)

Df(3R)p819

(Chen et al., 1996)

Df(3R)p-XT103

(Jung et al., 2006, Chen et al., 1996)

Df(3R)pydC2

(Chen et al., 1996)

Gene not disrupted in

Df(3R)p13

(Chen et al., 1996)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

pyd^C5

partially lethal - majority die

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

pyd^GD8691

viable, with Scer\GAL4^Mef2.PR

pyd^GD8691

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

pyd^GD8691

viable | maternal effect

pyd^B12

viable | maternal effect (with Df(3R)p-XT103)

pyd^B12

Sterility

Allele

female fertile

pyd^tam

fertile

male fertile

pyd^tam

Other Phenotypes

Allele

abnormal behavior | recessive

pyd¹

abnormal cell migration | pupal stage, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

abnormal cell shape

pyd^B12

abnormal learning | adult stage

pyd^11.272

increased cell number (with Df(3R)p-XT103)

increased cell number | adult stage, with Scer\GAL4^GMR.PU

pyd^UAS.P

increased cell number | pupal stage, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

majority die during embryonic stage (with pyd^B12)

pyd^ex147

majority die during embryonic stage (with pyd^ex147)

pyd^B12

some die during embryonic stage

some die during embryonic stage (with pyd^B12)

some die during embryonic stage (with pyd^ex147)

pyd^B12

some die during embryonic stage (with pyd^ex180)

pyd^B12

visible

visible, with Scer\GAL4^pnr-MD237

pyd^GD13813

visible (with Df(3R)p-XT103)

visible (with pyd^C5)

pyd^tam

visible (with pyd^ex147)

pyd^tam

visible (with pyd^tam)

visible | adult stage, with Scer\GAL4^ap.PU

visible | adult stage, with Scer\GAL4^GMR.PF

visible | recessive

pyd^unspecified

wild-type

Phenotype manifest in

Allele

adult abdominal sensillum

pyd⁶⁶

adult thorax

adult thorax, with Scer\GAL4^GMR.PF

pyd^RNAi.1.UAS

basement membrane | embryonic stage 16

cephalopharyngeal skeleton

pyd^J14

chaeta

chaeta, with Scer\GAL4^GMR.PF

pyd^RNAi.1.UAS

chaeta, with Scer\GAL4^pnr-MD237

pyd^GD13813

cone cell

pyd^J14

cone cell | increased number, with Scer\GAL4^GMR.PU

pyd^UAS.P

cone cell | pupal stage, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

dorsal tracheal branch primordium

dorsal tracheal branch primordium | somatic clone

pyd^C5

dorsocentral bristle

pyd⁶⁶

dorsocentral bristle | increased number (with Df(3R)p-XT103)

dorsocentral bristle | increased number (with pyd^C5)

pyd^tam

dorsocentral bristle | increased number (with pyd^tam)

pyd^C5

embryo | dorsal closure stage

embryo | dorsal closure stage (with pyd^B12)

embryo | dorsal closure stage (with pyd^ex147)

pyd^B12

embryo | dorsal closure stage (with pyd^ex180)

pyd^B12

embryonic/first instar larval cuticle

pyd^C5

embryonic/larval cuticle

pyd^B12

embryonic/larval dorsal tracheal branch

pyd^B12

embryonic/larval garland cell, with Scer\GAL4^sns.GCN

pyd^GD8691

embryonic/larval tracheal dorsal trunk

embryonic/larval tracheal lateral trunk

embryonic dorsal branch & cell-cell adherens junction

embryonic dorsal branch & cell-cell adherens junction | somatic clone

pyd^C5

embryonic ganglionic branch & cell-cell adherens junction

pyd^BG02748

embryonic garland cell

pyd^ZU5

embryonic garland cell | embryonic stage 16

embryonic head

embryonic head (with pyd^B12)

embryonic head (with pyd^ex147)

pyd^B12

embryonic head (with pyd^ex180)

pyd^B12

embryonic leading edge cell

embryonic leading edge cell (with pyd^B12)

embryonic leading edge cell (with pyd^ex147)

pyd^B12

embryonic leading edge cell (with pyd^ex180)

pyd^B12

eye

eye, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

eye | adult stage, with Scer\GAL4^GMR.PF

pyd^RNAi.1.UAS

eye | somatic clone

female germline stem cell | increased number (with Df(3R)p-XT103)

pyd^ex147

ganglionic tracheal branch primordium

germarium cap cell | increased number

germarium cap cell | increased number (with Df(3R)p-XT103)

pyd^ex147

interocellar bristle

pyd⁶⁶

interommatidial cell | increased number, with Scer\GAL4^GMR.PU

pyd^UAS.P

interommatidial precursor cell | pupal stage

interommatidial precursor cell | pupal stage | increased number

pyd^tex1

interommatidial precursor cell | pupal stage | increased number, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

larval tracheal system

macrochaeta

macrochaeta, with Scer\GAL4^ap.PU

pyd^UAS.P

macrochaeta & adult head | dorsal

pyd^tam

macrochaeta & adult thorax | dorsal

pyd^tam

macrochaeta | increased number

macrochaeta | increased number, with Scer\GAL4^ap.PU

pyd^ΔCC.UAS.P

mesothoracic metatarsus

pyd^unspecified

mesothoracic tarsal bristle

pyd^unspecified

microchaeta, with Scer\GAL4^ap.PU

pyd^UAS.P

ommatidium

ommatidium, with Scer\GAL4^GMR.PU

pyd^UAS.P

orbital bristle

pyd⁶⁶

presumptive embryonic/larval tracheal system

presumptive embryonic/larval tracheal system (with Df(3R)p-XT103)

primary pigment cell

pyd^J14

primary pigment cell | pupal stage, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

scutellar bristle

pyd⁶⁶

secondary pigment cell

pyd^hs.PT

sensory mother cell

pyd^J14

septate junction | ectopic | embryonic stage 16

slit diaphragm | embryonic stage 16

sternopleural bristle

pyd⁶⁶

terminal tracheal cell

tertiary pigment cell | pupal stage | increased number

tertiary pigment cell | pupal stage | increased number, with Scer\GAL4^GMR.PF

pyd^RNAi.3.UAS

thorax

thorax, with Scer\GAL4^ap.PU

tracheal fusion cell

tracheal fusion cell | somatic clone

pyd^C5

tracheal lateral trunk primordium

trichogen cell, with Scer\GAL4^pnr-MD237

pyd^GD13813

ventral denticle belt

pyd^J14

ventral head epidermis

ventral head epidermis (with pyd^B12)

ventral head epidermis (with pyd^ex147)

pyd^B12

ventral head epidermis (with pyd^ex180)

pyd^B12

vertical bristle

pyd⁶⁶

wing (with Df(3R)p-XT103)

wing (with pyd^ex147)

pyd^tam

wing (with pyd^tam)

pyd^ex147

wing sensillum

pyd^tam

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (54)

Hsap\TJP1

12 of 14

Yes

Hsap\TJP2

12 of 14

Yes

Hsap\TJP3

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CARD10

1 of 14

Yes

Hsap\CARD11

1 of 14

Hsap\CARD14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Tjp1

11 of 14

Yes

Rnor\Tjp2

11 of 14

Yes

Rnor\Tjp3

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Card10

1 of 14

Rnor\Card14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (31)

Mmus\Tjp1

11 of 14

Yes

Mmus\Tjp2

11 of 14

Yes

Mmus\Tjp3

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (33)

Xtro\tjp1

7 of 13

Yes

Xtro\tjp2

6 of 13

Yes

Xtro\tjp3

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\card14

1 of 13

Yes

Xtro\cfap20dc

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\magi3

1 of 13

Xtro\MGC76064

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (46)

Drer\tjp1b

11 of 14

Yes

Drer\tjp1a

10 of 14

Yes

Drer\tjp2a

10 of 14

Yes

Drer\tjp2b

10 of 14

Yes

Drer\tjp3

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\card11

1 of 14

Yes

Drer\card14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\zoo-1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP003546

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009630

1 of 12

Yes

Agam\AgaP_AGAP010230

1 of 12

Agam\AgaP_AGAP010778

1 of 12

Agam\AgaP_AGAP012008

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:pyd. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (15)

Dlg5

2 of 13

baz

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

oya

1 of 13

Patj

1 of 13

scrib

1 of 13

sdt

1 of 13

vari

1 of 13

X11Lβ

1 of 13

X11L

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

TJP2; tight junction protein 2

model of progressive familial intrahepatic cholestasis 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

pyd^HMS00263

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

pyd^EY01326

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TJP1; tight junction protein 1

12 of 14

601009

TJP2; tight junction protein 2

12 of 14

607709

progressive familial intrahepatic cholestasis 4

TJP3; tight junction protein 3

9 of 14

612689

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pyd - Cortactin

anti bait coimmunoprecipitation, western blot, two hybrid

(Katsube et al., 1998)

pyd - N

anti tag coimmunoprecipitation, anti tag western blot

(Shimizu et al., 2017)

pyd - Nedd4

two hybrid

(Djiane et al., 2011)

pyd - Nrg

filter binding

(Goossens et al., 2011)

pyd - Su(dx)

anti tag coimmunoprecipitation, western blot, colocalization, fluorescence microscopy, inferred by author, two hybrid, classical fluorescence spectroscopy, pull down, autoradiography

(Djiane et al., 2011)

pyd - Wee1

anti tag coimmunoprecipitation, anti tag western blot

(Sopko et al., 2014)

pyd - cno

two hybrid, pull down, autoradiography

(Takahashi et al., 1998)

pyd - drk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

pyd - dx

anti tag coimmunoprecipitation, anti tag western blot

(Shimizu et al., 2017)

pyd - kel

proximity-dependent biotin identification, Identification by mass spectrometry

(Mannix et al., 2019)

pyd - kirre

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Weavers et al., 2009)

pyd - scramb1

proximity-dependent biotin identification, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Castillo-Mancho et al., 2024)

pyd - sdk

pull down, anti tag western blot

(Letizia et al., 2019)

RNA-protein

Physical Interaction

Assay

References

pyd - Snrnp65

anti tag coimmunoprecipitation, reverse transcription pcr

(Li et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pyd

enhanceable

Delta

(Chen et al., 1996)

pyd

enhanceable

emc

(Chen et al., 1996)

pyd

enhanceable

ena

(Choi et al., 2011)

pyd

enhanceable

(Djiane et al., 2011)

pyd

enhanceable

hry

(Held, 1990)

pyd

suppressible

(Djiane et al., 2011)

pyd

enhanceable

(Djiane et al., 2011)

pyd

enhanceable

rst

(Seppa et al., 2008)

pyd

enhanceable

shg

(Seppa et al., 2008)

pyd

suppressible

Su(dx)

(Djiane et al., 2011)

pyd

enhanceable

tkv

(Seppa et al., 2008)

pyd

enhanceable

α-Cat

(Seppa et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm

suppressible

pyd

(Tegeder et al., 2019)

ena

enhanceable

pyd

(Choi et al., 2011)

hep

enhanceable

pyd

(Takahashi et al., 1998)

hry

enhanceable

pyd

(Held, 1990)

suppressible

pyd

(Chen et al., 1996)

Snr1

suppressible

pyd

(Tegeder et al., 2019)

Su(dx)

enhanceable

pyd

(Djiane et al., 2011)

tkv

enhanceable

pyd

(Seppa et al., 2008)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262614

MIST (genetic) - An integrated Molecular Interaction Database

41062

MIST (protein-protein) - An integrated Molecular Interaction Database

41062

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Hippo Signaling Pathway

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JQV8

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85B2-85B7

Sequence location

3R:8,827,068..8,931,896 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85B2-85B7

Limits computationally determined from genome sequence between P{lacW}l(3)L4740^L4740 and P{EP}D1^EP473

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Located in 85B1--85B6 by deficiency mapping (details unspecified).

(Takahisa et al., 1996)

85B1-85B6

(Takahisa, 1996.2.7)

85B1-85B6

85B (determined by in situ hybridisation)

(Takahisa et al., 1996)

85B9-85B9

(determined by in situ hybridisation)

(Chen et al., 1996)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-45.5

(Comeron et al., 2012)

(Takahisa, 1996.2.7)

3-48.1

(Ellis et al., 1995)

Left of (cM)

Right of (cM)

Notes

Maps to 3R.

(Ghabrial et al., 2011)

Stocks and Reagents

Stocks (38)

Genomic Clones (45)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (86)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP30509

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262614

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Carrasco-Rando et al., 2019, Djiane et al., 2011, Seppa et al., 2008, Wei and Ellis, 2001, Takahisa et al., 1996)

monoclonal

(Choi et al., 2011)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

PYD1
PYD2

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Most embryos lacking pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system.

(Choi et al., 2011)

Loss of maternal and zygotic pyd substantially compromises development.

(Choi et al., 2011)

?? need to add more comments and GO terms

(Choi et al., 2011)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Candidate gene for quantitative trait (QTL) locus determining bristle number.

(Nuzhdin et al., 1999)

cno protein binds directly to pyd protein.

(Takahashi et al., 1998)

The junction associated pyd protein is involved in the structural organisation or regulation of the putative components important for a signaling pathway to activate the emc expression.

(Takahisa et al., 1996)

"3-48.1" was stated as revision.

(Ellis et al., 1995)

In mutants of pyd inappropriate cell fate choices are made resulting in the presence of ectopic sensory organs. A decrease in pyd function results in defects in the process of cell to cell communication that normally restricts the sensory organ precursor to a single cell in each proneural cluster.

(Ellis et al., 1995)

Recessive P-element insert alleles have extra macrochaetae on head and thorax. Acts as a dominant enhancer of emc.

Relationship to Other Genes

Source for database merge of

Source for merge of: pyd tam

(Ellis, 1998.6.17)

Source for merge of: pyd CG11782 CG11962 CG12409 CG9729

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: pyd CG9731

(FlyBase Genome Annotators, 2011)

Additional comments

Annotations CG31349 and CG9731 merged as CG43140 in release 5.33 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Annotations CG9763, CG11782, CG11962, CG12409 and CG9729 merged as CG31349 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

'tam' means 'hairy' in Japanese.

(Takahisa et al., 1996)

Synonyms and Secondary IDs (26)

Reported As

Symbol Synonym

CG11782

CG11962

CG12409

CG31349

(Rosa-Ferreira et al., 2015, Christis and Munro, 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Deloger et al., 2009, Hazelett et al., 2009, Perkins et al., 2009, Sepp et al., 2008, Maisonhaute et al., 2007)

CG43140

(FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1)

CG9729

CG9731

(Keleman et al., 2009.8.5)

CG9763

(Norga et al., 2003)

CT36877

(Ceriani et al., 2002)

DZO-1

(Katsube et al., 1998)

Pch

Pyd/ZO-1

(Jung et al., 2006, Müller and Bossinger, 2003, Tepass et al., 2001)

Tamou

(Caruana, 2002, Campuzano, 2001)

ZO-1

(Mysh and Poulton, 2021, Yu and Guan, 2013, Bulgakova et al., 2012, Bakal et al., 2008, Anderson et al., 2004, Martin and Parkhurst, 2004, Roper and Brown, 2003, Knox and Brown, 2002, Bilder, 2001, Peifer and Tepass, 2000, Noselli and Agnes, 1999, Stronach and Perrimon, 1999, Ueda et al., 1999, Takahashi et al., 1998)

ZO1

(Jacinto et al., 2002)

dzo-1

(Yeaman et al., 1999)

polychaetoid

(Staudt et al., 2005)

pyd

(Fischer et al., 2024, Hersperger et al., 2024, Sood et al., 2024, Sutton et al., 2024, Corthals et al., 2023, Kozlov et al., 2023, Dow et al., 2022, Malin et al., 2022, Pavlidaki et al., 2022, Agrawal et al., 2021, Johnson, 2021, Michki et al., 2021, Parkhitko et al., 2021, Sang et al., 2021, Feuillette et al., 2020, Geigges et al., 2020, Li et al., 2020, Overton et al., 2020, Carrasco-Rando et al., 2019, Donde et al., 2019, Harbison et al., 2019, Letizia et al., 2019, Mannix et al., 2019, Meltzer et al., 2019, Ruiz, 2019.12.30, Tegeder et al., 2019, Millet-Boureima et al., 2018, Hermle et al., 2017, Rohde et al., 2017, Shimizu et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Piegholdt et al., 2016, Aradska et al., 2015, Chaston et al., 2015, Gene Disruption Project members, 2015-, Kavi et al., 2015, Matthews et al., 2015, Na et al., 2015, Zaessinger et al., 2015, Ashwal-Fluss et al., 2014, Chaturvedi et al., 2014, Ciglar et al., 2014, Xu et al., 2014, Carter, 2013, Das et al., 2013, Zhang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Choi et al., 2011, Chung et al., 2011, Djiane et al., 2011, Friedman et al., 2011, Goossens et al., 2011, Cook et al., 2010.2.12, Kong et al., 2010, Magwire et al., 2010, Flaherty et al., 2009, Weavers et al., 2009, Zhuang et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Font-Burgada et al., 2008, Seppa et al., 2008, Akdemir et al., 2007, Araujo et al., 2007, Kankel et al., 2007, Maisonhaute et al., 2007, Weiler, 2007, Yi et al., 2007, Jung et al., 2006, Held, 1990)

pyd(Z01)

(Brumby et al., 2004)

tam

(Ponting et al., 1997, Ueda et al., 1997, Takahisa, 1996.2.7, Takahisa et al., 1996)

xvt

Name Synonyms

Polychaetoid

(Finegan and Bergstralh, 2020, Yamagata, 2020, Guichard et al., 2013, Choi et al., 2011, Rodrigues et al., 2011, Chang et al., 2008, Araujo et al., 2007, Gabut et al., 2007, Jennings et al., 2007)

extra verticals

failed fusions

(Ghabrial et al., 2011)

polychaetoid

(Das et al., 2013, Eddison et al., 2012, Cammarato et al., 2011, FlyBase Genome Annotators, 2011, Ivarsson et al., 2011, Flaherty et al., 2009, Hazelett et al., 2009, Seppa et al., 2008, Sepp et al., 2008, Kankel et al., 2007, Jung et al., 2006, Burnette et al., 2005, Staudt et al., 2005)

tamou

(Dimitratos et al., 1999, Ponting et al., 1997, Ueda et al., 1997, Takahisa, 1996.2.7, Takahisa et al., 1996)

Secondary FlyBase IDs

FBgn0003177
FBgn0010330
FBgn0037639
FBgn0037641
FBgn0037642
FBgn0040533
FBgn0051349
FBgn0037640

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 125 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41062

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K6Y7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K6Y7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262614

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41062/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262614

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262614

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43140

MARRVEL_MODEL - MARRVEL (model organism gene)

41062

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262614

DroID - A comprehensive database of gene and protein interactions.

FBgn0262614

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

PYD1
PYD2

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262614

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31349

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006063

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

41062

MIST (protein-protein) - An integrated Molecular Interaction Database

41062

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JQV8

References (249)

The following external sites may use different assemblies or annotations than FlyBase.

-1.24

Report Sections