FlyBase Gene Report: Dmel\axo

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\axo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

axo_1
axo_2

Linkouts

Gene Ontology (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

serine-type endopeptidase inhibitor activity

inferred from electronic annotation with InterPro:IPR002223

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

transmission of nerve impulse

inferred from mutant phenotype

(Yuan and Ganetzky, 1999)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

extracellular region

inferred from sequence or structural similarity

(Yuan and Ganetzky, 1999)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 17

interface glial cell

(Yuan and Ganetzky, 1999)

presumptive embryonic/larval central nervous system | segmentally repeated

(Yuan and Ganetzky, 1999)

medial intersegmental nerve root glial cell

(Yuan and Ganetzky, 1999)

glial cell | subset

(Yuan and Ganetzky, 1999)

larval stage

embryonic/larval central nervous system | segmentally repeated

(Yuan and Ganetzky, 1999)

medial intersegmental nerve root glial cell

(Yuan and Ganetzky, 1999)

interface glial cell

(Yuan and Ganetzky, 1999)

glial cell | subset

(Yuan and Ganetzky, 1999)

Additional Descriptive Data

axo transcript is detected starting at embryonic stage 13 in the developing nervous system in a segmentally repeated pattern corresponding to a subset of glial cells, including the longitudinal glia and segmental boundary cells. This pattern is retained through third larval instar.

(Yuan and Ganetzky, 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic brain

(Yuan and Ganetzky, 1999)

neuron

• axon

(Yuan and Ganetzky, 1999)

presumptive embryonic/larval peripheral nervous system | restricted

(Yuan and Ganetzky, 1999)

ventral nerve cord

(Yuan and Ganetzky, 1999)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

axo protein is expressed in axonal tracts of the ventral nerve cord, brain, and parts of the PNS. Comparison to axo transcript expression suggests that axo protein is secreted from glia and subsequently localized to axonal tracts.

(Yuan and Ganetzky, 1999)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\axo in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\axo

View exonic expression by tissue for Dmel\axo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of axo

Transgenic constructs containing regulatory region of axo

Deletions and Duplications ( 1 )

Disrupted in

Df(3L)Exel7208

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

axo^EY10301

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

axo^EY10301

Other Phenotypes

Allele

neurophysiology defective | recessive | heat sensitive

axo^P12

paralytic | recessive | heat sensitive

axo^P12

visible, with Scer\GAL4^pnr-MD237

axo^GD15215

Phenotype manifest in

Allele

axon | heat sensitive

axo^P12

trichogen cell, with Scer\GAL4^pnr-MD237

axo^GD15215

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (27)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CNTNAP2

5 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (27)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cntnap2

5 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Wfdc13

1 of 15

Rattus norvegicus (Norway rat) (28)

Rnor\Cntnap4

4 of 13

Yes

Rnor\Cntnap5b

4 of 13

Yes

Rnor\Cntnap5c

4 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\LOC108348121

2 of 13

Yes

Rnor\LOC108348159

2 of 13

Yes

Rnor\Ambp

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (16)

Xtro\cntnap1

4 of 12

Yes

Xtro\cntnap4

4 of 12

Yes

Xtro\cntnap2

2 of 12

Xtro\cntnap5

2 of 12

Yes

Xtro\ambp

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\spint2

1 of 12

Xtro\tfpi2

1 of 12

Danio rerio (Zebrafish) (24)

Drer\cntnap1

4 of 15

Yes

Drer\cntnap2a

4 of 15

Yes

Drer\cntnap2b

4 of 15

Yes

Drer\cntnap3

4 of 15

Yes

Drer\cntnap5a

4 of 15

Yes

Drer\cntnap5b

4 of 15

Yes

Drer\cntnap5l

4 of 15

Yes

Drer\ambp

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\hhip

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\spint2

1 of 15

Yes

Drer\tfpi2

1 of 15

Drer\tfpia

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (41)

Cele\itx-1

9 of 15

Yes

Cele\nlr-1

4 of 15

Cele\apl-1

1 of 15

Cele\B0222.5

1 of 15

Yes

Cele\bli-5

1 of 15

Yes

Cele\C02F12.5

1 of 15

Yes

Cele\C06B8.11

1 of 15

Yes

Cele\C10G8.2

1 of 15

Yes

Cele\C10G8.3

1 of 15

Yes

Cele\C34F6.1

1 of 15

Cele\C54D10.10

1 of 15

Cele\E01G6.1

1 of 15

Yes

Cele\F22E12.1

1 of 15

Cele\F30H5.3

1 of 15

Yes

Cele\K01C8.2

1 of 15

Yes

Cele\K10D3.4

1 of 15

Cele\K11D12.6

1 of 15

Yes

Cele\K11D12.7

1 of 15

Yes

Cele\K11D12.11

1 of 15

Yes

Cele\K11D12.13

1 of 15

Yes

Cele\K12G11.6

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T22F7.3

1 of 15

Cele\T22F7.5

1 of 15

Yes

Cele\tag-290

1 of 15

Cele\W05B2.2

1 of 15

Yes

Cele\Y43F8B.3

1 of 15

Cele\Y49G5A.1

1 of 15

Cele\Y55F3BR.2

1 of 15

Yes

Cele\Y55F3BR.11

1 of 15

Yes

Cele\Y57A10A.24

1 of 15

Yes

Cele\ZC84.1

1 of 15

Yes

Cele\ZC84.6

1 of 15

Yes

Cele\ZC504.1

1 of 15

Yes

Cele\ZK287.4

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919006V )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14879

Drosophila persimilis

Dper\GL17936

Drosophila willistoni

Dwil\GK17598

Drosophila virilis

Dvir\GJ15482

Drosophila mojavensis

Dmoj\GI14154

Drosophila mojavensis

Dmoj\GI12577

Drosophila grimshawi

Dgri\GH15794

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501N6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17005496

Musca domestica

House fly

Mdoa\17005495

Glossina morsitans

Tsetse fly

Gmor\GMOY003987

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03545

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04813

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004587

Anopheles darlingi

American malaria mosquito

Adar\ADAC006901

Anopheles gambiae

Malaria mosquito

Agam\AGAP006513

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006837

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019169

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006838

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019170

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01FI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012092

Danaus plexippus

Monarch butterfly

Dple\DPOGS207309-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007112

Heliconius melpomene

Postman butterfly

Hmel\HMEL006288

Apis florea

Little honeybee

Aflo\2164631908

Apis mellifera

Western honey bee

Amel\GB54538

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11040

Bombus terrestris

Buff-tailed bumblebee

Bter\15203066

Linepithema humile

Argentine ant

Lhum\LH18341

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000d69

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG017828

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12721

Tribolium castaneum

Red flour beetle

Tcas\TC011508

Pediculus humanus

Human body louse

Phum\PHUM158570

Cimex lectularius

Bed bug

Clec\CLEC004514

Cimex lectularius

Bed bug

Clec\CLEC004516

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007428

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03793

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01DN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR015550

Strigamia maritima

European centipede

Smar\SMAR013513

Ixodes scapularis

Black-legged tick

Isca\ISCW017726

Ixodes scapularis

Black-legged tick

Isca\ISCW018801

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69827.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69828.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur19g02370

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_330735

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G024U )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-LamG/Egff2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (19)

Gene Symbol

Score

Source

Alignment

5 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

kon

1 of 10

Nrx-1

1 of 10

Ppn

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CNTNAP2; contactin associated protein 2

model of cortical dysplasia-focal epilepsy syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CNTNAP2; contactin associated protein 2

5 of 15

604569

cortical dysplasia-focal epilepsy syndrome

CNTNAP1; contactin associated protein 1

4 of 15

602346

CNTNAP3B; contactin associated protein family member 3B

4 of 15

CNTNAP3; contactin associated protein family member 3

4 of 15

610517

CNTNAP4; contactin associated protein family member 4

4 of 15

610518

CNTNAP5; contactin associated protein family member 5

4 of 15

610519

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262870

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-12

Cytogenetic map

64B12-64B13

Sequence location

3L:4,629,604..4,687,317 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64B12-64B13

Limits computationally determined from genome sequence between P{PZ}l(3)rG166^rG166 and P{PZ}sinu⁰⁶⁵²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

64C-64C

(Yuan, 1999.2.18)

64C1-64C3

(determined by in situ hybridisation)

(Yuan and Ganetzky, 1999)

Experimentally Determined Recombination Data

Location

3-12

(FlyBase, 2016)

3-10.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Bloomington

24012

w¹¹¹⁸; Mi{ET1}axo^MB02106

44889

y¹ w^*; Mi{MIC}axo^MI07858

50487

y¹ w^*; Mi{MIC}axo^MI08801

17660

y¹ w^67c23; P{EPgy2}axo^EY10301

65911

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06175}attP40

32826

y¹ w^*; Mi{MIC}MI02093a Mi{MIC}MI02093b axo^MI02093

v106338

v106616

v107491

v16809

w¹¹¹⁸; P{GD2309}v16809

v18866

w¹¹¹⁸; P{GD6017}v18866

v18867

w¹¹¹⁸; P{GD6017}v18867

More stocks available...

Genomic Clones (38)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

RH69543

Other clones

IP05277

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262870

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

AT01280

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43923

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Yuan and Ganetzky, 1999)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: axo CG18296

(Misra, 2000.4.6)

Source for merge of: CG13715 CG32234 axo

(FlyBase Genome Annotators, 2010)

Source for merge of: axo CG13717

(FlyBase Genome Annotators, 2011)

Additional comments

Annotations CG42664 and CG13717 merged as CG43225 in release 5.34 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Annotations CG13715, CG18296 and CG32234 merged as CG42664 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Other Comments

New annotation (CG32234) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

axo appears to be a component of a glial-neuronal signaling mechanism that helps to determine the membrane electrical properties of target axons.

(Yuan and Ganetzky, 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43923

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262870

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

axo_1
axo_2

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43923

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011508

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43225

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262870

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG13715

(Kong et al., 2010)

CG13717

(Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5)

CG18296

(Neuert et al., 2017, Christis and Munro, 2012, Keleman et al., 2009.8.5)

CG32234

(Çiçek et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5)

CG42664

(FlyBase Genome Annotators, 2010)

CG43225

(Hosono et al., 2015, FlyBase Genome Annotators, 2011, Perkins et al., 2009)

CT1277

(Hynes and Zhao, 2000)

axo

(Croset et al., 2018, Franz et al., 2017, Neuert et al., 2017, Ashwal-Fluss et al., 2014, Westholm et al., 2014, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wasbrough et al., 2010)

Name Synonyms

Axotactin

(Kwong et al., 2015)

axotactin

(Matsuno et al., 2019, Yuasa and Hiromi, 2007)

Secondary FlyBase IDs

FBgn0261546
FBgn0026729
FBgn0035564
FBgn0052234
FBgn0035566
FBgn0035562

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (52)

Report Sections

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