FB2019_05, released Oct 15, 2019

Gene: Dmel\Vha16-1

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General Information
Symbol
Dmel\Vha16-1
Species
D. melanogaster
Name
Vacuolar H+ ATPase 16kD subunit 1
Annotation Symbol
CG3161
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262736
Gene Model Status
Current
Stock Availability
25 publicly available
Gene Snapshot
Vacuolar H[+] ATPase 16kD subunit 1 (Vha16-1) encodes the proteolipid component of V-ATPase, which is a multi-functional channel protein. It contributes to vesicle-membrane fusion, hydrophilic molecule transport and intercellular communication. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As
Vha16, ductin, MRE15, Vacuolar H+ ATPase 16kD subunit
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:6,625,242..6,633,090 [-]
Recombination map
2-55
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the V-ATPase proteolipid subunit family. (P23380)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
contributes_to proton-transporting ATPase activity, rotational mechanism
Summaries
Gene Group (FlyBase)
VACUOLAR ATPASE V0 DOMAIN SUBUNITS -
The V0 domain of V-ATPases is the integral membrane domain responsible for the translocation of protons across the membrane. It is assembled from four to five different subunits (a, c, c'', d and e in D.mel) that are expressed as multiple isoforms in a tissue-specific manner. (Adapted from PMID:20450191 and FBrf0188241).
Protein Function (UniProtKB)
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
(UniProt, P23380)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Vha16-1 or the JBrowse view of Dmel\Vha16-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Vha16-1-RA
FBtr0086150
NM_057453
2833
159
Vha16-1-RB
FBtr0086151
NM_165474
2798
159
Vha16-1-RC
FBtr0086152
NM_165475
2981
159
Vha16-1-RD
FBtr0086153
NM_165476
2816
159
Additional Transcript Data and Comments
Reported size (kB)
3.1 (northern blot)
(Finbow et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Vha16-1-PA
FBpp0085483
16.3
159
8.78
NP_476801
AAF57359
Vha16-1-PB
FBpp0085484
16.3
159
8.78
NP_724474
AAF57361
Vha16-1-PC
FBpp0085485
16.3
159
8.78
NP_724475
AAF57360
Vha16-1-PD
FBpp0085486
16.3
159
8.78
NP_724476
AAM68381
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

159 aa isoforms: Vha16-1-PA, Vha16-1-PB, Vha16-1-PC, Vha16-1-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
159 (aa)
(Finbow et al., 1994, Meagher et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore).
(UniProt, P23380)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vha16-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
proton-transporting ATPase activity, rotational mechanism
inferred from biological aspect of ancestor with PANTHER:PTN000813763
(assigned by GO_Central )
(Gaudet et al., 2011)
contributes_to proton-transporting ATPase activity, rotational mechanism
inferred by curator from GO:0033181
(Allan et al., 2005)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
dsRNA transport
inferred from mutant phenotype
(Saleh et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
proton transmembrane transport
inferred by curator from GO:0033181
(Allan et al., 2005)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
fusome
inferred from direct assay
(Lighthouse et al., 2008)
plasma membrane proton-transporting V-type ATPase complex
inferred from mutant phenotype
(Allan et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000813763
(assigned by GO_Central )
(Gaudet et al., 2011)
vacuolar proton-transporting V-type ATPase, V0 domain
inferred from sequence or structural similarity with SGD:S000000753
(Dow, 1999)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ventral nerve cord | punctate
(Bohrmann and Bonafede, 2000)
embryonic/larval midgut primordium
(Bohrmann and Bonafede, 2000)
embryonic stage -- larval stage
embryonic/larval salivary gland
(Bohrmann and Bonafede, 2000)
larval stage
neuropil of embryonic/larval brain | punctate
(Bohrmann and Bonafede, 2000)
somatic muscle | punctate
(Bohrmann and Bonafede, 2000)
adult stage
adult midgut
(Bohrmann and Bonafede, 2000)
adult gnathal ganglion | punctate
(Bohrmann and Bonafede, 2000)
indirect flight muscle
(Bohrmann and Bonafede, 2000)
oogenesis & adult stage | female
follicle cell | apical | lateral
(Lautemann and Bohrmann, 2016)
polar follicle cell
(Lautemann and Bohrmann, 2016)
centripetally migrating follicle cell
(Lautemann and Bohrmann, 2016)
nurse cell
(Lautemann and Bohrmann, 2016)
nurse follicle cell
(Lautemann and Bohrmann, 2016)
oocyte
(Lautemann and Bohrmann, 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- first instar larval stage
organism

Comment: predominantly 29 kD isoform

(Bohrmann and Bonafede, 2000)
third instar larval stage
embryonic/larval hypodermal muscle

Comment: predominantly 21 kD isoform

(Bohrmann and Bonafede, 2000)
embryonic/larval brain

Comment: predominantly 16 kD isoform

(Bohrmann and Bonafede, 2000)
embryonic/larval salivary gland

Comment: predominantly 16, 21 kD isoform

(Bohrmann and Bonafede, 2000)
adult stage
adult head

Comment: predominantly 21 kD isoform

(Bohrmann and Bonafede, 2000)
adult thorax

Comment: predominantly 16 kD isoform

(Bohrmann and Bonafede, 2000)
oogenesis stage S1 -- S7
egg chamber

Comment: 29 kD isoform

(Bohrmann and Bonafede, 2000)
oogenesis stage S10
oocyte

Comment: 29 kD isoform

(Bohrmann and Bonafede, 2000)
nurse cell

Comment: 29 kD isoform

(Bohrmann and Bonafede, 2000)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
fusome
inferred from direct assay
(Lighthouse et al., 2008)
plasma membrane proton-transporting V-type ATPase complex
inferred from mutant phenotype
(Allan et al., 2005)
Expression Deduced from Reporters
Reporter: P{PTT-GA}Vha16-1CA06708
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
germarium
• fusome
(Lighthouse et al., 2008)
Reporter: PBac{544.SVS-1}Vha16-1CPTI100041
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind

Comment: adult brain cortex high expression in these neurons (too far from the fan-shaped body to be noduli)

(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Vha16-1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 50 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Vha16-1
Transgenic constructs containing regulatory region of Vha16-1
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATP6V0C
13 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atp6v0c
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Atp6v0c
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\atp6v0c
12 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\atp6v0ca
14 of 15
Yes
Yes
Drer\atp6v0cb
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\vha-2
12 of 15
Yes
Yes
Cele\vha-3
7 of 15
No
Yes
Cele\vha-1
6 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AVA-P2
8 of 9
Yes
Yes
Atha\AVA-P4
8 of 9
Yes
Yes
Atha\VHA-C3
5 of 9
No
Yes
Atha\AT2G16510
2 of 9
No
Yes
Atha\AVA-P1
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\VMA3
14 of 15
Yes
Yes
Scer\VMA11
8 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\vma3
12 of 12
Yes
Yes
Spom\vma11
6 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190HKS )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Vha16-1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005575
Drosophila simulans
Dsim\GD10321
Drosophila sechellia
Dsec\GM20869
Drosophila erecta
Dere\GG10820
Drosophila yakuba
Dyak\Vha16
Drosophila ananassae
Dana\GF13808
Drosophila pseudoobscura pseudoobscura
Dpse\GA16335
Drosophila persimilis
Dper\GL20293
Drosophila willistoni
Dwil\GK19648
Drosophila virilis
Dvir\GJ20880
Drosophila mojavensis
Dmoj\GI21278
Drosophila grimshawi
Dgri\GH22892
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150EB4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020365
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00749
Mayetiola destructor
Hessian fly
Mdes\Mdes013665
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000291
Anopheles darlingi
American malaria mosquito
Adar\ADAC001959
Anopheles gambiae
Malaria mosquito
Agam\AGAP028154
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011018
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0IFP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001302
Danaus plexippus
Monarch butterfly
Dple\DPOGS202679-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014521
Apis florea
Little honeybee
Aflo\2790359300
Apis mellifera
Western honey bee
Amel\vha16
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24751
Bombus terrestris
Buff-tailed bumblebee
Bter\15214491
Linepithema humile
Argentine ant
Lhum\LH19259
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00135c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010691
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06453
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00354
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06820
Tribolium castaneum
Red flour beetle
Tcas\TC011025
Pediculus humanus
Human body louse
Phum\PHUM061100
Rhodnius prolixus
Kissing bug
Rpro\RPRC015179
Cimex lectularius
Bed bug
Clec\CLEC025304
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003545
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12382
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0IJ9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011463
Ixodes scapularis
Black-legged tick
Isca\ISCW012283
Ixodes scapularis
Black-legged tick
Isca\ISCW018346
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60257.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g09130
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_231646
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0U1Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atp16
Ciona intestinalis
Vase tunicate
Cint\LOC100175987
Gallus gallus
Domestic chicken
Ggal\ATP6V0C
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Vha16-3
8 of 10
Vha16-4
7 of 10
Vha16-2
6 of 10
Vha16-5
5 of 10
VhaPPA1-1
2 of 10
VhaPPA1-2
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Vha16-1GD4523
    exacerbates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    Vha16-1GD17431
    exacerbates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATP6V0C; ATPase H+ transporting V0 subunit c
    13 of 15
    108745
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        RNA-protein
        Physical Interaction
        Assay
        References
        Vha16-1 - pum
        pull down, anti tag western blot
        (Gerber et al., 2006)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore).
        (UniProt, P23380 )
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-55
        Cytogenetic map
        42B2-42B2
        Sequence location
        2R:6,625,242..6,633,090 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        42B2-42B2
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        41-42
        (Finbow, 1994.1.17)
        42B1-42B2
        (Dow, 1999)
        42B1-42B2
        (determined by in situ hybridisation)
        (Finbow et al., 1994, Finbow et al., 1993)
        Experimentally Determined Recombination Data
        Location
        2-55
        (FlyBase, 2016)
        2-56.0
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (25)
        Genomic Clones (19)
        cDNA Clones (563)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: Vha16 CG3161
          (Bayraktaroglu, 2000.4.13)
          Source for merge of: Vha16 BcDNA:SD02875
          (FlyBase, 1996-)
          Source for merge of: Vha16-1 MRE15
          (FlyBase Genome Annotators, 2011)
          Additional comments
          MRE15 is part of the 3' UTR of Vha16-1.
          (FlyBase Genome Annotators, 2011)
          MRE15 corresponds to a portion of the 3' UTR of Vha16-1.
          (FlyBase Genome Annotators, 2011)
          Source for merge of Vha16 BcDNA:SD02875 was a shared cDNA ( date:020730 ).
          (FlyBase, 1996-)
          Other Comments
          dsRNA made from templates generated with primers directed against Vha16 that is transfected into S2 treated with Listeria monocytogenes reveals Vha16 to be involved in Listeria monocytogenes entry and vacuolar escape.
          (Cheng et al., 2005)
          Vha16 has been cloned and sequenced.
          (Finbow et al., 1994)
          Vha16 plays a role in gap junctional communication in the follicles. Evidence suggests that the Vha16 gene product may double as a component of an ATP driven proton pump and a component of a passive, non-selective, channel.
          (Finbow et al., 1993)
          A Vha16 cDNA has been cloned and sequenced.
          (Meagher et al., 1990)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 67 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (23)
          Reported As
          Symbol Synonym
          ATP6V0C
          (Adamson et al., 2011)
          BcDNA:SD02875
          CG3161
          (Neuert et al., 2017, Butzlaff et al., 2015, Meadows, 2014.12.12, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Quinones-Coello, 2007, Saleh et al., 2006, Allan et al., 2005, Laviolette et al., 2005, Wang et al., 2004, Norga et al., 2003, Labourier et al., 2002, Fulton et al., 2001)
          DucC
          EP2372
          MRE15
          (FlyBase Genome Annotators, 2011, Kageyama, 2007.2.28, Inagaki et al., 2005)
          V-ATPase
          (Allan et al., 2002)
          Vha1
          (Laviolette et al., 2005)
          Vha16
          (Neuert et al., 2017, Butzlaff et al., 2015, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Carreira et al., 2011, Reis et al., 2010, Lighthouse et al., 2008, Stofanko et al., 2008, Bai et al., 2007, Buszczak et al., 2007, Langille and Clark, 2007, Quinones-Coello, 2007, Saleh et al., 2006)
          Vha16-1
          (Mondragon et al., 2019, Şentürk et al., 2019, Tamirisa et al., 2018, Hsu and Drummond-Barbosa, 2017, Clandinin and Owens, 2016-, Chartier et al., 2015, Sieber and Spradling, 2015, Zhang et al., 2015, Chintapalli et al., 2013, Costa et al., 2013, Petzoldt et al., 2013, FlyBase Genome Annotators, 2011, Rendina et al., 2010, Rendina et al., 2010)
          Vhac
          vha16
          (Zoncu et al., 2011, Larsen et al., 2006, Cheng et al., 2005, Wang et al., 2004, Dow et al., 1997)
          vha16-1
          (Lin et al., 2015, Wang et al., 2014, Chintapalli et al., 2013, Adamson et al., 2011, Allan et al., 2005, Stark et al., 2005, Dow, 1999)
          Name Synonyms
          Ductin
          (Graham et al., 1997)
          Ductin subunit C
          Vacuolar H+ ATPase 16kD subunit
          (Cammarato et al., 2011)
          Vacuolar H+ ATPase 16kD subunit 1
          Vacuolar H+ ATPase subunit 16-1
          Vacuolar H+-ATPase c subunit
          c subunit
          (Dow et al., 1997)
          ductin
          (Bohrmann and Bonafede, 2000, Bohrmann and Braun, 1999, Bohrmann and Lammel, 1998, Guo et al., 1996)
          ductin, vacuolar H(+)-ATPase subunit C proteolipid
          (Finbow, 1994.1.17)
          mRNA-like ncRNA in embryogenesis 15
          Secondary FlyBase IDs
          • FBgn0004145
          • FBgn0011275
          • FBgn0015839
          • FBgn0033078
          • FBgn0044467
          • FBgn0046764
          • FBgn0086547
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (113)