Mdh, Mdh-1, cMdh
Gene model reviewed during 5.45
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdh1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mdh1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Mdh1 CG5362
For the electrophoretic variants, the Research Triangle Park conventions (1978) are used.
The response of Mdh1 to Juvenile hormone (JH) depends on the developmental stage of the fly relative to its endogenous titre of ecdysteroids. During the interecdysial period of the last instar Mdh1 rapidly responds to JH by increasing activity, little or no response is monitored in wandering (post feeding) larvae.
Pattern of allele frequency has been studied for seven loci, Aph-3, Est-6, Adh, Fdh, Aldox-1, Gpdh and Mdh1, in wild Indian populations of D.melanogaster : the allelic frequency patterns do not agree with those from temperate region populations.
The synergistic effects of the Adh locus, or a tightly linked locus, on the quantities of the Mdh1, Gpdh, Pgm, Idh, Men and Gapdh1 gene products in D.melanogaster derived from an African population has been determined.
No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.
The structural gene for the cytoplasmic, NAD-dependent malate dehydrogenase = (S)-Malate: NAD+ oxidoreductase (MDH1). Extracts from homozygotes produce two bands of activity plus a lighter, more electronegative band on gels; heterozygotes produce hybrid bands, indicating that the enzyme is a dimeric molecule. Subunit molecular weight estimated at 30,000 Daltons. Not necessary for survival, since Mdh1n1/Df(2L)J2 is viable. Purification and biochemical characterization carried out by McReynolds and Kitto (1970), Hay and Armstrong (1976) and Alahiotis (1979).