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Gene Dmel\Src64B

General Information
Symbol	Dmel\Src64B	Species	D. melanogaster
Name	Src oncogene at 64B	Annotation symbol	CG7524
Feature type	protein_coding_gene	FlyBase ID	FBgn0262733
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	Src64, dSrc, Src, DSrc64B, DSrc64, Src1, MRE5
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64B11-64B12	Sequence location	3L:4,592,447..4,626,196 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Src oncogene at 64B is referred to in FlyBase by the symbol Dmel\Src64B (CG7524, FBgn0262733). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity. There is experimental evidence for 24 unique biological process terms, many of which group under: cellular component organization or biogenesis; single-organism developmental process; ovarian nurse cell to oocyte transport; learning or memory; localization; macromolecule modification; biological regulation; system development; actin filament-based process; phosphorus metabolic process. 65 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organ system subdivision; anatomical structure; portion of tissue; adult segment; external compound sense organ; epithelial cell; adult; organelle; embryonic foregut; karyosome. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Src homology-3 domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Gene sequence location is 3L:4592447..4626196.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Src1: Src proto oncogene sequence Considered to be the Drosophila sequence homologous to mammalian c-src, based both on its origin and amino acid sequence as inferred from its nucleotide sequence. The polypeptide product as yet uncharacterized, but presumed to be a protein kinase; Drosophila extracts do exhibit tyrosine kinase activity (Simon et al., 1983). In the region of the polypeptide responsible for kinase and transforming activity, Drosophila amino acid sequence 54% homologous with that from v-src, 100 base pairs beginning with the tryosine-416 codon 62% homologous with Drosophila Abl (Hoffman, Fresco, Hoffman-Falk, and Shilo, 1983, Cell 35: 393-401). Src transcripts abundant in early embryos and in adult ovaries. Level declines in later embryos and is low in males and ovarectomized females; inferred to be a maternally acting gene whose product is required for early embryogenesis (Wadsworth, Madhaven, and Bilodeau-Wentworth, 1985, Nucleic Acids Res. 13: 2153-70).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64B11-64B12   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64B-64B   (determined by in situ hybridisation)   (Lev and Segev, 1986) 64B-64B   (determined by in situ hybridisation)   (Simon et al., 1985) 64B-64B   (determined by in situ hybridisation)   (Hoffman-Falk et al., 1983)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Src64B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Src64B-RB FBtr0073321  NM_080195   2782   552 Src64B-RC FBtr0100504  NM_001014562   2567   552 Src64B-RD FBtr0100505  NM_001014561   2815   552 Src64B-RE FBtr0100507  NM_001014564   2717   552 Src64B-RF FBtr0100508  NM_001014563   2956   552 Src64B-RG FBtr0302593  NM_001202121   2717   552 Src64B-RH FBtr0302594  NM_001202122   2510   552 Src64B-RI FBtr0304989  NM_001259700   4338   552 Src64B-RJ FBtr0304990  NM_001259699   4786   552
Additional Transcript Data & Comments
Reported size (kB)	4.8, 4.4, 3.0 (northern blot) (Kimchie et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Src64B-PB   FBpp0073177   63.0   552   7.15     NP_524934   AAF47922 Src64B-PC   FBpp0099944   63.0   552   7.15     NP_001014562   AAX52734 Src64B-PD   FBpp0099946   63.0   552   7.15     NP_001014561   AAX52735 Src64B-PE   FBpp0099947   63.0   552   7.15     NP_001014564   AAX52736 Src64B-PF   FBpp0099948   63.0   552   7.15     NP_001014563   AAX52737 Src64B-PG   FBpp0291749   63.0   552   7.15     NP_001189050   ADV37487 Src64B-PH   FBpp0291750   63.0   552   7.15     NP_001189051   ADV37488 Src64B-PI   FBpp0293526   63.0   552   7.15     NP_001246629   AFH04300 Src64B-PJ   FBpp0293527   63.0   552   7.15     NP_001246628   AFH04299
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) SH2 domain (IPR000980) Src homology-3 domain (IPR001452) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201492   AA203001   AA203056   AA246453   AA246486   AA246878   AA263639   AA263916   AA391520   AA392973   AA438424   AA438504   AA440113   AA440857   AA536524   AA540033   AA540475   AA541056   AA541165   AA541178   AA695235   AA802357   AA817015   AA942503   AA949123   AA949345   AA949522   AA949530   AA949916   AA950441   AA950574   AA951577   AA951581   AA979038   AE014296 AAF47922   AE014296 AAX52734   AE014296 AAX52735   AE014296 AAX52736   AE014296 AAX52737   AE014296 ADV37487   AE014296 ADV37488   AF067908   AE014296 AFH04299   AE014296 AFH04300   AI061916   AI062133   AI456081   AI456216   AI457036   AI512074   AI512553   AI513929   AI514783   AI515403   AI515889   AI542188   AI542462   AI544186   AJ002919 CAA05754   AQ073107   AW943026   AY051781 AAK93205   AY070851   BF503805   BG637848   BG639114   BG639135   BH759200   BI142193   BI164253   BI165221   BI165358   BI167225   BI168059   BI169240   BI170134   BI214528   BI228534   BI236921   BI236924   BI239270   BI239299   BI239977   BI241207   BI242882   BI242992   BI243104   BI351747   BI356233   BI357834   BI358683   BI361299   BI361411   BI363890   BI364324   BI365449   BI365909   BI367096   BI367653   BI370019   BI376148   BI481889   BI486596   BI567485   BI577877   BI605129   BI605743   BI609129   BI614408   BI615196   BI631653   BI632286   BP544900   BQ103458   BX036947   CA806695   CL868563   CO157056   CO179121   CO186057   CO186213   CO187883   CO263471   CO264824   CO265414   CO265470   CO265911   CO275217   CO276352   CO277634   CO280380   CO281648   CO283648   CO285080   CO287269   CO288294   CO291753   CO292615   CO293496   CO293955   CO295283   CO296795   CO306271   CO306706   CO310349   CO317376   CO317394   CO317729   CO321487   CO323552   CO324700   CO328245   CO329829   CO330636   CO332124   CO338969   CO339016   CO340255   CO340559   CO341017   CO341395   CO343127   CZ467161   CZ467407   CZ470596   CZ474483   CZ474504   CZ478179   CZ487603   CZ487604   CZ487663   CZ489665   CZ490363   DN154302   EC051522   EC051688   EC057621   EC057722   EC058382   EC058469   EC060977   EC061854   EC064206   EC068524   EC068777   EC069119   EC078160   EC084268   EC084471   EC085880   EC087239   EC087241   EC087844   EC196000   EC196200   EC198222   EC198835   EC200949   EC201404   EC205236   EC210801   EC211201   EC212346   EC212699   EC217516   EC226984   EC226985   EC230390   EC231723   EC232289   EC232295   EC233567   EC233763   EC235095   EC235103   EC235721   EC237006   EC242290   EC242760   EC242761   EC244092   EC244255   EC244820   EC244831   EC248982   EC249163   EC249173   EC250706   EC251619   EC252162   EC254249   EC254907   EC255960   EC257106   EC257787   EC260729   EC265866   ES693073   ES693074   ES693083   ES693084   ES693115   ES693118   ES693233   ES693237   ES693242   ES693297   GH752977   GH758840   GH771237   GH772959   GH777396   GH784526   GH785718   GH788824   GH793233   GH804177   GH808705   GH811264   GH815042   GH815668   GH816169   GH829988   GH846551   GH848563   GH854610   GH854839   GH858458   GH862002   GH862786   GH865912   GH877043   GH879150   GH881625   GH883795   GH885567   GH890873   GH897303   GH901217   GH901427   GH903194   GH909605   GH912738   GH915436   GH915740   GH916941   GH917554   GH918933   GH920351   GH926725   GH930022   GH938249   K01043 AAA28489   M11917 AAA28913
UniProtKB/Swiss-Prot	P00528
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
dot blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Wadsworth et al., 1985) prepupal stage -- pupal stage     (Wadsworth et al., 1985) adult stage | female     (Wadsworth et al., 1985) oogenesis & adult stage | female   ovary   (Wadsworth et al., 1985) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval dorsal vessel   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   oocyte   (Kimchie et al., 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   furrow canal | restricted   (Thomas and Wieschaus, 2004) adult stage & oogenesis   nurse cell | restricted   (Roulier et al., 1998) ring canal   (Roulier et al., 1998)
Additional Descriptive Data
	Src64B protein is localized to the cellularization front during cellularization of the embryo. (Thomas and Wieschaus, 2004) Src64B protein is detected in ring canals and nurse cell membranes. (Roulier et al., 1998)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
germline ring canal inferred from direct assay (O'Reilly et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    41 central nervous system, pupae P8    49 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    62 ovary, mated 4-day female    45 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3  (41) central nervous system, pupae P8  (49) head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female  (62) ovary, mated 4-day female  (45) testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    41 central nervous system, pupae P8    49 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    62 ovary, mated 4-day female    45 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    41 central nervous system, pupae P8    49 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    62 ovary, mated 4-day female    45 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    41 central nervous system, pupae P8    49 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    62 ovary, mated 4-day female    45 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3  (41) central nervous system, pupae P8  (49) head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female  (62) ovary, mated 4-day female  (45) testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    41 central nervous system, pupae P8    49 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    62 ovary, mated 4-day female    45 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    41 central nervous system, pupae P8    49 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    62 ovary, mated 4-day female    45 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    82 embryo 04-06hr    62 embryo 06-08hr    60 embryo 08-10hr    60 embryo 10-12hr    42 embryo 12-14hr    56 embryo 14-16hr    46 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    29 embryo 22-24hr    28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day    31 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (82) embryo 04-06hr  (62) embryo 06-08hr  (60) embryo 08-10hr  (60) embryo 10-12hr  (42) embryo 12-14hr  (56) embryo 14-16hr  (46) embryo 16-18hr  (34) embryo 18-20hr    17 embryo 20-22hr  (29) embryo 22-24hr  (28) larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day  (31) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    82 embryo 04-06hr    62 embryo 06-08hr    60 embryo 08-10hr    60 embryo 10-12hr    42 embryo 12-14hr    56 embryo 14-16hr    46 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    29 embryo 22-24hr    28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day    31 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    82 embryo 04-06hr    62 embryo 06-08hr    60 embryo 08-10hr    60 embryo 10-12hr    42 embryo 12-14hr    56 embryo 14-16hr    46 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    29 embryo 22-24hr    28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day    31 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    82 embryo 04-06hr    62 embryo 06-08hr    60 embryo 08-10hr    60 embryo 10-12hr    42 embryo 12-14hr    56 embryo 14-16hr    46 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    29 embryo 22-24hr    28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day    31 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (82) embryo 04-06hr  (62) embryo 06-08hr  (60) embryo 08-10hr  (60) embryo 10-12hr  (42) embryo 12-14hr  (56) embryo 14-16hr  (46) embryo 16-18hr  (34) embryo 18-20hr    17 embryo 20-22hr  29 embryo 22-24hr  28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day  31 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    82 embryo 04-06hr    62 embryo 06-08hr    60 embryo 08-10hr    60 embryo 10-12hr    42 embryo 12-14hr    56 embryo 14-16hr    46 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    29 embryo 22-24hr    28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day    31 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    82 embryo 04-06hr    62 embryo 06-08hr    60 embryo 08-10hr    60 embryo 10-12hr    42 embryo 12-14hr    56 embryo 14-16hr    46 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    29 embryo 22-24hr    28 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    18 white prepupae 12hr    22 white prepupae 24hr    23 pupae 2d postWPP    22 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    14 adult female 05day    31 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    14 ovary OSC    50 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  (30) ovary fGS/OSS    14 ovary OSC  (50) ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    14 ovary OSC    50 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    14 ovary OSC    50 ovary OSS    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    14 ovary OSC    50 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  30 ovary fGS/OSS    14 ovary OSC  (50) ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    14 ovary OSC    50 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    10 embryonic S3    21 leg disc CME L1    7 wing disc CME-W2    10 wing disc ML-DmD8    18 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    4 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    14 ovary OSC    50 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (29) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	BDGP expression data • LD30429
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4GMR.PF Src64BYF.Scer\UAS lethal | embryonic stage | maternal effect | recessive Src64BΔ17 lethal | heat sensitive Src64Bhs.2sev Src64BΔ540.hs.2sev lethal | partially | heat sensitive Src64BKR.hs.2sev partially lethal - majority die | embryonic stage | maternal effect Src64Bko partially lethal - majority die | embryonic stage | maternal effect (with Src64BD404N) Src64Bko partially lethal - majority die | embryonic stage | maternal effect (with Src64Bko) Src64BD404N Src64BΔ17 partially lethal - majority die | embryonic stage | maternal effect (with Src64BΔ17) Src64Bko viable Src64BBGT-T063 Src64BEY12445 Src64BEY16432 Src64BKG00213 Src64BPI Src64BΔ17 Src64BΔ19 viable, with Scer\GAL4pnr-MD237 Src64BGD12263 Sterility Allele female semi-sterile Src64Bko female semi-sterile (with Src64BD404N) Src64Bko female semi-sterile (with Src64Bko) Src64BD404N Src64BΔ17 female semi-sterile (with Src64BΔ17) Src64Bko female semi-sterile | recessive Src64BKG00213 Src64BPI Src64BΔ17 Src64BΔ19 female sterile | partially | recessive Src64BPI Src64BΔ17 Src64BΔ19 fertile Src64BBGT-T063 Src64BEY12445 Src64BEY16432 fertile | poor Src64BΔ17 male fertile Src64BPI Src64BΔ17 Src64BΔ19 Other Phenotypes Allele cell shape defective Src64BΔ17 increased cell death Src64BΔ17 increased cell death, with Scer\GAL4GMR.PF Src64BScer\UAS.cPa memory defective Src64Bchingis-khan mitotic cell cycle defective, with Scer\GAL4GMR.PF Src64BScer\UAS.cPa Src64BYF.Scer\UAS neuroanatomy defective Src64BPI neuroanatomy defective, with Scer\GAL47B Src64BScer\UAS.cCa Src64BUY1332 neuroanatomy defective, with Scer\GAL4ey-OK107 Src64BScer\UAS.cCa Src64BUY1332 visible Src64Bhs.2sev Src64BΔ540.hs.2sev Src64BΔ540.hs.sev Phenotype manifest in Allele actin filament Src64BΔ17 actin filament & nurse cell ring canal Src64BΔ17 actin filament | embryonic stage 5 Src64BΔ17 alpha-lobe & axon Src64BPI anterior commissure | heat sensitive Src64BKR.hs.2sev beta-lobe & axon Src64BPI border follicle cell, with Scer\GAL4slbo.2.6 Src64BScer\UAS.cCa centripetally migrating follicle cell, with Scer\GAL4slbo.2.6 Src64BScer\UAS.cCa denticle belt | heat sensitive Src64BΔ540.hs.2sev egg Src64BPI egg | maternal effect Src64BΔ17 egg chamber Src64Bko Src64BPI Src64BΔ19 Src64BΔ17 egg chamber, with Scer\GAL4nos.UTR.T:Hsim\VP16 Src64BYF.Scer\UAS egg chamber (with Src64Bko) Src64BΔ17 egg chamber (with Src64BΔ17) Src64Bko egg chamber | germline clone Src64BPI Src64BΔ17 embryonic/first instar larval cuticle | heat sensitive Src64BΔ540.hs.2sev embryonic/larval trachea, with Scer\GAL4btl.PS Src64BGS9618 extended germ band embryo | heat sensitive Src64BΔ540.hs.2sev Src64Bhs.2sev eye, with Scer\GAL4GMR.PF Src64BYF.Scer\UAS Src64BScer\UAS.cPa eye | heat sensitive Src64BKR.hs.2sev Src64BΔ540.hs.2sev Src64Bhs.2sev eye photoreceptor cell | heat sensitive Src64BΔ540.hs.2sev Src64Bhs.2sev filzkorper | heat sensitive Src64BΔ540.hs.2sev furrow canal Src64BΔ17 germline cyst Src64Bko Src64BΔ17 germline cyst, with Scer\GAL4nos.UTR.T:Hsim\VP16 Src64BYF.Scer\UAS inner nurse cell ring canal rim Src64BPI interfollicle cell Src64BΔ17 interommatidial bristle | ectopic, with Scer\GAL4GMR.PF Src64BScer\UAS.cPa karyosome Src64BΔ17 Kenyon cell, with Scer\GAL47B Src64BScer\UAS.cCa Src64BUY1332 Kenyon cell, with Scer\GAL4ey-OK107 Src64BScer\UAS.cCa Src64BUY1332 longitudinal connective | heat sensitive Src64BKR.hs.2sev Src64BΔ540.hs.2sev mushroom body Src64BPI mushroom body & axon, with Scer\GAL47B Src64BScer\UAS.cCa Src64BUY1332 mushroom body & axon, with Scer\GAL4ey-OK107 Src64BScer\UAS.cCa Src64BUY1332 mushroom body alpha-lobe, with Scer\GAL47B Src64BScer\UAS.cCa Src64BUY1332 mushroom body alpha-lobe, with Scer\GAL4ey-OK107 Src64BScer\UAS.cCa Src64BUY1332 mushroom body beta-lobe, with Scer\GAL47B Src64BScer\UAS.cCa Src64BUY1332 mushroom body beta-lobe, with Scer\GAL4ey-OK107 Src64BScer\UAS.cCa Src64BUY1332 nurse cell Src64Bko Src64BPI Src64BΔ17 Src64BH402L Src64BD404N nurse cell & nucleus Src64BΔ17 nurse cell fusome Src64BΔ17 nurse cell ring canal Src64Bko Src64BPI Src64BΔ19 Src64BΔ17 Src64BD204V Src64BG208E Src64BR217C Src64BD372N Src64BH402L Src64BD404N nurse cell ring canal (with Src64BD404N) Src64Bko nurse cell ring canal (with Src64Bko) Src64BD404N nurse cell ring canal | maternal effect Src64BΔ17 ommatidium | heat sensitive Src64BΔ540.hs.2sev Src64Bhs.2sev oocyte Src64Bko Src64BΔ17 outer nurse cell ring canal rim Src64BPI photoreceptor cell R7 Src64BΔ540.hs.sev plasma membrane | embryonic stage 5 Src64BΔ17 posterior commissure | heat sensitive Src64BKR.hs.2sev presumptive embryonic/larval nervous system | heat sensitive Src64BKR.hs.2sev Src64BΔ540.hs.2sev Src64Bhs.2sev presumptive embryonic salivary gland Src64BPI rhabdomere | heat sensitive Src64BKR.hs.2sev
Classical Alleles ( 44 )
For All Classical Alleles Show
Allele of Src64B Class Mutagen Stocks Known lesion Src64Bc04709 piggyBac transposase 2 -- Src64B5-SZ-3243 1 -- Src64Bc01424 piggyBac transposase 1 -- Src64BCB-6665-3 1 -- Src64Bd05355 P-element activity 1 -- Src64Be00290 piggyBac transposase 1 -- Src64BEY16432 P-element activity 1 -- Src64Bf05012 piggyBac transposase 1 -- Src64Bf07626 piggyBac transposase 1 -- Src64BG7151 P-element activity 1 -- Src64BGS9618 1 Yes Src64BKG00213 P-element activity 1 -- Src64BMB03494 1 -- Src64BMI00693 1 -- Src64BMI04396 1 -- Src64BPI.D ethyl methanesulfonate 1 Yes Src64BPI hypomorphic allele - genetic evidence Delta2-3 1 Yes Src64BUY1332 P-element activity 1 Yes Src64Bko amorphic allele - genetic evidence recombination SCEI endonuclease FLPase ends-out gene targeting 0 Yes Src64BBGT-T063 P-element activity 0 Yes Src64Bc01746 piggyBac transposase 0 -- Src64Bc06319 piggyBac transposase 0 -- Src64BC259Y ethyl methanesulfonate 0 Yes Src64Bchingis-khan P-element activity 0 -- Src64BCPTI000401 piggyBac transposase 0 Yes Src64BCPTI000567 piggyBac transposase 0 Yes Src64Bd05393 P-element activity 0 -- Src64BD204V ethyl methanesulfonate 0 Yes Src64BD372N ethyl methanesulfonate 0 Yes Src64BD404N ethyl methanesulfonate 0 Yes Src64BDG14509 P-element activity 0 -- Src64Be01280 0 -- Src64BEP3672 P-element activity 0 -- Src64BEY12445 P-element activity 0 -- Src64Bf05059 piggyBac transposase 0 -- Src64Bf06927 piggyBac transposase 0 -- Src64BG208E ethyl methanesulfonate 0 Yes Src64BH402L ethyl methanesulfonate 0 Yes Src64BP190L ethyl methanesulfonate 0 Yes Src64BR217C ethyl methanesulfonate 0 Yes Src64BR403C ethyl methanesulfonate 0 Yes Src64BS440F ethyl methanesulfonate 0 Yes Src64BΔ17 hypomorphic allele - genetic evidence Delta2-3 0 Yes Src64BΔ19 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Src64B Class Mutagen Stocks Known lesion Src64BGD12263 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Src64BGL00297 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Src64BJF03234 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Src64BScer\UAS.cCa in vitro construct - regulatory fusion 1 Yes Src64BAct5C.PG in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct 0 Yes Src64BAct5C.PW in vitro construct - regulatory fusion 0 Yes Src64BdsRNA.cWa in vitro construct - RNAi 0 Yes Src64Bhs.2sev in vitro construct - regulatory fusion 0 Yes Src64Bhs.PD in vitro construct - regulatory fusion 0 Yes Src64BK312R in vitro construct - amino acid replacement 0 Yes Src64Bko.Scer\SceI.RS in vitro construct 0 Yes Src64BKR.hs.2sev in vitro construct - regulatory fusion 0 Yes Src64BNIG.7524R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Src64Bosk.PO in vitro construct - regulatory fusion 0 Yes Src64BScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes Src64BY434F in vitro construct - amino acid replacement 0 Yes Src64BY547F in vitro construct - amino acid replacement 0 Yes Src64BYF.Scer\UAS in vitro construct - regulatory fusion 0 Yes Src64BαTub67C.PD in vitro construct - regulatory fusion 0 Yes Src64BΔ540.hs.2sev in vitro construct - regulatory fusion 0 Yes Src64BΔ540.hs.sev in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)GN19 (Feng et al., 1995) Df(3L)GN34 (Feng et al., 1995) Df(3L)HR277 (Feng et al., 1995) Df(3L)HR298 (Feng et al., 1995) Df(3L)TE1 (Feng et al., 1995) Df(3L)TE3 (Feng et al., 1995) Df(3L)X37 (Feng et al., 1995) T(2;3)TE2 (Feng et al., 1995)
Disrupted in	Df(3L)ems13 (Feng et al., 1995) Df(3L)Exel7208 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Src64B.D} NA P{S10-KR} NA P{S10-WT} NA P{S10-Δ540} NA P{Δ540} NA UAS construct P{GD12263} NA P{NIG.7524R} NA P{TRiP.GL00297} NA P{TRiP.JF03234} NA P{UAS-Src64B.C} NA P{UAS-Src64B.P} NA P{UAS-Src64B.YF} NA characterization construct P{FRT(w+mW.hs.Src64B.Scer\SceI.RS</up>)} NA P{RasMyr} NA P{SE-cswC583Ssrc90} NA P{sevhs-cswsrc90} NA P{sevhs-cswsrc90G2A} NA P{sev-Src90-Ras1V12.ΔCAAX} NA P{UAS-csw.src90} NA P{UAS-unc-5.Myr} NA P{αTub67C-Src64B.D} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Rpd3EP3672 NA P{EP}Src64BG7151 NA P{EPgy2}Src64BEY12445 NA P{EPgy2}Src64BEY16432 NA P{GSV6}Src64BGS9618 NA P{Mae-UAS.6.11}Src64BUY1332 NA P{XP}Src64Bd05355 NA P{XP}Src64Bd05393 NA miscellaneous insertions Mi{MIC}Src64BMI00693 NA Mi{MIC}Src64BMI04396 NA P{lwB.D}Src64BPI.D NA P{lwB.D}Src64BPI NA P{RS3}Src64BCB-6665-3 NA P{RS5}Src64B5-SZ-3243 NA P{SUPor-P}Src64BKG00213 NA P{wHy}Src64BDG14509 NA PBac{602.P.SVS-1}Src64BCPTI000401 NA PBac{602.P.SVS-1}Src64BCPTI000567 NA PBac{PB}Src64Bc01424 NA PBac{PB}Src64Bc01746 NA PBac{PB}Src64Bc04709 NA PBac{PB}Src64Bc06319 NA PBac{RB}Src64Be00290 NA PBac{RB}Src64Be01280 NA PBac{WH}Src64Bf05012 NA PBac{WH}Src64Bf05059 NA PBac{WH}Src64Bf06927 NA PBac{WH}Src64Bf07626 NA insertion of enhancer trap P{lacZ}Src64Bchingis-khan No P{lwB}Src64BBGT-T063 No insertion of enhancer trap binary system Mi{ET1}Src64BMB03494 No
Gene Ontology: Function, Process & Cellular Component ( 29 unique terms )
Terms Based on Experimental Evidence ( 25 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Djagaeva et al., 2005) adherens junction organization inferred from mutant phenotype (Shindo et al., 2008) cellularization inferred from mutant phenotype (Thomas and Wieschaus, 2004) epithelial cell-cell adhesion inferred from mutant phenotype (Shindo et al., 2008) female germline ring canal formation inferred from mutant phenotype (Dodson et al., 1998, O'Reilly et al., 2006) female germline ring canal formation, actin assembly inferred from mutant phenotype (Kelso et al., 2002) female germline ring canal stabilization inferred from mutant phenotype (Dodson et al., 1998) germarium-derived egg chamber formation inferred from mutant phenotype (O'Reilly et al., 2006) germarium-derived female germ-line cyst encapsulation inferred from mutant phenotype (O'Reilly et al., 2006) karyosome formation inferred from mutant phenotype (Djagaeva et al., 2005) learning or memory inferred from mutant phenotype (Dubnau et al., 2003) long-term memory inferred from mutant phenotype (Akalal et al., 2011) mushroom body development inferred from mutant phenotype (Nicolai et al., 2003) negative regulation of synaptic growth at neuromuscular junction inferred from genetic interaction with Fak (Tsai et al., 2008) olfactory learning inferred from mutant phenotype (Dubnau et al., 2003) oogenesis inferred from mutant phenotype (Djagaeva et al., 2005) open tracheal system development inferred from mutant phenotype (Shindo et al., 2008) ovarian fusome organization inferred from mutant phenotype (Djagaeva et al., 2005) ovarian nurse cell to oocyte transport inferred from mutant phenotype (Djagaeva et al., 2005) parallel actin filament bundle assembly inferred from mutant phenotype (Kelso et al., 2002) peptidyl-tyrosine phosphorylation inferred from genetic interaction with Src42A (Muda et al., 2002) protein phosphorylation inferred from genetic interaction with Src42A (Muda et al., 2002) regulation of actin polymerization or depolymerization inferred from mutant phenotype (Kelso et al., 2002) salivary gland morphogenesis inferred from mutant phenotype (Harris and Beckendorf, 2007)
Cellular Component
CV term Evidence References
germline ring canal inferred from direct assay (O'Reilly et al., 2006)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity inferred from electronic annotation with InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Simon et al., 1985) non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000, Swiss-Prot Project Members, 1986.7.21)
Biological Process
CV term Evidence References
dorsal closure traceable author statement (Harden, 2002) JNK cascade traceable author statement (Harden, 2002) protein phosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
germline ring canal traceable author statement (Deng and Lin, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Src64B - Cdc37 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Src64B - Nmdar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Src64B - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Src64B - olf186-F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Src64B allele Gene References Src64BBGT-T063 RhoGAPp190 (Billuart et al., 2001) Src64BPI Akap200 (Jackson and Berg, 2002) RhoGAPp190 (Billuart et al., 2001) Src42A (Tateno et al., 2000) Src64BScer\UAS.cPa Csk (Pedraza et al., 2004) Src64BΔ17 Btk29A (Roulier et al., 1998, Guarnieri et al., 1998) csw (Firth et al., 2000) phl (Li et al., 2000) Src64BΔ540.hs.2sev Ras85D (Kussick et al., 1993) sina (Kussick et al., 1993) Src64BΔ540.hs.sev csw (Cooper et al., 1996) drk (Cooper et al., 1996) unspecified Btk29A (Djagaeva et al., 2005, Chandrasekaran and Beckendorf, 2005, Djagaeva, 2005) Csk (O'Reilly et al., 2006, Read et al., 2004) E(Src64)2B (Wilson et al., 2000) pbl (Gregory et al., 2007) Ret (Read et al., 2005) Src42A (Takahashi et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262733 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P00528
Orthologs
OrthoDB Orthologs (104) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG612MR1 Dipteran inclusive ortholog search EOG6WSWJT Insect inclusive ortholog search EOG6893GR Arthropod inclusive ortholog search EOG6RXWFH Metazoa inclusive ortholog search EOG65BD7R
Orthologs in Drosophila Species (EOG612MR1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Src64B     Drosophila simulans   Dsim\Src64B Y   Drosophila sechellia   Dsec\Src64B Y   Drosophila erecta   Dere\GG14172 Y   Drosophila yakuba   Dyak\GE20600 Y   Drosophila ananassae   Dana\GF24724 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28339     Drosophila pseudoobscura pseudoobscura   Dpse\GA28338 Y   Drosophila persimilis   Dper\GL17941 Y   Drosophila willistoni   Dwil\GK17605 Y   Drosophila virilis   Dvir\GJ15487 Y   Drosophila mojavensis   Dmoj\GI12582 Y   Drosophila grimshawi   Dgri\GH15800 Y   Drosophila grimshawi   Dgri\GH12950
Orthologs in non-Drosophila Dipterans (EOG6WSWJT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004592   Anopheles gambiae Malaria mosquito  Agam\AGAP006510   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007458
Orthologs in non-Dipteran Insects (EOG6893GR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46371 Y Apis mellifera Western honey bee  Amel\LOC412588 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006407 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009605 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17550 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14042 Y Atta cephalotes Leafcutter ant  Acep\ACEP13303 Y Atta cephalotes Leafcutter ant  Acep\ACEP15825 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12800 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20575 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17508 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17309 Y Linepithema humile Argentine ant  Lhum\LH11572 Y Linepithema humile Argentine ant  Lhum\LH24553 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18301 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12394 Y Solenopsis invicta Red fire ant  Sinv\SINV19526 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001933 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001730 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012094 Y Pediculus humanus Human body louse  Phum\PHUM378190 Y Pediculus humanus Human body louse  Phum\PHUM305940 Y Tribolium castaneum Red flour beetle  Tcas\TC002522 Y Tribolium castaneum Red flour beetle  Tcas\TC009792 Y
Orthologs in non-Insect Arthropods (EOG6RXWFH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305164 Y Ixodes scapularis Deer tick  Isca\ISCW006822 Y Ixodes scapularis Deer tick  Isca\ISCW007829 Y
Orthologs in non-Arthropod Metazoa (EOG65BD7R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\src-2 Y Caenorhabditis elegans Nematode  Cele\src-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005419gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023261gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019224gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024525gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013522gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026766gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014473gn Y Danio rerio Zebrafish  Drer\yrk Y Danio rerio Zebrafish  Drer\OTTDARG00000030576 Y Danio rerio Zebrafish  Drer\yes1 Y Danio rerio Zebrafish  Drer\lyn Y Danio rerio Zebrafish  Drer\ENSDARG00000076399 Y Danio rerio Zebrafish  Drer\CU928042.1 Y Danio rerio Zebrafish  Drer\src Y Danio rerio Zebrafish  Drer\bltk Y Danio rerio Zebrafish  Drer\fynb Y Danio rerio Zebrafish  Drer\lck Y Danio rerio Zebrafish  Drer\fyna Y Xenopus tropicalis Western clawed frog  Xtro\fgr Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000006166 Y Xenopus tropicalis Western clawed frog  Xtro\fyn Y Xenopus tropicalis Western clawed frog  Xtro\lck Y Xenopus tropicalis Western clawed frog  Xtro\lyn Y Xenopus tropicalis Western clawed frog  Xtro\src Y Xenopus tropicalis Western clawed frog  Xtro\yes1 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000021626 Y Gallus gallus Domestic chicken  Ggal\SRC Y Gallus gallus Domestic chicken  Ggal\FRK Y Gallus gallus Domestic chicken  Ggal\BLK Y Gallus gallus Domestic chicken  Ggal\FYN Y Gallus gallus Domestic chicken  Ggal\YES1 Y Gallus gallus Domestic chicken  Ggal\HCK Y Mus musculus House mouse  Mmus\Frk Y Mus musculus House mouse  Mmus\Blk Y Mus musculus House mouse  Mmus\Lck Y Mus musculus House mouse  Mmus\Yes1 Y Mus musculus House mouse  Mmus\Fgr Y Mus musculus House mouse  Mmus\Lyn Y Mus musculus House mouse  Mmus\Src Y Mus musculus House mouse  Mmus\Hck Y Rattus norvegicus Norway rat  Rnor\Fyn Y Rattus norvegicus Norway rat  Rnor\Fgr Y Rattus norvegicus Norway rat  Rnor\Hck Y Rattus norvegicus Norway rat  Rnor\Blk Y Rattus norvegicus Norway rat  Rnor\Yes1 Y Rattus norvegicus Norway rat  Rnor\Src Y Rattus norvegicus Norway rat  Rnor\Frk Y Rattus norvegicus Norway rat  Rnor\Lck Y Rattus norvegicus Norway rat  Rnor\Lyn Y Homo sapiens Human  Hsap\ENSG00000010810 Y Homo sapiens Human  Hsap\LYN Y Homo sapiens Human  Hsap\FRK Y Homo sapiens Human  Hsap\LCK Y Homo sapiens Human  Hsap\YES1 Y Homo sapiens Human  Hsap\FGR Y Homo sapiens Human  Hsap\BLK Y Homo sapiens Human  Hsap\ENSG00000101336 Y Homo sapiens Human  Hsap\ENSG00000197122 Y
Human Orthologs (9)
Gene OMIM HGNC Hsap\ENSG00000010810     Hsap\LYN     Hsap\FRK     Hsap\LCK     Hsap\YES1     Hsap\FGR     Hsap\BLK     Hsap\ENSG00000101336     Hsap\ENSG00000197122
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Src64B Drosophila sechellia Dsec\Src64B Drosophila erecta Dere\GG14172 Drosophila yakuba Dyak\GE20600 Drosophila ananassae Dana\GF24724 Drosophila pseudoobscura pseudoobscura Dpse\GA28338 Drosophila persimilis Dper\GL17941 Drosophila willistoni Dwil\GK17605 Drosophila virilis Dvir\GJ15487 Drosophila mojavensis Dmoj\GI12582 Drosophila grimshawi Dgri\GH15800
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Bloomington	8477 w*; P{UAS-Src64B.C}2 24071 w1118; Mi{ET1}Src64BMB03494 30517 y1 v1; P{TRiP.JF03234}attP2
Harvard	- P{XP}Src64Bd05355 - PBac{PB}Src64Bc01424 - PBac{PB}Src64Bc04709 - PBac{RB}Src64Be00290 - PBac{WH}Src64Bf05012 - PBac{WH}Src64Bf07626
Kyoto	124169 w1118; P{RS3}Src64BCB-6665-3 125958 w1118; P{RS5}Src64B5-SZ-3243
VDRC	v35252 w1118 P{GD12263}v35252
	More stocks available...
Genomic Clones ( 2 )
	BACR05M07 BACR23H09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 252 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM03914 LD30429
Other clones	DPiM_LD30429
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01218 GM02456 GM04254 GM15974 GM30480 LD03514 LD03566 LD04571 LD05419 LD06770 LD07152 LD10390 LD10529 LD12141 LD12506 LD14701 LD15902 LD17169 LD19362 LD19972 LD20994 LD21013 LD21992 LD26755 LD27901 LD28209 LD28355 LD28363 LD28480 LD32179 LD32191 LD33284 LD34983 LD35917 LD36087 LD37252 LD43752 LD43812 LD45970 LD46470 LD47218 LD47638 RE03891 RE05061 RE05237 RE07561 RE08594 RE10352 RE11493 RE20363 RE26095 RE33051 RE33054 RE35719 RE35756 RE36616 RE38229 RE40359 RE40510 RE40659 RE42331 RE44424 RE45460 RE45616 RE48864 RE49413 RE51313 RE52773 RE53539 RE56381 RE64081 RE64503 RE70045 RE71636 RH13873 RH37887 RH43770 RH44768 RH61273 RH70660 RH71642 SD08326 SD08796 SD16207 SD26027
Other clones	7463 7590 14307 20791 29967 31249 31885 32173 34756 34908 35216 35813 39516 40132 42743 52720 60965 63694 63817 67609 70299 73780 75233 75475 79630 81617 81620 103851 104872 121523 144480 144652 163376 163426 164723 191129 214217.22 214219.2 214219.17 214351.2 214411.5 214439.22 214443.21 214479.21 274789 533608 AT05013 CK01.12D.F11 CK01.15B.G11 CK01.17C.G3 CK01.35C.E5 CK01.35C.F1 CK01.43D.H6 CK01.74C.G3 CK01.77B.D8 CK01.77D.F9 CK01.77D.G8 CK01.86B.G8 CK01.95C.E10 CK01.106B.E11 CK01.125A.A2 EC051522 EC051688 EK015526 EK017026 EK034616 EK058526 EK065409 EK068160 EK088620 EK116742 EK120604 EK125650 EK140420 EK142610 EK142742 EK144427 EK153925 EK157763 EK164006 EK168147 EK185757 EK190814 EK194540 EK198113 EK200605 EK203128 EK205230 EK209328 EK211403 EK215161 EK221305 EK250655 EK252016 EK267845 EK267912 EK268920 EK293953 EK295802 EK302550 EN09842 EP00443 EP00625 EP08822 EP10303 EP10904 EP11731 EP12359 EP16144 ESG014c.E21_F03 FGC028D06 LD05349 LD06062 LD20842 LD30227 LD41584 LD44457 RE50764 RP003039213 RP003041688 RP003047003 RP003057067 RP003066564 RP003068015 RP003069085 RP003090144 RP003108511 RP003108811 RP003110476 RP003150587 RP003155477 RP003155881 RP003160076 RP003162615 RP003172572 RP003201174 RP003210381 RP003213485 RP003234321 RP003239560 RP003252169 RP003261321 RP003270087 RP003278606 RP003292616 RP003305889 RP003353167 RP003354374 RP003386535 RP003386805 RP003387232 RP003411768 RP003445105 RP003453845 RP003457368 RP003472416 RP003502325 RP003526668 RP003573956 RP003577875 RP003617008 RP003663737 RP003670666 UUGC0864
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48973
Antibody Information
	polyclonal (Langton et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Src64B CG7524 (Bayraktaroglu, 2000.4.13) Source for merge of: Src64B MRE5 (FlyBase Genome Annotators, 2011)
Additional comments	MRE5 is part of the 3' UTR of Src64B. (FlyBase Genome Annotators, 2011) MRE5 corresponds to a portion of the 3' UTR of Src64B. (FlyBase Genome Annotators, 2011) Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	Based on the frequency of observed ovarian defects, the following Src64B alleles can be ranked from strongest to weakest as follows: Src64BΔ17 > Src64BPI > Src64BΔ19 > Src64BKG00213. (Djagaeva et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, a whole range of mitotic abnormalities, spindle abnormalities and chromosome abnormalities are seen. (Bettencourt-Dias et al., 2004) Src64B plays a role in the cytoskeletal dynamics that occur during cellularization of the blastoderm. (Thomas and Wieschaus, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Clonal analysis with Src64BPI shows that the requirement for Src64B in mushroom body beta-lobe development is cell autonomous. (Nicolai et al., 2003) Src64B is essential for the proper organization of actin in ovarian ring canals. (Kelso et al., 2002) Src64B is required for the proper growth and stability of ovarian ring canals. (Dodson et al., 1998) Phylogenetic analysis of the PTK family. (Suga et al., 1997) Abnormal eye development caused by ectopic expression of an activated form of Src64B is alleviated by dominant-negative mutations of csw or drk. (Cooper et al., 1996) The closest relative of vertebrate c-src so far found is not Src64B, but Src42A. (Takahashi et al., 1996) Phosphorylation of the C-terminal tail of the Src64B protein can repress the activity of the adjacent catalytic domain of the protein. (Kussick and Cooper, 1992) Considered to be the Drosophila sequence homologous to mammalian c-src, based both on its origin and amino acid sequence as inferred from its nucleotide sequence. (Lindsley and Zimm, 1992) Src64B inferred to be a maternally acting gene whose product is required for early embryogenesis. (Wadsworth et al., 1985)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080195 NM_001014561 NM_001014562 NM_001014563 NM_001014564 NM_001202121 NM_001202122 NM_001259699 NM_001259700 RefSeq (Proteins) • NP_524934 NP_001014561 NP_001014562 NP_001014563 NP_001014564 NP_001189050 NP_001189051 NP_001246628 NP_001246629 DDBJ / EMBL / GenBank • AA950574 AAA28489 AAA28913 AAF47922 AAF47922.1 AAK93205 AAX52734 AAX52735 AAX52736 AAX52737 ADV37487 ADV37488 AF067908 AFH04299 AFH04300 AJ002919 AQ073107 AW943026 AY051781 BH759200 CAA05754 CL868563 CZ467161 CZ467407 CZ470596 CZ474483 CZ474504 CZ478179 CZ487603 CZ487604 CZ487663 CZ489665 CZ490363 K01043 M11917 Entrez Gene - A searchable database of RefSeq genes. • 48973 UniProtKB/Swiss-Prot • P00528
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) SH2 domain (IPR000980) Src homology-3 domain (IPR001452) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD30429
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262733 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48973 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P00528
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	CG7524 (Dubnau et al., 2003, Morrison et al., 2000, Quinones-Coello, 2007, Perkins et al., 2009, Aerts et al., 2010, Ni et al., 2011.7.19) c-src (Drees et al., 1987) C-src1   DmHD-358 (Oates, 1997.11.10, ) Dm SRC1 (Gibson and Spring, 1998) dSrc (Wills et al., 2002, Juang and Hoffmann, 1999, Langton et al., 2007) dsrc (Colson, 1998.5.26) DSrc (Cooper et al., 1996) Dsrc (Kussick et al., 1993, Kussick and Cooper, 1992, Wadsworth, 1990, ) D-src (Pribyl et al., 1988) DSrc64 (Palmer et al., 1999) Dsrc64 (Wills et al., 1999, Takahashi et al., 1996) DSRC64 (Robinson and Cooley, 1996) D-Src64B (Bugga et al., 2009) DSrc64B (Jackson and Berg, 2002) Dsrc64B (Farazi et al., 2001, Dobrovolskaia and Belitsky, 1997, Comer et al., 1998, Hoffmann, 1991, Shishido et al., 1991) HD-358   MRE5 (FlyBase Genome Annotators, 2011, Kageyama, 2007.2.28, Inagaki et al., 2005) Src (Petit et al., 2002, Roche, 1998, Fashena and Zinn, 1997, Suga et al., 1997, Edgar, 2006, Gorfinkiel and Arias, 2007) src (Johnson Hamlet and Perkins, 2000) Src1 (Dodson et al., 1996, Gertler et al., 1995, Feng et al., 1995, Lindsley and Zimm, 1992) src1   Src64 (Djagaeva, 2005, Djagaeva et al., 2005, Laberge et al., 2005, Lu et al., 2004, Nicolai et al., 2003, Muda et al., 2002, Bates and Letsou, 2003, Kelso et al., 2002, Deng and Lin, 2001, Thomas and Wieschaus, 2003, Lu et al., 2003, Hudson and Cooley, 2002, Worby et al., 2002, Billuart et al., 2001, van der Flier and Sonnenberg, 2001, Stern and Beckendorf, 2001, Schock et al., 2001, Stern et al., 2000, Wilson et al., 2000, Tateno et al., 2000, Kelso and Cooley, 1999, Dodson et al., 1998, Guarnieri et al., 1998, Roulier et al., 1998, Cooley, 1998, Simon et al., 1998, Strong and Thomas, 2007, O'Reilly et al., 2006, Harris and Beckendorf, 2007) src64 (Thomas and Wieschaus, 2004, Kelso et al., 2001, Rorth et al., 2000, Strong et al., 2011) Src64B (Williams, 2009, Singh et al., 2010, FlyBase Genome Annotators, 2011, Gregory et al., 2007, Jordan et al., 2005, Quinones-Coello, 2007, Maines et al., 2007, Song et al., 2008, Tsai et al., 2008, Langton et al., 2007, Shindo et al., 2008, Wouda et al., 2008, Ranade et al., 2008, Xia et al., 2008, Junion et al., 2007, Langton et al., 2009, Csiszar et al., 2010, Aerts et al., 2010, Hazelett et al., 2009, Berger et al., 2008, MacDougall et al., 2004, Japanese National Institute of Genetics, 2012.5.21, Nelson et al., 2012) src64B (Gu and Gu, 2003) src64b (Michaut et al., 2003, McPhee et al., 2010) SRC 64B (Morrison et al., 2000)
Name Synonym	mRNA-like ncRNA in embryogenesis 5   Src oncogene at 64B   Src proto oncogene sequence (Lindsley and Zimm, 1992)
Secondary FlyBase IDs
	FBgn0003501 FBgn0022792 FBgn0035561 FBgn0086537
References ( 173 )
Generate a list of	All references relating to this gene ( 173 )
List References by type	Research paper  ( 96 ) Supplementary material  ( 9 ) Review  ( 18 ) Personal communication to FlyBase  ( 20 ) Abstract  ( 18 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Book  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Enomoto and Igaki, 2013, EMBO Rep. 14(1): 65--72 Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. [FBrf0220433] Nelson et al., 2012, Nat. Cell Biol. 14(5): 518--525 Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size. [FBrf0218197] Akalal et al., 2011, J. Neurosci. 31(15): 5643--5647 The Long-Term Memory Trace Formed in the Drosophila {alpha}/{beta} Mushroom Body Neurons Is Abolished in Long-Term Memory Mutants. [FBrf0213484] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Strong et al., 2011, PLoS ONE 6(11): e28100 Mutations in the Catalytic Loop HRD Motif Alter the Activity and Function of Drosophila Src64. [FBrf0216835] Strong and Thomas, 2011, genesis 49(12): 912--918 Maternal and zygotic requirements for src64 during Drosophila cellularization. [FBrf0216851] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...