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Gene Dmel\Rbp2

General Information
Symbol	Dmel\Rbp2	Species	D. melanogaster
Name	RNA-binding protein 2	Annotation symbol	CG4429
Feature type	protein_coding_gene	FlyBase ID	FBgn0262734
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	MRE9, RRM2
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14C6-14C8	Sequence location	X:16,342,710..16,349,005 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene RNA-binding protein 2 is referred to in FlyBase by the symbol Dmel\Rbp2 (CG4429, FBgn0262734). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding; translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: translational initiation. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Gene sequence location is X:16342710..16349005.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN28805 HFA20276
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14C6-14C8   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rbp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rbp2-RA FBtr0074279  NM_080220   3886   325 Rbp2-RB FBtr0074280  NM_167522   3883   324 Rbp2-RC FBtr0074281  NM_206764   2628   358
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rbp2-PA   FBpp0074055   35.1   325   9.83     NP_524959   AAF48616 Rbp2-PB   FBpp0074056   34.9   324   9.68     NP_727982   AAN09409 Rbp2-PC   FBpp0089381   38.3   358   9.83     NP_996487   AAS65388
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA433205   AA440056   AA539542   AA695022   AA696571   AA802279   AA803363   AA948964   AA951173   AE014298 AAF48616   AE014298 AAN09409   AE014298 AAS65388   AI387955   AI405078   AI512952   AI542566   AY094752   BI171415   BI216039   BI241194   BI364852   BI365575   BI564250   BI569132   BI569133   BI569605   BI586743   BI589793   BI592563   BI605031   BI607941   BI610780   BI618988   BI625229   BI641897   BP558479   BP558480   BQ102756   BT024190   BT088437   BT125964   CO153529   CO156166   CO176922   CO177728   CO180828   CO185480   CO185482   CO187020   CO190122   CO190948   CO191897   CO192516   CO193571   CO196208   CO196218   CO196220   CO196256   CO196257   CO262581   CO264128   CO266236   CO268305   CO271890   CO273720   CO275938   CO278631   CO279184   CO283465   CO287941   CO288632   CO289225   CO289248   CO289430   CO289896   CO290338   CO291718   CO296792   CO300522   CO302627   CO304862   CO305811   CO307678   CO307703   CO311240   CO312510   CO314230   CO315356   CO316958   CO317834   CO317938   CO317940   CO321974   CO321992   CO322557   CO322949   CO323339   CO324515   CO329284   CO331361   CO333476   CO334055   CO337764   CO343330   EC056735   EC057031   EC058135   EC058136   EC058786   EC061533   EC064773   EC066677   EC066716   EC068003   EC069611   EC074188   EC076744   EC077730   EC078025   EC083040   EC086839   EC195475   EC200569   EC202296   EC202476   EC203883   EC204246   EC204812   EC207625   EC207924   EC208315   EC210071   EC210085   EC211777   EC214773   EC214898   EC216473   EC216727   EC219209   EC222585   EC223989   EC224802   EC226478   EC226660   EC227309   EC228592   EC231578   EC232525   EC234884   EC235066   EC235899   EC240128   EC241997   EC242131   EC242775   EC243286   EC244201   EC244998   EC245374   EC249070   EC259868   EC261195   EC267959   ES688677   ES689532   ES693400   ES693964   EV583069   EV594961   EV596677   EV596976   EV597503   EV598120   EV598315   FE527555   GH943987   GH954127   GH959658   GH959965   GH961457   GH963267   GH963790   GH973286   S51692 AAB24623
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q26272 Q7KUX7 Q8IR13 Q9VXF8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Rbp2GD10708 Rbp2GD16570 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Rbp2 Class Mutagen Stocks Known lesion Rbp2EY00852 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rbp2 Class Mutagen Stocks Known lesion Rbp2GD10708 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rbp2GD16570 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rbp2KK108805 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC134 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10708} NA P{GD16570} NA P{KK108805} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Rbp2EY00852 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Kim, 1993.3.10) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000)
Biological Process
CV term Evidence References
translational initiation inferred from sequence or structural similarity (Lasko, 2000)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Lasko, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rbp2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262734
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19517 Dgri\GH24789 Dmoj\GI21487 Dper\GL20267 Dpse\GA18178 Dsec\GM13442 Dsim\GD17286 Dvir\GJ19028 Dwil\GK25675
Curated drosophilid orthologs	Dpse\GA18178
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	15830 y1 w67c23 P{EPgy2}Rbp2EY00852
VDRC	v100817 P{KK108805}VIE-260B v34301 w1118; P{GD10708}v34301 v48119 w1118; P{GD16570}v48119
Genomic Clones ( 1 )
	BACR47D09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 175 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM07660 RE23444 RH12113
Other clones	FI04456
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18665 GH24991 GM01955 GM04131 GM07905 GM10732 LD15135 LD17726 LD27680 LD31506 LD45112 RE13188 RE22840 RE38215 RE50043 RE50935 RH01708 RH03282 RH10285 RH12048 RH16572 RH26838 RH36123 RH49943 RH65525 RH70544 SD08949 SD25553
Other clones	148 11523 18630 18837 28910 35201 37146 43818 46791 57830 60824 60856 62545 63347 70291 75982 76261 81493 100953 102411 104647 108641 123702 146594 148678 149439 156495 156858 158303 162167 164508 165415 165528 174028 190354 214409.47 272859 281735 283175 527210 569613 AA433205 CK01.17B.G3 CK01.57B.E4 CK01.63B.H5 CK01.67B.B2 CK01.85A.E10 CK01.87B.F3 CK01.89C.G12 CK01.90B.G9 CK01.94D.H11 CK01.101D.H7 CK01.108B.H7 CK01.113A.F6 CK01.113A.G6 CK01.119B.E11 CK01.133A.F4 Dmel_dig_016326_0682_1060 Dmel_neb_006689_0948_1414 Dmel_neb_009592_0641_0376 Dmel_neb_011938_0925_2217 Dmel_neb_012097_0861_2134 Dmel_neb_013220_0885_0747 Dmel_neb_013340_0822_3577 DMG3-chrX.12978.pred.a EC12851 EC32366 EC33941 EC36413 EK001960 EK002042 EK002045 EK002442 EK002445 EK009717 EK009720 EK025348 EK046650 EK050224 EK051624 EK054137 EK067351 EK069022 EK070514 EK070545 EK071025 EK072402 EK073732 EK085832 EK090920 EK105046 EK112010 EK119204 EK130631 EK133726 EK137547 EK145518 EK163338 EK178423 EK184601 EK186916 EK186947 EK188363 EK189263 EK190246 EK194005 EK198033 EK215156 EK223856 EK229134 EK235458 EK246556 EK249461 EK255229 EK255321 EK261154 EK266364 EK269164 EK269827 EK269833 EK292432 EK299364 EK307035 EK308754 EN02307 EN07458 EN15244 EP16605 FGM315C04 RC0-DA0001-120700-017-H08 RC0-DA0001-130700-121-A02 RC0-DL0001-140700-015-B02 RC0-DL0001-140700-121-C11 RH01312 RP004119404 RP004243888 RP004384279 RP004510372 RP004517410 RP004535310 RP004550108 RP004553917 UUGC0140
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49809
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rbp2 anon-EST:fe1B9 (FlyBase, 1996-) Source for merge of: Rbp2 CG4429 (Misra, 2000.7.28) Source for merge of: Rbp2 MRE9 (FlyBase Genome Annotators, 2011)
Additional comments	MRE9 is part of the 3' UTR of Rbp2. (FlyBase Genome Annotators, 2011) MRE9 corresponds to a portion of the 3' UTR of Rbp2. (FlyBase Genome Annotators, 2011)
Other Comments
	A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs. (Kim and Baker, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080220 NM_167522 NM_206764 RefSeq (Proteins) • NP_524959 NP_727982 NP_996487 DDBJ / EMBL / GenBank • AA433205 AAB24623 AAF48616 AAN09409 AAS65388 S51692 Entrez Gene - A searchable database of RefSeq genes. • 49809 UniProtKB/TrEMBL • Q7KUX7 Q8IR13 Q9VXF8 Q26272
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262734 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49809
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-EST:fe1B9   cg4429 (Lasko, 2000) CG4429 (Lasko, 2000, Keleman et al., 2009.8.5, Hughes et al., 2008) eIF4H (Lasko, 2000) MRE9 (FlyBase Genome Annotators, 2011, Kageyama, 2007.2.28, Inagaki et al., 2005) Rbp2 (FlyBase Genome Annotators, 2011, Song and Tanouye, 2007, Maines et al., 2007, Akdemir et al., 2007, Lindsay et al., 2008, Popodi et al., 2010-) RRM2 (Kim, 1993.3.10, ) rrm2 (Kim and Baker, 1993)
Name Synonym	anon-fast-evolving-1B9   mRNA-like ncRNA in embryogenesis 9   RNA-binding protein 2
Secondary FlyBase IDs
	FBgn0010256 FBgn0025264 FBgn0030754 FBgn0086541
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...