Ago-1, Argonaute, dAGO1, MRE20, l(2)04845
Multiple (sequential) stage-specific extensions of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AGO1 using the Feature Mapper tool.
AGO1 transcripts are detected early and late in embryogenesis but transcripts containing the 3' UTR extension (~8.5 kb) are only detected at later stages and appear after the maternal-to-zygotic transition. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis). AGO1 transcripts are expressed nearly ubiquitously in the embryo but the extended 3' UTR isoforms are expressed primarily in neural tissues.
GBrowse - Visual display of RNA-Seq signalsView Dmel\AGO1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of AGO1 anon-WO0257455.29 was sequence comparison ( date:051113 ).
smg protein interacts with AGO1 protein, and AGO1 protein interacts with and is required for the translational repression of the smg target, nos mRNA. The AGO1 protein/nos mRNA interaction does not require a miRNA, but does require msg protein.
The miRNA strand selection of AGO1 is influenced by the presence of a 5' uridine residue in a strand of the miRNA duplex as well as thermodynamic asymmetry of the miRNA strands.
The Dcr-2-r2d2 heterodimer acts as a gatekeeper for the assembly of AGO2 complexes, promoting the incorporation of siRNAs and disfavoring miRNAs as loading substrates for AGO2. A separate mechanism acts in parallel to favor miRNA/miRNA* duplexes and exclude siRNAs from assembly into AGO1 complexes.
dsRNA made from templates generated with primers directed against this gene are used to infer a role for this gene in the miRNA pathway.
AGO1 is required for maintenance of long-distance chromosomal interactions between endogenous PcG target loci.
AGO1 protein associates with miRNA and cleaves target RNA completely complementary to the miRNA.
dsRNA has been made from templates generated with primers directed against this gene.
Local overexpression of AGO1 can alter wing vein patterns or cause transformation of posterior cell identity.
Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.