RSK, ign, rsk2, ignorant, p90 ribosomal S6 kinase
negatively regulates ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK - functions as a downstream effector and regulator of the MAP kinase pathway - involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.
910 (aa); 100 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6kII using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\S6kII in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: S6kII rsk2
S6kII negatively regulates bouton number at the larval neuromuscular junction.
Homologue of human RSK2 corresponding to Coffin-Lowry syndrome gene.
The rl-binding activity of S6kII, but not the phosphotransferase activity, is essential for the in vivo function of S6kII in eye and wing development. S6kII regulates rl activity by acting as a cytoplasmic anchor.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells is seen.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.