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Gene Dmel\Fas1

General Information
Symbol	Dmel\Fas1	Species	D. melanogaster
Name	Fasciclin 1	Annotation symbol	CG6588
Feature type	protein_coding_gene	FlyBase ID	FBgn0262742
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	FasI, MRE24, DROFASI, Fas I, fas-I
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89D5-89D6	Sequence location	3R:12,450,960..12,465,493 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fasciclin 1 is referred to in FlyBase by the symbol Dmel\Fas1 (CG6588, FBgn0262742). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cell adhesion molecule binding. There is experimental evidence that it is involved in the biological process: axon guidance; homophilic cell adhesion; calcium-independent cell-cell adhesion; neuron recognition. 31 alleles are reported. The phenotype of these alleles is annotated with: ocellar nerve. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: FAS1 domain. Gene sequence location is 3R:12450960..12465493.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Fas1: Fasciclin I Expression confined to neurons. In 12-14 h embryos high levels of fasciclin I are detectable in two commissural axon bundles (fascicles) per segment, a thick one in the posterior commissure and a thin one in the anterior commissure. In addition high expression is seen in two clusters of neuronal cell bodies per hemisegment as well as in the intersegmental and segmental nerve axons. Finally, fasciclin I is detected on the surface of all peripheral neurons. Postulated to be involved in neuron recognition during growth cone guidance. Flies deficient in FasI function are fully viable and CNS development apparently is normal.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms A1-7 VO2 motor neuron
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89D5-89D6   Limits computationally determined from genome sequence between P{lacW}CSN5L4032 and P{EP}MESK4EP1015
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89E1-89E2   (determined by in situ hybridisation) 89D (determined by in situ hybridisation)   (Zinn et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fas1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fas1-RA FBtr0083332  NM_169726   3002   649 Fas1-RB FBtr0083333  NM_169725   3011   652 Fas1-RC FBtr0083334  NM_169724   3073   655 Fas1-RD FBtr0112803  NM_001104344   3094   662 Fas1-RE FBtr0300036  NM_001144593   3214   624 Fas1-RF FBtr0300037  NM_001144594   3303   636 Fas1-RG FBtr0333726  NM_001275716   4814   661
Additional Transcript Data & Comments
Reported size (kB)	5.2, 5.0, 4.2, 4.0, 3.2, 3.0 (northern blot) (McAllister et al., 1992) 3.0 (longest cDNA) (Zinn et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fas1-PA   FBpp0082782   72.2   649   6.91     NP_732166   AAF55346 Fas1-PB   FBpp0082783   72.6   652   7.03     NP_732165   AAN13715 Fas1-PC   FBpp0082784   73.0   655   7.03     NP_732164   AAN13714 Fas1-PD   FBpp0111715   73.7   662   7.53     NP_001097814   ABW08688 Fas1-PE   FBpp0289313   69.5   624   6.91     NP_001138065   ACL83523 Fas1-PF   FBpp0289314   70.9   636   6.63     NP_001138066   ACL83524 Fas1-PG   FBpp0305873   73.6   661   6.63     NP_001262645   AGB96025
Additional Polypeptide Data & Comments
Reported size (kDa)	652 (aa); 70 (kD predicted) (Zinn et al., 1988) 72 (kD observed) (Hortsch and Goodman, 1990)
Comments	In Schneider 1 cells, Fas1 was found to be tightly associated with the lipid bilayer by a phosphotidylinositol lipid moiety. The proportion of membrane bound to soluble Fas1 was assayed during embryogenesis. The amount of membrane-bound, phosphatidylinositol-linked Fas1 was higher from blastoderm to early gastrulation stages. During germ band extension and retraction, the amount of soluble Fas1 was 3 times higher than membrane-bound Fas1. Later, as Fas1 expression became restricted to the nervous system and a few other tissues, the phosphatidylinositol linked form was once again the predominant form. (Hortsch and Goodman, 1990) Fas1 is an extrinsic membrane protein, composed of 4 homologous domains of 150 aa each. (Zinn et al., 1988)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • FAS1 domain (IPR000782) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1O70
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202408   AA438670   AA540394   AA540643   AA698495   AA735574   AA941423   AA950971   AE014297 AAF55346   AE014297 AAN13714   AE014297 AAN13715   AE014297 ABW08688   AE014297 ACL83523   AE014297 ACL83524   AE014297 AGB96025   AI062634   AI062941   AI114005   AI114025   AI134041   AI134747   AI292848   AI293265   AI387389   AI404748   AI405633   AI513459   AI516067   AW942737   AX093939   AY118531 AAM49900   BI164307   BI215550   BI216383   BI227761   BI228668   BI235780   BI236938   BI242784   BI243757   BI362000   BI366197   BI373674   BI376047   BI484218   BI568917   BI568918   BI569932   BI575534   BI576878   BI579013   BI579941   BI585262   BI589261   BI589339   BI590065   BI590278   BI626344   BI629262   BP541553   BP553093   BP555143   BP556645   BP556646   BP558634   BT015956   BT044209   CK086521   CK086522   CK657881   CL528259   CL705807   CO177119   CO177723   CO178085   CO178357   CO179288   CO179390   CO186453   CO186770   CO187673   CO187983   CO188915   CO189623   CO189922   CO190145   CO190623   CO190736   CO196520   CO262144   CO262618   CO262993   CO264322   CO267128   CO267215   CO269052   CO269550   CO271221   CO271532   CO272548   CO273270   CO273656   CO274947   CO275334   CO277953   CO280041   CO280118   CO280452   CO280541   CO283431   CO284481   CO286140   CO286430   CO286726   CO286828   CO287899   CO288138   CO288407   CO289853   CO289923   CO291466   CO291571   CO291707   CO295008   CO296248   CO297064   CO297933   CO298328   CO299223   CO300881   CO301787   CO304442   CO304643   CO305737   CO306795   CO307921   CO308435   CO310397   CO310535   CO312042   CO312635   CO313516   CO314348   CO315071   CO315099   CO315305   CO318402   CO318444   CO319554   CO320764   CO320824   CO321966   CO323247   CO323340   CO329391   CO332689   CO332874   CO333601   CO339101   CO339333   CO339343   CO342302   CO343715   CO344078   CO344314   CO345409   CZ468154   CZ478776   CZ479771   CZ479772   EC057907   EC058173   EC058996   EC061466   EC063199   EC063511   EC065535   EC066792   EC069005   EC069148   EC069341   EC069385   EC069497   EC070336   EC070571   EC072132   EC073375   EC075379   EC075804   EC076738   EC078271   EC078760   EC080147   EC080887   EC082071   EC082146   EC083365   EC083409   EC083565   EC084720   EC084769   EC084954   EC087526   EC087933   EC089108   EC195031   EC195635   EC195906   EC196088   EC196213   EC196253   EC197406   EC197478   EC201011   EC201854   EC203170   EC204319   EC205324   EC205411   EC205620   EC205746   EC206593   EC206656   EC207088   EC207914   EC208358   EC209833   EC210145   EC213469   EC214004   EC214215   EC215394   EC216279   EC216390   EC217742   EC217973   EC218408   EC220713   EC221294   EC222245   EC222859   EC222995   EC223382   EC223600   EC225455   EC225834   EC225884   EC227093   EC227380   EC227686   EC230164   EC230214   EC230324   EC231170   EC231660   EC233432   EC233887   EC234373   EC234724   EC235947   EC236584   EC236791   EC237251   EC237937   EC238340   EC240701   EC240705   EC240899   EC241336   EC241799   EC242013   EC243298   EC247494   EC247831   EC248823   EC248894   EC250119   EC250666   EC251155   EC252978   EC253860   EC254821   EC255303   EC255560   EC257688   EC259843   EC259990   EC260641   EC260683   ES692122   ES696234   EV590697   EV596932   EV598951   EY198748   GH942117   GH942123   GH943097   GH947179   GH947979   GH949349   GH952264   GH952344   GH954101   GH954763   GH955839   GH959861   GH961266   GH961331   GH962035   GH962791   GH964305   GH965095   GH965590   GH965638   GH967820   GH969265   GH971045   GH972175   GH972786   GH975464   GH979647   GH980731   GH982294   GH983605   GH983700   M20545 AAA28531   M32311 AAA28529
UniProtKB/Swiss-Prot	P10674
UniProtKB/TrEMBL	Q8INA9 Q9VES3 B7Z0L0 A8JR25 B7Z0L1 Q8MSW3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
dissected tissue Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 15   ventral nerve cord   (McAllister et al., 1992) Comment:reference states 10-13 hr AEL in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   gonad   (McAllister et al., 1992) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 1 -- 14   epidermis | dorsal   (McAllister et al., 1992) embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   neuroblast | segmentally repeated   (McAllister et al., 1992) ventral neurectoderm | segmentally repeated   (McAllister et al., 1992) central brain primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 12 -- 13   ectoderm   (McAllister et al., 1992) embryonic stage 12 -- 17   neuron of central nervous system | restricted   (McAllister et al., 1992) embryonic stage 13 -- 15   ventral nerve cord   (McAllister et al., 1992) Comment:reference states 10-13 hr AEL embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 17   presumptive embryonic/larval peripheral nervous system   (McAllister et al., 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (McAllister et al., 1992) larval stage     (McAllister et al., 1992) third instar larval stage     (McAllister et al., 1992) adult stage     (McAllister et al., 1992) oogenesis     (McAllister et al., 1992)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval spiracle   (McAllister et al., 1992) salivary gland body primordium   (McAllister et al., 1992) inclusive hindgut primordium   (McAllister et al., 1992) posterior midgut primordium   (McAllister et al., 1992) gonad   (McAllister et al., 1992) embryonic stage 1 -- 14   epidermis | dorsal   (McAllister et al., 1992) embryonic stage 9 -- 10   neuroblast | segmentally repeated   (McAllister et al., 1992) ventral neurectoderm | segmentally repeated   (McAllister et al., 1992) embryonic stage 12   VUM neuron   (McAllister et al., 1992) embryonic stage 12 -- 13   ectoderm   (McAllister et al., 1992) embryonic stage 12 -- 16   aCC neuron   (McAllister et al., 1992) RP1 motor neuron   (McAllister et al., 1992) embryonic stage 12 -- 17   neuron of central nervous system | restricted   (McAllister et al., 1992) embryonic stage 13 -- 16   terminal organ   (Zinn et al., 1988) Comment:11-14 hr AEL embryonic stage 13 -- 17   presumptive embryonic/larval peripheral nervous system   (McAllister et al., 1992) commissure   (McAllister et al., 1992) embryonic stage 14 -- 16   anterior commissure   (Zinn et al., 1988) Comment:reference states 11-14 hr AEL posterior commissure   (Zinn et al., 1988) Comment:reference states 11-14 hr AEL RP1 motor neuron   • neuronal cell body & axon (Zinn et al., 1988) segmental nerve   • axon (Zinn et al., 1988) aCC neuron   • neuronal cell body & axon (Zinn et al., 1988) antennal sense organ   (Zinn et al., 1988) Comment:11-14 hr AEL intersegmental nerve   • axon (Zinn et al., 1988)
Additional Descriptive Data
	The Fas1 protein is expressed in parts of the nervous system of 11-14 hr embryos. The protein is expressed on the axons of a subset of cells in the central nervous system, and on sensory axon pathways in the peripheral nervous system . Staining is first observed on a single axon fascicle in each commissure. The axons of peripheral nerve roots, and surfaces of sensory neurons in the PNS contain Fas1 protein. At 12-13 hours of development, two clusters of neuronal cells stain per hemisegment. The axons of the anterior and posterior fas icles, peripheral sensory axons, and the glia surrounding them, stain for Fas1 protein. Specific subsets of CNS neurons, such as the aCC and RP1 neurons, express Fas1 protein. Also strongly staining are the axons and cell bodies of head sensory structures, especially the dorsal and terminal organs of the antenno-maxillary complex. (Zinn et al., 1988)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Hortsch and Goodman, 1990, Khanna et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    200 central nervous system, pupae P8    185 head, virgin 1-day female    577 head, virgin 4-day female    473 head, virgin 20-day female    193 head, mated 1-day female    495 head, mated 4-day female    360 head, mated 20-day female    180 head, mated 1-day male    765 head, mated 4-day male    625 head, mated 20-day male    429 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    217 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8    43 carcass, larvae L3 wandering    61 carcass, 1-day adult    85 carcass, 4-day adult    72 carcass, 20-day adult    45 ovary, virgin 4-day female    67 ovary, mated 4-day female    76 testis, mated 4-day male    14 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (51) central nervous system, larvae L3  (200) central nervous system, pupae P8  (185) head, virgin 1-day female  (577) head, virgin 4-day female  (473) head, virgin 20-day female  (193) head, mated 1-day female  (495) head, mated 4-day female  (360) head, mated 20-day female  (180) head, mated 1-day male  (765) head, mated 4-day male  (625) head, mated 20-day male  (429) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (217) digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8  (43) carcass, larvae L3 wandering  (61) carcass, 1-day adult  (85) carcass, 4-day adult  (72) carcass, 20-day adult  (45) ovary, virgin 4-day female  (67) ovary, mated 4-day female  (76) testis, mated 4-day male    14 accessory gland, mated 4-day male  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3  (200) central nervous system, pupae P8  (185) head, virgin 1-day female  (577) head, virgin 4-day female  (473) head, virgin 20-day female  (193) head, mated 1-day female  (495) head, mated 4-day female  (360) head, mated 20-day female  (180) head, mated 1-day male  (765) head, mated 4-day male  (625) head, mated 20-day male  (429) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (217) digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8    43 carcass, larvae L3 wandering    61 carcass, 1-day adult    85 carcass, 4-day adult    72 carcass, 20-day adult    45 ovary, virgin 4-day female    67 ovary, mated 4-day female    76 testis, mated 4-day male    14 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    200 central nervous system, pupae P8    185 head, virgin 1-day female    577 head, virgin 4-day female    473 head, virgin 20-day female    193 head, mated 1-day female    495 head, mated 4-day female    360 head, mated 20-day female    180 head, mated 1-day male    765 head, mated 4-day male    625 head, mated 20-day male    429 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    217 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8    43 carcass, larvae L3 wandering    61 carcass, 1-day adult    85 carcass, 4-day adult    72 carcass, 20-day adult    45 ovary, virgin 4-day female    67 ovary, mated 4-day female    76 testis, mated 4-day male    14 accessory gland, mated 4-day male    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    200 central nervous system, pupae P8    185 head, virgin 1-day female    577 head, virgin 4-day female    473 head, virgin 20-day female    193 head, mated 1-day female    495 head, mated 4-day female    360 head, mated 20-day female    180 head, mated 1-day male    765 head, mated 4-day male    625 head, mated 20-day male    429 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    217 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8    43 carcass, larvae L3 wandering    61 carcass, 1-day adult    85 carcass, 4-day adult    72 carcass, 20-day adult    45 ovary, virgin 4-day female    67 ovary, mated 4-day female    76 testis, mated 4-day male    14 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (51) central nervous system, larvae L3  (200) central nervous system, pupae P8  (185) head, virgin 1-day female  (577) head, virgin 4-day female  (473) head, virgin 20-day female  (193) head, mated 1-day female  (495) head, mated 4-day female  (360) head, mated 20-day female  (180) head, mated 1-day male  (765) head, mated 4-day male  (625) head, mated 20-day male  (429) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (217) digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8  (43) carcass, larvae L3 wandering  (61) carcass, 1-day adult  (85) carcass, 4-day adult  (72) carcass, 20-day adult  (45) ovary, virgin 4-day female  (67) ovary, mated 4-day female  (76) testis, mated 4-day male    14 accessory gland, mated 4-day male  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3  (200) central nervous system, pupae P8  (185) head, virgin 1-day female  (577) head, virgin 4-day female  (473) head, virgin 20-day female  (193) head, mated 1-day female  (495) head, mated 4-day female  (360) head, mated 20-day female  (180) head, mated 1-day male  (765) head, mated 4-day male  (625) head, mated 20-day male  (429) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (217) digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8    43 carcass, larvae L3 wandering    61 carcass, 1-day adult    85 carcass, 4-day adult    72 carcass, 20-day adult    45 ovary, virgin 4-day female    67 ovary, mated 4-day female    76 testis, mated 4-day male    14 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    200 central nervous system, pupae P8    185 head, virgin 1-day female    577 head, virgin 4-day female    473 head, virgin 20-day female    193 head, mated 1-day female    495 head, mated 4-day female    360 head, mated 20-day female    180 head, mated 1-day male    765 head, mated 4-day male    625 head, mated 20-day male    429 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    217 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    19 fat body, pupae P8    43 carcass, larvae L3 wandering    61 carcass, 1-day adult    85 carcass, 4-day adult    72 carcass, 20-day adult    45 ovary, virgin 4-day female    67 ovary, mated 4-day female    76 testis, mated 4-day male    14 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    71 embryo 04-06hr    75 embryo 06-08hr    80 embryo 08-10hr    67 embryo 10-12hr    48 embryo 12-14hr    84 embryo 14-16hr    60 embryo 16-18hr    49 embryo 18-20hr    33 embryo 20-22hr    42 embryo 22-24hr    49 larva L1    32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    46 white prepupae 24hr    49 pupae 2d postWPP    51 pupae 3d postWPP    58 pupae 4d postWPP    77 adult male 01day    84 adult male 05day    76 adult male 30day    61 adult female 01day    59 adult female 05day    50 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr  (71) embryo 04-06hr  (75) embryo 06-08hr  (80) embryo 08-10hr  (67) embryo 10-12hr  (48) embryo 12-14hr  (84) embryo 14-16hr  (60) embryo 16-18hr  (49) embryo 18-20hr  (33) embryo 20-22hr  (42) embryo 22-24hr  (49) larva L1  (32) larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (38) white prepupae new  (45) white prepupae 12hr  (46) white prepupae 24hr  (49) pupae 2d postWPP  (51) pupae 3d postWPP  (58) pupae 4d postWPP  (77) adult male 01day  (84) adult male 05day  (76) adult male 30day  (61) adult female 01day  (59) adult female 05day  (50) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    71 embryo 04-06hr    75 embryo 06-08hr    80 embryo 08-10hr    67 embryo 10-12hr    48 embryo 12-14hr    84 embryo 14-16hr    60 embryo 16-18hr    49 embryo 18-20hr    33 embryo 20-22hr    42 embryo 22-24hr    49 larva L1    32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    46 white prepupae 24hr    49 pupae 2d postWPP    51 pupae 3d postWPP    58 pupae 4d postWPP    77 adult male 01day    84 adult male 05day    76 adult male 30day    61 adult female 01day    59 adult female 05day    50 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    71 embryo 04-06hr    75 embryo 06-08hr    80 embryo 08-10hr    67 embryo 10-12hr    48 embryo 12-14hr    84 embryo 14-16hr    60 embryo 16-18hr    49 embryo 18-20hr    33 embryo 20-22hr    42 embryo 22-24hr    49 larva L1    32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    46 white prepupae 24hr    49 pupae 2d postWPP    51 pupae 3d postWPP    58 pupae 4d postWPP    77 adult male 01day    84 adult male 05day    76 adult male 30day    61 adult female 01day    59 adult female 05day    50 adult female 30day    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    71 embryo 04-06hr    75 embryo 06-08hr    80 embryo 08-10hr    67 embryo 10-12hr    48 embryo 12-14hr    84 embryo 14-16hr    60 embryo 16-18hr    49 embryo 18-20hr    33 embryo 20-22hr    42 embryo 22-24hr    49 larva L1    32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    46 white prepupae 24hr    49 pupae 2d postWPP    51 pupae 3d postWPP    58 pupae 4d postWPP    77 adult male 01day    84 adult male 05day    76 adult male 30day    61 adult female 01day    59 adult female 05day    50 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr  (71) embryo 04-06hr  (75) embryo 06-08hr  (80) embryo 08-10hr  (67) embryo 10-12hr  (48) embryo 12-14hr  (84) embryo 14-16hr  (60) embryo 16-18hr  (49) embryo 18-20hr  (33) embryo 20-22hr  (42) embryo 22-24hr  (49) larva L1  32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (38) white prepupae new  (45) white prepupae 12hr  (46) white prepupae 24hr  (49) pupae 2d postWPP  (51) pupae 3d postWPP  (58) pupae 4d postWPP  (77) adult male 01day  (84) adult male 05day  (76) adult male 30day  (61) adult female 01day  (59) adult female 05day  (50) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    71 embryo 04-06hr    75 embryo 06-08hr    80 embryo 08-10hr    67 embryo 10-12hr    48 embryo 12-14hr    84 embryo 14-16hr    60 embryo 16-18hr    49 embryo 18-20hr    33 embryo 20-22hr    42 embryo 22-24hr    49 larva L1    32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    46 white prepupae 24hr    49 pupae 2d postWPP    51 pupae 3d postWPP    58 pupae 4d postWPP    77 adult male 01day    84 adult male 05day    76 adult male 30day    61 adult female 01day    59 adult female 05day    50 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    71 embryo 04-06hr    75 embryo 06-08hr    80 embryo 08-10hr    67 embryo 10-12hr    48 embryo 12-14hr    84 embryo 14-16hr    60 embryo 16-18hr    49 embryo 18-20hr    33 embryo 20-22hr    42 embryo 22-24hr    49 larva L1    32 larva L2    18 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    46 white prepupae 24hr    49 pupae 2d postWPP    51 pupae 3d postWPP    58 pupae 4d postWPP    77 adult male 01day    84 adult male 05day    76 adult male 30day    61 adult female 01day    59 adult female 05day    50 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    3 embryonic 1182-4H    116 embryonic GM2    92 embryonic Kc167    12 embryonic S1    63 embryonic S3    0 leg disc CME L1    5 wing disc CME-W2    65 wing disc ML-DmD8    62 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    151 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    141 eye-antennal disc ML-DmD11    186 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    108 ovary fGS/OSS    235 ovary OSC    364 ovary OSS    222 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4    3 embryonic 1182-4H  (116) embryonic GM2  (92) embryonic Kc167    12 embryonic S1  (63) embryonic S3    0 leg disc CME L1    5 wing disc CME-W2  (65) wing disc ML-DmD8  (62) wing disc ML-DmD9  (93) wing disc ML-DmD16-c3  (77) wing disc ML-DmD21  (151) wing disc ML-DmD32  (92) haltere disc ML-DmD17-c3  (141) eye-antennal disc ML-DmD11  (186) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1  (127) CNS ML-DmBG2-c2    17 tumorous blood cells mbn2  (108) ovary fGS/OSS  (235) ovary OSC  (364) ovary OSS  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    3 embryonic 1182-4H  (116) embryonic GM2    92 embryonic Kc167    12 embryonic S1    63 embryonic S3    0 leg disc CME L1    5 wing disc CME-W2    65 wing disc ML-DmD8    62 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    77 wing disc ML-DmD21  (151) wing disc ML-DmD32    92 haltere disc ML-DmD17-c3  (141) eye-antennal disc ML-DmD11  (186) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1  (127) CNS ML-DmBG2-c2    17 tumorous blood cells mbn2  (108) ovary fGS/OSS  (235) ovary OSC  (364) ovary OSS  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    3 embryonic 1182-4H    116 embryonic GM2    92 embryonic Kc167    12 embryonic S1    63 embryonic S3    0 leg disc CME L1    5 wing disc CME-W2    65 wing disc ML-DmD8    62 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    151 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    141 eye-antennal disc ML-DmD11    186 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    108 ovary fGS/OSS    235 ovary OSC    364 ovary OSS    222 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    3 embryonic 1182-4H    116 embryonic GM2    92 embryonic Kc167    12 embryonic S1    63 embryonic S3    0 leg disc CME L1    5 wing disc CME-W2    65 wing disc ML-DmD8    62 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    151 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    141 eye-antennal disc ML-DmD11    186 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    108 ovary fGS/OSS    235 ovary OSC    364 ovary OSS    222 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4    3 embryonic 1182-4H  (116) embryonic GM2  (92) embryonic Kc167    12 embryonic S1  (63) embryonic S3    0 leg disc CME L1    5 wing disc CME-W2  (65) wing disc ML-DmD8  (62) wing disc ML-DmD9  (93) wing disc ML-DmD16-c3  (77) wing disc ML-DmD21  (151) wing disc ML-DmD32  (92) haltere disc ML-DmD17-c3  (141) eye-antennal disc ML-DmD11  (186) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1  (127) CNS ML-DmBG2-c2    17 tumorous blood cells mbn2  (108) ovary fGS/OSS  (235) ovary OSC  (364) ovary OSS  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    3 embryonic 1182-4H  116 embryonic GM2    92 embryonic Kc167    12 embryonic S1    63 embryonic S3    0 leg disc CME L1    5 wing disc CME-W2    65 wing disc ML-DmD8    62 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    77 wing disc ML-DmD21  (151) wing disc ML-DmD32    92 haltere disc ML-DmD17-c3  141 eye-antennal disc ML-DmD11  (186) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1  127 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2  108 ovary fGS/OSS  (235) ovary OSC  (364) ovary OSS  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    3 embryonic 1182-4H    116 embryonic GM2    92 embryonic Kc167    12 embryonic S1    63 embryonic S3    0 leg disc CME L1    5 wing disc CME-W2    65 wing disc ML-DmD8    62 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    151 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    141 eye-antennal disc ML-DmD11    186 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    108 ovary fGS/OSS    235 ovary OSC    364 ovary OSS    222 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    46 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    113 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    181 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    162 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    101 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    88 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (65) cold shock, 4-day adult  (46) heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (49) Cadmium 100 mM 48 hrs, 4-day adult  (113) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (181) Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult  (162) Ethanol 2.5% 3 hrs, larvae L3  (65) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (101) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (100) Paraquat 10 mM 48 hrs, 4-day adult  (88) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    46 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult  (113) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (181) Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult  (162) Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  101 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    88 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    46 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    113 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    181 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    162 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    101 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    88 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    46 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    113 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    181 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    162 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    101 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    88 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (65) cold shock, 4-day adult  (46) heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (49) Cadmium 100 mM 48 hrs, 4-day adult  (113) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (181) Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult  (162) Ethanol 2.5% 3 hrs, larvae L3  (65) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (101) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (100) Paraquat 10 mM 48 hrs, 4-day adult  (88) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    46 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult  113 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (181) Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult  (162) Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  101 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    88 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    46 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    113 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    181 Zinc 5 mM 12 hrs, larvae L3    18 Zinc 4.5 mM 48 hrs, 4-day adult    162 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    101 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    88 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • FI05280
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Fas1EY06622 viable, with Scer\GAL4pnr-MD237 Fas1GD12817 Sterility Allele fertile Fas1EY06622 Other Phenotypes Allele behavior defective | recessive Fas1TE77 neuroanatomy defective Fas1+t23 Fas1TE89Da neuroanatomy defective, with Scer\GAL4MS1075 Fas1+3.Scer\UAS neurophysiology defective Fas1+t23 Fas1TE89Da wild-type Fas1+t23 Phenotype manifest in Allele ocellar nerve, with Scer\GAL4MS1075 Fas1+3.Scer\UAS
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of Fas1 Class Mutagen Stocks Known lesion Fas1A071 1 -- Fas1c02707 piggyBac transposase 1 -- Fas1DG16410 1 -- Fas1e00944 piggyBac transposase 1 -- Fas1EY06622 P-element activity 1 -- Fas1KG09729 P-element activity 1 -- Fas1MI03699 1 -- Fas1NP1305 1 -- Fas1R3 amorphic allele - genetic evidence gamma ray 0 -- Fas1R40.1 amorphic allele - genetic evidence gamma ray X ray 0 -- Fas1R8 amorphic allele - genetic evidence X ray 0 -- Fas1TE77 amorphic allele - genetic evidence P-element activity 0 Yes Fas1TE89Da loss of function allele, amorphic allele - genetic evidence 0 Yes Fas15-HA-2279 0 -- Fas1e01965 piggyBac transposase 0 -- Fas1HC164A P-element activity 0 Yes Fas1R18.1 gamma ray 0 -- Fas1R2481 gamma ray 0 -- Fas1R9 gamma ray 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fas1 Class Mutagen Stocks Known lesion Fas1GD12817 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Fas1GL01282 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fas1HMS02580 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fas1KK109572 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fas1+3.Scer\UAS in vitro construct - regulatory fusion 0 Yes Fas1+t23 in vitro construct - genomic fragment 0 Yes Fas1cMa in vitro construct 0 Yes Fas1hs.PE in vitro construct - regulatory fusion 0 Yes Fas1hs.PH in vitro construct - regulatory fusion 0 Yes Fas1MtnA.PI in vitro construct - regulatory fusion 0 Yes Fas1NIG.6588R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Fas1Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6270 (Ryder, 2004.4.26) Df(3R)Ubx109 (Zinn et al., 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12817} NA P{KK109572} NA P{NIG.6588R} NA P{TRiP.GL01282} NA P{TRiP.HMS02580} NA P{UAS-Fas1.+3} NA P{UAS-Fas1.H} NA characterization construct P{fas1+} NA P{UAS-Fas1::nrg180} NA P{UAS-hh::Fas1.GPI} NA P{UAS-hh::Fas1.ΔGPI} NA P{UAS-sns.GPI} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Fas1MI03699 NA P{RS5}Fas15-HA-2279 NA P{SUPor-P}Fas1KG09729 NA P{white-un1}Fas1TE77 NA P{wHy}Fas1DG16410 NA PBac{5HPw+}Fas1A071 NA PBac{PB}Fas1c02707 NA PBac{RB}Fas1e00944 NA PBac{RB}Fas1e01965 NA insertion of mobile activating element P{EPgy2}Fas1EY06622 NA P{GSV1}C607C607 NA insertion of enhancer trap binary system P{GawB}Fas1NP1305 No insertion of enhancer trap P{HomingPigeon.FRT}Fas1HC164A No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
cell adhesion molecule binding inferred from direct assay (Elkins et al., 1990)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Abl (Elkins et al., 1990) calcium-independent cell-cell adhesion inferred from direct assay (Elkins et al., 1990) homophilic cell adhesion inferred from direct assay (Elkins et al., 1990) neuron recognition inferred from direct assay (Zinn et al., 1988)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Hortsch and Goodman, 1990, Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance non-traceable author statement (Lindsley and Zimm, 1992) neuron cell-cell adhesion inferred from sequence or structural similarity with UniProtKB:P10675 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1989.7.1) neuron recognition non-traceable author statement (Lindsley and Zimm, 1992)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1989.7.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fas1 allele Gene References Fas1TE89Da bif (Bahri et al., 1997)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262742
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69CQT5 Dipteran inclusive ortholog search EOG6575FR Insect inclusive ortholog search EOG6M90MN, EOG64QRX2 Arthropod inclusive ortholog search EOG6HT77B, EOG6V41QT Metazoa inclusive ortholog search EOG6T4RNB
Orthologs in Drosophila Species (EOG69CQT5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Fas1     Drosophila simulans   Dsim\GD19117 Y   Drosophila sechellia   Dsec\GM15175     Drosophila sechellia   Dsec\GM15176     Drosophila erecta   Dere\GG21753 Y   Drosophila yakuba   Dyak\GE24584 Y   Drosophila ananassae   Dana\GF17065 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19705 Y   Drosophila persimilis   Dper\GL24322 Y   Drosophila willistoni   Dwil\GK22538 Y   Drosophila virilis   Dvir\GJ24396 Y   Drosophila mojavensis   Dmoj\GI22362 Y   Drosophila grimshawi   Dgri\GH20264 Y   Drosophila grimshawi   Dgri\GH13158
Orthologs in non-Drosophila Dipterans (EOG6575FR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003044   Anopheles gambiae Malaria mosquito  Agam\AGAP000968   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014130
Orthologs in non-Dipteran Insects (EOG6M90MN, EOG64QRX2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44849   Apis mellifera Western honey bee  Amel\GB44848   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020485   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25961   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25960   Atta cephalotes Leafcutter ant  Acep\ACEP17534   Atta cephalotes Leafcutter ant  Acep\ACEP17532   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17944   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18304   Linepithema humile Argentine ant  Lhum\LH20005   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22219   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22217   Solenopsis invicta Red fire ant  Sinv\SINV25562   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007083   Bombyx mori Silkmoth  Bmor\BGIBMGA012513   Pediculus humanus Human body louse  Phum\PHUM259650   Tribolium castaneum Red flour beetle  Tcas\TC011300   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15746
Orthologs in non-Insect Arthropods (EOG6HT77B, EOG6V41QT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_196790   Ixodes scapularis Deer tick  Isca\ISCW003439
Orthologs in non-Arthropod Metazoa (EOG6T4RNB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F26E4.7
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19117 Drosophila erecta Dere\GG21753 Drosophila yakuba Dyak\GE24584 Drosophila ananassae Dana\GF17065 Drosophila pseudoobscura pseudoobscura Dpse\GA19705 Drosophila persimilis Dper\GL24322 Drosophila willistoni Dwil\GK22538 Drosophila virilis Dvir\GJ24396 Drosophila mojavensis Dmoj\GI22362 Drosophila grimshawi Dgri\GH20264
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	21537 y1 w67c23; P{wHy}Fas1DG16410 19855 y1 w67c23; P{EPgy2}Fas1EY06622 42887 y1 sc* v1; P{TRiP.HMS02580}attP40 41854 y1 v1; P{TRiP.GL01282}attP2/TM3, Sb1 36987 y1 w*; Mi{MIC}Fas1MI03699/TM3, Sb1 Ser1 16488 y1; ry506 P{SUPor-P}Fas1KG09729/TM3, Sb1 Ser1
Harvard	- PBac{PB}Fas1c02707 - PBac{RB}Fas1e00944
Kyoto	103974 y* w*; P{GawB}Fas1NP1305 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v101779 P{KK109572}VIE-260B v23014 w1118; P{GD12817}v23014 v23015 w1118; P{GD12817}v23015
	More stocks available...
Genomic Clones ( 1 )
	BACR48L13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 301 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25556 RH66459
Other clones	FI05280
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01917 GH02326 GH10623 GH10684 GH11381 GH12287 GH15855 GH16416 GH17908 GH24570 GH25722 HL04806 LD02579 LD12991 LD19872 LD20402 LD21549 LD31166 LD41813 LD45738 RE03959 RE22078 RE23507 RE24984 RE26287 RE29115 RE31705 RE33069 RE40209 RE41489 RE46449 RE51680 RE61036 RE63969 RE67282 RE72977 RE74049 RH02136 RH02942 RH02944 RH03627 RH03873 RH24844 RH31239 RH31639 RH31755 RH33531 RH58105 RH67040
Other clones	8795 10550 11111 13559 14255 20056 30455 30943 33859 34117 39389 40143 40382 41828 41846 43746 53641 53923 55504 58493 60798 63411 64403 70197 70349 76287 77009 78756 82216 82459 83801 98523 98987 99628 102241 104403 105004 107121 107808 108507 117579 118448 119262 119473 120274 121970 146729 154618 158122 162359 165185 166709 166781 166938 167187 174699 183069 183306 190630 191965 193870 214221.56 214279.65 214281.35 214371.73 214377.33 214415.37 214447.43 214475.36 214535.40 214541.27 277115 280466 282214 CK01.14A.F11 CK01.21B.B1 CK01.21C.H10 CK01.25D.D8 CK01.30C.H5 CK01.31B.G5 CK01.31B.G7 CK01.36D.A12 CK01.36D.H11 CK01.37C.D1 CK01.41C.H6 CK01.52B.H2 CK01.55D.B12 CK01.58A.H6 CK01.60C.F6 CK01.63D.C7 CK01.63D.D11 CK01.66C.C4 CK01.67B.H3 CK01.69A.B6 CK01.71A.C11 CK01.75B.D10 CK01.75D.G12 CK01.79D.H12 CK01.81B.D7 CK01.85D.A2 CK01.86D.C4 CK01.88A.B10 CK01.92D.D2 CK01.99C.H12 CK01.101D.A10 CK01.103D.E3 CK01.105B.E11 CK01.107B.E10 CK01.112C.F10 CK01.116D.D4 CK01.122B.B10 CK01.132A.G5 CK01.133C.G8 CK01.142D.E5 Dmel_neb_008255_0872_0428 Dmel_neb_010652_0381_2433 Dmel_neb_010666_0820_2177 DMG2-chr3R.13.057.a EK005346 EK019902 EK022848 EK031236 EK035463 EK042361 EK044738 EK045609 EK046763 EK048855 EK049437 EK052542 EK054130 EK055239 EK056510 EK058947 EK059260 EK061864 EK062816 EK063655 EK064012 EK067108 EK067833 EK068442 EK072237 EK072545 EK079518 EK084462 EK085933 EK087018 EK093437 EK094927 EK102406 EK103809 EK107557 EK110319 EK111751 EK116019 EK117146 EK127908 EK138463 EK148805 EK149125 EK152302 EK152643 EK154115 EK154313 EK163153 EK166146 EK170940 EK172752 EK174825 EK179603 EK182150 EK186908 EK190031 EK190247 EK197649 EK198022 EK208144 EK213223 EK215831 EK221531 EK221943 EK227748 EK229543 EK233153 EK235903 EK238932 EK239039 EK244713 EK245413 EK249329 EK252417 EK256209 EK258144 EK261016 EK271935 EK272146 EK279108 EK288021 EK288337 EK292740 EK304230 EK304927 EK307425 EP00841 EP01632 EP01643 EP14433 EP17863 EP18632 EP19038 EP22007 FGC002H07 FGM222E05 FGM233F10 FGM304G02 FGM316B10 RH01182 RP004090369 RP004109081 RP004119690 RP004145659 RP004146365 RP004186479 RP004202850 RP004207558 RP004208020 RP004212032 RP004222381 RP004238010 RP004248492 RP004252296 RP004259188 RP004259235 RP004342167 RP004392099 RP004401495 RP004418255 RP004443793 RP004462928 RP004489040 RP004491239 RP004496280 RP004505319 RP004521493 RP004529381 RP004536084 RP004537599 RP004551846
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42025
Antibody Information
	monoclonal, polyclonal (Hortsch and Goodman, 1990) polyclonal (Zinn et al., 1988)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Fas1 MRE24 (FlyBase Genome Annotators, 2011)
Additional comments	MRE24 is part of the 3' UTR of Fas1. (FlyBase Genome Annotators, 2011) MRE24 corresponds to a portion of the 3' UTR of Fas1. (FlyBase Genome Annotators, 2011)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) Area matching Fas1, Acc. No. M32311. (Davies, 2001.3.15) The complete sequence of the bithorax complex is available. (Martin et al., 1995) The phenotypes of Fas1, Fas2, Fas3 and nac mutants were analysed in the developing wing: the axon tracts in the CNS for the most part remain unaltered, and none of the phenotypes are 100% penetrant, indicating a fine-tuning role for these molecules in both the PNS and CNS. (Whitlock, 1993) Identification: Isolated from Drosophila embryonic cDNA libraries using a fasciclin I probe from grasshopper. (Lindsley and Zimm, 1992) Flies deficient in Fas1 function are fully viable and CNS development apparently is normal. (Lindsley and Zimm, 1992) Postulated to be involved in neuron recognition during growth cone guidance. (Lindsley and Zimm, 1992) Detailed molecular analysis of Fas1 reveals alternative splicing of the 6-9 base pair micro-exons. (McAllister et al., 1992) Fas1 plays an important role in growth cone guidance, as revealed in an Abl mutant background. (Elkins et al., 1990) Mutant phenotypes can be rescued by element mediated transformation of a wild type copy of Fas1. (Elkins et al., 1990) A screening procedure was used to recover second-site mutations that would shift the lethal phase of Abl mutant homozygotes and Nrt mutant heterozygotes from embryonic or larval stages back to pupal. ena mutations allow complete recovery of Abl- Fas1- double mutants as fertile adults. (Gertler et al., 1990) Fas1 protein is tightly associated with the lipid bilayer in Schneider 1 cells. In Drosophila embryos a significant amount of Fas1 protein is present in a free, soluble form, the ration of the free and membrane bound forms varying considerably during embryogenesis. (Hortsch and Goodman, 1990) Study of the expression pattern supports the hypothesis that Fas1 is a neuronal surface recognition molecule. (Zinn et al., 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169724 NM_169725 NM_169726 NM_001104344 NM_001144593 NM_001144594 NM_001275716 RefSeq (Proteins) • NP_732164 NP_732165 NP_732166 NP_001097814 NP_001138065 NP_001138066 NP_001262645 DDBJ / EMBL / GenBank • AA941423 AAA28529 AAA28531 AAF55346 AAM49900 AAN13714 AAN13715 ABW08688 ACL83523 ACL83524 AGB96025 AW942737 AX093939 AY118531 CL528259 CL705807 CZ468154 CZ478776 CZ479771 CZ479772 M20545 M32311 U31961 Entrez Gene - A searchable database of RefSeq genes. • 42025 UniProtKB/Swiss-Prot • P10674 UniProtKB/TrEMBL • A8JR25 B7Z0L0 B7Z0L1 Q8INA9 Q8MSW3 Q9VES3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • FAS1 domain (IPR000782) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1O70 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI05280
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262742 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42025
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG6588 (Schiess et al., 2009, Lim et al., 2011, Molnar et al., 2006, Keleman et al., 2009.8.5, Khanna et al., 2010, Ni et al., 2010.12.1) DROFAS (Schug et al., 1998) DROFAS1 (Schug et al., 1997) DROFASI (Fernando Vazquez et al., 2000, Lopez et al., 1999) fas1 (Hilgers et al., 2011, Hilgers et al., 2012, Smibert et al., 2012) Fas1 (FlyBase Genome Annotators, 2011, Turner et al., 2008, Gilfillan et al., 2006, Shigenobu et al., 2006, Molnar et al., 2006, Kristiansen et al., 2005, Cherbas et al., 2011, Japanese National Institute of Genetics, 2012.5.21) FasI (Bender and Hudson, 2000, Van Etten, 1999, Speicher et al., 1998, Zhong and Shanley, 1995, Desai et al., 1994, Choksi et al., 2006, Koles et al., 2012) Fas I (Liu and Seeger, 2000) fasI (Garcia-Alonso, 1999, Chien, 1998, Bahri et al., 1997, Budnik, 1996, Chien, 1996, Therianos et al., 1995, Hamilton et al., 1995, Broadie et al., 1993, Goodman et al., 1989, Noll et al., 1993, Wang et al., 1993, Phillis et al., 1993, Whitlock, 1993, Nambu et al., 1993, McAllister et al., 1992, McAllister et al., 1992, ) fas-I (Pulido, 1993, Jimenez et al., 1993) fas I (Gertler et al., 1990) gasI (Palka, 1993) MRE24 (FlyBase Genome Annotators, 2011, Kageyama, 2007.2.28, Inagaki et al., 2005)
Name Synonym	Fasciclin 1 (Tan et al., 2009, Lim et al., 2011, Stofanko et al., 2008, Khanna et al., 2010, Khanna et al., 2010) Fasciclin-1 (Hoehne et al., 2005) Fasciclin I (Southall and Brand, 2009, Goodman and Doe, 1993, Panakova et al., 2005, Choksi et al., 2006, Koles et al., 2012) fasciclin I (Burghes et al., 2001, Malhotra et al., 1998, Therianos et al., 1994, Wilson, 1993, Seeger, 1994, Grenningloh and Goodman, 1992, Hortsch and Bieber, 1991, Elkins et al., 1990, McAllister et al., 1992, Hortsch and Goodman, 1990) mRNA-like ncRNA in embryogenesis 24
Secondary FlyBase IDs
	FBgn0000634 FBgn0026839 FBgn0086555
References ( 115 )
Generate a list of	All references relating to this gene ( 115 )
List References by type	Research paper  ( 59 ) Supplementary material  ( 7 ) Review  ( 18 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) Book  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Hilgers et al., 2012, Genes Dev. 26(20): 2259--2264 ELAV mediates 3' UTR extension in the Drosophila nervous system. [FBrf0219699] Koles et al., 2012, J. Biol. Chem. 287(20): 16820--16834 Mechanism of evenness interrupted (evi)-exosome release at synaptic boutons. [FBrf0218323] Smibert et al., 2012, Cell Rep. 1(3): 277--289 Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila. [FBrf0218523] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Hilgers et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(38): 15864--15869 Neural-specific elongation of 3' UTRs during Drosophila development. [FBrf0215804] Lim et al., 2011, FEBS Lett. 585(19): 3079--3085 The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. [FBrf0216303] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...