FB2020_06, released Dec 22, 2020

Gene: Dmel\S6kII

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General Information
Symbol
Dmel\S6kII
Species
D. melanogaster
Name
Ribosomal protein S6 kinase II
Annotation Symbol
CG17596
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262866
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

RSK, ign, p90 ribosomal S6 kinase, ignorant, rsk2

Key Links
Genomic Location
Cytogenetic map
20C1-20C1
Sequence location
X:22,529,964..22,536,371 [+]
Recombination map

1-66

RefSeq locus
NC_004354 REGION:22529964..22536371
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (26 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables mitogen-activated protein kinase binding
inferred from physical interaction with FLYBASE:rl; FB:FBgn0003256
(Kim et al., 2006)
enables ribosomal protein S6 kinase activity
inferred from direct assay
(Kim et al., 2006)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables magnesium ion binding
inferred from electronic annotation with InterPro:IPR016239
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN007797242
(assigned by GO_Central )
(Gaudet et al., 2011)
enables ribosomal protein S6 kinase activity
inferred from sequence or structural similarity
(Wassarman et al., 1994)
inferred from biological aspect of ancestor with PANTHER:PTN001219146
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (15 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in associative learning
inferred from mutant phenotype
(Putz et al., 2004)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Kim et al., 2006)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Kim et al., 2006)
involved_in locomotor rhythm
inferred from mutant phenotype
(Akten et al., 2009)
involved_in negative regulation of compound eye cone cell fate specification
inferred from mutant phenotype
(Kim et al., 2006)
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from direct assay
(Kim et al., 2006)
involved_in negative regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Kim et al., 2006)
involved_in negative regulation of pigment cell differentiation
inferred from mutant phenotype
(Kim et al., 2006)
involved_in negative regulation of protein import into nucleus
inferred from direct assay
(Kim et al., 2006)
involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
inferred from mutant phenotype
(Kim et al., 2006)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Fischer et al., 2009)
involved_in operant conditioning
inferred from mutant phenotype
(Putz et al., 2004)
involved_in regulation of neuromuscular junction development
inferred from mutant phenotype
(Beck et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in peptidyl-serine phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN007797242
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
inferred from sequence or structural similarity
(Wassarman et al., 1994)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Kim et al., 2006)
located_in neuromuscular junction
inferred from direct assay
(Fischer et al., 2009)
located_in perikaryon
inferred from direct assay
(Beck et al., 2015)
located_in presynapse
inferred from direct assay
(Beck et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN007797243
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN007797243
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
AGC KINASES (UNCLASSIFIED) -
The AGC kinase subfamily are serine/threonine kinases that were originally defined based on the sequence similarity of the catalytic domain. The AGC KINASE (UNCLASSIFIED) gene group represents AGC kinases that do not fall into the PKA, PKC or PKG families. (Adapted from FBrf0132098 and PMID:20027184).
Summary (Interactive Fly)

negatively regulates ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK - functions as a downstream effector and regulator of the MAP kinase pathway - involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\S6kII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
gene
(Olson et al., 2007)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
S6kII-RA
FBtr0077360
NM_078713
3777
911
S6kII-RB
FBtr0333715
NM_001272850
6055
911
Additional Transcript Data and Comments
Reported size (kB)

3.137 (longest cDNA)

(Wassarman et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
S6kII-PA
FBpp0077052
100.4
911
6.95
NP_523437
AAF50945
S6kII-PB
FBpp0305864
100.4
911
6.95
NP_001259779
AGB95617
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

911 aa isoforms: S6kII-PA, S6kII-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

910 (aa); 100 (kD predicted)

(Wassarman et al., 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6kII using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head

Comment: displays circadian cycling

(Akten et al., 2009)
Additional Descriptive Data

S6kII transcripts were analyzed by qRT-PCR in adult head tissue. Levels of S6kII change in a diurnal manner with peak abundance occurring between Zeitgeber time 22 and 1.

(Akten et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Akten et al., 2009)
Additional Descriptive Data

S6kII protein levels were measured at six time points across the diurnal cycle and were found to be relatively constant across the cycle in adult head extracts.

(Akten et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Kim et al., 2006)
located_in neuromuscular junction
inferred from direct assay
(Fischer et al., 2009)
located_in perikaryon
inferred from direct assay
(Beck et al., 2015)
located_in presynapse
inferred from direct assay
(Beck et al., 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\S6kII in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of S6kII
Transgenic constructs containing regulatory region of S6kII
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
semi-fertile
Other Phenotypes
Allele
learning defective
learning defective (with Df(1)R29)
learning defective (with S6kIIign-Δ24-3)
learning defective (with S6kIIign-Δ58-1)
learning defective | dominant
learning defective | male limited
locomotor rhythm defective
memory defective
memory defective | male limited
memory defective | recessive
neuroanatomy defective
neuroanatomy defective | larval stage
neuroanatomy defective | third instar larval stage
neurophysiology defective
short lived
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4pnr-MD237
visible (with Df(1)R8A)
visible | recessive
Phenotype manifest in
Allele
chaeta | supernumerary, with Scer\GAL4pnr-MD237
cone cell
cone cell (with Df(1)R8A)
embryonic/larval neuromuscular junction
eye photoreceptor cell
eye photoreceptor cell, with Scer\GAL4hs.2sev
eye photoreceptor cell (with Df(1)R8A)
interommatidial bristle, with Scer\GAL4GMR.PF
mesothoracic tergum, with Scer\GAL4pnr-MD237
mitochondrion
NMJ bouton
NMJ bouton | larval stage
NMJ bouton | supernumerary
NMJ bouton | third instar larval stage
ommatidial precursor cluster
ommatidial precursor cluster (with Df(1)R8A)
ommatidium, with Scer\GAL4GMR.PF
pigment cell
pigment cell (with Df(1)R8A)
presynaptic active zone
retina, with Scer\GAL4GMR.PF
rhabdomere, with Scer\GAL4GMR.PF
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4en-e16E
wing vein | ectopic
wing vein | ectopic (with Df(1)R8A)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RPS6KA2
12 of 15
Yes
Yes
Hsap\RPS6KA3
12 of 15
Yes
Yes
1  
Hsap\RPS6KA1
11 of 15
No
Yes
Hsap\RPS6KA6
10 of 15
No
Yes
Hsap\RPS6KA4
3 of 15
No
No
Hsap\RPS6KA5
3 of 15
No
No
Hsap\RPS6KB1
3 of 15
No
No
2  
Hsap\RPS6KB2
3 of 15
No
No
Hsap\AKT1
1 of 15
No
No
Hsap\AKT2
1 of 15
No
No
5  
Hsap\AKT3
1 of 15
No
No
Hsap\RPS6KC1
1 of 15
No
No
Hsap\RPS6KL1
1 of 15
No
No
Hsap\SGK1
1 of 15
No
No
Hsap\SGK2
1 of 15
No
No
Hsap\SNX15
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rps6ka2
12 of 15
Yes
Yes
Mmus\Rps6ka3
11 of 15
No
Yes
Mmus\Rps6ka1
10 of 15
No
Yes
Mmus\Rps6ka6
10 of 15
No
Yes
Mmus\Rps6ka4
3 of 15
No
No
Mmus\Rps6ka5
3 of 15
No
No
Mmus\Rps6kb1
3 of 15
No
No
Mmus\Rps6kb2
3 of 15
No
No
Mmus\Akt1
1 of 15
No
No
Mmus\Akt2
1 of 15
No
No
Mmus\Akt3
1 of 15
No
No
Mmus\Rps6kc1
1 of 15
No
No
Mmus\Rps6kl1
1 of 15
No
No
Mmus\Sgk1
1 of 15
No
No
Mmus\Sgk2
1 of 15
No
No
Mmus\Snx15
1 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Rps6ka3
10 of 13
Yes
Yes
Rnor\Rps6ka2
9 of 13
No
Yes
Rnor\Rps6ka6
9 of 13
No
Yes
Rnor\Rps6ka1
8 of 13
No
Yes
Rnor\Rps6ka4
2 of 13
No
No
Rnor\Rps6ka5
2 of 13
No
No
Rnor\Rps6kb1
2 of 13
No
No
Rnor\Rps6kb2
2 of 13
No
No
Rnor\Rps6kc1
1 of 13
No
No
Rnor\Rps6kl1
1 of 13
No
No
Rnor\Snx15
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\rps6ka3
7 of 12
Yes
Yes
Xtro\rps6ka1
6 of 12
No
Yes
Xtro\rps6ka2
6 of 12
No
Yes
Xtro\rps6ka6
6 of 12
No
Yes
Xtro\rps6ka4
2 of 12
No
No
Xtro\rps6kb1
2 of 12
No
No
Xtro\akt2
1 of 12
No
No
Xtro\rps6ka5
1 of 12
No
No
Xtro\rps6kl1
1 of 12
No
No
Xtro\sgk1
1 of 12
No
No
Xtro\sgk2
1 of 12
No
No
Xtro\snx15
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\rps6ka3b
12 of 15
Yes
Yes
Drer\rps6ka2
11 of 15
No
Yes
Drer\rps6ka3a
9 of 15
No
Yes
Drer\rps6kal
9 of 15
No
Yes
Drer\rps6ka1
5 of 15
No
Yes
Drer\rps6ka4
3 of 15
No
No
Drer\rps6ka5
3 of 15
No
No
Drer\rps6kb1a
2 of 15
No
No
Drer\rps6kb1b
2 of 15
No
No
Drer\akt2
1 of 15
No
No
Drer\akt3a
1 of 15
No
No
Drer\sgk1
1 of 15
No
No
Drer\sgk2a
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\rskn-1
13 of 15
Yes
Yes
Cele\rskn-2
3 of 15
No
No
Cele\rsks-1
3 of 15
No
No
Cele\R04A9.7
2 of 15
No
No
Cele\akt-1
1 of 15
No
No
Cele\akt-2
1 of 15
No
No
Cele\rskd-1
1 of 15
No
No
Cele\sgk-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\PK1
3 of 9
Yes
No
Atha\S6K2
3 of 9
Yes
No
Atha\CDPK9
1 of 9
No
No
Atha\CIPK17
1 of 9
No
No
Atha\CPK1
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\YPK3
4 of 15
Yes
Yes
Scer\SCH9
2 of 15
No
No
Scer\YPK1
2 of 15
No
No
Scer\YPK2
2 of 15
No
No
Scer\CTK1
1 of 15
No
No
Scer\FPK1
1 of 15
No
Yes
Scer\KIN82
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\psk1
4 of 12
Yes
Yes
Spom\gad8
1 of 12
No
No
Spom\ppk1
1 of 12
No
Yes
Spom\sck1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902IG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010478
Drosophila simulans
Dsim\GD17550
Drosophila sechellia
Dsec\GM11736
Drosophila erecta
Dere\GG19750
Drosophila yakuba
Dyak\S6kII
Drosophila ananassae
Dana\GF26852
Drosophila pseudoobscura pseudoobscura
Dpse\GA14570
Drosophila persimilis
Dper\GL13301
Drosophila willistoni
Dwil\GK25774
Drosophila virilis
Dvir\GJ18812
Drosophila mojavensis
Dmoj\GI26271
Drosophila grimshawi
Dgri\GH24077
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501TU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017445
Glossina morsitans
Tsetse fly
Gmor\GMOY007366
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00189
Mayetiola destructor
Hessian fly
Mdes\Mdes007991
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004474
Anopheles darlingi
American malaria mosquito
Adar\ADAC005504
Anopheles gambiae
Malaria mosquito
Agam\AGAP003040
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014359
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0217 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011088
Bombyx mori
Silkmoth
Bmor\BGIBMGA000142
Danaus plexippus
Monarch butterfly
Dple\DPOGS203202-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205511-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005786
Heliconius melpomene
Postman butterfly
Hmel\HMEL011296
Heliconius melpomene
Postman butterfly
Hmel\HMEL015753
Apis florea
Little honeybee
Aflo\2452734196
Apis florea
Little honeybee
Aflo\4102039604
Apis mellifera
Western honey bee
Amel\S6kII
Apis mellifera
Western honey bee
Amel\GB40565
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18811
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11539
Bombus terrestris
Buff-tailed bumblebee
Bter\15207129
Bombus terrestris
Buff-tailed bumblebee
Bter\15216629
Linepithema humile
Argentine ant
Lhum\LH21897
Linepithema humile
Argentine ant
Lhum\LH19909
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00270f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002f1a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013142
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004335
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01859
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03427
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09351
Tribolium castaneum
Red flour beetle
Tcas\TC001074
Tribolium castaneum
Red flour beetle
Tcas\TC000021
Pediculus humanus
Human body louse
Phum\PHUM508900
Pediculus humanus
Human body louse
Phum\PHUM599900
Rhodnius prolixus
Kissing bug
Rpro\RPRC003727
Rhodnius prolixus
Kissing bug
Rpro\RPRC000863
Cimex lectularius
Bed bug
Clec\CLEC007762
Cimex lectularius
Bed bug
Clec\CLEC007763
Cimex lectularius
Bed bug
Clec\CLEC006450
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI47192
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004772
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17521
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00262
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03WL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011282
Strigamia maritima
European centipede
Smar\SMAR015072
Strigamia maritima
European centipede
Smar\SMAR001186
Strigamia maritima
European centipede
Smar\SMAR015647
Ixodes scapularis
Black-legged tick
Isca\ISCW017390
Ixodes scapularis
Black-legged tick
Isca\ISCW012610
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82508.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68004.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65578.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64654.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66159.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g08980
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g01350
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g14060
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_225339
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_23503
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_318992
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05Z7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-P70rsk
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rsk1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rska2
Ciona intestinalis
Vase tunicate
Cint\LOC100175855
Gallus gallus
Domestic chicken
Ggal\RPS6KB1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000022512
Gallus gallus
Domestic chicken
Ggal\RPS6KA2
Gallus gallus
Domestic chicken
Ggal\RPS6KA6
Gallus gallus
Domestic chicken
Ggal\RPS6KA
Gallus gallus
Domestic chicken
Ggal\RPS6KA3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
S6k
5 of 10
JIL-1
4 of 10
Akt1
1 of 10
CG7156
1 of 10
S6KL
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
S6kIIign-Δ58-1
model of  Coffin-Lowry syndrome
CEA
(Beck et al., 2015)
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RPS6KA2; ribosomal protein S6 kinase A2
12 of 15
601685
      RPS6KA3; ribosomal protein S6 kinase A3
      12 of 15
      300075
       
      RPS6KA1; ribosomal protein S6 kinase A1
      11 of 15
      601684
          RPS6KA6; ribosomal protein S6 kinase A6
          10 of 15
          300303
              RPS6KA4; ribosomal protein S6 kinase A4
              3 of 15
              603606
                  RPS6KA5; ribosomal protein S6 kinase A5
                  3 of 15
                  603607
                      RPS6KB1; ribosomal protein S6 kinase B1
                      3 of 15
                      608938
                           
                          RPS6KB2; ribosomal protein S6 kinase B2
                          3 of 15
                          608939
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              esyN Network Diagram
                              Show neighbor-neighbor interactions:
                              Select Layout:
                              Legend:
                              Protein
                              RNA
                              Selected Interactor(s)
                              Interactions Browser
                              View in Interactions Browser
                              Please see the Physical Interaction reports below for full details
                              protein-protein
                              Physical Interaction
                              Assay
                              References
                              S6kII - 14-3-3ε
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - ACC
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - AGO2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Acn
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Act42A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Aldh
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Ankle2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Arc1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Bap111
                              anti tag coimmunoprecipitation, anti tag western blot
                              (Vinayagam et al., 2013)
                              S6kII - Bap55
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Brr2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CCT1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CCT2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CCT5
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG10333
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG11417
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG11583
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG13096
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG13097
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG15019
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG1513
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG1542
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG15784
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG1677
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG1703
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG17593
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG2691
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG30122
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG32409
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG3335
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG3817
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG42354
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG4266
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG4806
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG5033
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG5645
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG5787
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG7065
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG7564
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG9246
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG9253
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CG9776
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Caf1-55
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Cdc5
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CkIIα
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - CkIIβ
                              anti tag coimmunoprecipitation, anti tag western blot
                              (Akten et al., 2009)
                              S6kII - Claspin
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Cpsf5
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Cpsf6
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Ctf4
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Droj2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Fib
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Fmr1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Gnf1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Gp150
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - HDAC1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Hrb98DE
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Hsc70-3
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Imp
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Kap-α3
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Mi-2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Nipped-B
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Non3
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Nop60B
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Nopp140
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Nph
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Ns1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Nup358
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - PH4αEFB
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Pnn
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Pp2B-14D
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Prp19
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Prp8
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RAF2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Rack1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Ranbp9
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Rbcn-3A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Ref1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RhoGAP18B
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Rip11
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Rm62
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpI1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpI135
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL10
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL10Ab
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL13
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL13A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL14
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL15
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL17
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL18
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL18A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL19
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL23A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL26
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL27
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL28
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL31
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL35
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL35A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL36
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL4
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL6
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL7
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL7A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL8
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpL9
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpLP1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS11
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS14a
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS15
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS15Aa
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS16
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS17
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS23
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS25
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS4
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS5a
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS6
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS7
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - RpS9
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Rtf1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - SF1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - SF2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - ScsβA
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Sec63
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Sf3b2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Spt5
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - SrpRα
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Ssb-c31a
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Taf3
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - TfIIFα
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - TfIIFβ
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Tsc1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - UQCR-C2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - Zn72D
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - alt
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - bif
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - brm
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - bsf
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - cindr
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - cora
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3a
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3b
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3c
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3d1
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3e
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3h
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3i
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3k
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF3m
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eIF4A
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - eRF3
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - gig
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - hts
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - kis
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - kst
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - kuk
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - l(2)09851
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - larp
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - lds
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - mRpL12
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - mahj
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - mask
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - mor
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - msn
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - ncd
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - ncm
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - nonA
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - peng
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - pic
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - pont
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - ppan
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - pzg
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - qkr58E-3
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - rept
                              anti tag coimmunoprecipitation, anti tag western blot
                              (Vinayagam et al., 2016)
                              S6kII - row
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - rump
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - rush
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - scaf6
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - sgg
                              anti tag coimmunoprecipitation, western blot, anti tag western blot, enzymatic study
                              (Beck et al., 2018)
                              S6kII - sip2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - sle
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - smid
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - spoon
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - sqd
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - ssx
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - vig
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - vig2
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - yps
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - zda
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - α-Spec
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - βTub60D
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              S6kII - βTub97EF
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              Summary of Genetic Interactions
                              esyN Network Diagram
                              esyN Network Key:
                              Suppression
                              Enhancement
                              View in Interactions Browser
                              Please look at the allele data for full details of the genetic interactions
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              S6kII
                              suppressible
                              CkIIα
                              (Akten et al., 2009)
                              S6kII
                              suppressible
                              CkIIβ
                              (Akten et al., 2009)
                              S6kII
                              enhanceable
                              Dsor1
                              (Kim et al., 2006)
                              S6kII
                              suppressible
                              Pdk1
                              (Rintelen et al., 2001)
                              S6kII
                              enhanceable
                              Raf
                              (Kim et al., 2006)
                              S6kII
                              enhanceable
                              Ras85D
                              (Kim et al., 2006)
                              S6kII
                              enhanceable
                              rl
                              (Kim et al., 2006)
                              S6kII
                              suppressible
                              rl
                              (Fischer et al., 2009)
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Raf
                              suppressible
                              S6kII
                              (Kim et al., 2006)
                              Raf
                              enhanceable
                              S6kII
                              (Kim et al., 2006)
                              Ras85D
                              enhanceable
                              S6kII
                              (Kim et al., 2006)
                              Ras85D
                              suppressible
                              S6kII
                              (Kim et al., 2006)
                              sev
                              suppressible
                              S6kII
                              (Kim et al., 2006)
                              External Data
                              Linkouts
                              DroID - A comprehensive database of gene and protein interactions.
                              MIST (genetic) - An integrated Molecular Interaction Database
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Signaling Pathways (FlyBase)
                              Metabolic Pathways
                              External Data
                              Linkouts
                              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              X
                              Recombination map

                              1-66

                              Cytogenetic map
                              20C1-20C1
                              Sequence location
                              X:22,529,964..22,536,371 [+]
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              20C1-20C1
                              Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              20-20
                              (Wassarman, 1994.10.14)
                              20-20
                              (determined by in situ hybridisation)
                              (Wassarman et al., 1994)
                              Experimentally Determined Recombination Data
                              Location

                              1-66

                              (FlyBase, 2016)

                              1-66.3

                              (Comeron et al., 2012)
                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (14)
                              Genomic Clones (12)
                               

                              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                              cDNA Clones (29)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequenced
                              BDGP DGC clones
                              Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                Antibody Information
                                Laboratory Generated Antibodies
                                 

                                polyclonal

                                (Fischer et al., 2009)
                                Commercially Available Antibodies
                                 
                                Other Information
                                Relationship to Other Genes
                                Source for database identify of
                                Source for database merge of

                                Source for merge of: S6kII rsk2

                                (Restifo, 2011.1.20)
                                Additional comments
                                Other Comments

                                S6kII negatively regulates bouton number at the larval neuromuscular junction.

                                (Fischer et al., 2009)

                                Homologue of human RSK2 corresponding to Coffin-Lowry syndrome gene.

                                (Olson et al., 2007)

                                The rl-binding activity of S6kII, but not the phosphotransferase activity, is essential for the in vivo function of S6kII in eye and wing development. S6kII regulates rl activity by acting as a cytoplasmic anchor.

                                (Kim et al., 2006)

                                When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells is seen.

                                (Bettencourt-Dias et al., 2004)

                                One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

                                (Inlow and Restifo, 2004)

                                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                (Kiger et al., 2003)

                                A S6kII cDNA has been cloned and sequenced.

                                (Wassarman et al., 1994)
                                Origin and Etymology
                                Discoverer
                                Etymology
                                Identification
                                External Crossreferences and Linkouts ( 44 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                Other crossreferences
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                Linkouts
                                DroID - A comprehensive database of gene and protein interactions.
                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                Synonyms and Secondary IDs (18)
                                Reported As
                                Symbol Synonym
                                CG17596
                                (Ni et al., 2011.7.19, Ni et al., 2010.12.1, Sun et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Putz et al., 2004, Morrison et al., 2000)
                                D-RSK
                                (Fischer and Raabe, 2018)
                                RSK
                                (Beck et al., 2018, Beck et al., 2015, Akten et al., 2009, Bjorklund et al., 2006, Kim et al., 2006, Brembs, 2003, Morrison et al., 2000, Johansen et al., 1999, Wassarman, 1994.10.14)
                                Rsk
                                S6KII
                                (Zhu, 2013, Tangredi et al., 2012, Slack et al., 2010, Akten et al., 2009, Neuser et al., 2008, Putz et al., 2004, Wassarman et al., 1994)
                                S6kII
                                (Wang et al., 2020, Hegazi et al., 2019, Mast and DiPrimio, 2019.3.12, Transgenic RNAi Project members, 2017-, Yang and Veraksa, 2017, Dobson et al., 2016, Schwartz et al., 2016, Vinayagam et al., 2016, Cugusi et al., 2015, Sopko et al., 2014, Vinayagam et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Korcsmáros et al., 2011, Restifo, 2011.1.20, Sun et al., 2010, Akten et al., 2009)
                                dRSK
                                (Pospisilik et al., 2010, Rintelen et al., 2001)
                                dRsk
                                (Okray and Hassan, 2013)
                                ign
                                (Kuntz et al., 2017, Neuser et al., 2008, Putz et al., 2004, Brembs, 2003)
                                rsk
                                (Scholz et al., 2019, Beck et al., 2018, Fischer et al., 2009)
                                rsk2
                                (Restifo, 2011.1.20, Olson et al., 2007)
                                Name Synonyms
                                RPS6-protein kinase-II
                                Ribosomal protein S6 kinase II
                                Ribosomal-S6-kinase
                                S6 kinase II
                                (Neuser et al., 2008)
                                ignorant
                                (Neuser et al., 2008, Putz et al., 2004, Brembs, 2003)
                                p90 ribosomal S6 kinase
                                (Akten et al., 2009, Kim et al., 2006, Brembs, 2003)
                                ribosomal-S6-kinase
                                (Pospisilik et al., 2010)
                                Secondary FlyBase IDs
                                • FBgn0011285
                                • FBgn0086241
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (81)