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Gene Dmel\CG43143

General Information
Symbol	Dmel\CG43143	Species	D. melanogaster
Name		Annotation symbol	CG43143
Feature type	protein_coding_gene	FlyBase ID	FBgn0262617
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	CG11870, CG11871
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86A7-86A7	Sequence location	3R:6,090,028..6,134,189 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG43143 (FBgn0262617). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein serine/threonine kinase activity. It is reported to be involved in the biological process: protein phosphorylation. 21 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Gene sequence location is 3R:6090028..6134189.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86A7-86A7   Limits computationally determined from genome sequence between P{EP}Fmr1EP3517&P{PZ}tws02414 and P{PZ}jumu06439&P{lacW}l(3)j8B6j8B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG43143 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene merge based on RNA-Seq junction data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG43143-RA FBtr0305352  NM_141734   4588   1427 CG43143-RB FBtr0305354  NM_169337   5076   1427 CG43143-RC FBtr0305353  NM_206470   4793   1427 CG43143-RD FBtr0305351  NM_206469   5997   1180 CG43143-RE FBtr0305355  NM_141736   8836   2537 CG43143-RF FBtr0305356  NM_001260090   5918   1532 CG43143-RG FBtr0305357  NM_001260091   5566   1199 CG43143-RH FBtr0337049  NM_001275528   5525   1551 CG43143-RI FBtr0337050  NM_001275529   9381   2556
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG43143-PA   FBpp0293891   153.4   1427   9.08     NP_649991   AAF54516 CG43143-PB   FBpp0293893   153.4   1427   9.08     NP_731469   AAF54517 CG43143-PC   FBpp0293892   153.4   1427   9.08     NP_996192   AAS65134 CG43143-PD   FBpp0293890   127.7   1180   8.33     NP_996191   AAS65135 CG43143-PE   FBpp0293894   274.9   2537   9.94     NP_649993   AAF54518 CG43143-PF   FBpp0293895   163.9   1532   9.50     NP_001247019   AFH06337 CG43143-PG   FBpp0293896   130.0   1199   8.55     NP_001247020   AFH06338 CG43143-PH   FBpp0307978   166.1   1551   9.57     NP_001262457   AGB95839 CG43143-PI   FBpp0307979   277.2   2556   9.96     NP_001262458   AGB95840
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54516   AE014297 AAF54517   AE014297 AAF54518   AE014297 AAS65134   AE014297 AAS65135   AE014297 AFH06337   AE014297 AFH06338   AE014297 AGB95839   AE014297 AGB95840   AI238357   AI257536   AY070859   BF486369   BF492825   BF492826   BF493583   BF498153   BF500565   BF505954   BG632815   BG634289   BG634965   BI571655   BI591877   BI627160   BT010033 AAQ22502   BT024316   BT050462   BT100199   BT125633   CK658832   CK659886   CO152732   CO179051   CO188091   CO196240   CO263191   CO264660   CO278163   CO286057   CO287520   CO287813   CO289774   CO290311   CO290731   CO294343   CO303661   CO305902   CO308416   CO309982   CO311074   CO319509   CO322466   CO340678   CO341920   CO344961   CZ466856   CZ467516   CZ469696   CZ484327   CZ485604   EC052023   EC052033   EC052530   EC052534   EC053059   EC054540   EC055026   EC055030   EC055347   EC056302   EC061066   EC063963   EC069825   EC070076   EC070356   EC074009   EC079625   EC079626   EC079627   EC080546   EC196391   EC197209   EC202008   EC204462   EC205812   EC206695   EC208193   EC216998   EC217196   EC226014   EC237606   EC240314   EC241817   EC244327   EC247295   EC249311   EC250266   EC258999   EC259800   EC260787   EW713079   GH808162   GH923534
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KSS0 Q0KI87 Q9VH03 Q7YU19
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    4 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    10 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    6 embryo 12-14hr    10 embryo 14-16hr    17 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    14 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    14 adult male 05day    14 adult male 30day    12 adult female 01day    8 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    6 embryonic S3    2 leg disc CME L1    2 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG43143GD7410 CG43143GD7411 Phenotype manifest in Allele
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of CG43143 Class Mutagen Stocks Known lesion CG43143c01070 piggyBac transposase 1 -- CG43143c01868 piggyBac transposase 1 -- CG43143c05031 piggyBac transposase 1 -- CG43143EY22355 P-element activity 1 -- CG43143f01840 piggyBac transposase 1 -- CG43143f03049 piggyBac transposase 1 -- CG43143KG02855 1 -- CG43143MB01720 1 -- CG43143MB02272 1 -- CG43143MI02494 1 -- CG43143MI04137 1 -- CG43143NP7501 1 -- CG43143DG03103 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG43143 Class Mutagen Stocks Known lesion CG43143GD7411 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG43143GD7410 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43143GL00066 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43143JF02162 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43143KK107440 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43143NIG.11870R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG43143NIG.11871R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG43143NIG.11872R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6156 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.11870R} NA P{NIG.11871R} NA P{NIG.11872R} NA P{TRiP.GL00066} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG43143MI02494 NA Mi{MIC}CG43143MI04137 NA P{SUPor-P}CG43143KG02855 NA P{wHy}CG43143DG03103 NA PBac{PB}CG43143c01070 NA PBac{PB}CG43143c01868 NA PBac{PB}CG43143c05031 NA PBac{WH}CG43143f01840 NA PBac{WH}CG43143f03049 NA insertion of enhancer trap binary system Mi{ET1}CG43143MB01720 No Mi{ET1}CG43143MB02272 No P{GawB}CG43143NP7501 No insertion of mobile activating element P{EPgy2}CG43143EY22355 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG43143 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262617 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KI87
Orthologs
OrthoDB Orthologs (23) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NGH61 Dipteran inclusive ortholog search EOG6C2HK1 Insect inclusive ortholog search EOG608M4C Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG696BJH
Orthologs in Drosophila Species (EOG6NGH61)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11694     Drosophila melanogaster fruit fly  Dmel\CG43143     Drosophila simulans   Dsim\GD18683 Y Y Drosophila sechellia   Dsec\GM23874 Y Y Drosophila erecta   Dere\GG17504 Y Y Drosophila yakuba   Dyak\GE26026 Y Y Drosophila ananassae   Dana\GF17462 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28506   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11248 Y Y Drosophila persimilis   Dper\GL23689 Y Y Drosophila willistoni   Dwil\GK12830   Y Drosophila virilis   Dvir\GJ23555 Y Y Drosophila mojavensis   Dmoj\GI23581 Y Y Drosophila mojavensis   Dmoj\GI10818   Y Drosophila grimshawi   Dgri\GH19124 Y Y
Orthologs in non-Drosophila Dipterans (EOG6C2HK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012613 Y Anopheles gambiae Malaria mosquito  Agam\AGAP003175 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003299 Y
Orthologs in non-Dipteran Insects (EOG608M4C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014120 Y Pediculus humanus Human body louse  Phum\PHUM135300 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG696BJH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\B0496.3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015349gn Y Danio rerio Zebrafish  Drer\si:dkey-261e22.1 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (20) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18682 Drosophila simulans Dsim\GD18683 Drosophila sechellia Dsec\GM23873 Drosophila sechellia Dsec\GM23874 Drosophila erecta Dere\GG17493 Drosophila erecta Dere\GG17504 Drosophila yakuba Dyak\GE26024 Drosophila yakuba Dyak\GE26026 Drosophila ananassae Dana\GF17461 Drosophila ananassae Dana\GF17462 Drosophila pseudoobscura pseudoobscura Dpse\GA11248 Drosophila pseudoobscura pseudoobscura Dpse\GA26704 Drosophila persimilis Dper\GL23688 Drosophila persimilis Dper\GL23689 Drosophila virilis Dvir\GJ23554 Drosophila virilis Dvir\GJ23555 Drosophila mojavensis Dmoj\GI23579 Drosophila mojavensis Dmoj\GI23581 Drosophila grimshawi Dgri\GH19123 Drosophila grimshawi Dgri\GH19124
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	31885 y1 v1; P{TRiP.JF02162}attP2 23429 w1118; Mi{ET1}CG43143MB02272 36443 y1 w*; Mi{MIC}CG43143MI02494
Harvard	- PBac{PB}CG43143c01070 - PBac{PB}CG43143c01868 - PBac{PB}CG43143c05031 - PBac{WH}CG43143f01840 - PBac{WH}CG43143f03049
VDRC	v106088 P{KK107440}VIE-260B v31585 w1118 P{GD7411}v31585 v45401 w1118; P{GD7411}v45401 v16334 w1118; P{GD7410}v16334/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR03L12 BACR28B01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM10858 IP11347 LP05937
Other clones	FI03914 MIP13066 MIP25257
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01885 AT08289 AT12523 AT15549 AT20648 AT30447 AT31386 LP16086 LP18006 RH06922 RH07682 RH68390
Other clones	16832 31046 55239 76103 76512 97539 120551 146960 174130 214253.38 214405.51 473594 AT01228 CK01.2A.G4 CK01.2A.G6 CK01.3A.E3 CK01.37D.G11 CK01.44C.D8 CK01.74A.H8 CK01.78A.E6 CK01.84A.F10 CK01.92B.F11 CK01.94C.F2 CK01.104D.G5 CK01.111D.F10 CK01.113A.D8 CK01.123D.C7 EC052023 EC052033 EC052530 EC052534 EC053059 EC054540 EC055026 EC055030 EC055347 EC056302 EK002334 EK037248 EK058264 EK061608 EK066102 EK066855 EK072024 EK073653 EK075003 EK087727 EK129117 EK139829 EK188207 EK206617 EK220144 EK223262 EK242332 EK249648 EK258106 EK278392 EN00320 EP11122 EP13423 EP21028 GH14385 RP003058653 RP003343228
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41256
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG11870 CG11871 (FlyBase Genome Annotators, 2002-2003) Source for merge of: CG11870 CG11872 (FlyBase Genome Annotators, 2011)
Additional comments	Annotations CG11870 and CG11872 merged as CG43143 in release 5.33 of the genome annotation. (FlyBase Genome Annotators, 2011) Annotations CG11870 and CG11871 merged as CG11870 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141734 NM_141736 NM_169337 NM_206469 NM_206470 NM_001260090 NM_001260091 NM_001275528 NM_001275529 RefSeq (Proteins) • NP_649991 NP_649993 NP_731469 NP_996191 NP_996192 NP_001247019 NP_001247020 NP_001262457 NP_001262458 DDBJ / EMBL / GenBank • AAF54516 AAF54517 AAF54518 AAQ22502 AAS65134 AAS65135 AFH06337 AFH06338 AGB95839 AGB95840 AI257536 BF492826 BT010033 CZ466856 CZ467516 CZ469696 CZ484327 CZ485604 Entrez Gene - A searchable database of RefSeq genes. • 41256 41258 UniProtKB/TrEMBL • Q0KI87 Q7KSS0 Q7YU19 Q9VH03
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262617 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41256 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KI87
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG11870 (Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19, Japanese National Institute of Genetics, 2012.5.21) CG11871 (Amin et al., 2009, Luschnig, 2003.12.17, ) CG11872 (Japanese National Institute of Genetics, 2012.5.21) CG43143 (FlyBase Genome Annotators, 2011) EMK/KIAA0537 (Morrison et al., 2000) NUAK (Amin et al., 2009) Omphk1 (Hirano et al., 2006)
Name Synonym
Secondary FlyBase IDs
	FBgn0037804 FBgn0037805 FBgn0037806
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 17 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Shaukat et al., 2012, PLoS ONE 7(10): e47447 A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. [FBrf0219770] Show all research papers ...