FB2025_02 , released April 17, 2025
Gene: Dmel\pyd
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General Information
Symbol
Dmel\pyd
Species
D. melanogaster
Name
polychaetoid
Annotation Symbol
CG43140
Feature Type
FlyBase ID
FBgn0262614
Gene Model Status
Stock Availability
Gene Summary
polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

ZO-1, tamou, tam, Pyd/ZO-1

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:8827068..8931896
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (25 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:kirre; FB:FBgn0028369
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001015414
Biological Process (17 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from high throughput mutant phenotype
involved_in cell-cell adhesion
inferred from mutant phenotype
involved_in chaeta development
inferred from mutant phenotype
inferred from mutant phenotype
involved_in dorsal closure
inferred from mutant phenotype
inferred from mutant phenotype
involved_in head involution
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:scramb1; FB:FBgn0052056
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:rst; FB:FBgn0003285
inferred from genetic interaction with FLYBASE:shg; FB:FBgn0003391
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cell-cell adhesion
inferred from biological aspect of ancestor with PANTHER:PTN001015414
inferred from biological aspect of ancestor with PANTHER:PTN001015414
Cellular Component (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from direct assay
located_in axon
inferred from direct assay
inferred from direct assay
located_in plasma membrane
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001015414
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001015414
Protein Family (UniProt)
-
Summaries
Gene Snapshot
polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
Positive Regulators of Hippo Signaling Pathway -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
pyd: polychaetoid
Extra bristles present in homozygote at or near almost all normal bristle locations but most frequently in dorsocentral and scutellar regions. Heterozygote in some stocks occasionally shows extra bristles, especially vibrissae. Character expressed better at low temperatures and in large flies. Combinations with h and Hw generally superadditive for bristle number. RK3.
Summary (Interactive Fly)

scaffolding protein, PDZ domain protein, MAGUK - involved in sensory organ development - mutations have a neurogenic effect - suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation

Gene Model and Products
Number of Transcripts
12
Number of Unique Polypeptides
11

Please see the JBrowse view of Dmel\pyd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4K6Y7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.42

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.31

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0305297
7195
2090
FBtr0305295
5688
1371
FBtr0305296
5024
1293
FBtr0305294
4196
1149
FBtr0305299
5048
1301
FBtr0305298
5505
1386
FBtr0305301
6665
1735
FBtr0305302
5744
1446
FBtr0305303
5123
1285
FBtr0305304
6058
1301
FBtr0310205
8533
2395
FBtr0479647
5408
1390
Additional Transcript Data and Comments
Reported size (kB)

10.5, 9.5, 8.1, 6.7, 5.6 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0293840
230.2
2090
8.24
FBpp0293838
148.8
1371
9.47
FBpp0293839
140.5
1293
9.78
FBpp0293837
125.6
1149
9.10
FBpp0293842
142.1
1301
9.76
FBpp0293841
150.4
1386
9.43
FBpp0293844
187.9
1735
8.91
FBpp0293845
159.5
1446
9.15
FBpp0293846
141.0
1285
9.39
FBpp0293847
142.1
1301
9.76
FBpp0301889
263.8
2395
8.81
FBpp0424324
153.0
1390
9.82
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1301 aa isoforms: pyd-PG, pyd-PM
Additional Polypeptide Data and Comments
Reported size (kDa)

180 (kD observed)

1367 (aa); 170, 160 (kD observed); 148 (kD predicted)

Comments

Antisera specific to the the larger pyd protein was prepared.

Cortactin protein SH3 domain binds to a PXXP motif in the pyd protein proline-rich domain. This binding is abolished when the central 2 P residues in a motif consisting of 3 overlapping PXXP motifs are mutated to A. Cortactin and pyd proteins coimmunoprecipitate from Drosophila embryo lysates.

tam protein contains three discs-large homologous regions, an SH3 domain, a guanylate kinase domain and a proline rich terminal region. It is a structural homolog of mammalian ZO-1.

External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pyd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.24

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

tam protein is localized at cell-cell junctions in a position slightly basal to shg.

The large form of pyd protein was assayed in embryos and wing discs and is present in both.

The larger form of pyd protein is localized at the adherens junction.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
located_in axon
inferred from direct assay
inferred from direct assay
located_in plasma membrane
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\pyd in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 71 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pyd
Transgenic constructs containing regulatory region of pyd
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
embryonic dorsal branch & cell-cell adherens junction
embryonic dorsal branch & cell-cell adherens junction | somatic clone
embryonic ganglionic branch & cell-cell adherens junction
macrochaeta & adult head | dorsal
macrochaeta & adult thorax | dorsal
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (54)
12 of 14
Yes
Yes
12 of 14
Yes
Yes
9 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
2  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (28)
11 of 14
Yes
Yes
11 of 14
Yes
Yes
8 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Mus musculus (laboratory mouse) (31)
11 of 14
Yes
Yes
11 of 14
Yes
Yes
9 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (33)
7 of 13
Yes
Yes
6 of 13
No
Yes
4 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Danio rerio (Zebrafish) (46)
11 of 14
Yes
Yes
10 of 14
No
Yes
10 of 14
No
Yes
10 of 14
No
Yes
7 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
11 of 14
Yes
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (20)
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:pyd. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (15)
2 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    Interaction Browsers

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    enhanceable
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    enhanceable
    suppressible
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-48
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    85B2-85B7
    Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Located in 85B1--85B6 by deficiency mapping (details unspecified).
    85B1-85B6
    85B (determined by in situ hybridisation)
    85B9-85B9
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (38)
    Genomic Clones (45)
    cDNA Clones (86)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Most embryos lacking pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system.

        Loss of maternal and zygotic pyd substantially compromises development.

        ?? need to add more comments and GO terms

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        Candidate gene for quantitative trait (QTL) locus determining bristle number.

        cno protein binds directly to pyd protein.

        The junction associated pyd protein is involved in the structural organisation or regulation of the putative components important for a signaling pathway to activate the emc expression.

        "3-48.1" was stated as revision.

        In mutants of pyd inappropriate cell fate choices are made resulting in the presence of ectopic sensory organs. A decrease in pyd function results in defects in the process of cell to cell communication that normally restricts the sensory organ precursor to a single cell in each proneural cluster.

        Recessive P-element insert alleles have extra macrochaetae on head and thorax. Acts as a dominant enhancer of emc.

        Relationship to Other Genes
        Source for database merge of

        Source for merge of: pyd tam

        Source for merge of: pyd CG11782 CG11962 CG12409 CG9729

        Source for merge of: pyd CG9731

        Additional comments

        Annotations CG31349 and CG9731 merged as CG43140 in release 5.33 of the genome annotation.

        Annotations CG9763, CG11782, CG11962, CG12409 and CG9729 merged as CG31349 in release 3 of the genome annotation.

        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology

        'tam' means 'hairy' in Japanese.

        Synonyms and Secondary IDs (26)
        Reported As
        Symbol Synonym
        CG11782
        CG11962
        CG12409
        CG9729
        Pch
        polychaetoid
        pyd
        (Fischer et al., 2024, Hersperger et al., 2024, Sood et al., 2024, Sutton et al., 2024, Corthals et al., 2023, Kozlov et al., 2023, Dow et al., 2022, Malin et al., 2022, Pavlidaki et al., 2022, Agrawal et al., 2021, Johnson, 2021, Michki et al., 2021, Parkhitko et al., 2021, Sang et al., 2021, Feuillette et al., 2020, Geigges et al., 2020, Li et al., 2020, Overton et al., 2020, Carrasco-Rando et al., 2019, Donde et al., 2019, Harbison et al., 2019, Letizia et al., 2019, Mannix et al., 2019, Meltzer et al., 2019, Ruiz, 2019.12.30, Tegeder et al., 2019, Millet-Boureima et al., 2018, Hermle et al., 2017, Rohde et al., 2017, Shimizu et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Piegholdt et al., 2016, Aradska et al., 2015, Chaston et al., 2015, Gene Disruption Project members, 2015-, Kavi et al., 2015, Matthews et al., 2015, Na et al., 2015, Zaessinger et al., 2015, Ashwal-Fluss et al., 2014, Chaturvedi et al., 2014, Ciglar et al., 2014, Xu et al., 2014, Carter, 2013, Das et al., 2013, Zhang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Choi et al., 2011, Chung et al., 2011, Djiane et al., 2011, Friedman et al., 2011, Goossens et al., 2011, Cook et al., 2010.2.12, Kong et al., 2010, Magwire et al., 2010, Flaherty et al., 2009, Weavers et al., 2009, Zhuang et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Font-Burgada et al., 2008, Seppa et al., 2008, Akdemir et al., 2007, Araujo et al., 2007, Kankel et al., 2007, Maisonhaute et al., 2007, Weiler, 2007, Yi et al., 2007, Jung et al., 2006, Held, 1990)
        xvt
        Secondary FlyBase IDs
        • FBgn0003177
        • FBgn0010330
        • FBgn0037639
        • FBgn0037641
        • FBgn0037642
        • FBgn0040533
        • FBgn0051349
        • FBgn0037640
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 125 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        References (249)