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Gene Dmel\Arp3

General Information
Symbol	Dmel\Arp3	Species	D. melanogaster
Name	Actin-related protein 3	Annotation symbol	CG7558
Feature type	protein_coding_gene	FlyBase ID	FBgn0262716
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	arp66B
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66B6-66B6	Sequence location	3L:8,106,507..8,109,002 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Actin-related protein 3 is referred to in FlyBase by the symbol Dmel\Arp3 (CG7558, FBgn0262716). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton; actin binding. There is experimental evidence for 13 unique biological process terms, many of which group under: cellular component organization or biogenesis; single-organism developmental process; biological regulation; localization; regulation of cellular component organization; positive regulation of biological process; actin filament-based process; sensory organ development; muscle cell differentiation; system development. 10 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord commissure; trichogen cell; bouton; neuromuscular junction; filopodium; embryonic myoblast; synapse; embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Actin-related protein; Actin-related protein 3 (Arp3); Actin/actin-like conserved site. Gene sequence location is 3L:8106507..8109002.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms positive regulation of lamellipodium assembly
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66B6-66B6   Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66B-66B     (Fyrberg, 1993.5.4) 66B-66B   (determined by in situ hybridisation)   (Fyrberg et al., 1994) 66B-66B   (determined by in situ hybridisation)   (Fyrberg and Fyrberg, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Arp3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Arp3-RA FBtr0076737  NM_079244   1983   418 Arp3-RB FBtr0334087  NM_001274630   1585   418
Additional Transcript Data & Comments
Reported size (kB)	1.257 (longest cDNA) (Fyrberg et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Arp3-PA   FBpp0076460   47.0   418   5.84     NP_523968   AAF50488 Arp3-PB   FBpp0306212   47.0   418   5.84     NP_001261559   AGB94254
Additional Polypeptide Data & Comments
Reported size (kDa)	418 (aa) (Fyrberg et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-related protein (IPR004000) Actin-related protein 3 (Arp3) (IPR015623) Actin/actin-like conserved site (IPR020902)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141603   AA263272   AA264573   AA391209   AA392122   AA440364   AA539046   AA816281   AA990739   AE014296 AAF50488   AE014296 AGB94254   AI257880   AI406084   AI518886   AI532221   AI541650   AQ073082   AW943300   AX260176   AY051859 AAK93283   BG636514   BI161804   BI163961   BI164729   BI168337   BI169388   BI170679   BI170933   BI171251   BI227829   BI228078   BI232951   BI236271   BI240013   BI242933   BI356521   BI358231   BI365701   BI368499   BI368512   BI372053   BI374532   BI374533   BI565314   BI577460   BI578159   BI580909   BI638856   BP540413   BP548450   BP551723   BP554368   CO153288   CO154834   CO155248   CO155769   CO178017   CO184728   CO262620   CO279012   CO306592   CO306861   CO310603   CO315293   CO315461   CO325762   CO331379   CO331473   CO332370   CO332866   EC058268   EC062883   EC065904   EC070606   EC077821   EC078179   EC079254   EC081984   EC083610   EC084189   EC198743   EC203150   EC205323   EC212316   EC236623   EC250947   EC264533   EC265660   EC267529   EV587523   GH749387   GH749438   GH751003   GH756046   GH761129   GH771726   GH772085   GH773592   GH776323   GH778490   GH784685   GH788258   GH788583   GH788985   GH794187   GH796047   GH798085   GH800472   GH804319   GH808628   GH814062   GH820309   GH820863   GH826523   GH827170   GH828541   GH829709   GH830489   GH832351   GH834067   GH837461   GH838285   GH838889   GH842280   GH848834   GH851161   GH851595   GH852231   GH852825   GH853603   GH854575   GH856300   GH857032   GH865610   GH871513   GH871699   GH874815   GH876101   GH876884   GH878594   GH881335   GH890481   GH891347   GH894790   GH895228   GH897617   GH904367   GH904840   GH906209   GH906822   GH908350   GH909563   GH910240   GH915438   GH915679   GH915964   GH918175   GH918358   GH919721   GH919956   GH922860   GH929491   GH932303   GH932517   GH933545   GH934226   GH936330   GH937331   GH938610   X71789 CAA50674
UniProtKB/Swiss-Prot	P32392
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference oogenesis stage S9   nurse cell ring canal   • cytoplasm (Hudson and Cooley, 2002)
Additional Descriptive Data
	Arp3 protein distribution was followed with an Arp3-GFP fusion protein. The GFP fusion protein is abundant in the cytoplasm of germ cells and is enriched in ring canals. Some enrichment at cortical membranes was also observed. (Hudson and Cooley, 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lamellipodium inferred from direct assay (Iwasa and Mullins, 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    50 digestive system, 4-day adult    46 digestive system, 20-day adult    49 fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering    37 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    49 ovary, mated 4-day female    44 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (44) central nervous system, pupae P8  (32) head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering  (81) digestive system, 1-day adult  (50) digestive system, 4-day adult  (46) digestive system, 20-day adult  (49) fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering  (37) carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female  (49) ovary, mated 4-day female  (44) testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    50 digestive system, 4-day adult    46 digestive system, 20-day adult    49 fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering    37 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    49 ovary, mated 4-day female    44 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    50 digestive system, 4-day adult    46 digestive system, 20-day adult    49 fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering    37 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    49 ovary, mated 4-day female    44 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    50 digestive system, 4-day adult    46 digestive system, 20-day adult    49 fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering    37 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    49 ovary, mated 4-day female    44 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (44) central nervous system, pupae P8  32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering  (81) digestive system, 1-day adult  (50) digestive system, 4-day adult  (46) digestive system, 20-day adult  (49) fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering  (37) carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female  (49) ovary, mated 4-day female  (44) testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    50 digestive system, 4-day adult    46 digestive system, 20-day adult    49 fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering    37 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    49 ovary, mated 4-day female    44 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    44 central nervous system, pupae P8    32 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    12 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    81 digestive system, 1-day adult    50 digestive system, 4-day adult    46 digestive system, 20-day adult    49 fat body, larvae L3 wandering    7 fat body, white prepupae    19 fat body, pupae P8    18 carcass, larvae L3 wandering    37 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    49 ovary, mated 4-day female    44 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    98 embryo 04-06hr    50 embryo 06-08hr    64 embryo 08-10hr    84 embryo 10-12hr    99 embryo 12-14hr    70 embryo 14-16hr    65 embryo 16-18hr    61 embryo 18-20hr    47 embryo 20-22hr    53 embryo 22-24hr    50 larva L1    48 larva L2    56 larva L3 12hr old    38 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    52 white prepupae new    63 white prepupae 12hr    41 white prepupae 24hr    44 pupae 2d postWPP    33 pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day    47 adult female 05day    62 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr  (98) embryo 04-06hr  (50) embryo 06-08hr  (64) embryo 08-10hr  (84) embryo 10-12hr  (99) embryo 12-14hr  (70) embryo 14-16hr  (65) embryo 16-18hr  (61) embryo 18-20hr  (47) embryo 20-22hr  (53) embryo 22-24hr  (50) larva L1  (48) larva L2  (56) larva L3 12hr old  (38) larva L3 puffstage 1-2  (39) larva L3 puffstage 3-6  (43) larva L3 puffstage 7-9  (52) white prepupae new  (63) white prepupae 12hr  (41) white prepupae 24hr  (44) pupae 2d postWPP  (33) pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day  (47) adult female 05day  (62) adult female 30day  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    98 embryo 04-06hr    50 embryo 06-08hr    64 embryo 08-10hr    84 embryo 10-12hr    99 embryo 12-14hr    70 embryo 14-16hr    65 embryo 16-18hr    61 embryo 18-20hr    47 embryo 20-22hr    53 embryo 22-24hr    50 larva L1    48 larva L2    56 larva L3 12hr old    38 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    52 white prepupae new    63 white prepupae 12hr    41 white prepupae 24hr    44 pupae 2d postWPP    33 pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day    47 adult female 05day    62 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    98 embryo 04-06hr    50 embryo 06-08hr    64 embryo 08-10hr    84 embryo 10-12hr    99 embryo 12-14hr    70 embryo 14-16hr    65 embryo 16-18hr    61 embryo 18-20hr    47 embryo 20-22hr    53 embryo 22-24hr    50 larva L1    48 larva L2    56 larva L3 12hr old    38 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    52 white prepupae new    63 white prepupae 12hr    41 white prepupae 24hr    44 pupae 2d postWPP    33 pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day    47 adult female 05day    62 adult female 30day    60 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    98 embryo 04-06hr    50 embryo 06-08hr    64 embryo 08-10hr    84 embryo 10-12hr    99 embryo 12-14hr    70 embryo 14-16hr    65 embryo 16-18hr    61 embryo 18-20hr    47 embryo 20-22hr    53 embryo 22-24hr    50 larva L1    48 larva L2    56 larva L3 12hr old    38 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    52 white prepupae new    63 white prepupae 12hr    41 white prepupae 24hr    44 pupae 2d postWPP    33 pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day    47 adult female 05day    62 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr  (98) embryo 04-06hr  (50) embryo 06-08hr  (64) embryo 08-10hr  (84) embryo 10-12hr  (99) embryo 12-14hr  (70) embryo 14-16hr  (65) embryo 16-18hr  (61) embryo 18-20hr  (47) embryo 20-22hr  (53) embryo 22-24hr  (50) larva L1  (48) larva L2  (56) larva L3 12hr old  (38) larva L3 puffstage 1-2  (39) larva L3 puffstage 3-6  (43) larva L3 puffstage 7-9  (52) white prepupae new  (63) white prepupae 12hr  (41) white prepupae 24hr  (44) pupae 2d postWPP  (33) pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day  (47) adult female 05day  (62) adult female 30day  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    98 embryo 04-06hr    50 embryo 06-08hr    64 embryo 08-10hr    84 embryo 10-12hr    99 embryo 12-14hr    70 embryo 14-16hr    65 embryo 16-18hr    61 embryo 18-20hr    47 embryo 20-22hr    53 embryo 22-24hr    50 larva L1    48 larva L2    56 larva L3 12hr old    38 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    52 white prepupae new    63 white prepupae 12hr    41 white prepupae 24hr    44 pupae 2d postWPP    33 pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day    47 adult female 05day    62 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    98 embryo 04-06hr    50 embryo 06-08hr    64 embryo 08-10hr    84 embryo 10-12hr    99 embryo 12-14hr    70 embryo 14-16hr    65 embryo 16-18hr    61 embryo 18-20hr    47 embryo 20-22hr    53 embryo 22-24hr    50 larva L1    48 larva L2    56 larva L3 12hr old    38 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    52 white prepupae new    63 white prepupae 12hr    41 white prepupae 24hr    44 pupae 2d postWPP    33 pupae 3d postWPP    24 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    23 adult male 30day    22 adult female 01day    47 adult female 05day    62 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    379 Schneider line 2 Sg4    165 embryonic 1182-4H    147 embryonic GM2    85 embryonic Kc167    82 embryonic S1    99 embryonic S3    125 leg disc CME L1    128 wing disc CME-W2    132 wing disc ML-DmD8    75 wing disc ML-DmD9    91 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    112 wing disc ML-DmD32    104 haltere disc ML-DmD17-c3    140 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    100 CNS ML-DmBG1-c1    106 CNS ML-DmBG2-c2    121 tumorous blood cells mbn2    169 ovary fGS/OSS    44 ovary OSC    78 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (379) Schneider line 2 Sg4  (165) embryonic 1182-4H  (147) embryonic GM2  (85) embryonic Kc167  (82) embryonic S1  (99) embryonic S3  (125) leg disc CME L1  (128) wing disc CME-W2  (132) wing disc ML-DmD8  (75) wing disc ML-DmD9  (91) wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (112) wing disc ML-DmD32  (104) haltere disc ML-DmD17-c3  (140) eye-antennal disc ML-DmD11  (68) antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1  (100) CNS ML-DmBG1-c1  (106) CNS ML-DmBG2-c2  (121) tumorous blood cells mbn2  (169) ovary fGS/OSS  (44) ovary OSC  (78) ovary OSS  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (379) Schneider line 2 Sg4  (165) embryonic 1182-4H  (147) embryonic GM2    85 embryonic Kc167    82 embryonic S1    99 embryonic S3  (125) leg disc CME L1  (128) wing disc CME-W2  (132) wing disc ML-DmD8    75 wing disc ML-DmD9    91 wing disc ML-DmD16-c3    89 wing disc ML-DmD21  (112) wing disc ML-DmD32  104 haltere disc ML-DmD17-c3  (140) eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1    100 CNS ML-DmBG1-c1  106 CNS ML-DmBG2-c2  (121) tumorous blood cells mbn2  (169) ovary fGS/OSS    44 ovary OSC    78 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    379 Schneider line 2 Sg4    165 embryonic 1182-4H    147 embryonic GM2    85 embryonic Kc167    82 embryonic S1    99 embryonic S3    125 leg disc CME L1    128 wing disc CME-W2    132 wing disc ML-DmD8    75 wing disc ML-DmD9    91 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    112 wing disc ML-DmD32    104 haltere disc ML-DmD17-c3    140 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    100 CNS ML-DmBG1-c1    106 CNS ML-DmBG2-c2    121 tumorous blood cells mbn2    169 ovary fGS/OSS    44 ovary OSC    78 ovary OSS    49 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    379 Schneider line 2 Sg4    165 embryonic 1182-4H    147 embryonic GM2    85 embryonic Kc167    82 embryonic S1    99 embryonic S3    125 leg disc CME L1    128 wing disc CME-W2    132 wing disc ML-DmD8    75 wing disc ML-DmD9    91 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    112 wing disc ML-DmD32    104 haltere disc ML-DmD17-c3    140 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    100 CNS ML-DmBG1-c1    106 CNS ML-DmBG2-c2    121 tumorous blood cells mbn2    169 ovary fGS/OSS    44 ovary OSC    78 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (379) Schneider line 2 Sg4  (165) embryonic 1182-4H  (147) embryonic GM2  (85) embryonic Kc167  (82) embryonic S1  (99) embryonic S3  (125) leg disc CME L1  (128) wing disc CME-W2  (132) wing disc ML-DmD8  (75) wing disc ML-DmD9  (91) wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (112) wing disc ML-DmD32  (104) haltere disc ML-DmD17-c3  (140) eye-antennal disc ML-DmD11  (68) antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1  (100) CNS ML-DmBG1-c1  (106) CNS ML-DmBG2-c2  (121) tumorous blood cells mbn2  (169) ovary fGS/OSS  (44) ovary OSC  (78) ovary OSS  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (379) Schneider line 2 Sg4  (165) embryonic 1182-4H  (147) embryonic GM2    85 embryonic Kc167    82 embryonic S1    99 embryonic S3  125 leg disc CME L1  128 wing disc CME-W2  132 wing disc ML-DmD8    75 wing disc ML-DmD9    91 wing disc ML-DmD16-c3    89 wing disc ML-DmD21  112 wing disc ML-DmD32  104 haltere disc ML-DmD17-c3  140 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1    100 CNS ML-DmBG1-c1  106 CNS ML-DmBG2-c2  121 tumorous blood cells mbn2  (169) ovary fGS/OSS    44 ovary OSC    78 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    379 Schneider line 2 Sg4    165 embryonic 1182-4H    147 embryonic GM2    85 embryonic Kc167    82 embryonic S1    99 embryonic S3    125 leg disc CME L1    128 wing disc CME-W2    132 wing disc ML-DmD8    75 wing disc ML-DmD9    91 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    112 wing disc ML-DmD32    104 haltere disc ML-DmD17-c3    140 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    100 CNS ML-DmBG1-c1    106 CNS ML-DmBG2-c2    121 tumorous blood cells mbn2    169 ovary fGS/OSS    44 ovary OSC    78 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    14 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    32 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    48 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    14 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  (46) Cadmium 50 mM 12 hrs, larvae L3  (43) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3  (32) Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3  (57) Ethanol 10% 3 hrs, larvae L3  (45) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (32) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (31) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (48) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    14 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    32 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    48 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    14 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    32 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    48 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    14 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    32 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    48 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    14 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  (46) Cadmium 50 mM 12 hrs, larvae L3  (43) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3  32 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3  (57) Ethanol 10% 3 hrs, larvae L3  (45) Caffeine 1.5 mg/ml 4 hrs, larvae L3  32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (48) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    14 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    32 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    48 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    14 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    32 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    48 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Arp383F Arp3515FC Arp31066PC lethal (with Arp383F) Arp3EP3640 lethal (with Arp3515FC) Arp3EP3640 lethal (with Arp31066PC) Arp3EP3640 lethal (with Arp3EP3640) Arp383F Arp3515FC Arp31066PC lethal | pharate adult stage | recessive, with Scer\GAL4[-]: Arp3EP3640 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Arp3GD12273 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4C57 Arp3GD12273 visible, with Scer\GAL4pnr-MD237 Arp3GD12273 Phenotype manifest in Allele anterior dorsocentral bristle | pharate adult stage, with Scer\GAL4[-]: Arp3EP3640 bouton, with Scer\GAL4C57 Arp3GD12273 embryonic/larval somatic muscle Arp3schwachling embryonic/larval somatic muscle (with Arp3EP3640) Arp3schwachling embryonic/larval somatic muscle (with Arp3schwachling) Arp3EP3640 embryonic myoblast Arp3EP3640 external sensory organ precursor cell IIa | somatic clone Arp383F Arp3515FC external sensory organ precursor cell IIb | somatic clone Arp383F Arp3515FC female germline cyst | somatic clone Arp3515FC filopodium Arp3EP3640 interfollicle cell | somatic clone Arp3515FC macrochaeta | pharate adult stage, with Scer\GAL4[-]: Arp3EP3640 macrochaeta | somatic clone Arp383F mechanosensory chaeta | somatic clone Arp31066PC Arp3515FC microchaeta | somatic clone Arp383F myoblast | embryonic stage Arp3schwachling myoblast | embryonic stage (with Arp3EP3640) Arp3schwachling myoblast | embryonic stage (with Arp3schwachling) Arp3EP3640 myoblast | embryonic stage (with Df(3L)ZP1) Arp3schwachling neuromuscular junction, with Scer\GAL4C57 Arp3GD12273 nurse cell & actin filament | germ-line clone, with Scer\GAL4[-]: Arp3EP3640 nurse cell | germline clone, with Scer\GAL4[-]: Arp3EP3640 nurse cell ring canal | germline clone, with Scer\GAL4[-]: Arp3EP3640 oocyte | germline clone, with Scer\GAL4[-]: Arp3EP3640 plasma membrane | embryonic stage Arp3schwachling synapse, with Scer\GAL4C57 Arp3GD12273 trichogen cell, with Scer\GAL4pnr-MD237 Arp3GD12273 ventral nerve cord commissure (with Df(3L)pbl-X1), with Scer\GAL4[-]: Arp3EP3640
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Arp3 Class Mutagen Stocks Known lesion Arp3515FC 1 Yes Arp383F 1 Yes Arp3EP3640 P-element activity 1 -- Arp31066PC 0 Yes Arp3schwachling ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Arp3 Class Mutagen Stocks Known lesion Arp3Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes Arp3GD12273 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Arp3HMS00711 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Arp3KK102278 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Arp3NIG.7558R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)66C-G28 (Rajan et al., 2009) Df(3L)Exel6112 (Ryder, 2004.4.26) Df(3L)Exel7591 (Rajan et al., 2009) Df(3L)Exel8065 (Rajan et al., 2009) Df(3L)pbl-X1 (Fyrberg et al., 1994, Rajan et al., 2009, Berger et al., 2008) Df(3L)ZP1 (Rajan et al., 2009, Berger et al., 2008)
Not disrupted in	Df(3L)Exel7593 (Rajan et al., 2009) Df(3L)Exel7930 (Rajan et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.7558R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Arp3EP3640 NA
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Richardson et al., 2007) actin filament reorganization involved in cell cycle inferred from physical interaction with Sop2 (Stevenson et al., 2002) axonal fasciculation inferred from mutant phenotype (Zallen et al., 2002) cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) chaeta development inferred from mutant phenotype (Rajan et al., 2009) intracellular protein transport inferred from mutant phenotype (Rajan et al., 2009) myoblast fusion inferred from genetic interaction with WASp (Berger et al., 2008) inferred from mutant phenotype (Richardson et al., 2007, Berger et al., 2008) ovarian follicle cell stalk formation inferred from mutant phenotype (Rajan et al., 2009) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of filopodium assembly inferred from mutant phenotype (Gonçalves-Pimentel et al., 2011) positive regulation of lamellipodium assembly inferred from mutant phenotype (Georgiou and Baum, 2010) positive regulation of Notch signaling pathway inferred from mutant phenotype (Rajan et al., 2009) pseudocleavage involved in syncytial blastoderm formation inferred from physical interaction with Sop2 (Stevenson et al., 2002)
Cellular Component
CV term Evidence References
lamellipodium inferred from direct assay (Iwasa and Mullins, 2007)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity with Saccharomyces ARP3 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR015623 (FlyBase Curators et al., 2004-) structural constituent of cytoskeleton inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with human ACTR3 (Hudson and Cooley, 2002)
Biological Process
CV term Evidence References
Arp2/3 complex-mediated actin nucleation inferred from sequence or structural similarity with human ACTR3 (Hudson and Cooley, 2002) cytoskeleton organization inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with Saccharomyces ARP3 (FlyBase, 1992-) regulation of actin polymerization or depolymerization non-traceable author statement (Swiss-Prot Project Members, 1993.10.1)
Cellular Component
CV term Evidence References
actin cytoskeleton non-traceable author statement (Swiss-Prot Project Members, 1993.10.1) actin filament inferred from sequence or structural similarity with EMBL:M81068 (Fyrberg et al., 1994) Arp2/3 protein complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with human ACTR3 (Hudson and Cooley, 2002) inferred from sequence or structural similarity with Saccharomyces ARP3 (FlyBase, 1992-) non-traceable author statement (Fyrberg, 1993.5.4, Vartiainen and Machesky, 2004)
Sequence Ontology: Class of Gene
	gene (Griemert et al., 2007) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Arp3 - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - Act57B experimental knowledge based (Guruharsha et al., 2011) Arp3 - Arp2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Arp3 - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp3 - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp3 - Arpc3A experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Arp3 - Arpc3B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp3 - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp3 - CG10641 experimental knowledge based (Guruharsha et al., 2011) Arp3 - CG13751 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - CG4806 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - CG8578 experimental knowledge based (Guruharsha et al., 2011) Arp3 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - Smn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - cpa experimental knowledge based (Guruharsha et al., 2011) Arp3 - cpb experimental knowledge based (Guruharsha et al., 2011) Arp3 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp3 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Arp3 allele Gene References Arp66BEP3640 Arpc1 (Zallen et al., 2002)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262716 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P32392
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6256CM Dipteran inclusive ortholog search EOG66DMB8 Insect inclusive ortholog search EOG6WH7G3 Arthropod inclusive ortholog search EOG6RN8QS Metazoa inclusive ortholog search EOG6P5Z3H
Orthologs in Drosophila Species (EOG6256CM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Arp3     Drosophila simulans   Dsim\GD17591 Y   Drosophila sechellia   Dsec\GM24973 Y   Drosophila erecta   Dere\GG14922 Y   Drosophila yakuba   Dyak\GE20375 Y   Drosophila ananassae   Dana\GF10484 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20439 Y   Drosophila persimilis   Dper\GL22484 Y   Drosophila willistoni   Dwil\GK19880 Y   Drosophila virilis   Dvir\GJ13271 Y   Drosophila mojavensis   Dmoj\GI12000 Y   Drosophila grimshawi   Dgri\GH15291 Y
Orthologs in non-Drosophila Dipterans (EOG66DMB8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012310   Anopheles gambiae Malaria mosquito  Agam\AGAP005110   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015392   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016054
Orthologs in non-Dipteran Insects (EOG6WH7G3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410115   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001088   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17223   Atta cephalotes Leafcutter ant  Acep\ACEP27796   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13547   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13124   Linepithema humile Argentine ant  Lhum\LH21384   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19987   Solenopsis invicta Red fire ant  Sinv\SINV25951   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001871   Bombyx mori Silkmoth  Bmor\BGIBMGA001921   Pediculus humanus Human body louse  Phum\PHUM623380   Pediculus humanus Human body louse  Phum\PHUM581040   Pediculus humanus Human body louse  Phum\PHUM623180   Tribolium castaneum Red flour beetle  Tcas\TC002963
Orthologs in non-Insect Arthropods (EOG6RN8QS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_304740
Orthologs in non-Arthropod Metazoa (EOG6P5Z3H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\arx-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010631gn   Danio rerio Zebrafish  Drer\OTTDARG00000031782   Danio rerio Zebrafish  Drer\ENSDARG00000091138   Danio rerio Zebrafish  Drer\ENSDARG00000076772   Xenopus tropicalis Western clawed frog  Xtro\actr3   Gallus gallus Domestic chicken  Ggal\ACTR3   Gallus gallus Domestic chicken  Ggal\ACTR3B   Mus musculus House mouse  Mmus\Actr3   Mus musculus House mouse  Mmus\ENSMUSG00000056367   Rattus norvegicus Norway rat  Rnor\Actr3   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031855   Homo sapiens Human  Hsap\ACTR3   Homo sapiens Human  Hsap\ACTR3B
Human Orthologs (2)
Gene OMIM HGNC Hsap\ACTR3     Hsap\ACTR3B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17591 Drosophila sechellia Dsec\GM24973 Drosophila erecta Dere\GG14922 Drosophila yakuba Dyak\GE20375 Drosophila ananassae Dana\GF10484 Drosophila pseudoobscura pseudoobscura Dpse\GA20439 Drosophila persimilis Dper\GL22484 Drosophila willistoni Dwil\GK19880 Drosophila virilis Dvir\GJ13271 Drosophila mojavensis Dmoj\GI12000 Drosophila grimshawi Dgri\GH15291
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	39721 P{UASp-Arp3.GFP}1, w* 39723 w*; P{UASp-Arp3.GFP}2 39722 w*; P{UASp-Arp3.GFP}3/TM6B, Tb1 17149 w1118; P{EP}Arp3EP3640/TM6B, Tb1 32921 y1 sc* v1; P{TRiP.HMS00711}attP2 39726 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}80B Arp383F/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb1 39727 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}80B Arp3515FC/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb1
VDRC	v35258 w1118; P{GD12273}v35258 v35260 w1118; P{GD12273}v35260
Genomic Clones ( 2 )
	BACR06E04 BACR09I19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 163 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35711
Other clones	DPiM_LD35711
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26284 LD01138 LD06361 LD08213 LD10403 LD12492 LD14941 LD17202 LD34583 LP06369 RE01303 RE03507 RE04461 RE09048 RE10547 RE12217 RE12565 RE12976 RE25208 RE25505 RE29209 RE32311 RE36655 RE40442 RE42690 RE44933 RE48462 RE54479 RE54492 RE57653 RE62151 RE62152 RE71141 RE71984 RE75157 RH63061 SD03633 SD05905 SD14245 SD21250
Other clones	14757 18877 19574 59886 69935 99589 121408 145304 158378 165032 272659 275515 280440 522250 524668 525557 CK01.68D.E5 CK01.102A.A10 CK02073 Dmel_neb_014277_0114_0429 EC28482 EK055015 EK085935 EK132861 EK197414 EK222111 EK251529 EK252620 EK261001 EK261537 EK299437 EK299901 EK303264 EK304911 EN01647 EN04905 EN05714 EN06718 FGA004B08 FGH127H08 FGM214D10 FGM229E02 RP003000526 RP003010357 RP003023805 RP003046752 RP003047361 RP003049079 RP003055501 RP003060414 RP003062430 RP003063420 RP003075980 RP003082520 RP003084868 RP003090638 RP003098409 RP003102925 RP003102976 RP003111142 RP003128547 RP003143816 RP003148717 RP003163121 RP003167067 RP003189505 RP003211635 RP003213406 RP003227557 RP003233670 RP003234375 RP003238270 RP003238898 RP003241797 RP003241809 RP003274380 RP003275085 RP003280118 RP003281772 RP003288923 RP003293940 RP003297222 RP003306695 RP003311226 RP003328447 RP003332718 RP003338544 RP003340129 RP003351681 RP003352168 RP003378146 RP003378252 RP003381447 RP003409874 RP003416101 RP003426977 RP003439069 RP003450192 RP003452584 RP003470189 RP003475304 RP003475333 RP003486605 RP003490017 RP003504033 RP003506396 RP003513628 RP003541061 RP003544467 RP003562041 RP003564803 RP003566460 RP003575254 RP003581341 RP003584220 RP003596542 RP003629125 RP003636767 RP003641973 RP003667105 RP003673712
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38898
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Arp3 Arp66B (FlyBase, 2009-)
Source for database merge of	Source for merge of: Arp66B schwachling (Berger et al., 2008)
Additional comments	FlyBase Curator comment: 'Arp66B' renamed to 'Arp3' to rationalize the nomenclature of Actin-related protein (Arp) genes (by orthology with the mammalian and yeast genes) and better reflect community usage. (FlyBase, 2009-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The Arp66B protein part of the Arp2/3 complex. (Stevenson et al., 2002) The Arp2/3 complex (including Arp66B) is required for actin cap expansion and pseudocleavage furrow formation during syncytial blastoderm divisions. (Stevenson et al., 2002) Isolation and characterisation of actin-related proteins Arp14D, Arp53D, Arp66B and Arp87C. (Fyrberg et al., 1994) Isolation and partial characterisation of Arp66B. (Fyrberg and Fyrberg, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079244 NM_001274630 RefSeq (Proteins) • NP_523968 NP_001261559 DDBJ / EMBL / GenBank • AAF50488 AAK93283 AGB94254 AI518886 AQ073082 AW943300 AX260176 AY051859 CAA50674 X71789 Entrez Gene - A searchable database of RefSeq genes. • 38898 UniProtKB/Swiss-Prot • P32392
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-related protein (IPR004000) Actin-related protein 3 (Arp3) (IPR015623) Actin/actin-like conserved site (IPR020902)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38898 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P32392
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	Actr66B (Fyrberg and Fyrberg, 1993, ) AcTr66B   anon-WO0172774.138   Arp3 (Giagtzoglou et al., 2012, Rotkopf et al., 2011, Isaji et al., 2011, Grevengoed et al., 2003, Bogdan et al., 2004, Rogers et al., 2003, Noguchi et al., 2005, Rorth, 2002, Frank et al., 2005, Vartiainen and Machesky, 2004, Noguchi et al., 2004, Lundquist, 2003, Zallen et al., 2002, Hudson and Cooley, 2002, Miller, 2002, Jacinto et al., 2002, Kiehart and Franke, 2002, Hudson and Cooley, 2002, Stevenson et al., 2002, Rogat and Miller, 2002, Tal et al., 2002, Hudson and Cooley, 2001, Rajan et al., 2007, Iwasa and Mullins, 2007, Richardson and Baylies, 2008, Schäfer et al., 2008, Richardson et al., 2007, Biyasheva et al., 2004, Price et al., 2006, Jovceva et al., 2007, Berger et al., 2008, Rajan et al., 2009, Massarwa et al., 2009, Serio et al., 2010, Beltzner and Pollard, 2004, Eriksson et al., 2010, Leibfried et al., 2013, Sarpal et al., 2012, Reed et al., 2012) arp3 (Rogat and Miller, 2002, Frankel and Mooseker, 1996, Frank et al., 2006, Noguchi et al., 2008, Leibfried et al., 2008, Nahm et al., 2010, Hatan et al., 2011) ARP3 (Goldstein and Gunawardena, 2000, Reed et al., 2012) arp66B (Fyrberg, 1993.5.4, Johnson et al., 2008, Georgiou et al., 2008, Wang et al., 2008, Sánchez-Soriano et al., 2010) Arp66B (Stroschein-Stevenson et al., 2006, Stuart et al., 2007, Bakal et al., 2007, Berger et al., 2008, Gonçalves-Pimentel et al., 2011, D'Ambrosio and Vale, 2010, Rotkopf et al., 2011, Japanese National Institute of Genetics, 2012.5.21) arp66b (Georgiou and Baum, 2010) CG7558 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) schwachling
Name Synonym	Actin-related protein (Fyrberg and Fyrberg, 1993) actin-related protein-3 (Rajan et al., 2009) Actin-related protein 3   Actin-related protein 66B (Fyrberg et al., 1994, ) schwachling (Griemert et al., 2007, Berger et al., 2008)
Secondary FlyBase IDs
	FBgn0011744 FBgn0046458 FBgn0086714
References ( 88 )
Generate a list of	All references relating to this gene ( 88 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 9 ) Review  ( 9 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 9 )
	Ingerman et al., 2013, J. Cell Biol. 200(5): 619--633 Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly. [FBrf0220981] Leibfried et al., 2013, Development 140(2): 362--371 A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. [FBrf0220348] Giagtzoglou et al., 2012, J. Cell Biol. 196(1): 65--83 dEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions. [FBrf0217836] Reed et al., 2012, Cell. Microbiol. 14(4): 529--545 Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. [FBrf0217748] Sarpal et al., 2012, J. Cell Sci. 125(1): 233--245 Mutational analysis supports a core role for Drosophila α-Catenin in adherens junction function. [FBrf0217336] Gonçalves-Pimentel et al., 2011, PLoS ONE 6(3): e18340 Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. [FBrf0213367] Hatan et al., 2011, J. Cell Biol. 192(2): 307--319 The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures. [FBrf0212807] Isaji et al., 2011, PLoS ONE 6(8): e22755 Myosin VI Regulates Actin Structure Specialization through Conserved Cargo-Binding Domain Sites. [FBrf0214724] Rotkopf et al., 2011, Development 138(13): 2729--2739 The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. [FBrf0213892] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...