Vha16, ductin, MRE15, Vacuolar H+ ATPase 16kD subunit
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
3.1 (northern blot)
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vha16-1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Vha16-1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against Vha16 that is transfected into S2 treated with Listeria monocytogenes reveals Vha16 to be involved in Listeria monocytogenes entry and vacuolar escape.
Vha16 plays a role in gap junctional communication in the follicles. Evidence suggests that the Vha16 gene product may double as a component of an ATP driven proton pump and a component of a passive, non-selective, channel.