RSK, ign, p90 ribosomal S6 kinase, ignorant, rsk2
negatively regulates ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK - functions as a downstream effector and regulator of the MAP kinase pathway - involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.
Please see the JBrowse view of Dmel\S6kII for information on other features
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Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
3.137 (longest cDNA)
910 (aa); 100 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6kII using the Feature Mapper tool.
Comment: displays circadian cycling
S6kII protein levels were measured at six time points across the diurnal cycle and were found to be relatively constant across the cycle in adult head extracts.
GBrowse - Visual display of RNA-Seq signals
View Dmel\S6kII in GBrowse 21-66
1-66
1-66.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: S6kII rsk2
S6kII negatively regulates bouton number at the larval neuromuscular junction.
Homologue of human RSK2 corresponding to Coffin-Lowry syndrome gene.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells is seen.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
A S6kII cDNA has been cloned and sequenced.