ZO-1, tamou, tam, Pyd/ZO-1
scaffolding protein, PDZ domain protein, MAGUK - involved in sensory organ development - mutations have a neurogenic effect - suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation
Please see the JBrowse view of Dmel\pyd for information on other features
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Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.31
10.5, 9.5, 8.1, 6.7, 5.6 (northern blot)
180 (kD observed)
1367 (aa); 170, 160 (kD observed); 148 (kD predicted)
Antisera specific to the the larger pyd protein was prepared.
tam protein contains three discs-large homologous regions, an SH3 domain, a guanylate kinase domain and a proline rich terminal region. It is a structural homolog of mammalian ZO-1.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pyd using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
GBrowse - Visual display of RNA-Seq signals
View Dmel\pyd in GBrowse 23-48
Maps to 3R.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal
Source for merge of: pyd tam
Source for merge of: pyd CG11782 CG11962 CG12409 CG9729
Source for merge of: pyd CG9731
Annotations CG31349 and CG9731 merged as CG43140 in release 5.33 of the genome annotation.
Annotations CG9763, CG11782, CG11962, CG12409 and CG9729 merged as CG31349 in release 3 of the genome annotation.
Most embryos lacking pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system.
Loss of maternal and zygotic pyd substantially compromises development.
?? need to add more comments and GO terms
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
"3-48.1" was stated as revision.
Recessive P-element insert alleles have extra macrochaetae on head and thorax. Acts as a dominant enhancer of emc.
Spencer, 31st Aug. 1939.
'tam' means 'hairy' in Japanese.