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Gene Dmel\Nup160

General Information
Symbol	Dmel\Nup160	Species	D. melanogaster
Name	Nucleoporin 160kD	Annotation symbol	CG4738
Feature type	protein_coding_gene	FlyBase ID	FBgn0262647
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32D4-32D4	Sequence location	2L:11,123,779..11,129,335 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleoporin 160kD is referred to in FlyBase by the symbol Dmel\Nup160 (CG4738, FBgn0262647). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: SMAD protein import into nucleus. 33 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleoporin Nup120/160. Gene sequence location is 2L:11123779..11129335.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32D4-32D4   Limits computationally determined from genome sequence between P{EP}ppoEP2478&P{lacW}l(2)k15817k15817 and P{lacW}RfC38k13807
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32D1-32D1     (Oh et al., 2003)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nup160 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nup160-RA FBtr0080199  NM_135649   4745   1411
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nup160-PA   FBpp0079788   160.3   1411   5.02     NP_609493   AAF53075
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nucleoporin Nup120/160 (IPR021717)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141258   AA735872   AA817279   AA817424   AA942269   AA951640   AE014134 AAF53075   AB082740   AI260009   AI512813   AI515713   AQ025986   BF491520   BF494805   BF495585   BF496571   BF496908   BF500625   BF503106   BF503184   BG633775   BI216230   BI241676   BI355569   BI357373   BI375008   BI375011   BP543081   BP543082   BT015261 AAT94490   CK133360   CO155312   CO155438   CO178326   CO186759   CO277674   CO278395   CO286670   CO291709   CO292626   CO324114   EC069515   EC084094   EC195809   EC207416   EC210034   EC224003   EC235221   EC235595   EC262911   EC266567   EV594983   FE527371
UniProtKB/Swiss-Prot	Q9VKJ3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female  26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female  26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    1 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    23 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    59 embryo 04-06hr    61 embryo 06-08hr    40 embryo 08-10hr    34 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (59) embryo 04-06hr  (61) embryo 06-08hr  (40) embryo 08-10hr  (34) embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day  26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    59 embryo 04-06hr    61 embryo 06-08hr    40 embryo 08-10hr    34 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    59 embryo 04-06hr    61 embryo 06-08hr    40 embryo 08-10hr    34 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day    26 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    59 embryo 04-06hr    61 embryo 06-08hr    40 embryo 08-10hr    34 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (59) embryo 04-06hr  (61) embryo 06-08hr  (40) embryo 08-10hr  (34) embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day  26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    59 embryo 04-06hr    61 embryo 06-08hr    40 embryo 08-10hr    34 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    59 embryo 04-06hr    61 embryo 06-08hr    40 embryo 08-10hr    34 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    14 embryo 16-18hr    12 embryo 18-20hr    5 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    14 adult male 30day    12 adult female 01day    13 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1    26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1  26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (32) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1    26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1    26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1    26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1  26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  32 eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1    26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    24 embryonic 1182-4H    15 embryonic GM2    21 embryonic Kc167    21 embryonic S1    26 embryonic S3    25 leg disc CME L1    17 wing disc CME-W2    21 wing disc ML-DmD8    16 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    25 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    15 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Nup160EP372M18 Nup160EP372M25 Nup160EP372M26 Nup160EP372M39 Nup160EP372M54 Nup160EP372M55 Nup160EP372M64 Nup160EP372M75 Nup160EP372M85 Nup160EP372M121 Nup160EP372M123 Nup160EP372M133 Nup160EP372M142 Nup160EP372M161 Nup160EP372M185 Nup160EP372M215 Nup160EP372M227 lethal, with Scer\GAL4pnr-MD237 Nup160GD11413 lethal | recessive Nup160EP372M94 Nup160SH2055 partially lethal - majority die | recessive Nup160EP372 Nup160SH2055 viable Nup160EP372M206 Nup160EP372M230 Nup160EP372M241 Other Phenotypes Allele cell growth defective Nup160dsRNA.cMa Phenotype manifest in Allele
Classical Alleles ( 26 )
For All Classical Alleles Show
Allele of Nup160 Class Mutagen Stocks Known lesion Nup160EP372 hypomorphic allele P-element activity 2 -- Nup160e00704 1 -- Nup160EP372M180 amorphic allele - molecular evidence Delta2-3 0 Yes Nup160EP372M121 Delta2-3 0 Yes Nup160EP372M123 Delta2-3 0 Yes Nup160EP372M133 Delta2-3 0 Yes Nup160EP372M142 Delta2-3 0 Yes Nup160EP372M161 Delta2-3 0 Yes Nup160EP372M185 Delta2-3 0 Yes Nup160EP372M18 Delta2-3 0 Yes Nup160EP372M206 Delta2-3 0 Yes Nup160EP372M215 Delta2-3 0 Yes Nup160EP372M227 Delta2-3 0 Yes Nup160EP372M230 Delta2-3 0 Yes Nup160EP372M241 Delta2-3 0 Yes Nup160EP372M25 Delta2-3 0 Yes Nup160EP372M26 Delta2-3 0 Yes Nup160EP372M39 Delta2-3 0 Yes Nup160EP372M54 Delta2-3 0 Yes Nup160EP372M55 Delta2-3 0 Yes Nup160EP372M64 Delta2-3 0 Yes Nup160EP372M69 Delta2-3 0 Yes Nup160EP372M75 Delta2-3 0 Yes Nup160EP372M85 Delta2-3 0 Yes Nup160EP372M94 Delta2-3 0 Yes Nup160SH2055 hypomorphic allele P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nup160 Class Mutagen Stocks Known lesion Nup160GD11413 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nup160HMS00385 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nup160+t9 in vitro construct - genomic fragment 0 Yes Nup160dsRNA.cMa in vitro construct - RNAi 0 Yes Nup160KK104805 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Nup160NIG.4738R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Nup160Scer\UAS.cTa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)EP372M190 (Maehara et al., 2012) Df(2L)EP372M201 (Maehara et al., 2012) Df(2L)EP372M203 (Maehara et al., 2012) Df(2L)EP372M219 (Maehara et al., 2012) Df(2L)Exel6027 (Ryder, 2004.4.26)
Partially disrupted in	Df(2L)EP372M190 (Maehara et al., 2012) Df(2L)EP372M201 (Maehara et al., 2012) Df(2L)EP372M203 (Maehara et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK104805} NA P{NIG.4738R} NA P{TRiP.HMS00385} NA P{UAS-Nup160.T} NA characterization construct P{Nup160+t9} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Nup160EP372 NA miscellaneous insertions P{?EP}Nup160EP372M18 NA P{?EP}Nup160EP372M25 NA P{?EP}Nup160EP372M26 NA P{?EP}Nup160EP372M39 NA P{?EP}Nup160EP372M54 NA P{?EP}Nup160EP372M55 NA P{?EP}Nup160EP372M64 NA P{?EP}Nup160EP372M69 NA P{?EP}Nup160EP372M75 NA P{?EP}Nup160EP372M85 NA P{?EP}Nup160EP372M94 NA P{?EP}Nup160EP372M121 NA P{?EP}Nup160EP372M123 NA P{?EP}Nup160EP372M133 NA P{?EP}Nup160EP372M142 NA P{?EP}Nup160EP372M161 NA P{?EP}Nup160EP372M180 NA P{?EP}Nup160EP372M185 NA P{?EP}Nup160EP372M206 NA P{?EP}Nup160EP372M215 NA P{?EP}Nup160EP372M227 NA P{?EP}Nup160EP372M230 NA P{?EP}Nup160EP372M241 NA PBac{RB}RfC38e00704 NA insertion of enhancer trap P{lacW}Nup160SH2055 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:Q9VCH5 (assigned by UniProtKB) (Tang and Presgraves, 2009)
Biological Process
CV term Evidence References
SMAD protein import into nucleus inferred from mutant phenotype (Chen and Xu, 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nucleocytoplasmic transporter activity inferred from sequence or structural similarity with human NUP160 (Curators, 2008--)
Biological Process
CV term Evidence References
mRNA export from nucleus inferred from sequence or structural similarity with human NUP160 (Curators, 2008--)
Cellular Component
CV term Evidence References
nuclear pore outer ring inferred from sequence or structural similarity with human NUP160 (Curators, 2008--)
Sequence Ontology: Class of Gene
	gene (Mendjan et al., 2006) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Nup160 - Nup50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nup160 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262647
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60VW7W Dipteran inclusive ortholog search EOG63BMWT Insect inclusive ortholog search EOG62Z3K1 Arthropod inclusive ortholog search EOG6JWSV9 Metazoa inclusive ortholog search EOG63JQXB
Orthologs in Drosophila Species (EOG60VW7W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Nup160     Drosophila simulans   Dsim\Nup160 Y   Drosophila sechellia   Dsec\GM18918 Y   Drosophila erecta   Dere\GG23708 Y   Drosophila yakuba   Dyak\GE18515 Y   Drosophila ananassae   Dana\GF15643 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18394 Y   Drosophila persimilis   Dper\GL19544 Y   Drosophila willistoni   Dwil\GK14894 Y   Drosophila virilis   Dvir\GJ13938 Y   Drosophila mojavensis   Dmoj\GI20597 Y   Drosophila grimshawi   Dgri\GH10764 Y
Orthologs in non-Drosophila Dipterans (EOG63BMWT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012793   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002339   Anopheles gambiae Malaria mosquito  Agam\AGAP004671   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003931
Orthologs in non-Dipteran Insects (EOG62Z3K1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41883   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022516   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022526   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12430   Atta cephalotes Leafcutter ant  Acep\ACEP16997   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21257   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22516   Linepithema humile Argentine ant  Lhum\LH14335   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20525   Solenopsis invicta Red fire ant  Sinv\SINV24122   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009518   Bombyx mori Silkmoth  Bmor\BGIBMGA011675   Pediculus humanus Human body louse  Phum\PHUM010870   Tribolium castaneum Red flour beetle  Tcas\TC011717
Orthologs in non-Insect Arthropods (EOG6JWSV9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Serpinb3   Ixodes scapularis Deer tick  Isca\ISCW014695
Orthologs in non-Arthropod Metazoa (EOG63JQXB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026230gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003723gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004582gn   Danio rerio Zebrafish  Drer\zgc:66306   Danio rerio Zebrafish  Drer\CABZ01080568.2   Xenopus tropicalis Western clawed frog  Xtro\nup160   Gallus gallus Domestic chicken  Ggal\Gga.4690   Gallus gallus Domestic chicken  Ggal\ENSGALG00000012902   Mus musculus House mouse  Mmus\Nup160   Rattus norvegicus Norway rat  Rnor\Nup160   Homo sapiens Human  Hsap\NUP160
Human Orthologs (1)
Gene OMIM HGNC Hsap\NUP160
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Nup160 Drosophila sechellia Dsec\GM18918 Drosophila erecta Dere\GG23708 Drosophila yakuba Dyak\GE18515 Drosophila ananassae Dana\GF15643 Drosophila pseudoobscura pseudoobscura Dpse\GA18394 Drosophila persimilis Dper\GL19544 Drosophila willistoni Dwil\GK14894 Drosophila virilis Dvir\GJ13938 Drosophila mojavensis Dmoj\GI20597 Drosophila grimshawi Dgri\GH10764
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	17278 w1118; P{EP}Nup160EP372/CyO 32391 y1 sc* v1; P{TRiP.HMS00385}attP2
Harvard	- PBac{RB}RfC38e00704
Kyoto	114468 yd2 w1118 P{ey-FLP.N}2; P{EP}Nup160EP372 P{neoFRT}40A/CyO y+
VDRC	v21937 w1118; P{GD11413}v21937
Genomic Clones ( 2 )
	BACR09F02 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD39963
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03549 AT04534 AT10345 AT10915 AT15616 AT19016 AT19106 AT28280 AT29683 GM10010 GM31401 LD22508 LD22817 LD26377 LD32276 LD41363 LD44873 LP03646 RE38794 RE43841 RE62714 RE62717
Other clones	17777 65531 70477 72047 291901 291978 CK01.60B.H11 CK01.71A.E7 CK01.76B.G5 CK01477 Dmel_neb_014844_0566_1909 DMG3-chr2L.1443.pred.a EK022808 EK056420 EK063530 EK125751 EK129951 EK192560 EK198024 EK200622 EN05820 EN06041 FGC018E08 RE23178
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34549
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Nup160 CG4738 (Tang and Presgraves, 2009) Source for merge of: Nup160 l(2)SH2055 (Sawamura et al., 2010)
Additional comments
Other Comments
	1 allele of l(2)SH2055 recovered in a P-insertion screen. (Oh et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135649 RefSeq (Proteins) • NP_609493 DDBJ / EMBL / GenBank • AAF53075 AAT94490 AB082740 AQ025986 BI216230 BT015261 Entrez Gene - A searchable database of RefSeq genes. • 34549 UniProtKB/Swiss-Prot • Q9VKJ3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nucleoporin Nup120/160 (IPR021717)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262647 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34549
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG4738 (Kallappagoudar et al., 2010, Sawamura et al., 2010, Tang and Presgraves, 2009, Doumanis et al., 2009, Zhou et al., 2008, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21, Sabri et al., 2007) l(2)SH2 2055 (Oh et al., 2002.3.26) l(2)SH2055 (Sawamura et al., 2010, ) Nup160 (Finan et al., 2011, Maehara et al., 2012, Sawamura et al., 2010, Tang and Presgraves, 2009, Mendjan et al., 2006, Neumann et al., 2010) nup160 (Chen and Xu, 2010) Nup160mel (Tang and Presgraves, 2009)
Name Synonym	CG4738   lethal (2) SH2055   nuclear pore protein 160   Nucleoporin 160   Nucleoporin 160kD
Secondary FlyBase IDs
	FBgn0032347 FBgn0065273 FBgn0250730 FBgn0260937
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 2 )
	Maehara et al., 2012, Genes & Genet. Systems 87(2): 99--106 Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila. [FBrf0218968] Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Show all research papers ...