FlyBase Gene Report: Dmel\S6kII

General Information

Symbol

Dmel\S6kII

Species

D. melanogaster

Name

Ribosomal protein S6 kinase II

Annotation Symbol

CG17596

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262866

Gene Model Status

Stock Availability

14 publicly available

Gene Summary

Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

RSK, ign, p90 ribosomal S6 kinase, ignorant, rsk2

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:22,529,964..22,536,371 [+]

Recombination map

1-66

RefSeq locus

NC_004354 REGION:22529964..22536371

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (26 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables mitogen-activated protein kinase binding

inferred from physical interaction with FLYBASE:rl; FB:FBgn0003256

(Kim et al., 2006)

enables ribosomal protein S6 kinase activity

inferred from direct assay

(Kim et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables magnesium ion binding

inferred from electronic annotation with InterPro:IPR016239

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN007797242

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ribosomal protein S6 kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001219146

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Wassarman et al., 1994)

Biological Process (15 terms)

Terms Based on Experimental Evidence (13 terms)

CV Term

Evidence

References

involved_in associative learning

inferred from mutant phenotype

(Putz et al., 2004)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Kim et al., 2006)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Kim et al., 2006)

involved_in locomotor rhythm

inferred from mutant phenotype

(Akten et al., 2009)

involved_in negative regulation of compound eye cone cell fate specification

inferred from mutant phenotype

(Kim et al., 2006)

involved_in negative regulation of ERK1 and ERK2 cascade

inferred from direct assay

(Kim et al., 2006)

involved_in negative regulation of photoreceptor cell differentiation

inferred from mutant phenotype

(Kim et al., 2006)

involved_in negative regulation of pigment cell differentiation

inferred from mutant phenotype

(Kim et al., 2006)

involved_in negative regulation of protein import into nucleus

inferred from direct assay

(Kim et al., 2006)

involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

inferred from mutant phenotype

(Kim et al., 2006)

involved_in neuromuscular junction development

inferred from mutant phenotype

(Fischer et al., 2009)

involved_in operant conditioning

inferred from mutant phenotype

(Putz et al., 2004)

involved_in regulation of neuromuscular junction development

inferred from mutant phenotype

(Beck et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in peptidyl-serine phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN007797242

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein phosphorylation

inferred from sequence or structural similarity

(Wassarman et al., 1994)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Kim et al., 2006)

located_in neuromuscular junction

inferred from direct assay

(Fischer et al., 2009)

located_in perikaryon

inferred from direct assay

(Beck et al., 2015)

located_in presynapse

inferred from direct assay

(Beck et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN007797243

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in nucleoplasm

inferred from biological aspect of ancestor with PANTHER:PTN007797243

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

AGC KINASES (UNCLASSIFIED)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

AGC KINASES (UNCLASSIFIED) -: The AGC kinase subfamily are serine/threonine kinases that were originally defined based on the sequence similarity of the catalytic domain. The AGC KINASE (UNCLASSIFIED) gene group represents AGC kinases that do not fall into the PKA, PKC or PKG families. (Adapted from FBrf0132098 and PMID:20027184).

Summary (Interactive Fly)

negatively regulates ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK - functions as a downstream effector and regulator of the MAP kinase pathway - involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\S6kII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

(Olson et al., 2007)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0077360

3777

911

FBtr0333715

6055

911

Additional Transcript Data and Comments

Reported size (kB)

3.137 (longest cDNA)

(Wassarman et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0077052

100.4

911

6.95

FBpp0305864

100.4

911

6.95

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

911 aa isoforms: S6kII-PA, S6kII-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

910 (aa); 100 (kD predicted)

(Wassarman et al., 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6kII using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

S6kII_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

Comment: displays circadian cycling

(Akten et al., 2009)

Additional Descriptive Data

S6kII transcripts were analyzed by qRT-PCR in adult head tissue. Levels of S6kII change in a diurnal manner with peak abundance occurring between Zeitgeber time 22 and 1.

(Akten et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

(Akten et al., 2009)

Additional Descriptive Data

S6kII protein levels were measured at six time points across the diurnal cycle and were found to be relatively constant across the cycle in adult head extracts.

(Akten et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Kim et al., 2006)

located_in neuromuscular junction

inferred from direct assay

(Fischer et al., 2009)

located_in perikaryon

inferred from direct assay

(Beck et al., 2015)

located_in presynapse

inferred from direct assay

(Beck et al., 2015)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\S6kII in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\S6kII

View exonic expression by tissue for Dmel\S6kII

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33139/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262866

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011285

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262866

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17596

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 28 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of S6kII

Transgenic constructs containing regulatory region of S6kII

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)S6kII-ignΔ67-1

(Putz et al., 2004)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

S6kII^D1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

S6kII^GD1254

viable, with Scer\GAL4^Mef2.PR

S6kII^GD1254

viable, with Scer\GAL4^pnr-MD237

S6kII^GD1254

viable, with Scer\GAL4^tin.CΔ4

S6kII^GD1254

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

S6kII^GL00207

S6kII^D1

Other Phenotypes

Allele

abnormal learning

abnormal learning (with Df(1)R29)

S6kII^ign-Δ24-3

abnormal learning (with S6kII^ign-Δ24-3)

S6kII^ign-Δ58-1

abnormal learning (with S6kII^ign-Δ58-1)

S6kII^ign-Δ24-3

abnormal learning | dominant

S6kII^ign-Δ24-3

abnormal learning | male limited

S6kII^ign-P1

abnormal locomotor rhythm

S6kII^ign-Δ58-1

abnormal memory

S6kII^ign-Δ58-1

abnormal memory | male limited

S6kII^ign-P1

abnormal memory | recessive

S6kII^ign-Δ24-3

abnormal neuroanatomy

abnormal neuroanatomy | larval stage

S6kII^UAS.cRa

abnormal neuroanatomy | third instar larval stage

abnormal neurophysiology

S6kII^ign-Δ58-1

S6kII^D1

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^pnr-MD237

S6kII^GD1254

visible (with Df(1)R8A)

S6kII^D1

visible | recessive

S6kII^D1

Phenotype manifest in

Allele

chaeta | increased number, with Scer\GAL4^pnr-MD237

S6kII^GD1254

S6kII^D1

cone cell (with Df(1)R8A)

S6kII^D1

embryonic/larval neuromuscular junction

eye photoreceptor cell

S6kII^D1

eye photoreceptor cell, with Scer\GAL4^hs.2sev

S6kII^{K231R.UAS.Tag:MYC}

eye photoreceptor cell (with Df(1)R8A)

S6kII^D1

interommatidial bristle, with Scer\GAL4^GMR.PF

S6kII^UAS.Tag:MYC

mesothoracic tergum, with Scer\GAL4^pnr-MD237

S6kII^GD1254

S6kII^ign-Δ58-1

NMJ bouton | increased number

NMJ bouton | larval stage

S6kII^UAS.cRa

NMJ bouton | third instar larval stage

ommatidial precursor cluster

S6kII^D1

ommatidial precursor cluster (with Df(1)R8A)

S6kII^D1

ommatidium, with Scer\GAL4^GMR.PF

S6kII^D1

pigment cell (with Df(1)R8A)

S6kII^D1

presynaptic active zone

retina, with Scer\GAL4^GMR.PF

rhabdomere, with Scer\GAL4^GMR.PF

S6kII^UAS.Tag:MYC

wing vein, with Scer\GAL4^Bx-MS1096

S6kII^UAS.Tag:MYC

wing vein, with Scer\GAL4^en-e16E

wing vein | ectopic

S6kII^D1

wing vein | ectopic (with Df(1)R8A)

S6kII^D1

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

12 of 15

Yes

Yes

1

11 of 15

No

Yes

10 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2

3 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

5

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

11 of 15

No

Yes

10 of 15

No

Yes

10 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (11)

10 of 13

Yes

Yes

9 of 13

No

Yes

9 of 13

No

Yes

8 of 13

No

Yes

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (12)

7 of 12

Yes

Yes

6 of 12

No

Yes

6 of 12

No

Yes

6 of 12

No

Yes

2 of 12

No

No

2 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (13)

12 of 15

Yes

Yes

11 of 15

No

Yes

9 of 15

No

Yes

9 of 15

No

Yes

5 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (8)

13 of 15

Yes

Yes

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (5)

3 of 9

Yes

No

3 of 9

Yes

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

Saccharomyces cerevisiae (Brewer's yeast) (7)

4 of 15

Yes

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

Schizosaccharomyces pombe (Fission yeast) (4)

4 of 12

Yes

Yes

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

No

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902IG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00010478

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501TU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY007366

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00189

Mayetiola destructor

Hessian fly

Mdes\Mdes007991

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004474

Anopheles darlingi

American malaria mosquito

Adar\ADAC005504

Anopheles gambiae

Malaria mosquito

Agam\AGAP003040

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014359

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0217 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA011088

Bombyx mori

Silkmoth

Bmor\BGIBMGA000142

Danaus plexippus

Monarch butterfly

Dple\DPOGS203202-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS205511-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005786

Heliconius melpomene

Postman butterfly

Hmel\HMEL011296

Heliconius melpomene

Postman butterfly

Hmel\HMEL015753

Apis florea

Little honeybee

Aflo\2452734196

Apis florea

Little honeybee

Aflo\4102039604

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00270f

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002f1a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013142

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004335

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM508900

Pediculus humanus

Human body louse

Phum\PHUM599900

Rhodnius prolixus

Kissing bug

Rpro\RPRC003727

Rhodnius prolixus

Kissing bug

Rpro\RPRC000863

Cimex lectularius

Bed bug

Clec\CLEC007762

Cimex lectularius

Bed bug

Clec\CLEC007763

Cimex lectularius

Bed bug

Clec\CLEC006450

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI47192

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004772

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17521

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00262

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03WL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011282

Strigamia maritima

European centipede

Smar\SMAR015072

Strigamia maritima

European centipede

Smar\SMAR001186

Strigamia maritima

European centipede

Smar\SMAR015647

Ixodes scapularis

Black-legged tick

Isca\ISCW017390

Ixodes scapularis

Black-legged tick

Isca\ISCW012610

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82508.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68004.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65578.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM64654.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66159.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g08980

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g01350

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g14060

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_225339

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_23503

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_318992

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05Z7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\LOC100175855

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000022512

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

5 of 10

4 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

S6kII^ign-Δ58-1

model of Coffin-Lowry syndrome

CEA

(Beck et al., 2015)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

RPS6KA3; ribosomal protein S6 kinase A3

model of non-syndromic X-linked intellectual disability 19

IEA

(FlyBase, 2019-)

model of Coffin-Lowry syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPS6KA2; ribosomal protein S6 kinase A2

12 of 15

RPS6KA3; ribosomal protein S6 kinase A3

12 of 15

RPS6KA1; ribosomal protein S6 kinase A1

11 of 15

RPS6KA6; ribosomal protein S6 kinase A6

10 of 15

RPS6KA4; ribosomal protein S6 kinase A4

3 of 15

RPS6KA5; ribosomal protein S6 kinase A5

3 of 15

RPS6KB1; ribosomal protein S6 kinase B1

3 of 15

RPS6KB2; ribosomal protein S6 kinase B2

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

S6kII - 14-3-3ε

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot

(Vinayagam et al., 2013)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG10333

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG11417

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG11583

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG13096

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG13097

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG15019

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG15784

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG17593

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG30122

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG32409

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - CG42354

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Caf1-55

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot

(Akten et al., 2009)

S6kII - Claspin

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Hrb98DE

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Hsc70-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Kap-α3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Nipped-B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Nopp140

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - PH4αEFB

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Pp2B-14D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Rbcn-3A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - RhoGAP18B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - RpL10Ab

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - RpS15Aa

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - Ssb-c31a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - TfIIFα

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - TfIIFβ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - UQCR-C2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - l(2)09851

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - qkr58E-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, western blot

(Beck et al., 2018)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - α-Spec

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - βTub60D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6kII - βTub97EF

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Akten et al., 2009)

suppressible

(Akten et al., 2009)

enhanceable

(Kim et al., 2006)

suppressible

(Rintelen et al., 2001)

enhanceable

(Kim et al., 2006)

enhanceable

(Kim et al., 2006)

suppressible

(Fischer et al., 2009)

enhanceable

(Kim et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Kim et al., 2006)

suppressible

(Kim et al., 2006)

enhanceable

(Kim et al., 2006)

suppressible

(Kim et al., 2006)

suppressible

(Kim et al., 2006)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262866

MIST (genetic) - An integrated Molecular Interaction Database

S6kII

MIST (protein-protein) - An integrated Molecular Interaction Database

S6kII

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

mTOR signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-66

Cytogenetic map

Sequence location

X:22,529,964..22,536,371 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

20C1-20C1

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

20-20

(Wassarman, 1994.10.14)

20-20

(determined by in situ hybridisation)

(Wassarman et al., 1994)

Experimentally Determined Recombination Data

Location

1-66

(FlyBase, 2016)

1-66.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

81107

w¹¹¹⁸ S6kII^K347E/FM7a

81108

w¹¹¹⁸ TI{TI}S6kII^KO/FM7a

61202

y¹ v¹; P{TRiP.HMJ22923}attP40

8714

w¹¹¹⁸; P{UAS-S6kII.B}85/TM3, Sb¹

32601

w^* P{EP}S6kII^G1845 CG17600^G1845

27731

y¹ v¹; P{TRiP.JF02814}attP2/TM3, Sb¹

35583

y¹ sc^* v¹ sev²¹; P{TRiP.GL00207}attP2

76396

y¹ sc^* v¹ sev²¹; P{TKO.GS00565}attP40

78190

y¹ sc^* v¹ sev²¹; P{TOE.GS01363}attP40

v101451

P{KK109199}VIE-260B

v5702

w¹¹¹⁸; P{GD1254}v5702

v342041

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01424}attP40/CyO-GFP

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD05277

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262866

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33139

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Fischer et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: S6kII rsk2

(Restifo, 2011.1.20)

Additional comments

Other Comments

S6kII negatively regulates bouton number at the larval neuromuscular junction.

(Fischer et al., 2009)

Homologue of human RSK2 corresponding to Coffin-Lowry syndrome gene.

(Olson et al., 2007)

The rl-binding activity of S6kII, but not the phosphotransferase activity, is essential for the in vivo function of S6kII in eye and wing development. S6kII regulates rl activity by acting as a cytoplasmic anchor.

(Kim et al., 2006)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells is seen.

(Bettencourt-Dias et al., 2004)

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

A S6kII cDNA has been cloned and sequenced.

(Wassarman et al., 1994)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33139

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262866

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33139/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262866

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

S6kII_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011285

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262866

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17596

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33139

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG17596

MARRVEL_MODEL - MARRVEL (model organism gene)

33139

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24496

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262866

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

mTOR signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

S6kII

MIST (protein-protein) - An integrated Molecular Interaction Database

S6kII

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG17596

(Lee et al., 2021, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Sun et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Putz et al., 2004, Morrison et al., 2000)

D-RSK

(Fischer and Raabe, 2018)

RSK

(Mariano et al., 2020, Beck et al., 2018, Beck et al., 2015, Akten et al., 2009, Bjorklund et al., 2006, Kim et al., 2006, Brembs, 2003, Morrison et al., 2000, Johansen et al., 1999, Wassarman, 1994.10.14)

Rsk

S6KII

(Zhu, 2013, Tangredi et al., 2012, Slack et al., 2010, Akten et al., 2009, Neuser et al., 2008, Putz et al., 2004, Wassarman et al., 1994)

S6kII

(Lee et al., 2021, Wang et al., 2020, Hegazi et al., 2019, Mast and DiPrimio, 2019.3.12, Transgenic RNAi Project members, 2017-, Yang and Veraksa, 2017, Dobson et al., 2016, Schwartz et al., 2016, Vinayagam et al., 2016, Cugusi et al., 2015, Sopko et al., 2014, Vinayagam et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Korcsmáros et al., 2011, Restifo, 2011.1.20, Sun et al., 2010, Akten et al., 2009)

dRSK

(Pospisilik et al., 2010, Rintelen et al., 2001)

dRsk

(Okray and Hassan, 2013)

ign

(Kuntz et al., 2017, Neuser et al., 2008, Putz et al., 2004, Brembs, 2003)

rsk

(Scholz et al., 2019, Beck et al., 2018, Fischer et al., 2009)

rsk2

(Restifo, 2011.1.20, Olson et al., 2007)

Name Synonyms

RPS6-protein kinase-II

Ribosomal protein S6 kinase II

Ribosomal-S6-kinase

S6 kinase II

(Neuser et al., 2008)

ignorant

(Neuser et al., 2008, Putz et al., 2004, Brembs, 2003)

p90 ribosomal S6 kinase

(Akten et al., 2009, Kim et al., 2006, Brembs, 2003)

ribosomal-S6-kinase

(Pospisilik et al., 2010)

Secondary FlyBase IDs

FBgn0011285
FBgn0086241

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (84)

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