FlyBase Gene Report: Dmel\Arp3

ACTIN-RELATED PROTEIN 2/3 COMPLEX -: The Actin-related protein 2/3 complex is involved in the organization of the actin cytoskeleton, in particular, the nucleation of branched actin filaments. (Adapted from FBrf0144947).
ACTIN-RELATED PROTEINS -: Actin-related proteins (Arp) share significant sequence identity with actins. Arps broadly fall into two groups: nuclear Arps, involved in chromatin remodeling; and cytoplasmic Arps, associated with actin. (Adapted from PMID:21859859).

Protein Function (UniProtKB)

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline (PubMed:25739458).

(UniProt, P32392)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Arp3 or the JBrowse view of Dmel\Arp3 for information on other features

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Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene

(Griemert et al., 2007)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Arp3-RA

FBtr0076737

NM_079244

1983

418

Arp3-RB

FBtr0334087

NM_001274630

1585

418

Additional Transcript Data and Comments

Reported size (kB)

1.257 (longest cDNA)

(Fyrberg et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Arp3-PA

FBpp0076460

47.0

418

5.84

NP_523968

AAF50488

Arp3-PB

FBpp0306212

47.0

418

5.84

NP_001261559

AGB94254

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

418 aa isoforms: Arp3-PA, Arp3-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

418 (aa)

(Fyrberg et al., 1994)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the Arp2/3 complex.

(UniProt, P32392)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P32392

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arp3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Arp3_1

Linkouts

Gene Ontology (21 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

contributes_to actin filament binding

inferred from biological aspect of ancestor with PANTHER:PTN000233796

(assigned by GO_Central )

(Gaudet et al., 2011)

ATP binding

inferred from electronic annotation with InterPro:IPR015623

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

structural constituent of cytoskeleton

inferred from sequence or structural similarity with HGNC:170

(Hudson and Cooley, 2002)

Biological Process (14 terms)

Terms Based on Experimental Evidence (13 terms)

CV Term

Evidence

References

actin cytoskeleton organization