• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Imp

General Information
Symbol	Dmel\Imp	Species	D. melanogaster
Name	IGF-II mRNA-binding protein	Annotation symbol	CG1691
Feature type	protein_coding_gene	FlyBase ID	FBgn0262735
Gene Model Status	Current	Stock availability	27 publicly available
Also Known As	dIMP, MRE11, l(1)G0072, IMP-1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	9F1-9F4	Sequence location	X:10,682,721..10,716,815 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene IGF-II mRNA-binding protein is referred to in FlyBase by the symbol Dmel\Imp (CG1691, FBgn0262735). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: nervous system development; synaptic growth at neuromuscular junction; spermatogenesis. 62 alleles are reported. The phenotypes of these alleles are annotated with: chorion; NMJ bouton; egg; macrochaeta; dorsal appendage. It has 11 annotated transcripts and 11 annotated polypeptides. Protein features are: K Homology; K Homology, type 1; K Homology, type 1, subgroup; Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Gene sequence location is X:10682721..10716815.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Vazquez-Pianzola et al., 2011, Dev. Biol. 357(2): 404--418
FB2012_01	Sequence features BKN22717 HFA18861 HFA18857 HFA20255
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 9F1-9F4   Limits computationally determined from genome sequence between P{EP}sesBEP319&P{EP}ImpEP760 and P{EP}EP1321EP1321&P{EP}CG2061EP1537
Experimentally Determined Cytological Location
Cytogenetic map Notes References 9F1-9F4   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 9C3-9C4   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Imp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Imp-RA FBtr0073420  NM_078556   3296   566 Imp-RB FBtr0073419  NM_167254   2859   566 Imp-RC FBtr0073418  NM_167255   6758   566 Imp-RD FBtr0073416  NM_167249   8741   573 Imp-RE FBtr0073417  NM_167250   3700   573 Imp-RF FBtr0073413  NM_167251   4477   573 Imp-RG FBtr0073415  NM_167252   5578   573 Imp-RH FBtr0073414  NM_167253   7373   573 Imp-RJ FBtr0301409  NM_001169246   3938   580 Imp-RK FBtr0305149     3401   631 Imp-RL FBtr0305150     11030   638
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Imp-PA   FBpp0073276   62.1   566   10.16     NP_511111   AAF47958 Imp-PB   FBpp0073275   62.1   566   10.16     NP_727456   AAN09274 Imp-PC   FBpp0073274   62.1   566   10.16     NP_727457   AAN09275 Imp-PD   FBpp0073272   62.7   573   9.32     NP_727451   AAN09269 Imp-PE   FBpp0073273   62.7   573   9.32     NP_727452   AAN09270 Imp-PF   FBpp0073269   62.7   573   9.32     NP_727453   AAN09271 Imp-PG   FBpp0073271   62.7   573   9.32     NP_727454   AAN09272 Imp-PH   FBpp0073270   62.7   573   9.32     NP_727455   AAN09273 Imp-PJ   FBpp0290623   63.4   580   8.77     NP_001162717   ACZ95252 Imp-PK   FBpp0293679   69.4   631   9.72       Imp-PL   FBpp0293680   69.9   638   8.29
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • K Homology, type 1, subgroup (IPR018111) K Homology (IPR004087) K Homology, type 1 (IPR004088) RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141244   AA142188   AA142189   AA433245   AA695399   AA735742   AE014298 AAF47958   AE014298 AAN09269   AE014298 AAN09270   AE014298 AAN09271   AE014298 AAN09272   AE014298 AAN09273   AE014298 AAN09274   AE014298 AAN09275   AE014298 ACZ95252   AF241237 AAF63331   AI534274   AI543547   AJ426851   AJ569406   AJ569407   AJ569408   AJ569409   AJ569410   AJ569411   AJ569412   AJ569414   AJ569415   AJ569416   AJ569417   AJ569418   AJ569419   AJ569420   AJ569421   AJ569422   AJ569423   AJ569425   AJ569426   AJ569427   AJ569428   AJ569429   AJ569430   AJ569431   AQ025352   AQ254772   AW941345   AW944480   AX154690   AY060869   AY060967 AAL28515   AY069821 AAL39966   AY070894   AY094765   BE977342   BF489876   BF501371   BI164823   BI169440   BI173815   BI212268   BI214030   BI232134   BI234694   BI361533   BI367336   BI483833   BI487061   BI569187   BI578973   BI638664   BI641373   BP540412   BP540998   BP541000   BP541147   BP541855   BP541888   BP542550   BP543661   BP543662   BP544458   BP544459   BP546202   BP546451   BP549546   BP549547   BP553261   BP553262   BP553482   BP553483   BP553621   BP553622   BP555695   BP555696   BP555713   BP555714   BP556176   BP556177   BP557609   BP557610   BP559738   BP559739   BQ103733   BT001739 AAN71494   BT011069   BT120349   BX028935   CO152662   CO154152   CO155151   CO176811   CO177242   CO177946   CO189926   CO190316   CO190796   CO264794   CO265628   CO269920   CO273663   CO278733   CO278828   CO279808   CO280358   CO280848   CO282594   CO284973   CO286424   CO286447   CO287805   CO289977   CO292518   CO292826   CO296665   CO302911   CO303992   CO304163   CO308273   CO308953   CO309508   CO311674   CO311692   CO311943   CO312422   CO312868   CO314364   CO315312   CO315521   CO315758   CO315912   CO317194   CO320192   CO320356   CO321272   CO324087   CO324121   CO324888   CO326175   CO329492   CO330543   CO332543   CO333175   CO336429   CO337414   CO338012   CO338342   CO339384   CO344725   CZ471596   CZ472474   CZ472695   CZ472696   CZ474115   CZ474753   CZ476107   CZ476112   CZ476309   CZ482294   CZ482305   CZ482306   CZ488707   CZ490556   CZ490557   DN154427   DQ327759   EC056664   EC057990   EC059699   EC061177   EC061373   EC064993   EC065007   EC065084   EC070021   EC072009   EC073182   EC073432   EC074074   EC075132   EC076270   EC077896   EC078627   EC080172   EC081122   EC083878   EC086154   EC087681   EC087753   EC089229   EC089577   EC090052   EC196779   EC196780   EC198358   EC200736   EC202538   EC203108   EC203446   EC203904   EC204121   EC206218   EC210737   EC211830   EC213773   EC216323   EC216627   EC216982   EC218233   EC218369   EC219148   EC224790   EC226175   EC226562   EC227776   EC230519   EC235576   EC236448   EC245202   EC249649   EC249676   EC250388   EC251239   EC253307   EC257698   EC261718   EC262337   EC262891   EC263119   EC265193   EC265276   EC265551   EC268003   EG974120   EG974144   ES690006   EV575851   EV578259   EV581975   EV584940   EV589108   EV596774   EV598835   EV598946
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGK4 Q8IR99 Q95S41 Q9VZ69 Q0KHU2 E1JJM0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   pole plasm | posterior   (Lecuyer et al., 2007) organism | ubiquitous & uniform   (Nielsen et al., 2000) Comment:maternally deposited embryonic stage 4 -- 14   pole cell   (Nielsen et al., 2000) embryonic stage 5   pole cell   (Lecuyer et al., 2007) embryonic stage 6 -- 7   organism | striped   (Nielsen et al., 2000) Comment:4 diffuse circumferential stripes that broaded with time embryonic stage 8 -- 9   ventral furrow   (Nielsen et al., 2000) cephalic furrow   (Nielsen et al., 2000) ventral neurogenic region   (Nielsen et al., 2000) procephalic neurogenic region   (Nielsen et al., 2000) embryonic stage 10 -- 12   ventral nerve cord primordium   (Nielsen et al., 2000) embryonic stage 10 -- 16   presumptive embryonic/larval central nervous system   (Nielsen et al., 2000) embryonic stage 11   embryonic epidermis   (Nielsen et al., 2000)
Additional Descriptive Data
	Imp expression at embryonic stages 1-4 is localized to the posterior pole of the embryo. (Lecuyer et al., 2007)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4elav.PU ImpRE.Scer\UAS lethal (with Df(1)HC133) ImpH44 ImpH149 lethal | adult stage ImpG0072 lethal | embryonic stage, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 ImpSD.Scer\UAS lethal | embryonic stage | germline clone | maternal effect | recessive ImpH44 lethal | pharate adult stage ImpG0072 lethal | pharate adult stage, with Scer\GAL4Act5C.PU ImpRE.Scer\UAS ImpSD.Scer\UAS lethal | pharate adult stage | recessive ImpH44 ImpH149 lethal | recessive ImpG0072 viable ImpCB04573 ImpPTT viable, with Scer\GAL4Act5C.PU ImpKH.Scer\UAS viable, with Scer\GAL4elav.PU ImpKH.Scer\UAS ImpSD.Scer\UAS viable, with Scer\GAL4pnr-MD237 ImpGD9232 Sterility Allele female fertile, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 ImpKH.Scer\UAS ImpRE.Scer\UAS fertile ImpPTT Other Phenotypes Allele locomotor behavior defective | adult stage, with Scer\GAL4elav.PU ImpRE.Scer\UAS locomotor behavior defective | adult stage (with ImpH44) ImpH149 locomotor behavior defective | adult stage (with ImpH149) ImpH44 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 ImpEP1433 neuroanatomy defective | third instar larval stage, with Scer\GAL4elav.PU ImpRE.Scer\UAS neuroanatomy defective | third instar larval stage (with ImpH44) ImpH149 neuroanatomy defective | third instar larval stage (with ImpH149) ImpH44 uncoordinated | adult stage, with Scer\GAL4elav.PU ImpRE.Scer\UAS uncoordinated | adult stage (with ImpH44) ImpH149 uncoordinated | adult stage (with ImpH149) ImpH44 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 ImpEP1433 chorion, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 ImpScer\UAS.cGa dorsal appendage, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 ImpSD.Scer\UAS egg, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 ImpScer\UAS.cGa macrochaeta ImpBG01822 NMJ bouton, with Scer\GAL4elav.PU ImpRE.Scer\UAS NMJ bouton (with ImpH44) ImpH149 NMJ bouton (with ImpH149) ImpH44
Classical Alleles ( 55 )
For All Classical Alleles Show
Allele of Imp Class Mutagen Stocks Known lesion ImpBG02083 1 -- ImpCB-5523-3 1 -- ImpCB-6236-3 1 -- ImpCB-6504-3 1 -- ImpCB-6657-3 1 -- Impd00435 P-element activity 1 -- Impd01837 P-element activity 1 -- Impd02239 P-element activity 1 -- Impd04757 P-element activity 1 -- Impd08578 P-element activity 1 -- Impe04542 piggyBac transposase 1 -- Impe04556 piggyBac transposase 1 -- ImpEP760 P-element activity 1 -- Impf06066 piggyBac transposase 1 -- Impf07810 piggyBac transposase 1 -- ImpG0072 P-element activity 1 -- ImpKG08397 1 -- ImpNP0519 1 -- ImpNP0783 1 -- ImpNP2784 1 -- ImpNP5012 1 -- ImpNP6059 1 -- ImpZCL0310 1 -- ImpZCL2884X 1 -- Imp2 P-element activity 0 Yes Imp5-HA-2179 0 -- Imp5-HA-2280 0 -- Imp5-HA-2419 0 -- Imp7 P-element activity 0 Yes Imp8 P-element activity 0 Yes ImpBG01822 P-element activity 0 Yes ImpCB-6780-3 0 -- ImpCB04573 P-element activity 0 Yes ImpCPTI003910 piggyBac transposase 0 Yes ImpCPTI004044 piggyBac transposase 0 Yes ImpCPTI004117 piggyBac transposase 0 Yes Impd05843 P-element activity 0 -- Impd08180 P-element activity 0 -- Impd08187 P-element activity 0 -- Impd10873 0 -- ImpEP1330 P-element activity 0 -- ImpEP1433 P-element activity 0 Yes ImpG00080 P-element activity 0 -- ImpG00152 P-element activity 0 Yes ImpG0171X 0 -- ImpG0293X 0 Yes ImpGG01224 0 -- ImpGG01290 0 -- ImpH149 Delta2-3 0 Yes ImpH44 Delta2-3 0 Yes ImpHC133 0 -- ImpNP4135 0 -- ImpPTT 0 Yes ImpYB0057 Delta2-3 0 -- ImpYD0166 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Imp Class Mutagen Stocks Known lesion ImpGD9232 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ImpHMS01168 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ImpKH.Scer\UAS in vitro construct - deletion 0 Yes ImpRE.Scer\UAS in vitro construct - regulatory fusion 0 Yes ImpScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes ImpSD.Scer\UAS in vitro construct - regulatory fusion 0 Yes ImpαTub67C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(1)N110 (Roote, 1999.10.28)
Disrupted in	Df(1)HC133 (Roote, 1999.10.28, Boylan et al., 2008) Df(1)v64f (Roote, 1999.10.28)
Duplicated in	Dp(1;Y)v+y+ (Boylan et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9232} NA P{TRiP.HMS01168} NA P{UAS-Imp.G} NA P{UASp-Imp.KH} NA P{UASp-Imp.RE} NA P{UASp-Imp.SD} NA characterization construct P{αTub67C-Imp.T:Avic\GFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP1207EP1207 NA P{EP}ImpEP760 NA P{EP}ImpEP1330 NA P{EP}ImpEP1433 NA P{Mae-UAS.6.11}GG01082GG01082 NA P{Mae-UAS.6.11}ImpGG01224 NA P{Mae-UAS.6.11}ImpGG01290 NA P{XP}Impd00435 NA P{XP}Impd01837 NA P{XP}Impd02239 NA P{XP}Impd04757 NA P{XP}Impd05843 NA P{XP}Impd08180 NA P{XP}Impd08187 NA P{XP}Impd08578 NA P{XP}Impd10873 NA miscellaneous insertions P{?PTT-un1}ImpH44 NA P{GT1}ImpBG01822 NA P{GT1}ImpBG02083 NA P{PTT-GB}ImpCB04573 NA P{PTT-GB}ImpYB0057 NA P{PTT-un1}ImpG00080 NA P{PTT-un1}ImpG00152 NA P{PTT-un1}ImpG0171X NA P{PTT-un1}ImpG0293X NA P{PTT-un1}ImpPTT NA P{PTT-un1}ImpZCL0310 NA P{PTT-un1}ImpZCL2884X NA P{RS3}ImpCB-5523-3 NA P{RS3}ImpCB-6236-3 NA P{RS3}ImpCB-6504-3 NA P{RS3}ImpCB-6657-3 NA P{RS3}ImpCB-6780-3 NA P{RS5}Imp5-HA-2179 NA P{RS5}Imp5-HA-2280 NA P{RS5}Imp5-HA-2419 NA P{SUPor-P}ImpKG08397 NA PBac{802.P.SVS-2}ImpCPTI003910 NA PBac{806.LOX-SVS-2}ImpCPTI004044 NA PBac{806.LOX-SVS-2}ImpCPTI004117 NA PBac{HpaI-GFP.A}ImpYD0166 NA PBac{RB}Impe04542 NA PBac{RB}Impe04556 NA PBac{WH}Impf06066 NA PBac{WH}Impf07810 NA insertion of enhancer trap binary system P{GawB}ImpNP0519 No P{GawB}ImpNP0783 No P{GawB}ImpNP2784 No P{GawB}ImpNP4135 No P{GawB}ImpNP5012 No P{GawB}ImpNP6059 No insertion of enhancer trap P{lacW}ImpG0072 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nervous system development inferred from mutant phenotype (Koizumi et al., 2007) spermatogenesis inferred from expression pattern (Fabrizio et al., 2008) synaptic growth at neuromuscular junction inferred from mutant phenotype (Boylan et al., 2008)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Nielsen, 2000.3.2) inferred from sequence or structural similarity with EMBL:AF061569 (FlyBase, 1992-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Imp allele Gene References unspecified grim (Mueller et al., 2005) H (Mueller et al., 2005) p53 (Mueller et al., 2005) rpr (Mueller et al., 2005) W (Mueller et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262735
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20264 Dere\GG18899 Dgri\GH12054 Dmoj\GI15803 Dper\GL12935 Dpse\GA14212 Dsec\GM11285 Dsim\Imp Dvir\GJ18657 Dwil\GK16164 Dyak\GE15370
Curated drosophilid orthologs	Dpse\GA14212   Dsim\Imp
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 27 )
Harvard	- P{XP}Impd00435 - P{XP}Impd01837 - P{XP}Impd02239 - P{XP}Impd04757 - P{XP}Impd08578 - PBac{RB}Impe04542 - PBac{RB}Impe04556 - PBac{WH}Impf06066 - PBac{WH}Impf07810
Kyoto	110711 P{PTT-un1}ImpZCL0310 110921 P{PTT-un1}ImpZCL2884X
VDRC	v20321 w1118; P{GD9232}v20321
	More stocks available...
Genomic Clones ( 1 )
	CH223-05O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 185 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH27591 GM03661 GM09444 GM09708 LP02726 RE19990 RE72930 SD07045
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16666 AT26053 GM02754 RE04571 RE10617 RE16929 RE17326 RE19720 RE28152 RE30442 RE45784 RE53078 RE66783 RE70566 SD10340 SD21014 SD24633
Other clones	11485 18084 28149 30684 32811 38478 40092 41820 42745 56313 61467 64696 64746 71770 72350 81239 84073 101624 102444 102595 104110 104344 105341 120629 124837 146387 153707 157063 157465 158056 158804 160146 163130 164486 175691 177802 179566 190539 192423 241130 277088 281334 288538 291748 293242 294815 297864 299227 299746 AA433245 bs62f02 CK01.14D.H1 CK01.56C.H3 CK01.58D.C4 CK01.61D.G2 CK01.68B.F2 CK01.81B.B8 CK01.83D.C12 CK01.93A.C4 CK01.103D.C3 CK01.111A.B6 CK01.111C.A10 CK01.125C.G5 CK00322 CK01444 Dmel_dig_004308_0705_1017 Dmel_dig_004320_0618_0345 Dmel_dig_014144_0701_3116 Dmel_dig_015270_0677_3092 Dmel_neb_010565_0842_3325 Dmel_neb_011441_0929_2692 Dmel_neb_012663_0894_2864 Dmel_neb_015598_0415_1929 EC253307 EC257698 EK045623 EK047742 EK049657 EK051064 EK053005 EK054753 EK062808 EK062840 EK066842 EK072742 EK096706 EK111761 EK131358 EK131808 EK136059 EK140341 EK143240 EK153844 EK155041 EK160808 EK167748 EK185138 EK192509 EK192659 EK195101 EK200351 EK201030 EK214612 EK218028 EK225763 EK225918 EK227260 EK228725 EK230434 EK235938 EK243343 EK244021 EK257315 EK259756 EK260239 EK261027 EK261735 EK262403 EK263028 EK267312 EK282656 EK284426 EK290620 EK292953 EK295526 EK303826 EK306120 EN00119 EN03611 EN05456 EN12520 EN14516 EN15759 EN16539 EP01904 EP03357 EP19802 FGA004B07 FGA009G01 FGA009G03 FGA011A07 FGC006B08 FGC006F06 FGC014D01 FGC021F12 FGC026A04 FGH103H07 FGH106E09 FGM102B01 FGM223E03 FGM224F08 FGM225D06 FGM236F07 FGM236G04 FGM301G12 FGM310C04 FGM322F04 RC0-DA0003-130700-022-F02 RH01342 UUGC1144
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32009
Antibody Information
	polyclonal (Geng and Macdonald, 2006, Adolph et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: IGF-II CG1691 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Imp anon-EST:fe2B3 (FlyBase, 1996-) Source for merge of: Imp l(1)G0072 (Peter et al., 2002) Source for merge of: Imp MRE11 (FlyBase Genome Annotators, 2011)
Additional comments	MRE11 is part of the 3' UTR of Imp. (FlyBase Genome Annotators, 2011) MRE11 corresponds to a portion of the 3' UTR of Imp. (FlyBase Genome Annotators, 2011) Source for merge of: Imp anon-WO0140519.39 Source for merge of Imp anon-WO0140519.39 was sequence comparison (date:051113). (FlyBase, 1996-) Source for identity of IGF-II CG1691 was sequence comparison (date:000414). (FlyBase, 1996-)
Other Comments
	Imp plays no essential role in the assembly or function of the pole plasm. (Munro et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078556 NM_167249 NM_167250 NM_167251 NM_167252 NM_167253 NM_167254 NM_167255 NM_001169246 RefSeq (Proteins) • NP_511111 NP_727451 NP_727452 NP_727453 NP_727454 NP_727455 NP_727456 NP_727457 NP_001162717 DDBJ / EMBL / GenBank • AA142189 AA433245 AA735742 AAF47958 AAF63331 AAL28515 AAL39966 AAN09269 AAN09270 AAN09271 AAN09272 AAN09273 AAN09274 AAN09275 AAN71494 ABI30974 ACZ95252 AF241237 AI534274 AI543547 AJ426851 AJ569406 AJ569407 AJ569408 AJ569409 AJ569410 AJ569411 AJ569412 AJ569414 AJ569415 AJ569416 AJ569417 AJ569418 AJ569419 AJ569420 AJ569421 AJ569422 AJ569423 AJ569425 AJ569426 AJ569427 AJ569428 AJ569429 AJ569430 AJ569431 AQ025352 AQ254772 AW941345 AW944480 AX154690 AY060967 AY069821 BI578973 BT001739 CZ471596 CZ472474 CZ472695 CZ472696 CZ474115 CZ474753 CZ476107 CZ476112 CZ476309 CZ482294 CZ482305 CZ482306 CZ488707 CZ490556 CZ490557 DQ327759 Entrez Gene - A searchable database of RefSeq genes. • 32009 UniProtKB/TrEMBL • E1JJM0 Q0KHU2 Q8IGK4 Q8IR99 Q9VZ69 Q95S41
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • K Homology, type 1, subgroup (IPR018111) K Homology (IPR004087) K Homology, type 1 (IPR004088) RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262735 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32009
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	anon-EST:fe2B3   anon-WO0140519.39   CG1691 (Maia et al., 2007, Norga et al., 2003, Labourier et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Quinones-Coello, 2007, Grieder et al., 2007, Brandt et al., 2008, Worringer et al., 2009, Herold et al., 2009, Ni et al., 2011.7.19) cg1691 (Lasko, 2000) dIMP (Korey et al., 2001, Nielsen et al., 2000, Nielsen et al., 2002, Adolph et al., 2009) IGF-II   Imp (Gan et al., 2010, Maia et al., 2007, Saja et al., 2010, FlyBase Genome Annotators, 2011, Quinones-Coello et al., 2007, Terry et al., 2006, Buszczak et al., 2007, Quinones-Coello, 2007, Lecuyer et al., 2007, Grieder et al., 2007, Geng and MacDonald, 2007, Geng and Macdonald, 2006, Bilen and Bonini, 2007, Boylan et al., 2008, Koizumi et al., 2007, Mensch et al., 2008, Snee and Macdonald, 2009, Manak et al., 2006, Fabrizio et al., 2008, Wasbrough et al., 2010, Wasbrough et al., 2010) imp (Munro et al., 2006) IMP (Munro et al., 2005, Munro et al., 2006, Worringer et al., 2009, Nystul and Spradling, 2010) IMP-1 (Herold et al., 2009, Vazquez-Pianzola et al., 2011) l(1)G0072 (Schaefer et al., 1999.6.15, Schaefer et al., 1999.3.29, ) MRE11 (FlyBase Genome Annotators, 2011, Kageyama, 2007.2.28, Inagaki et al., 2005, Dronamraju and Mason, 2009) ORE-9 (Maia et al., 2007)
Name Synonym	anon-fast-evolving-2B3   IGF-II mRNA-binding protein (Quinones-Coello et al., 2007, Nielsen, 2000.3.2, Terry et al., 2006, Nielsen et al., 2002, Boylan et al., 2008, Fabrizio et al., 2008, Wasbrough et al., 2010) insulin-like growth factor II (Adolph et al., 2009) KH-domain protein (Kraut et al., 2001, Kraut et al., 2001) mRNA-like ncRNA in embryogenesis 11
Secondary FlyBase IDs
	FBgn0025229 FBgn0026687 FBgn0030235 FBgn0044592 FBgn0086543
References ( 71 )
Generate a list of	All references relating to this gene ( 71 )
List References by type	Research paper  ( 37 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Shimada et al., 2011, Dev. Biol. 355(2): 250--262 Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis. [FBrf0213933] Vazquez-Pianzola et al., 2011, Dev. Biol. 357(2): 404--418 Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation. [FBrf0214798] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Nystul and Spradling, 2010, Genetics 184(2): 503--515 Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary. [FBrf0209788] Saja et al., 2010, Neurobiol. Disease 40(1): 135--145 Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. [FBrf0211567] Wasbrough et al., 2010, J. Proteomics 73(11): 2171--2185 The Drosophila melanogaster sperm proteome-II (DmSP-II). [FBrf0211978] Show all research papers ...