Src64, Src, Dsrc64B, Src1, MRE5
Src homolog: a protein tyrosine kinase with SH3 and SH2 domains - plays a role in ring canal morphogenesis during oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of Src42A.
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.53
Gene model reviewed during 6.01
4.8, 4.4, 3.0 (northern blot)
Interacts with hzg.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Src64B using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Src64B in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Src64B expression induces JNK-mediated apoptosis or tissue overgrowth when apoptosis is blocked with p35.
Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, a whole range of mitotic abnormalities, spindle abnormalities and chromosome abnormalities are seen.
Src64B plays a role in the cytoskeletal dynamics that occur during cellularization of the blastoderm.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Src64B is essential for the proper organization of actin in ovarian ring canals.
Phylogenetic analysis of the PTK family.
Phosphorylation of the C-terminal tail of the Src64B protein can repress the activity of the adjacent catalytic domain of the protein.
Considered to be the Drosophila sequence homologous to mammalian c-src, based both on its origin and amino acid sequence as inferred from its nucleotide sequence.