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General Information
Symbol
Dmel\Myc
Species
D. melanogaster
Name
Myc
Annotation Symbol
CG10798
Feature Type
FlyBase ID
FBgn0262656
Gene Model Status
Stock Availability
Gene Snapshot
Myc (Myc) encodes a transcription factor that is homologous to vertebrate Myc proto-oncogenes. It contributes to cell growth, cell competition and regenerative proliferation. [Date last reviewed: 2019-03-14]
Also Known As

dMyc, dm, diminutive, d-myc, l(1)G0139

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:3,373,159..3,391,697 [+]
Recombination map

1-3

RefSeq locus
NC_004354 REGION:3373159..3391697
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (37 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from physical interaction with FLYBASE:lid; FB:FBgn0031759
inferred from physical interaction with UniProtKB:Q9V3K3
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VH07
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VC56
(assigned by UniProt )
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:P01106
(assigned by UniProt )
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
Biological Process (26 terms)
Terms Based on Experimental Evidence (25 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with histone locus body
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001691821
(assigned by GO_Central )
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Protein Function (UniProtKB)
Participates in the regulation of gene transcription (PubMed:8929412, PubMed:16087886, PubMed:24173801, PubMed:24615015, PubMed:25999153, PubMed:25858587). Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG (PubMed:8929412). Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth (PubMed:16087886, PubMed:25999153, PubMed:25858587). Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex (PubMed:25999153). Inhibits the demethylase activity of Lid (PubMed:17311883). Activates transcription of mbm (PubMed:24615015). Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1 (PubMed:25858587). Able to induce the SCF E3 ubiquitin-protein ligase member archipelago (ago) which functions in its degradation (PubMed:15182669, PubMed:24173801). It may therefore create a negative feedback loop with ago that is regulated by the ubiquitin hydrolase puf (PubMed:24173801).
(UniProt, Q9W4S7)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
dm: diminutive
Bristles and body small and slender. Viability excellent. Females sterile. Oocyte cyst development abnormal; nurse-cell nuclei swell in stage 7, subsequently becoming pycnotic (King and Burnett, 1957, Growth 21: 263-80); cuboidal follicle cells covering developing oocyte in stage 8 fail to show normal growth and degenerate rather than becoming columnar (King and Vanoucek, 1960, Growth 24: 333-38). Chambers degenerate around stage 8; phenotype of homozygous dm less severe than that of dm/Df(1)dm (King and Vanoucek). RK1.
Summary (Interactive Fly)

bHLH - leucine zipper - homologous to vertebrate Myc proto-oncogenes - controls cell cycle progression, cell growth, cell competition and regenerative proliferation - suppresses tumor invasion and cell migration by inhibiting the JNK signaling

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Myc or the JBrowse view of Dmel\Myc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.55

Shares 5' exon(s) with downstream non-coding gene; shared promoter.

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070525
3484
717
FBtr0331605
9166
717
Additional Transcript Data and Comments
Reported size (kB)

6 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070501
79.3
717
6.22
FBpp0303995
79.3
717
6.22
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

717 aa isoforms: Myc-PA, Myc-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Efficient DNA binding requires dimerization with another bHLH protein (PubMed:8929412). Binds DNA as a heterodimer with Max (PubMed:8929412). Interacts with ago (PubMed:15182669, PubMed:24173801). Interacts with lid (PubMed:17311883). Part of a complex containing lid, Myc and ash2 (PubMed:17311883). Component of a complex with pont and rept (PubMed:16087886). Interacts with puf (PubMed:24173801).

(UniProt, Q9W4S7)
Post Translational Modification

Probably targeted for ubiquitination by the SFC ubiquitin ligase complex member ago, leading to its proteasomal degradation.

(UniProt, Q9W4S7)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Myc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
pole plasm

Comment: maternally deposited

organism

Comment: maternally deposited

anterior endoderm anlage

Comment: anlage in statu nascendi

endoderm anlage

Comment: anlage in statu nascendi

head mesoderm anlage

Comment: anlage in statu nascendi

posterior ectoderm anlage

Comment: anlage in statu nascendi

trunk mesoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Myc is ubiquitously expressed in second instar larval wing discs, and then intensifies at the wing hinge in early third instar larvae.

In wandering third instar larvae, Myc expression intensifies in the dorsal mesothoracic tergum (notum) primoridum and in the wing pouch, but is restricted from the anterior-posterior compartment boundary of the wing disc.

High levels aof Myc expression are observed at the tip of the germarium in germline stem cells and also in late cysts. Myc levels are significantly lower in 1- to 2-day-old cysts.

Expression at embryonic stage 5 is observed in an anterior stripe. Expression at embryonic stages 10-11 is observed in the ectoderm and in the developing optic lobes. Expression at embryonic stages 13-16 is observed in the midgut.

expression of dm in the eye disc is at low levels, with a stronger stripe immediately posterior to the morphogenetic furrow.

The dm transcript is detected at higher levels in early embryos and in adult females, and at very low levels in larvae and pupae. Additional transcripts of smaller sizes are found in early embryos and in adult females. In situ hybridization experiments reveal that the dm transcript is at first ubiquitous in early embryogenesis, but that it subsequently becomes concentrated in anterior and posterior regions. During gastrulation, additional dm expression is detected in the presumptive mesoderm, along the ventral midline. The mesodermal expression of dm intensifies at germ band extension, and continues through late embryogenesis. The anterior and posterior staining follow the anterior and posterior midgut primordia through extended germ band stages. dm is also transiently detected in salivary gland placodes. dm is expressed in mitotically dividing, as well as in endoreplicating, tissues. During oogenesis, dm transcript is detected in the germarium and at lower levels in stage 1 and stage 2 egg chambers. From stage 3 onward, dm is detected in all cell types of the eggchamber.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

At 72 hours after egg laying (AEL), expression of Myc transiently overlaps with expression of wg in hinge cells and inner ring of the wing disc. In wandering third instar larvae, Myc is expressed in the dorsal mesothoracic tergum (notum) primoridum and in the wing pouch, but is restricted from the anterior-posterior compartment boundary of the wing disc.

High levels aof Myc protein are observed at the tip of the germarium in germline stem cells and also in late cysts. Myc levels are significantly lower in 1- to 2-day-old cysts.

Myc is highly expressed in stem cells and cystoblasts but is downregulated in 16-cell cysts.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with histone locus body
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
Reporter: P{GawB}MycPG45
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Myc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Myc
Transgenic constructs containing regulatory region of Myc
Deletions and Duplications ( 41 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
follicle cell & nucleus | somatic clone
follicle cell & nucleus | somatic clone, with Scer\GAL4Act5C.PP
larval salivary gland & nucleolus, with Scer\GAL4en-e16E
nurse cell & actin filament
nurse cell & nucleus | germ-line clone
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
 
5  
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
4 of 13
Yes
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
4 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (12)
4 of 15
Yes
Yes
3 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190G6S )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CE1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EP1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Dendroctonus ponderosae
Mountain pine beetle
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EQT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
RNA-protein
Physical Interaction
Assay
References
RNA-RNA
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
suppressible
External Data
Subunit Structure (UniProtKB)
Efficient DNA binding requires dimerization with another bHLH protein (PubMed:8929412). Binds DNA as a heterodimer with Max (PubMed:8929412). Interacts with ago (PubMed:15182669, PubMed:24173801). Interacts with lid (PubMed:17311883). Part of a complex containing lid, Myc and ash2 (PubMed:17311883). Component of a complex with pont and rept (PubMed:16087886). Interacts with puf (PubMed:24173801).
(UniProt, Q9W4S7 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map

1-3

Cytogenetic map
Sequence location
X:3,373,159..3,391,697 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
3D2-3D4
Limits computationally determined from genome sequence between P{EP}dncEP973 and P{EP}PargEP351; Left limit from in situ hybridisation (FBrf0125103) Right limit from in situ hybridisation (FBrf0125103)
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
3D3-3D4
(determined by in situ hybridisation)
3D1-3D4
(determined by in situ hybridisation)
3D4-3D7
(determined by in situ hybridisation)
3D5-3D5
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (56)
Genomic Clones (23)
cDNA Clones (56)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Myc dm

    Source for database merge of

    Source for merge of: dm anon-WO03040301.171

    Source for merge of: dm l(1)G0354 l(1)G0359

    Additional comments

    Changed from 'dm' ('diminutive') to 'Myc' to reflect preferred usage in the Drosophila literature and facilitate access to information on this gene for naive/non-Drosophila researchers.

    "l(1)G0354" may affect "dm".

    Source for merge of dm anon-WO03040301.171 was sequence comparison ( date:051113 ).

    "l(1)G0359" may affect "dm".

    Other Comments

    dm expression stimulates glycolysis but impairs oxidative phosphorylation.

    Expansion of dm cell populations requires p53 only during competition.

    dm activates Sxl in males.

    Many activities of the dm protein do not, or only partly, require association with the Max protein.

    S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show a slowing down in G1 phase and a decrease in cell size in all phases of the cell cycle.

    Targets for transcriptional regulation by the dm product are characterized by the presence of an E-box, typically within the first 100 nucleotides of the promoter.

    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    dm plays an essential role in promoting the rapid growth that must occur in both the germline and the surrounding follicle cells for oogenesis to proceed.

    Mutations in dm and Cdk4 do not induce autophagy in the fat body.

    dm regulates organ size by inducing cell competition.

    dm links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism. wg patterns growth in the wing primordium by modulating dm expression.

    Loss of function mutations cause a growth disadvantage. Over-expression causes a growth advantage. Neither loss of dm nor its overexpression causes pattern abnormalities.

    Myc is isolated from an embryonic library by interacting with mouse MaxΔ9 bait protein in the yeast two-hybrid assay. The ability of P-element-mediated ectopic expression of Myc to reverse a subset of the phenotypic alterations associated with the dm mutation suggests that dm may correspond to Myc. This finding, along with the localisation of Myc expression to zones of high proliferative activity in the embryo, implicates Myc as an integral regulator of growth and development.

    The product of dm has been isolated as a binding partner for human Max in a two hybrid library screen.

    Origin and Etymology
    Discoverer

    Nichols-Skoog, 9th Oct. 1933.

    Etymology

    Named 'Myc' after the human ortholog.

    Identification
    External Crossreferences and Linkouts ( 52 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (32)
    Reported As
    Symbol Synonym
    EG:BACN5I9.1
    Myc
    (Baker et al., 2019, Chen and Read, 2019, Coelho and Moreno, 2019, Fahey-Lozano et al., 2019, Grendler et al., 2019, Khezri and Rusten, 2019, Lahvic and Hariharan, 2019, Mazaud et al., 2019, Ramanathan et al., 2019, Sanchez et al., 2019, Schaub et al., 2019, Shokri et al., 2019, Singh et al., 2019, Skouloudaki et al., 2019, Su et al., 2019, Tiwari et al., 2019, Zirin et al., 2019, Akishina et al., 2018, Alpar et al., 2018, Kale et al., 2018, Lee et al., 2018, Li et al., 2018, Rust et al., 2018, Sollazzo et al., 2018, Sriskanthadevan-Pirahas et al., 2018, Von Stetina et al., 2018, Xu et al., 2018, Akishina et al., 2017, Atkinson et al., 2017, Chen et al., 2017, Gerlach et al., 2017, Hariharan and Serras, 2017, Lee et al., 2017, Liu et al., 2017, Ma et al., 2017, Paiardi et al., 2017, Tauc et al., 2017, Transgenic RNAi Project members, 2017-, Wu et al., 2017, Xiang et al., 2017, Xu et al., 2017, Atkins et al., 2016, Gallant, 2016.4.26, Gallant, 2016.4.26, Harris et al., 2016, Jaszczak and Halme, 2016, Levayer and Moreno, 2016, Merino et al., 2016, Oyallon et al., 2016, Suijkerbuijk et al., 2016, Yadav et al., 2016, Das and Dobens, 2015, Doggett et al., 2015, Edgar et al., 2015.4.9, Enzo et al., 2015, Fernando et al., 2015, Gogna et al., 2015, Grewal, 2015, He et al., 2015, Herter et al., 2015, Li et al., 2015, Nagy et al., 2015, Pitoniak and Bohmann, 2015, Schertel et al., 2015, Spratford and Kumar, 2015, Hovhanyan et al., 2014, Wang et al., 2014, Das et al., 2013, Doumpas et al., 2013, Ibar et al., 2013, Ilanges et al., 2013, Levayer and Moreno, 2013, Nagy et al., 2013, Ren et al., 2013, Chen et al., 2012, Cordero et al., 2012, Fausti et al., 2012, Marshall et al., 2012, Pirooznia et al., 2012, Baker, 2011, Daneshvar et al., 2011, Hogan et al., 2011, Qian et al., 2011, Read, 2011, Reddy and Irvine, 2011, Vincent et al., 2011, Furrer et al., 2010, Li et al., 2010, Hamaratoglu et al., 2009, Nuzhdin et al., 2009, Read et al., 2009, Schwinkendorf and Gallant, 2009, Xiong et al., 2009, Simcox et al., 2008, Smith-Bolton et al., 2008, Steiger et al., 2008, Wang et al., 2008, Berry and Baehrecke, 2007, Goodliffe et al., 2007, Li and Baker, 2007, Mortimer and Moberg, 2007, Rodrigues and Bach, 2007, Axelrod, 2006, Nolo et al., 2006, Vidal and Cagan, 2006, Wodarz and Gonzalez, 2006, Perez-Garijo et al., 2005, Ralston and Blair, 2005, Donaldson and Duronio, 2004, Lipsick, 2004, Moberg et al., 2004, Scott et al., 2004, Neufeld, 2003, Orian et al., 2003, Orian et al., 2003, Ryoo and Steller, 2003, Xue and Noll, 2002, Foley and Sprenger, 2000, Wan et al., 2000)
    anon-WO03040301.171
    dMyc
    (Boulan et al., 2019, Hsieh et al., 2019, Johansson et al., 2019, Sanuki et al., 2019, Wong et al., 2019, Akagi et al., 2018, Akai et al., 2018, Álvarez-Rendón et al., 2018, Funakoshi et al., 2018, Kon, 2018, Perochon et al., 2018, Pinal et al., 2018, Richardson and Portela, 2018, Schwartz and Rhiner, 2018, Sriskanthadevan-Pirahas et al., 2018, Yanku et al., 2018, Deliu et al., 2017, Shu and Deng, 2017, Tue et al., 2017, Barron and Moberg, 2016, Bielmeier et al., 2016, Bonfini et al., 2016, Brookheart and Duncan, 2016, Jiang et al., 2016, Strigini and Leulier, 2016, Valzania et al., 2016, Aradhya et al., 2015, Casas-Tintó et al., 2015, Fernández-Hernández and Rhiner, 2015, Grifoni et al., 2015, Kim et al., 2015, Kuo et al., 2015, Li et al., 2015, Li et al., 2015, Morata and Ballesteros-Arias, 2015, Panneton et al., 2015, Siudeja et al., 2015, Tokusumi et al., 2015, Yan et al., 2015, Zhang et al., 2015, Antonucci et al., 2014, Ferreira et al., 2014, Hasygar and Hietakangas, 2014, Koe et al., 2014, Lam et al., 2014, Pargett et al., 2014, Singh et al., 2014, Tipping and Perrimon, 2014, Fernández-Hernández et al., 2013, Gallant, 2013, Lee et al., 2013, Merzetti et al., 2013, Mortimer and Moberg, 2013, Parisi et al., 2013, Pérez-Garijo et al., 2013, Ren et al., 2013, Tamori and Deng, 2013, Zoranovic et al., 2013, Fausti et al., 2012, Kamoshida et al., 2012, Killip and Grewal, 2012, Legent et al., 2012, Liu et al., 2012, Marshall et al., 2012, Pirooznia et al., 2012, San Juan et al., 2012, Becam et al., 2011, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, Kawamori and Yamaguchi, 2011, Lindquist et al., 2011, Marinho et al., 2011, Nakajima et al., 2011, Rajan and Perrimon, 2011, Zhao et al., 2011, Chi et al., 2010, Delanoue et al., 2010, Froldi et al., 2010, Herranz et al., 2010, Li et al., 2010, Menéndez et al., 2010, Portela et al., 2010, Rhiner et al., 2010, Taniue et al., 2010, Wu and Johnston, 2010, Zeng et al., 2010, Ziosi et al., 2010, Baltzer et al., 2009, Galletti et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, Nicholson et al., 2009, Read et al., 2009, Szuplewski et al., 2009, Wang and Huang, 2009, Wang et al., 2009, Blanco et al., 2008, Erives et al., 2008, Furrer et al., 2008, Harris and Ashe, 2008, Herranz et al., 2008, Layalle et al., 2008, Montero et al., 2008, Neumuller et al., 2008, Pierce et al., 2008, Rafel and Milán, 2008, Schwinkendorf and Gallant, 2008, Secombe et al., 2008, Senoo-Matsuda and Johnston, 2008, Silva and Johnston, 2008, Wang et al., 2008, Wu and Johnston, 2008, Bergman et al., 2007, Chilukuri et al., 2007, Cova and Johnston, 2007, Galletti et al., 2007, Goodliffe et al., 2007, Goodliffe et al., 2007, Grifoni et al., 2007, Hafezi and Hariharan, 2007, Mortimer and Moberg, 2007, Orian et al., 2007, Orian et al., 2007, Parisi et al., 2007, Secombe et al., 2007, Senoo-Matsuda and . Johnston, 2007, Senoo-Matsuda and Johnston, 2007, Tountas and Fortini, 2007, Betschinger et al., 2006, Bjorklund et al., 2006, DiAngelo and Birnbaum, 2006, Herz et al., 2006, Ho et al., 2006, Mortimer and Moberg, 2006, Orian, 2006, Parker, 2006, Secombe et al., 2006, Senoo-Matsuda and Johnston, 2006, Wang et al., 2006, Bellosta et al., 2005, Colombani et al., 2005, Grewal et al., 2005, Grewal et al., 2005, Grifoni et al., 2005, Hulf et al., 2005, Loo et al., 2005, Mortimer and Moberg, 2005, Perez-Garijo et al., 2005, Shingleton, 2005, Amati, 2004, Coffman, 2004, Jorgensen and Tyers, 2004, Li and Gallant, 2004, Maines et al., 2004, Tromans, 2004, Gallant and Montero, 2003, Gallant et al., 2003, Grewal et al., 2003, Li et al., 2003, Pagliarini and Xu, 2003, Britton et al., 2002, Hennig and Neufeld, 2002, Montero and Gallant, 2002, Plow et al., 2002, Prober and Edgar, 2002, Yost et al., 2002, Edgar and Orr-Weaver, 2001, Montero and Gallant, 2001, Nasi et al., 2001, Prober and Edgar, 2001, Tapon et al., 2001, Yost et al., 2001, Oldham et al., 2000, Prober and Edgar, 2000, Prober and Edgar, 2000, Elend and Eilers, 1999, Gallant et al., 1999, Johnston et al., 1999, Polymenis and Schmidt, 1999, Loo et al., 1998, Gallant et al., 1997, Gallant et al., 1996)
    l(1)G0354
    l(1)G0359
    Secondary FlyBase IDs
    • FBgn0000472
    • FBgn0028362
    • FBgn0066838
    • FBgn0028316
    • FBgn0040170
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    Project
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    References (620)