FB2020_03, released Jun 16, 2020

Gene: Dmel\Myc

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General Information
Symbol
Dmel\Myc
Species
D. melanogaster
Name
Myc
Annotation Symbol
CG10798
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262656
Gene Model Status
Current
Stock Availability
56 publicly available
Gene Snapshot
Myc (Myc) encodes a transcription factor that is homologous to vertebrate Myc proto-oncogenes. It contributes to cell growth, cell competition and regenerative proliferation. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

dMyc, dm, diminutive, d-myc, l(1)G0139

Key Links
Genomic Location
Cytogenetic map
3D2-3D4
Sequence location
X:3,373,159..3,391,697 [+]
Recombination map

1-3

RefSeq locus
NC_004354 REGION:3373159..3391697
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (37 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
DNA binding
inferred from direct assay
(assigned by UniProt )
(Gallant et al., 1996)
DNA-binding transcription factor activity
inferred from direct assay
(Kim et al., 2015)
inferred from direct assay
(assigned by UniProt )
(Schreiber-Agus et al., 1997)
protein binding
inferred from physical interaction with FLYBASE:lid; FB:FBgn0031759
(Secombe et al., 2007)
inferred from physical interaction with UniProtKB:Q9V3K3
(assigned by UniProt )
(Bellosta et al., 2005)
inferred from physical interaction with UniProtKB:Q9VH07
(assigned by UniProt )
(Bellosta et al., 2005)
ubiquitin-specific protease binding
inferred from physical interaction with UniProtKB:Q9VC56
(assigned by UniProt )
(Li et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
(Gaudet et al., 2011)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from sequence or structural similarity with UniProtKB:P01106
(assigned by UniProt )
(UniProt Curators, 2002-)
protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (26 terms)
Terms Based on Experimental Evidence (25 terms)
CV Term
Evidence
References
cell competition in a multicellular organism
inferred from mutant phenotype
(Ziosi et al., 2010, de la Cova et al., 2004, Moreno and Basler, 2004)
cellular response to insulin stimulus
inferred from direct assay
(Parisi et al., 2011)
cellular response to nutrient
inferred from direct assay
(Parisi et al., 2011)
DNA endoreduplication
inferred from mutant phenotype
(Maines et al., 2004, Pierce et al., 2004)
embryonic pattern specification
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Orian et al., 2007)
insulin receptor signaling pathway
inferred from direct assay
(Zirin et al., 2019, Parisi et al., 2011, Demontis and Perrimon, 2009)
inferred from genetic interaction with FLYBASE:chico; FB:FBgn0024248
(Wang et al., 2019)
lipid homeostasis
inferred from mutant phenotype
(Parisi et al., 2013)
neurogenesis
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Orian et al., 2007)
nucleologenesis
inferred from mutant phenotype
(Wu et al., 2017)
positive regulation of cell size
inferred from mutant phenotype
(Parisi et al., 2013)
inferred from mutant phenotype
(assigned by UniProt )
(Kuo et al., 2015)
positive regulation of developmental growth
inferred from mutant phenotype
(Teleman et al., 2008)
positive regulation of growth
inferred from mutant phenotype
(Furrer et al., 2010)
positive regulation of imaginal disc growth
inferred from mutant phenotype
(Parisi et al., 2013)
positive regulation of multicellular organism growth
inferred from mutant phenotype
(Parisi et al., 2013)
positive regulation of neurogenesis
inferred from mutant phenotype
(Fernández-Hernández et al., 2013)
positive regulation of organ growth
inferred from mutant phenotype
(Demontis and Perrimon, 2009)
positive regulation of transcription by RNA polymerase I
inferred from direct assay
(Steiger et al., 2008)
positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Kim et al., 2015, Orian et al., 2007)
positive regulation of transcription by RNA polymerase III
inferred from direct assay
(Steiger et al., 2008)
inferred from physical interaction with FLYBASE:Brf; FB:FBgn0038499
(Steiger et al., 2008)
regulation of apoptotic process
inferred from mutant phenotype
(Montero et al., 2008)
regulation of autophagy
inferred from mutant phenotype
(Nagy et al., 2013)
regulation of organ growth
inferred from mutant phenotype
(de la Cova et al., 2004)
regulation of transcription, DNA-templated
inferred from direct assay
(assigned by UniProt )
(Schreiber-Agus et al., 1997, Gallant et al., 1996)
inferred from mutant phenotype
(Hulf et al., 2005)
regulation of trehalose metabolic process
inferred from mutant phenotype
(Parisi et al., 2013)
response to starvation
inferred from mutant phenotype
(Parisi et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
positive regulation of cell growth
traceable author statement
(Bergmann and Lane, 2003)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with histone locus body
inferred from direct assay
(Daneshvar et al., 2011)
nucleus
inferred from direct assay
(assigned by UniProt )
(Kuo et al., 2015, Li et al., 2013)
protein-containing complex
inferred from physical interaction with FLYBASE:gro; FB:FBgn0001139
(Orian et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Protein Function (UniProtKB)
Participates in the regulation of gene transcription (PubMed:8929412, PubMed:16087886, PubMed:24173801, PubMed:24615015, PubMed:25999153, PubMed:25858587). Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG (PubMed:8929412). Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth (PubMed:16087886, PubMed:25999153, PubMed:25858587). Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex (PubMed:25999153). Inhibits the demethylase activity of Lid (PubMed:17311883). Activates transcription of mbm (PubMed:24615015). Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1 (PubMed:25858587). Able to induce the SCF E3 ubiquitin-protein ligase member archipelago (ago) which functions in its degradation (PubMed:15182669, PubMed:24173801). It may therefore create a negative feedback loop with ago that is regulated by the ubiquitin hydrolase puf (PubMed:24173801).
(UniProt, Q9W4S7)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
dm: diminutive
Bristles and body small and slender. Viability excellent. Females sterile. Oocyte cyst development abnormal; nurse-cell nuclei swell in stage 7, subsequently becoming pycnotic (King and Burnett, 1957, Growth 21: 263-80); cuboidal follicle cells covering developing oocyte in stage 8 fail to show normal growth and degenerate rather than becoming columnar (King and Vanoucek, 1960, Growth 24: 333-38). Chambers degenerate around stage 8; phenotype of homozygous dm less severe than that of dm/Df(1)dm (King and Vanoucek). RK1.
Summary (Interactive Fly)

bHLH - leucine zipper - homologous to vertebrate Myc proto-oncogenes - controls cell cycle progression, cell growth, cell competition and regenerative proliferation - suppresses tumor invasion and cell migration by inhibiting the JNK signaling

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Myc or the JBrowse view of Dmel\Myc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.55

Shares 5' exon(s) with downstream non-coding gene; shared promoter.

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Myc-RA
FBtr0070525
NM_080323
3484
717
Myc-RB
FBtr0331605
NM_001272275
9166
717
Additional Transcript Data and Comments
Reported size (kB)

6 (northern blot)

(Gallant et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Myc-PA
FBpp0070501
79.3
717
6.22
NP_525062
AAF45866
Myc-PB
FBpp0303995
79.3
717
6.22
NP_001259204
AGB95050
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

717 aa isoforms: Myc-PA, Myc-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

717 (aa)

(Gallant et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)

Efficient DNA binding requires dimerization with another bHLH protein (PubMed:8929412). Binds DNA as a heterodimer with Max (PubMed:8929412). Interacts with ago (PubMed:15182669, PubMed:24173801). Interacts with lid (PubMed:17311883). Part of a complex containing lid, Myc and ash2 (PubMed:17311883). Component of a complex with pont and rept (PubMed:16087886). Interacts with puf (PubMed:24173801).

(UniProt, Q9W4S7)
Post Translational Modification

Probably targeted for ubiquitination by the SFC ubiquitin ligase complex member ago, leading to its proteasomal degradation.

(UniProt, Q9W4S7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Myc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
extended germ band stage
posterior midgut primordium
(Gallant et al., 1996)
anterior midgut primordium
(Gallant et al., 1996)
oogenesis stage S10 & adult stage | female
nurse cell
(Quinn et al., 2004)
follicle cell
(Quinn et al., 2004)
third instar larval stage
wing disc | restricted

Comment: proliferating regions

(Quinn et al., 2004)
eye disc
(Moberg et al., 2004)
morphogenetic furrow
(Moberg et al., 2004)
embryonic stage 5
organism | restricted

Comment: anterior stripe

(Herr and Harris, 2004)
embryonic stage 7 -- 10
ectoderm
(Herr and Harris, 2004)
embryonic stage 13 -- 16
embryonic/larval midgut primordium
(Herr and Harris, 2004)
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic anal pad
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic salivary gland duct
(Fisher et al., 2012)
embryonic/larval corpus cardiacum
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
embryonic stage 1 -- 3
pole plasm

Comment: maternally deposited

(Fisher et al., 2012)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland body specific anlage

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
salivary gland body primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 4
organism | anterior | posterior
(Gallant et al., 1996)
oogenesis
female germline stem cell
(Rhiner et al., 2009)
female germline cyst
(Rhiner et al., 2009)
second instar larval stage
wing disc | ubiquitous

Comment: 68 hours AEL

(Wu and Johnston, 2010)
early third instar larval stage
wing disc | ubiquitous

Comment: 72-76 hours AEL

(Wu and Johnston, 2010)
wing hinge primordium

Comment: 72-76 hours AEL

(Wu and Johnston, 2010)
wandering third instar larval stage
wing disc | ubiquitous

Comment: 80 hours AEL

(Wu and Johnston, 2010)
wing pouch | restricted

Comment: 87-111 hours AEL

(Wu and Johnston, 2010)
mesothoracic tergum primordium | dorsal

Comment: 87-111 hours AEL

(Wu and Johnston, 2010)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
(Gallant et al., 1996)
embryonic stage 9 -- 17
mesoderm | presumptive
(Gallant et al., 1996)
embryonic stage -- adult stage
(Gallant et al., 1996)
Additional Descriptive Data

Myc is ubiquitously expressed in second instar larval wing discs, and then intensifies at the wing hinge in early third instar larvae.

(Wu and Johnston, 2010)

In wandering third instar larvae, Myc expression intensifies in the dorsal mesothoracic tergum (notum) primoridum and in the wing pouch, but is restricted from the anterior-posterior compartment boundary of the wing disc.

(Wu and Johnston, 2010)

High levels aof Myc expression are observed at the tip of the germarium in germline stem cells and also in late cysts. Myc levels are significantly lower in 1- to 2-day-old cysts.

(Rhiner et al., 2009)

Expression at embryonic stage 5 is observed in an anterior stripe. Expression at embryonic stages 10-11 is observed in the ectoderm and in the developing optic lobes. Expression at embryonic stages 13-16 is observed in the midgut.

(Herr and Harris, 2004)

expression of dm in the eye disc is at low levels, with a stronger stripe immediately posterior to the morphogenetic furrow.

(Moberg et al., 2004)

The dm transcript is detected at higher levels in early embryos and in adult females, and at very low levels in larvae and pupae. Additional transcripts of smaller sizes are found in early embryos and in adult females. In situ hybridization experiments reveal that the dm transcript is at first ubiquitous in early embryogenesis, but that it subsequently becomes concentrated in anterior and posterior regions. During gastrulation, additional dm expression is detected in the presumptive mesoderm, along the ventral midline. The mesodermal expression of dm intensifies at germ band extension, and continues through late embryogenesis. The anterior and posterior staining follow the anterior and posterior midgut primordia through extended germ band stages. dm is also transiently detected in salivary gland placodes. dm is expressed in mitotically dividing, as well as in endoreplicating, tissues. During oogenesis, dm transcript is detected in the germarium and at lower levels in stage 1 and stage 2 egg chambers. From stage 3 onward, dm is detected in all cell types of the eggchamber.

(Gallant et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
embryonic neuroblast
(Orian et al., 2007)
oogenesis
cystoblast
(Neumuller et al., 2008)
female germline stem cell
(Rhiner et al., 2009, Neumuller et al., 2008)
female germline cyst
(Rhiner et al., 2009)
early third instar larval stage
wing disc | ubiquitous

Comment: 72 hours AEL

(Wu and Johnston, 2010)
wing hinge primordium

Comment: 72 hours AEL

(Wu and Johnston, 2010)
wandering third instar larval stage
wing pouch | restricted

Comment: 111 hours AEL

(Wu and Johnston, 2010)
mesothoracic tergum primordium | dorsal

Comment: 111 hours AEL

(Wu and Johnston, 2010)
Additional Descriptive Data

At 72 hours after egg laying (AEL), expression of Myc transiently overlaps with expression of wg in hinge cells and inner ring of the wing disc. In wandering third instar larvae, Myc is expressed in the dorsal mesothoracic tergum (notum) primoridum and in the wing pouch, but is restricted from the anterior-posterior compartment boundary of the wing disc.

(Wu and Johnston, 2010)

High levels aof Myc protein are observed at the tip of the germarium in germline stem cells and also in late cysts. Myc levels are significantly lower in 1- to 2-day-old cysts.

(Rhiner et al., 2009)

Myc is highly expressed in stem cells and cystoblasts but is downregulated in 16-cell cysts.

(Neumuller et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with histone locus body
inferred from direct assay
(Daneshvar et al., 2011)
nucleus
inferred from direct assay
(assigned by UniProt )
(Kuo et al., 2015, Li et al., 2013)
protein-containing complex
inferred from physical interaction with FLYBASE:gro; FB:FBgn0001139
(Orian et al., 2007)
Expression Deduced from Reporters
Reporter: P{GawB}MycPG45
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female & oogenesis
follicle cell
(Zappia et al., 2011, Elalayli et al., 2008)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Myc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Myc
Transgenic constructs containing regulatory region of Myc
Deletions and Duplications ( 41 )
Not disrupted in
Df(1)HC244
(Johnston et al., 1999)
Df(1)HM406
(Kramers et al., 1983)
Df(1)N-54l9
(Kramers et al., 1991, Kramers et al., 1983, Mohler, 1956)
Df(1)N-69h9
(Craymer and Roy, 1980)
Df(1)N-71h
(Craymer and Roy, 1980)
Df(1)Pgd-kz
(Kramers et al., 1991, Eeken et al., 1985)
Df(1)Sp2F-3A
(Schalet, 1986)
Df(1)TEM1
(Kramers et al., 1991)
Df(1)TEM7
(Kramers et al., 1991)
Df(1)TEM202
(Kramers et al., 1991)
Df(1)TEM304
(Kramers et al., 1991, Eeken et al., 1985)
Df(1)TEM501
(Kramers et al., 1991)
Df(1)w67k30
(Kramers et al., 1991)
Df(1)w258-48
(Kramers et al., 1991)
Df(1)w-EM18
(Montgomery et al., 1991)
Df(1)w-rJ1
(Kramers et al., 1991)
Not duplicated in
Dp(1;2;Y)w+
(Kramers et al., 1991, Kramers et al., 1983)
Dp(1;2)76f
(Welshons and Welshons, 1986)
Dp(1;3)wvco
(Schalet, 1986, Eeken et al., 1985)
Dp(1;f)R
(Eeken et al., 1985)
Disrupted in
Df(1)BSC531
(Christensen et al., 2008.6.11)
Df(1)BSC834
(Christensen et al., 2009.7.21)
Df(1)dm75e19
(Johnston et al., 1999, Craymer and Roy, 1980)
Df(1)Exel6233
(Ryder, 2004.4.26)
Df(1)GA102
(Johnston et al., 1999)
Df(1)N-8
(Johnston et al., 1999, Kramers et al., 1991, Eeken et al., 1985, Kramers et al., 1983)
Df(1)N-62b1
(Welshons, 1974)
Df(1)N-264-31
(Slizynska, 1938)
Df(1)N-264-36
(Slizynska, 1938)
Df(1)N-264-38
(Slizynska, 1938)
Df(1)N-264-58
(Demerec, 1940)
Df(1)N-264-105
(Kramers et al., 1991, Kramers et al., 1983)
Df(1)N55l
(Hillman, 1958)
Df(1)N-h77.2
Df(1)wm258-44
In(1)wm4h
(Reuter et al., 1985)
Duplicated in
Dp(1;2)51b
(Judd, 1995, Kramers et al., 1991, Welshons and Welshons, 1986, Kramers et al., 1983, Poulson and Lefevre, 1982, Welshons, 1974)
Dp(1;2)w-ec
(Eeken et al., 1985)
Dp(1;3)DC059
(Popodi, 2010.10.8)
Dp(1;3)DC060
(Popodi et al., 2010-, Venken et al., 2010)
Dp(1;f)A1
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Ncra\QFPsc-ET40
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal | adult stage
lethal | female
lethal | female limited
lethal | heat sensitive, with Scer\GAL4Myc-PG45
lethal | larval stage | recessive
lethal | pharate adult stage
lethal | pupal stage
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4da.G32
lethal - all die before end of P-stage | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL4Cg.PA
lethal - all die before end of pupal stage | recessive
partially lethal
partially lethal, with Scer\GAL4Act5C.PU
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4c42
partially lethal - majority die, with Scer\GAL4tsh-c724
partially lethal - majority die | larval stage | recessive
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
female sterile (with Myc2)
female sterile (with Myc3)
female sterile (with Mycdm-1)
female sterile (with MycPG45)
female sterile | germline clone
female sterile | recessive
fertile
male sterile
Other Phenotypes
Allele
body size defective | adult stage
cell growth defective, with Scer\GAL4Aug21
cell growth defective | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP
cell growth defective | somatic clone
cell growth defective | somatic clone, with Scer\GAL4Act5C.PP
cell migration defective, with Scer\GAL4ptc-559.1
decreased cell death | recessive
decreased cell growth | somatic clone
decreased cell number, with Scer\GAL4Cg.PA
decreased cell number | adult stage
decreased cell number | adult stage, with Scer\GAL4en-e16E
decreased cell number | larval stage, with Scer\GAL4insc-Mz1407
decreased cell number | larval stage | somatic clone
decreased cell number | recessive
decreased cell number | somatic clone
decreased cell number | somatic clone, with Scer\GAL4αTub84B.PP
decreased cell number | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
decreased cell size
decreased cell size, with Scer\GAL4Cg.PA
decreased cell size, with Scer\GAL4en.PU
decreased cell size, with Scer\GAL4ppl.PU
decreased cell size | adult stage
decreased cell size | cell non-autonomous | somatic clone
decreased cell size | germline clone
decreased cell size | somatic clone
decreased cell size | third instar larval stage
developmental rate defective
developmental rate defective, with Scer\GAL4Cg.PA
developmental rate defective | nutrition conditional
developmental rate defective | recessive
endomitotic cell cycle defective, with Scer\GAL4moody.PS
endomitotic cell cycle defective, with Scer\GAL4ptc-559.1
endomitotic cell cycle defective | somatic clone, with Scer\GAL4Act5C.PP
endomitotic cell cycle defective | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
increased cell death, with Scer\GAL4ap-md544
increased cell death, with Scer\GAL4dpp.blk1
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4αTub84B.PC
increased cell death | cell non-autonomous, with Scer\GAL4dpp.blk1
increased cell death | cell non-autonomous | somatic clone
increased cell death | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP
increased cell death | larval stage, with Scer\GAL4ey.PU, MycP0
increased cell death | larval stage, with Scer\GAL4ey.PU, MycUAS.AB
increased cell death | larval stage, with Scer\GAL4ey.PU, MycUAS.PII
increased cell death | larval stage, with Scer\GAL4ey.PU, MycUAS.PV
increased cell death | larval stage, with Scer\GAL4ey.PU, MycUAS.WT
increased cell death | somatic clone
increased cell death | somatic clone, with Scer\GAL4Act5C.PP
increased cell death | somatic clone, with Scer\GAL4hh.PU
increased cell growth | somatic clone
increased cell growth | somatic clone, with Scer\GAL4Act5C.CoinFLP-FRT
increased cell growth | somatic clone, with Scer\GAL4Act5C.PI
increased cell growth | somatic clone | third instar larval stage, with Scer\GAL4unspecified
increased cell number, with Scer\GAL4Cg.PA
increased cell number | cell autonomous | somatic clone
increased cell number | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
increased cell number | third instar larval stage, with Scer\GAL4repo.PU
increased cell size, with Scer\GAL4Cg.PA
increased cell size, with Scer\GAL4en.PU
increased cell size, with Scer\GAL4GMR.PF
increased cell size, with Scer\GAL4ppl.PU
increased cell size, with Scer\GAL4ptc-559.1
increased cell size | adult stage, with Scer\GAL4en-e16E
increased cell size | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | larval stage | somatic clone, with Scer\GAL4en-e16E
increased cell size | somatic clone, with Scer\GAL4Act5C.PI
increased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | somatic clone, with Scer\GAL4αTub84B.PL
increased cell size | somatic clone, with Scer\GAL4αTub84B.PP
increased occurrence of cell division | larval stage, with Scer\GAL4bbg-C96
increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4αTub84B.PL
large body, with Scer\GAL4Cg.PA
long lived | dominant
mitotic cell cycle defective, with Scer\GAL4Act5C.PP
mitotic cell cycle defective | somatic clone, with Scer\GAL4Act5C.PP
neoplasia | third instar larval stage, with Scer\GAL4repo.PU
neuroanatomy defective | larval stage, with Scer\GAL4insc-Mz1407
neuroanatomy defective | temperature conditional, with Scer\GAL4hs.PU
neuroanatomy defective | third instar larval stage, with Scer\GAL4repo.PU
radiation sensitive | recessive
short lived, with Scer\GAL4Act.PU, Scer\GAL80ts.αTub84B
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
size defective
size defective, with Scer\GAL4en-e16E
size defective, with Scer\GAL4ey.PU, MycP0
size defective, with Scer\GAL4ey.PU, MycUAS.WT
size defective, with Scer\GAL4GMR.PU
size defective, with Scer\GAL4ptc-559.1
size defective | adult stage, with Scer\GAL4en-e16E
size defective | adult stage, with Scer\GAL4ey.PU, MycP0
size defective | adult stage, with Scer\GAL4ey.PU, MycUAS.AB
size defective | adult stage, with Scer\GAL4ey.PU, MycUAS.PI
size defective | adult stage, with Scer\GAL4ey.PU, MycUAS.PII
size defective | adult stage, with Scer\GAL4ey.PU, MycUAS.PV
size defective | adult stage, with Scer\GAL4GMR.PF
size defective | larval stage, with Scer\GAL4ptc-559.1
size defective | larval stage | somatic clone
size defective | somatic clone, with Scer\GAL4Act5C.PI
size defective | third instar larval stage, with Scer\GAL4ptc-559.1
small body
small body, with Scer\GAL4Cg.PA
small body | adult stage, with Scer\GAL4Ilp2.PR
small body | dominant | third instar larval stage
small body | female (with Myc2)
small body | female (with Myc3)
small body | female (with Mycdm-1)
small body | female | recessive
small body | larval stage
small body | larval stage, with Scer\GAL4da.G32
small body | larval stage | recessive
small body | male | recessive
small body | pupal stage | recessive
some die during larval stage
some die during larval stage, with Scer\GAL4da.G32
some die during pharate adult stage | recessive
some die during pupal stage
some die during pupal stage | recessive
starvation stress response defective, with Scer\GAL4Cg.PA
starvation stress response defective | recessive
starvation stress response defective | somatic clone, with Scer\GAL4unspecified
visible
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4ptc-559.1
visible | adult stage
visible | adult stage, with Scer\GAL4GMR.PF
visible | conditional
visible | recessive
visible | somatic clone
wild-type
wound healing defective
Phenotype manifest in
Allele
1st posterior cell, with Scer\GAL4ptc-559.1
abdominal dorsal adult muscle precursor cell | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
abdominal lateral adult muscle precursor cell | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
abdominal ventral adult muscle precursor cell | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
adult
adult Malpighian tubule, with Scer\GAL4c42
adult Malpighian tubule, with Scer\GAL4tsh-c724
cell, with Scer\GAL4Act5C.PP
cell, with Scer\GAL4bbg-C96
cell, with Scer\GAL4en-e16E
cell cycle, with Scer\GAL4Act5C.PP
cell cycle, with Scer\GAL4bbg-C96
chaeta
dorsal-ventral compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4sd-SG29.1
embryonic/larval brain | third instar larval stage, with Scer\GAL4repo.PU
embryonic/larval dorsal branch 7, with Scer\GAL4bs-1348
embryonic/larval dorsal branch, with Scer\GAL4bs-1348
embryonic/larval fat body
embryonic/larval fat body | somatic clone, with Scer\GAL4unspecified
embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4unspecified
embryonic/larval glial cell | third instar larval stage, with Scer\GAL4repo.PU
embryonic/larval midgut
embryonic/larval salivary gland
embryonic/larval salivary gland | larval stage, with Scer\GAL4ptc-559.1
embryonic/larval trachea, with Scer\GAL4bs-1348
eye
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | somatic clone
eye | somatic clone, with Scer\GAL4Act5C.CoinFLP-FRT
eye | somatic clone, with Scer\GAL4Act5C.PI
eye disc, with Scer\GAL4GMR.PF
eye disc | third instar larval stage, with Scer\GAL4repo.PU
eye photoreceptor cell, with Scer\GAL4ey.PU, MycP0
eye photoreceptor cell, with Scer\GAL4ey.PU, MycUAS.AB
eye photoreceptor cell, with Scer\GAL4ey.PU, MycUAS.PII
eye photoreceptor cell, with Scer\GAL4ey.PU, MycUAS.PV
eye photoreceptor cell, with Scer\GAL4ey.PU, MycUAS.WT
eye photoreceptor cell, with Scer\GAL4GMR.PF
fat body | somatic clone, with Scer\GAL4αTub84B.PP
follicle cell
follicle cell & nucleus | somatic clone
follicle cell & nucleus | somatic clone, with Scer\GAL4Act5C.PP
germline cell
glial cell, with Scer\GAL4repo.PU
larva | third instar larval stage
larval salivary gland & nucleolus, with Scer\GAL4en-e16E
lateral G branch 7, with Scer\GAL4bs-1348
lateral G branch, with Scer\GAL4bs-1348
lipid droplet, with Scer\GAL4Cg.PA
macrochaeta
macrochaeta | female (with Myc2)
macrochaeta | female (with Myc3)
macrochaeta | female (with Mycdm-1)
mesothoracic tergum | cell non-autonomous | pupal stage | somatic clone
mesothoracic tergum | pupal stage | somatic clone, with Scer\GAL4FRT.Act5C
microchaeta
mitochondrion
mitochondrion | somatic clone
mitotic cell cycle, with Scer\GAL4Act5C.PP
mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
neuroblast | temperature conditional, with Scer\GAL4hs.PU
nucleolus, with Scer\GAL4en-e16E
nucleolus, with Scer\GAL4ptc-559.1
nucleolus, with Scer\GAL4sca-109-68
nucleolus | larval stage, with Scer\GAL4insc-Mz1407
nucleolus | somatic clone
nucleus, with Scer\GAL4ptc-559.1
nucleus, with Scer\GAL4sca-109-68
nurse cell
nurse cell & actin filament
nurse cell & nucleus | germ-line clone
nurse cell | germline clone
ommatidium
ommatidium, with Scer\GAL4Cg.PA
ommatidium, with Scer\GAL4ey.PU, MycP0
ommatidium, with Scer\GAL4ey.PU, MycUAS.AB
ommatidium, with Scer\GAL4ey.PU, MycUAS.PI
ommatidium, with Scer\GAL4ey.PU, MycUAS.PII
ommatidium, with Scer\GAL4ey.PU, MycUAS.PV
ommatidium, with Scer\GAL4ey.PU, MycUAS.WT
ommatidium, with Scer\GAL4GMR.PB
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PU
ommatidium | somatic clone
ommatidium | somatic clone, with Scer\GAL4αTub84B.PBb
oocyte | oogenesis stage S11
ovary | germline clone
pigment cell, with Scer\GAL4GMR.PF
posterior scutellar bristle, with Scer\GAL4sca-109-68
pupa
ring canal, with Scer\GAL4Aug21
rough endoplasmic reticulum, with Scer\GAL4ptc-559.1
salivary gland | somatic clone, with Scer\GAL4Act5C.PP
secondary neuroblast | larval stage, with Scer\GAL4insc-Mz1407
subperineurial glial cell, with Scer\GAL4moody.PS
tracheal lumen, with Scer\GAL4bs-1348
trichogen cell, with Scer\GAL4sca-109-68
ventral nerve cord primordium, with Scer\GAL4rho.PU
wing
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4Bx-MS1096-KE
wing, with Scer\GAL4Cg.PA
wing, with Scer\GAL4ppl.PU
wing, with Scer\GAL4αTub84B.PC
wing | conditional
wing | posterior, with Scer\GAL4en.PU
wing | posterior, with Scer\GAL4en-e16E
wing basal cell 1, with Scer\GAL4ptc-559.1
wing blade
wing disc
wing disc, with Scer\GAL4ap-md544
wing disc, with Scer\GAL4ptc-559.1
wing disc | cell non-autonomous | somatic clone
wing disc | larval stage | somatic clone
wing disc | larval stage | somatic clone, with Scer\GAL4Act5C.PP
wing disc | larval stage | somatic clone, with Scer\GAL4en-e16E
wing disc | somatic clone
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing disc | third instar larval stage, with Scer\GAL4ptc-559.1
wing disc posterior compartment
wing posterior compartment, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MYC
6 of 15
Yes
Yes
 
5  
Hsap\MYCL
2 of 15
No
Yes
Hsap\MYCN
2 of 15
No
Yes
Hsap\MAX
1 of 15
No
No
Hsap\MNT
1 of 15
No
No
Hsap\MXD1
1 of 15
No
Yes
Hsap\MXD3
1 of 15
No
No
Hsap\MXD4
1 of 15
No
Yes
Hsap\MXI1
1 of 15
No
No
Hsap\MYCLP1
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Myc
6 of 15
Yes
Yes
Mmus\Mycl
2 of 15
No
Yes
Mmus\Mycn
2 of 15
No
Yes
Mmus\Mycs
2 of 15
No
Yes
Mmus\Bmyc
1 of 15
No
Yes
Mmus\Max
1 of 15
No
No
Mmus\Mnt
1 of 15
No
No
Mmus\Mxd1
1 of 15
No
Yes
Mmus\Mxd3
1 of 15
No
No
Mmus\Mxd4
1 of 15
No
Yes
Mmus\Mxi1
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Myc
4 of 13
Yes
Yes
Rnor\Bmyc
1 of 13
No
Yes
Rnor\Mnt
1 of 13
No
No
Rnor\Mxd1
1 of 13
No
Yes
Rnor\Mxd3
1 of 13
No
Yes
Rnor\Mxd4
1 of 13
No
Yes
Rnor\Mxi1
1 of 13
No
Yes
Rnor\Mycl
1 of 13
No
Yes
Rnor\Mycn
1 of 13
No
Yes
Rnor\Mycs
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
Xtro\myc
4 of 12
Yes
Yes
Xtro\max
1 of 12
No
No
Xtro\mnt
1 of 12
No
No
Xtro\mxd3
1 of 12
No
No
Xtro\mxd4
1 of 12
No
Yes
Xtro\mxi1
1 of 12
No
Yes
Xtro\mycl
1 of 12
No
Yes
Xtro\mycn
1 of 12
No
Yes
Danio rerio (Zebrafish) (12)
Drer\mycb
4 of 15
Yes
Yes
Drer\myca
3 of 15
No
Yes
Drer\mych
2 of 15
No
Yes
Drer\max
1 of 15
No
No
Drer\mntb
1 of 15
No
No
Drer\mxd1
1 of 15
No
Yes
Drer\mxd3
1 of 15
No
No
Drer\mxd4
1 of 15
No
Yes
Drer\mxi1
1 of 15
No
No
Drer\mycla
1 of 15
No
Yes
Drer\myclb
1 of 15
No
Yes
Drer\mycn
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\mdl-1
1 of 15
Yes
No
Cele\mxl-1
1 of 15
Yes
No
Cele\mxl-3
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190G6S )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006088
Drosophila simulans
Dsim\GD16640
Drosophila sechellia
Dsec\GM19268
Drosophila erecta
Dere\GG18655
Drosophila yakuba
Dyak\GE16299
Drosophila ananassae
Dana\GF19606
Drosophila pseudoobscura pseudoobscura
Dpse\GA10565
Drosophila persimilis
Dper\GL13122
Drosophila willistoni
Dwil\GK24977
Drosophila virilis
Dvir\GJ18771
Drosophila mojavensis
Dmoj\GI14431
Drosophila grimshawi
Dgri\GH12538
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CE1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013208
Glossina morsitans
Tsetse fly
Gmor\GMOY005597
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06542
Mayetiola destructor
Hessian fly
Mdes\Mdes017407
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL017286
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009795
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EP1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS212323-PA
Apis mellifera
Western honey bee
Amel\GB53503
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24146
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25134
Bombus terrestris
Buff-tailed bumblebee
Bter\15208239
Linepithema humile
Argentine ant
Lhum\LH22754
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12281
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EQT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012418
Strigamia maritima
European centipede
Smar\SMAR008056
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67911.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g00120
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_7346
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Max
1 of 10
Mnt
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
MYC; MYC proto-oncogene, bHLH transcription factor
model of  Burkitt lymphoma
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MYC; MYC proto-oncogene, bHLH transcription factor
6 of 15
190080
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Myc
Hsap\MYC
(Benassayag et al., 2005)
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser
View in Interactions Browser
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Myc - Act57B
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Arc1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Atac3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Atu
anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, pull down, autoradiography, proximity ligation assay, fluorescence microscopy
(Gerlach et al., 2017)
Myc - Brf
anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography
(Steiger et al., 2008)
Myc - CCT1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - CG13775
two hybrid array
(Shokri et al., 2019)
Myc - CG1620
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - CG30122
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - CG31550
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - CG34132
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - CG4360
two hybrid array
(Shokri et al., 2019)
Myc - CaMKII
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Capr
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - CkIIα
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Ctf4
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Ctr9
anti tag coimmunoprecipitation, anti tag western blot
(Gerlach et al., 2017)
Myc - Ets21C
two hybrid array
(Shokri et al., 2019)
Myc - Hcf
pull down, autoradiography, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation
(Furrer et al., 2010)
Myc - Hsc70-3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Max
anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, Identification by mass spectrometry
(Vinayagam et al., 2016, Steiger et al., 2008, Orian et al., 2007)
Myc - Mlc-c
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Ns3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Nup50
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Osbp
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - PIP4K
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Prp19
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL10Ab
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL13A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL17
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL18A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL19
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL23A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL28
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL30
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL4
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL6
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpL7A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpLP1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpLP2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpS16
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpS17
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpS23
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpS6
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpS7
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - RpS9
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Sarm
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - TBPH
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Usp10
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - Vha26
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - ago
two hybrid, anti tag coimmunoprecipitation, western blot, anti tag western blot, tandem affinity purification, Identification by mass spectrometry
(Moberg et al., 2004)
Myc - ana2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - ash2
anti bait coimmunoprecipitation, western blot
(Secombe et al., 2007)
Myc - atms
anti tag coimmunoprecipitation, anti tag western blot
(Gerlach et al., 2017)
Myc - bif
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - brm
anti bait coimmunoprecipitation, western blot
(Secombe et al., 2007)
Myc - cindr
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - fliI
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - gro
pull down, autoradiography, anti tag western blot, anti bait coimmunoprecipitation, western blot
(Orian et al., 2007)
Myc - gw
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - hang
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - hyd
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - hyx
anti tag coimmunoprecipitation, western blot
(Gerlach et al., 2017)
Myc - iPLA2-VIA
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - kst
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - l(2)09851
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - larp
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - lid
anti bait coimmunoprecipitation, western blot, pull down, autoradiography
(Li et al., 2010, Secombe et al., 2007)
Myc - lqfR
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - lva
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - mask
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - msn
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - nito
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - org-1
two hybrid array
(Shokri et al., 2019)
Myc - pcm
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - puf
anti bait coimmunoprecipitation, western blot
(Li et al., 2013)
Myc - rin
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - rump
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - sip2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - smid
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - ssx
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - sta
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - toy
two hybrid array
(Shokri et al., 2019)
Myc - wuho
anti tag coimmunoprecipitation, western blot
(Rastegari et al., 2020)
Myc - yps
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - zda
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Myc - α-Spec
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
RNA-protein
Physical Interaction
Assay
References
Myc - BicC
anti bait coimmunoprecipitation, quantitative reverse transcription pcr
(Gamberi et al., 2017)
Myc - brat
anti tag coimmunoprecipitation, primer specific pcr
(Loedige et al., 2015)
RNA-RNA
Physical Interaction
Assay
References
Myc - mir-308
quantitative reverse transcription pcr, western blot
(Daneshvar et al., 2013)
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Myc
suppressible
ago
(Li et al., 2013, Moberg et al., 2004)
Myc
enhanceable
ago
(Li et al., 2013, Secombe et al., 2007)
Myc
suppressible
ash2
(Furrer et al., 2010, Secombe et al., 2007)
Myc
suppressible
Asx
(Secombe et al., 2007)
Myc
suppressible
Atg1
(Nagy et al., 2013)
Myc
suppressible
Atg8a
(Nagy et al., 2013)
Myc
suppressible
Atg17
(Nagy et al., 2013)
Myc
suppressible
Atg18a
(Nagy et al., 2013)
Myc
suppressible
brm
(Secombe et al., 2007)
Myc|ref(2)P
suppressible
cnc
(Nagy et al., 2013)
Myc
suppressible
cnc
(Nagy et al., 2013)
Myc
suppressible
Desat1
(Parisi et al., 2013)
Myc
suppressible
dia
(Levayer et al., 2015)
Myc
suppressible
Diap1
(Levayer et al., 2015)
Myc
suppressible
Dp
(Reis and Edgar, 2004)
Myc
suppressible
dpp
(Moreno and Basler, 2004)
Myc
suppressible
Ets97D
(Baltzer et al., 2009)
Myc
suppressible
fwe
(Rhiner et al., 2010)
Myc
suppressible
Gcn5
(Furrer et al., 2010, Secombe et al., 2007)
Myc
suppressible
hay
(Lee et al., 2015)
Myc
enhanceable
Hcf
(Furrer et al., 2010)
Myc
suppressible
Hcf
(Furrer et al., 2010)
Myc
suppressible
hep
(de la Cova et al., 2004)
Myc
enhanceable
hfp
(Quinn et al., 2004)
Myc
suppressible
hfp
(Quinn et al., 2004)
Myc
suppressible
Ilp5
(Parisi et al., 2013)
Myc
suppressible
Keap1
(Nagy et al., 2013)
Myc|ref(2)P
suppressible
Keap1
(Nagy et al., 2013)
Myc
enhanceable
lid
(Li et al., 2010, Secombe et al., 2007)
Myc
suppressible
lid
(Secombe et al., 2007)
Myc
suppressible
LTV1
(Kim et al., 2015)
Myc
suppressible
Max
(Steiger et al., 2008, Steiger et al., 2008)
Myc
suppressible
mir-308
(Daneshvar et al., 2013)
Myc
suppressible
Mnt
(Steiger et al., 2008, Steiger et al., 2008)
Myc
suppressible
mor
(Secombe et al., 2007)
Myc
suppressible
nclb
(Liu et al., 2017)
Myc
suppressible
p53
(de la Cova et al., 2014)
Myc
suppressible
PEK
(Nagy et al., 2013)
Myc
suppressible
Pi3K59F
(Nagy et al., 2013)
Myc
enhanceable
pont
(Bellosta et al., 2005)
Myc
suppressible
pont
(Bellosta et al., 2005)
Myc
suppressible
puc
(Moreno and Basler, 2004)
Myc
suppressible
puf
(Li et al., 2013)
ago|Myc
suppressible
puf
(Li et al., 2013)
Myc
enhanceable
puf
(Li et al., 2013)
ago|Myc
enhanceable
puf
(Li et al., 2013)
Myc
suppressible
put
(Moreno and Basler, 2004)
Myc
suppressible
Rab5
(Moreno and Basler, 2004)
Myc
suppressible
ref(2)P
(Nagy et al., 2013)
Myc
enhanceable
rept
(Bellosta et al., 2005)
Myc
suppressible
RpI135
(Grewal et al., 2005)
Myc
suppressible
RpL8
(Xu et al., 2008)
Myc
suppressible
run
(Kappes et al., 2011)
Myc
suppressible
sc
(Kappes et al., 2011)
Myc
suppressible
shg
(Levayer et al., 2015)
Myc
enhanceable
Sin3A
(Das et al., 2013)
Myc
suppressible
sisA
(Kappes et al., 2011)
Myc
suppressible
Snr1
(Secombe et al., 2007)
Myc
suppressible
SPARC
(Portela et al., 2010)
Myc
enhanceable
SPARC
(Portela et al., 2010)
Myc
suppressible
sqh
(Levayer et al., 2015)
Myc
suppressible
su(Hw)
(Lindsley and Grell, 1968)
Myc
suppressible
Su(z)2
(Secombe et al., 2007)
Myc
suppressible
tkv
(Moreno and Basler, 2004)
Myc
suppressible
vito
(Marinho et al., 2011)
Myc
enhanceable
yki
(Reddy and Irvine, 2011)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
BicC
suppressible
Myc
(Gamberi et al., 2017)
brat
suppressible
Myc
(Reichardt et al., 2018)
brk
suppressible
Myc
(Doumpas et al., 2013)
CNBP
suppressible
Myc
(Antonucci et al., 2014)
crol
suppressible
Myc
(Mitchell et al., 2008)
dac
enhanceable
Myc
(Jiao et al., 2001)
Dcr-1
suppressible
Myc
(Herranz et al., 2010)
ds
enhanceable
Myc
(Ziosi et al., 2010)
dup
suppressible
Myc
(Unhavaithaya and Orr-Weaver, 2012)
ex
enhanceable
Myc
(Ziosi et al., 2010)
ft
enhanceable
Myc
(Ziosi et al., 2010)
gsb
suppressible
Myc
(Jiao et al., 2001)
hay|hfp
suppressible
Myc
(Lee et al., 2015)
hfp
suppressible
Myc
(Lee et al., 2015)
HUWE1
suppressible
Myc
(Yanku et al., 2018)
l(2)gl
suppressible
Myc
(Froldi et al., 2010)
L
suppressible
Myc
(Wang and Huang, 2009)
Larp4B
suppressible
Myc
(Funakoshi et al., 2018)
lid
enhanceable
Myc
(Secombe et al., 2007)
LTV1
suppressible
Myc
(Kim et al., 2015)
Mef2
suppressible
Myc
(Jiao et al., 2001)
mir-308
suppressible
Myc
(Daneshvar et al., 2013)
mir-ban
suppressible
Myc
(Wu et al., 2017, Reddy and Irvine, 2011)
N
suppressible
Pink1|Myc
(Lee et al., 2013)
N
suppressible
Myc
(Djiane et al., 2013, Lee et al., 2013, Orian et al., 2007)
N
suppressible
Marf|Myc
(Lee et al., 2013)
Nipped-B
suppressible
Myc
(Wu et al., 2015)
numb
suppressible
Myc
(Wu et al., 2017)
numb
suppressible
HUWE1|Myc
(Wu et al., 2017)
Pi3K21B
suppressible
Myc
(Pierce et al., 2004)
Pi3K92E|btl::Egfr
suppressible
Myc
(Read et al., 2009)
Poxm
suppressible
Myc
(Jiao et al., 2001)
Poxn
suppressible
Myc
(Jiao et al., 2001)
prd
suppressible
Myc
(Xue and Noll, 2002, Jiao et al., 2001)
puf
enhanceable
Myc
(Li et al., 2013)
puf
suppressible
Myc
(Li et al., 2013)
Ras85D
suppressible
Myc
(Prober and Edgar, 2000)
REG
suppressible
Myc
(Li et al., 2015)
sim
suppressible
Myc
(Jiao et al., 2001)
sv
suppressible
Myc
(Jiao et al., 2001)
Sxl
suppressible
Myc
(Kappes et al., 2011)
Tor
suppressible
Myc
(Wang and Huang, 2009, Hennig and Neufeld, 2002)
Tsc1|gig
suppressible
Myc
(Tapon et al., 2001)
upd1
suppressible
Myc
(Mukherjee et al., 2006)
yki
enhanceable
Myc
(Reddy and Irvine, 2011)
yki
suppressible
Myc
(Reddy and Irvine, 2011, Neto-Silva et al., 2010, Ziosi et al., 2010)
External Data
Subunit Structure (UniProtKB)
Efficient DNA binding requires dimerization with another bHLH protein (PubMed:8929412). Binds DNA as a heterodimer with Max (PubMed:8929412). Interacts with ago (PubMed:15182669, PubMed:24173801). Interacts with lid (PubMed:17311883). Part of a complex containing lid, Myc and ash2 (PubMed:17311883). Component of a complex with pont and rept (PubMed:16087886). Interacts with puf (PubMed:24173801).
(UniProt, Q9W4S7 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map

1-3

Cytogenetic map
3D2-3D4
Sequence location
X:3,373,159..3,391,697 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
3D2-3D4
Limits computationally determined from genome sequence between P{EP}dncEP973 and P{EP}PargEP351; Left limit from in situ hybridisation (FBrf0125103) Right limit from in situ hybridisation (FBrf0125103)
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
3D3-3D4
(determined by in situ hybridisation)
(Peter et al., 2002, Schäfer et al., 1999.8.12)
3D1-3D4
(determined by in situ hybridisation)
(Schäfer et al., 1999.12.2)
3D4-3D7
(Schreiber-Agus, 1996.12.9)
3D5-3D5
(Gallant, 1996.11.4)
3D4-3D7
(determined by in situ hybridisation)
(Schreiber-Agus et al., 1997)
3D5-3D5
(determined by in situ hybridisation)
(Gallant et al., 1996)
Experimentally Determined Recombination Data
Location

1-3

(FlyBase, 2016)

1-3.1

(Comeron et al., 2012)

1-4.0

Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (56)
Genomic Clones (23)
cDNA Clones (56)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Myc dm

    (Edgar et al., 2015.4.9)
    Source for database merge of

    Source for merge of: dm anon-WO03040301.171

    (Peter et al., 2002, FlyBase, 1996-)

    Source for merge of: dm l(1)G0354 l(1)G0359

    (Neto-Silva et al., 2010)
    Additional comments

    Changed from 'dm' ('diminutive') to 'Myc' to reflect preferred usage in the Drosophila literature and facilitate access to information on this gene for naive/non-Drosophila researchers.

    (Edgar et al., 2015.4.9)

    "l(1)G0354" may affect "dm".

    (Peter et al., 2002)

    Source for merge of dm anon-WO03040301.171 was sequence comparison ( date:051113 ).

    (Peter et al., 2002, FlyBase, 1996-)

    "l(1)G0359" may affect "dm".

    (Peter et al., 2002)
    Other Comments

    dm expression stimulates glycolysis but impairs oxidative phosphorylation.

    (de la Cova et al., 2014)

    Expansion of dm cell populations requires p53 only during competition.

    (de la Cova et al., 2014)

    dm activates Sxl in males.

    (Kappes et al., 2011)

    Many activities of the dm protein do not, or only partly, require association with the Max protein.

    (Steiger et al., 2008)

    S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show a slowing down in G1 phase and a decrease in cell size in all phases of the cell cycle.

    (Hulf et al., 2005)

    Targets for transcriptional regulation by the dm product are characterized by the presence of an E-box, typically within the first 100 nucleotides of the promoter.

    (Hulf et al., 2005)

    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    (Boutros et al., 2004)

    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    (Boutros et al., 2004)

    dm plays an essential role in promoting the rapid growth that must occur in both the germline and the surrounding follicle cells for oogenesis to proceed.

    (Maines et al., 2004)

    Mutations in dm and Cdk4 do not induce autophagy in the fat body.

    (Scott et al., 2004)

    dm regulates organ size by inducing cell competition.

    (de la Cova et al., 2004)

    dm links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism. wg patterns growth in the wing primordium by modulating dm expression.

    (Johnston et al., 1999)

    Loss of function mutations cause a growth disadvantage. Over-expression causes a growth advantage. Neither loss of dm nor its overexpression causes pattern abnormalities.

    (Johnston et al., 1999)

    Myc is isolated from an embryonic library by interacting with mouse MaxΔ9 bait protein in the yeast two-hybrid assay. The ability of P-element-mediated ectopic expression of Myc to reverse a subset of the phenotypic alterations associated with the dm mutation suggests that dm may correspond to Myc. This finding, along with the localisation of Myc expression to zones of high proliferative activity in the embryo, implicates Myc as an integral regulator of growth and development.

    (Schreiber-Agus et al., 1997)

    The product of dm has been isolated as a binding partner for human Max in a two hybrid library screen.

    (Gallant et al., 1996)
    Origin and Etymology
    Discoverer

    Nichols-Skoog, 9th Oct. 1933.

    Etymology

    Named 'Myc' after the human ortholog.

    (Edgar et al., 2015.4.9)
    Identification
    External Crossreferences and Linkouts ( 52 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (32)
    Reported As
    Symbol Synonym
    CG10798
    (Moskalev et al., 2018, Hosono et al., 2015, Antonucci et al., 2014, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Baltzer et al., 2009, Demontis and Perrimon, 2009, Keleman et al., 2009.8.5, Krejcí et al., 2009, Perkins et al., 2009.1.15, Stevens et al., 2008, Stevens et al., 2008, Gandhi et al., 2007, Quinones-Coello, 2007, Bourbon et al., 2002)
    D-Myc
    (Jiao et al., 2001)
    DM
    (Joyce et al., 2012, Papatheodorou et al., 2012)
    DMYc
    (Diffley and Evan, 2000)
    Dm
    (Cordero et al., 2012, Krejcí et al., 2009)
    Dmyc
    (Gallant et al., 2001)
    EG:BACN5I9.1
    MYC
    (Mirzoyan et al., 2019, Percival-Smith, 2017, Grifoni and Bellosta, 2015, Ferrandon, 2013, Papatheodorou et al., 2012, van Steensel et al., 2010)
    Myc
    (Baker et al., 2019, Chen and Read, 2019, Coelho and Moreno, 2019, Fahey-Lozano et al., 2019, Grendler et al., 2019, Khezri and Rusten, 2019, Lahvic and Hariharan, 2019, Mazaud et al., 2019, Ramanathan et al., 2019, Sanchez et al., 2019, Schaub et al., 2019, Shokri et al., 2019, Singh et al., 2019, Skouloudaki et al., 2019, Su et al., 2019, Tiwari et al., 2019, Zirin et al., 2019, Akishina et al., 2018, Alpar et al., 2018, Kale et al., 2018, Lee et al., 2018, Li et al., 2018, Rust et al., 2018, Sollazzo et al., 2018, Sriskanthadevan-Pirahas et al., 2018, Von Stetina et al., 2018, Xu et al., 2018, Akishina et al., 2017, Atkinson et al., 2017, Chen et al., 2017, Gerlach et al., 2017, Hariharan and Serras, 2017, Lee et al., 2017, Liu et al., 2017, Ma et al., 2017, Paiardi et al., 2017, Tauc et al., 2017, Transgenic RNAi Project members, 2017-, Wu et al., 2017, Xiang et al., 2017, Xu et al., 2017, Atkins et al., 2016, Gallant, 2016.4.26, Gallant, 2016.4.26, Harris et al., 2016, Jaszczak and Halme, 2016, Levayer and Moreno, 2016, Merino et al., 2016, Oyallon et al., 2016, Suijkerbuijk et al., 2016, Yadav et al., 2016, Das and Dobens, 2015, Doggett et al., 2015, Edgar et al., 2015.4.9, Enzo et al., 2015, Fernando et al., 2015, Gogna et al., 2015, Grewal, 2015, He et al., 2015, Herter et al., 2015, Li et al., 2015, Nagy et al., 2015, Pitoniak and Bohmann, 2015, Schertel et al., 2015, Spratford and Kumar, 2015, Hovhanyan et al., 2014, Wang et al., 2014, Das et al., 2013, Doumpas et al., 2013, Ibar et al., 2013, Ilanges et al., 2013, Levayer and Moreno, 2013, Nagy et al., 2013, Ren et al., 2013, Chen et al., 2012, Cordero et al., 2012, Fausti et al., 2012, Marshall et al., 2012, Pirooznia et al., 2012, Baker, 2011, Daneshvar et al., 2011, Hogan et al., 2011, Qian et al., 2011, Read, 2011, Reddy and Irvine, 2011, Vincent et al., 2011, Furrer et al., 2010, Li et al., 2010, Hamaratoglu et al., 2009, Nuzhdin et al., 2009, Read et al., 2009, Schwinkendorf and Gallant, 2009, Xiong et al., 2009, Simcox et al., 2008, Smith-Bolton et al., 2008, Steiger et al., 2008, Wang et al., 2008, Berry and Baehrecke, 2007, Goodliffe et al., 2007, Li and Baker, 2007, Mortimer and Moberg, 2007, Rodrigues and Bach, 2007, Axelrod, 2006, Nolo et al., 2006, Vidal and Cagan, 2006, Wodarz and Gonzalez, 2006, Perez-Garijo et al., 2005, Ralston and Blair, 2005, Donaldson and Duronio, 2004, Lipsick, 2004, Moberg et al., 2004, Scott et al., 2004, Neufeld, 2003, Orian et al., 2003, Orian et al., 2003, Ryoo and Steller, 2003, Xue and Noll, 2002, Foley and Sprenger, 2000, Wan et al., 2000)
    anon-WO03040301.171
    bHLHe57
    (Stevens et al., 2008)
    c-MYC
    (Jin et al., 2004)
    c-Myc
    (Atkey et al., 2006, Findlay et al., 2005)
    c-myc
    (Arbouzova and Zeidler, 2006)
    cMyc
    (Liu et al., 2017)
    d-myc
    (Gamberi et al., 2017, Zhai et al., 2012, Huen et al., 2010, González et al., 2009, Saucedo and Edgar, 2002, Chartier et al., 1998, Zaffran et al., 1998)
    dMYC
    (Di Giacomo et al., 2017, Zaytseva and Quinn, 2017, Guo et al., 2016, Lee et al., 2015, Li et al., 2010, Tamori et al., 2010, Levens, 2003, Merriam and Guild, 2002, Coelho and Leevers, 2000)
    dMyc
    (Boulan et al., 2019, Hsieh et al., 2019, Johansson et al., 2019, Sanuki et al., 2019, Wong et al., 2019, Akagi et al., 2018, Akai et al., 2018, Álvarez-Rendón et al., 2018, Funakoshi et al., 2018, Kon, 2018, Perochon et al., 2018, Pinal et al., 2018, Richardson and Portela, 2018, Schwartz and Rhiner, 2018, Sriskanthadevan-Pirahas et al., 2018, Yanku et al., 2018, Deliu et al., 2017, Shu and Deng, 2017, Tue et al., 2017, Barron and Moberg, 2016, Bielmeier et al., 2016, Bonfini et al., 2016, Brookheart and Duncan, 2016, Jiang et al., 2016, Strigini and Leulier, 2016, Valzania et al., 2016, Aradhya et al., 2015, Casas-Tintó et al., 2015, Fernández-Hernández and Rhiner, 2015, Grifoni et al., 2015, Kim et al., 2015, Kuo et al., 2015, Li et al., 2015, Li et al., 2015, Morata and Ballesteros-Arias, 2015, Panneton et al., 2015, Siudeja et al., 2015, Tokusumi et al., 2015, Yan et al., 2015, Zhang et al., 2015, Antonucci et al., 2014, Ferreira et al., 2014, Hasygar and Hietakangas, 2014, Koe et al., 2014, Lam et al., 2014, Pargett et al., 2014, Singh et al., 2014, Tipping and Perrimon, 2014, Fernández-Hernández et al., 2013, Gallant, 2013, Lee et al., 2013, Merzetti et al., 2013, Mortimer and Moberg, 2013, Parisi et al., 2013, Pérez-Garijo et al., 2013, Ren et al., 2013, Tamori and Deng, 2013, Zoranovic et al., 2013, Fausti et al., 2012, Kamoshida et al., 2012, Killip and Grewal, 2012, Legent et al., 2012, Liu et al., 2012, Marshall et al., 2012, Pirooznia et al., 2012, San Juan et al., 2012, Becam et al., 2011, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, Kawamori and Yamaguchi, 2011, Lindquist et al., 2011, Marinho et al., 2011, Nakajima et al., 2011, Rajan and Perrimon, 2011, Zhao et al., 2011, Chi et al., 2010, Delanoue et al., 2010, Froldi et al., 2010, Herranz et al., 2010, Li et al., 2010, Menéndez et al., 2010, Portela et al., 2010, Rhiner et al., 2010, Taniue et al., 2010, Wu and Johnston, 2010, Zeng et al., 2010, Ziosi et al., 2010, Baltzer et al., 2009, Galletti et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, Nicholson et al., 2009, Read et al., 2009, Szuplewski et al., 2009, Wang and Huang, 2009, Wang et al., 2009, Blanco et al., 2008, Erives et al., 2008, Furrer et al., 2008, Harris and Ashe, 2008, Herranz et al., 2008, Layalle et al., 2008, Montero et al., 2008, Neumuller et al., 2008, Pierce et al., 2008, Rafel and Milán, 2008, Schwinkendorf and Gallant, 2008, Secombe et al., 2008, Senoo-Matsuda and Johnston, 2008, Silva and Johnston, 2008, Wang et al., 2008, Wu and Johnston, 2008, Bergman et al., 2007, Chilukuri et al., 2007, Cova and Johnston, 2007, Galletti et al., 2007, Goodliffe et al., 2007, Goodliffe et al., 2007, Grifoni et al., 2007, Hafezi and Hariharan, 2007, Mortimer and Moberg, 2007, Orian et al., 2007, Orian et al., 2007, Parisi et al., 2007, Secombe et al., 2007, Senoo-Matsuda and . Johnston, 2007, Senoo-Matsuda and Johnston, 2007, Tountas and Fortini, 2007, Betschinger et al., 2006, Bjorklund et al., 2006, DiAngelo and Birnbaum, 2006, Herz et al., 2006, Ho et al., 2006, Mortimer and Moberg, 2006, Orian, 2006, Parker, 2006, Secombe et al., 2006, Senoo-Matsuda and Johnston, 2006, Wang et al., 2006, Bellosta et al., 2005, Colombani et al., 2005, Grewal et al., 2005, Grewal et al., 2005, Grifoni et al., 2005, Hulf et al., 2005, Loo et al., 2005, Mortimer and Moberg, 2005, Perez-Garijo et al., 2005, Shingleton, 2005, Amati, 2004, Coffman, 2004, Jorgensen and Tyers, 2004, Li and Gallant, 2004, Maines et al., 2004, Tromans, 2004, Gallant and Montero, 2003, Gallant et al., 2003, Grewal et al., 2003, Li et al., 2003, Pagliarini and Xu, 2003, Britton et al., 2002, Hennig and Neufeld, 2002, Montero and Gallant, 2002, Plow et al., 2002, Prober and Edgar, 2002, Yost et al., 2002, Edgar and Orr-Weaver, 2001, Montero and Gallant, 2001, Nasi et al., 2001, Prober and Edgar, 2001, Tapon et al., 2001, Yost et al., 2001, Oldham et al., 2000, Prober and Edgar, 2000, Prober and Edgar, 2000, Elend and Eilers, 1999, Gallant et al., 1999, Johnston et al., 1999, Polymenis and Schmidt, 1999, Loo et al., 1998, Gallant et al., 1997, Gallant et al., 1996)
    dMyc1
    (Schreiber-Agus et al., 1997)
    dm
    (Bischof et al., 2018, Reichardt et al., 2018, Sollazzo et al., 2018, Vinayagam et al., 2016, Doggett et al., 2015, Grifoni and Bellosta, 2015, Kuo et al., 2015, Loedige et al., 2015, Spratford and Kumar, 2015, Ugrankar et al., 2015, Wong et al., 2015, Antonucci et al., 2014, Boyle et al., 2014, de la Cova et al., 2014, Hovhanyan et al., 2014, Jiang and Singh, 2014, Bonke et al., 2013, Djiane et al., 2013, Doumpas et al., 2013, Greer et al., 2013, Merzetti et al., 2013, Nagy et al., 2013, Neumüller et al., 2013, Ren et al., 2013, Schertel et al., 2013, Terriente-Felix et al., 2013, Yang et al., 2013, Spokony and White, 2012.5.22, Fay et al., 2011, Kalinka and Tomancak, 2011, Kappes et al., 2011, Lindquist et al., 2011, Dalton et al., 2010, Froldi et al., 2010, Neto-Silva et al., 2010, Popodi, 2010.10.8, Popodi et al., 2010-, Potter and Luo, 2010.3.5, Rhodes et al., 2010, Swaminathan et al., 2010, Venken et al., 2010, Wu and Johnston, 2010, Alvarez-Ponce et al., 2009, Christensen et al., 2009.7.21, Khan et al., 2009, Krejcí et al., 2009, Christensen et al., 2008.6.11, Erives et al., 2008, Mitchell et al., 2008, Pierce et al., 2008, Steiger et al., 2008, Steiger et al., 2008, Thao et al., 2008, Jensen et al., 2007, Mortimer and Moberg, 2007, Muse et al., 2007, Orian et al., 2007, Quinones-Coello, 2007, Tomancak et al., 2007, Mukherjee et al., 2006, Walser et al., 2006, Loop et al., 2004, Reis and Edgar, 2004, Pickeral et al., 2000)
    dm/dMyc
    (Sandmann et al., 2007)
    dm/myc
    (Rhodes et al., 2010)
    dmyc
    (Pragati et al., 2020, Rastegari et al., 2020, Toshniwal et al., 2019, Wu et al., 2019, Moon et al., 2018, Hao and Jin, 2017, Wu et al., 2017, Levayer et al., 2015, Merino et al., 2015, Yasunaga et al., 2014, Daneshvar et al., 2013, Levayer and Moreno, 2013, Li et al., 2013, Zoranovic et al., 2013, Carney et al., 2012, Pennetier et al., 2012, Unhavaithaya and Orr-Weaver, 2012, Cranna et al., 2011, Daneshvar et al., 2011, Repiso et al., 2011, Yang and Xu, 2011, Andersen et al., 2010, Froldi et al., 2010, Neto-Silva et al., 2010, Portela et al., 2010, Rhiner et al., 2010, Demontis and Perrimon, 2009, Khan et al., 2009, Rhiner et al., 2009, Jin et al., 2008, Rodrigues and Bach, 2008, Thao et al., 2008, VanZomeren-Dohm et al., 2008, Steiger and Gallant, 2007, Ziosi et al., 2007, Cova and Johnston, 2006, Jaklevic et al., 2006, Steiger et al., 2006, Tan et al., 2006, Benassayag et al., 2005, de la Cova et al., 2005, Garoia et al., 2005, Goodliffe et al., 2005, Goodliffe et al., 2005, Nowell et al., 2005, de la Cova et al., 2004, Quinn et al., 2004, Secombe et al., 2004, de la Cova and Johnston, 2003, Goodliffe et al., 2003, Hulf and Gallant, 2003, Lee and Orr-Weaver, 2003, Perrin et al., 2003, Johnston and Gallant, 2002, Quinn et al., 2002, Bellosta et al., 2001, Tapon et al., 2001, Vidwans and Su, 2001, Weinkove and Leevers, 2000, Johnston et al., 1999, Ridley, 1999)
    dmyc1
    (Schreiber-Agus et al., 1997, Schreiber-Agus, 1996.12.9)
    l(1)G0139
    (Schäfer et al., 1999.8.12)
    l(1)G0354
    l(1)G0359
    myc
    (Ahmed-de-Prado and Baonza, 2018, Eusebio et al., 2018, Kaur et al., 2018, Baker, 2017, Bhattacharya et al., 2017, Strilbytska et al., 2017, Dorsett, 2016, Hirabayashi, 2016, Bosch et al., 2015, Pasco et al., 2015, Wu et al., 2015, Johnston, 2014, Slattery et al., 2014, Bausek, 2013, Djiane et al., 2013, Greer et al., 2013, Grifoni et al., 2013, Khan et al., 2013, Neumüller et al., 2013, Vincent et al., 2011, Walker et al., 2011, Zhang et al., 2011, Bernard et al., 2010, Flannery et al., 2010, Mitchell et al., 2010, Khan et al., 2009, Krejcí et al., 2009, Teleman et al., 2008, Xu et al., 2008, Lecuit and Le Goff, 2007, Li and Baker, 2007, Bateman and McNeill, 2004, Scott et al., 2004, Bergmann and Lane, 2003, Maines et al., 2003, Potter and Xu, 2001, Gura, 2000, Paro, 1994)
    Name Synonyms
    Myc
    (Clavería and Torres, 2016, Amoyel and Bach, 2014)
    diminuitive
    (Neumüller et al., 2013)
    diminutive
    (Dorsett, 2016, Bennett et al., 2015, Grifoni and Bellosta, 2015, Loedige et al., 2015, Spratford and Kumar, 2015, Antonucci et al., 2014, Greer et al., 2013, Ren et al., 2013, Kalinka and Tomancak, 2011, Kappes et al., 2011, Lindquist et al., 2011, Bernard et al., 2010, Froldi et al., 2010, Neto-Silva et al., 2010, Rhodes et al., 2010, Swaminathan et al., 2010, Khan et al., 2009, Krejcí et al., 2009, Erives et al., 2008, Neumuller et al., 2008, Schwinkendorf and Gallant, 2008, Jensen et al., 2007, Tadros et al., 2007, Mukherjee et al., 2006)
    lethal (1) G0354
    lethal (1) G0359
    Secondary FlyBase IDs
    • FBgn0000472
    • FBgn0028362
    • FBgn0066838
    • FBgn0028316
    • FBgn0040170
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (620)