FlyBase Gene Report: Dmel\CG43155

General Information

Symbol

Dmel\CG43155

Species

D. melanogaster

Name

Annotation Symbol

CG43155

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262685

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

10B14-10B14

Sequence location

X:11,459,786..11,476,504 [+]

Recombination map

1-34

RefSeq locus

NC_004354 REGION:11459786..11476504

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables potassium channel activity

inferred from sequence or structural similarity with FLYBASE:Task7; FB:FBgn0037690, FLYBASE:Task6; FB:FBgn0038165

(FlyBase Curators, 2008-)

enables potassium ion leak channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000108561

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in potassium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000108561

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with FLYBASE:Task7; FB:FBgn0037690, FLYBASE:Task6; FB:FBgn0038165

(FlyBase Curators, 2008-)

involved_in stabilization of membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN000108561

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity with FLYBASE:Task7; FB:FBgn0037690, FLYBASE:Task6; FB:FBgn0038165

(FlyBase Curators, 2008-)

is_active_in integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000108561

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

TWO-PORE DOMAIN K⁺ CHANNEL SUBUNITS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

TWO-PORE DOMAIN K⁺ CHANNEL SUBUNITS -: The two-pore domain K⁺ (K2P) channels possess four transmembrane domains and two pore domains; they assemble as dimers. K2P channels have been implicated in a number of processes such as maintaining resting potential (leak K⁺ conductance), responding to volatile anesthetics, chemo- and mechanosensation. (Adapted from FBrf0188365 and PMID:11121510).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG43155 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VYY5)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG43155-RC

FBtr0305607

NM_132492

1762

411

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG43155-PC

FBpp0294058

45.7

411

8.12

NP_572720

AAF48048

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VYY5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43155 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG43155 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43155

View exonic expression by tissue for Dmel\CG43155

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32092/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262685

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262685

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1756

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43155

Transgenic constructs containing regulatory region of CG43155

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

CG43155^KK109309

lethal | recessive

CG43155^PG107

partially lethal - majority die, with Scer\GAL4^pnr-MD237

CG43155^GD4013

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

CG43155^GD4013

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG43155^GD4013

viable, with Scer\GAL4^Mef2.PR

CG43155^GD4013

viable, with Scer\GAL4^tin.CΔ4

CG43155^GD4013

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

CG43155^GD4013

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\KCNK1

3 of 15

Yes

Hsap\KCNK6

3 of 15

Yes

Hsap\KCNK16

3 of 15

Yes

Hsap\KCNK17

3 of 15

Yes

Hsap\KCNK18

3 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Kcnk1

3 of 15

Yes

Mmus\Kcnk2

3 of 15

Yes

Mmus\Kcnk6

3 of 15

Yes

Mmus\Kcnk16

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (14)

Rnor\Kcnk16

4 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (13)

Xtro\LOC100486031

4 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (21)

Drer\kcnk1b

3 of 15

Yes

Drer\kcnk5b

3 of 15

Yes

Drer\kcnk17

3 of 15

Yes

Drer\kcnk18

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Drer\si:ch211-261a10.5

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (49)

Cele\twk-4

6 of 15

Yes

Cele\twk-40

6 of 15

Yes

Cele\egl-23

5 of 15

Yes

Cele\twk-2

5 of 15

Yes

Cele\twk-7

5 of 15

Yes

Cele\twk-13

5 of 15

Yes

Cele\twk-16

5 of 15

Yes

Cele\twk-23

5 of 15

Yes

Cele\twk-29

5 of 15

Yes

Cele\twk-3

4 of 15

Yes

Cele\twk-5

4 of 15

Yes

Cele\twk-9

4 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

Yes

Cele\twk-43

4 of 15

Yes

Cele\twk-45

4 of 15

Cele\twk-46

4 of 15

Yes

Cele\twk-10

3 of 15

Yes

Cele\twk-17

3 of 15

Yes

Cele\twk-22

3 of 15

Cele\twk-32

3 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

Yes

Cele\twk-48

3 of 15

Cele\unc-58

3 of 15

Yes

Cele\sup-9

2 of 15

Cele\twk-1

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Cele\twk-49

2 of 15

Yes

Cele\B0310.1

1 of 15

Cele\C27F2.6

1 of 15

Yes

Cele\kvs-4

1 of 15

Cele\Y71H9A.10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (6)

Atha\KCO2

3 of 9

Yes

Atha\KCO5

3 of 9

Yes

Atha\TPK4

3 of 9

Yes

Atha\KCO1

2 of 9

Atha\KCO3

2 of 9

Yes

Atha\KCO6

2 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\TOK1

5 of 15

Yes

Scer\CTF3

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

5 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KCNK1; potassium two pore domain channel subfamily K member 1

3 of 15

601745

KCNK6; potassium two pore domain channel subfamily K member 6

3 of 15

603939

KCNK16; potassium two pore domain channel subfamily K member 16

3 of 15

607369

KCNK17; potassium two pore domain channel subfamily K member 17

3 of 15

607370

KCNK18; potassium two pore domain channel subfamily K member 18

3 of 15

613655

MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13; MGR13

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262685

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0262685

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-34

Cytogenetic map

10B14-10B14

Sequence location

X:11,459,786..11,476,504 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10B14-10B14

Limits computationally determined from genome sequence between P{EP}CG11756^EP1610 and P{EP}CG32666^EP1452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-34

(FlyBase, 2016)

1-36.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27033

y¹ v¹; P{TRiP.JF02359}attP2

59687

y¹ w^* Mi{MIC}CG43155^MI14285

84044

y¹ sc^* v¹ sev²¹; P{TKO.GS04455}attP40

55299

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03986}attP2

VDRC

v101483

P{KK109309}VIE-260B

v37516

w¹¹¹⁸; P{GD4013}v37516

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262685

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32092

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG1756 anon-WO0109301.51 anon-WO0109301.52

(FlyBase, 1996-)

Source for merge of: CG1756 anon-WO0109301.9

(FlyBase, 1996-)

Source for merge of: CG15194 CG1756

(FlyBase Genome Annotators, 2011)

Additional comments

Annotations CG15194 and CG1756 merged as CG43155 in release 5.33 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Source for merge of: CG1756 anon-WO0109301.51 anon-WO0109301.52

(FlyBase, 1996-)

Source for merge of CG1756 anon-WO0109301.9 was sequence comparison ( date:030912 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32092

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VYY5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VYY5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VYY5

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262685

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32092/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262685

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262685

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1756

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0262685

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32092

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43155

MARRVEL_MODEL - MARRVEL (model organism gene)

32092

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262685

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG15194

(Keleman et al., 2009.8.5)

CG1756

(Walcott et al., 2018, Menuz et al., 2014, Tsubouchi et al., 2012, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009.3.31, Döring et al., 2006, Buckingham et al., 2005, Wang et al., 2004)

CG43155

(Scaplen and Petruccelli, 2021, Perry et al., 2020, Walcott et al., 2018, Transgenic RNAi Project members, 2017-, Ou et al., 2016, Pimentel et al., 2016, FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1)

anon-WO0109301.51

anon-WO0109301.52

anon-WO0109301.9

Name Synonyms

Secondary FlyBase IDs