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Gene Dmel\axo

General Information
Symbol	Dmel\axo	Species	D. melanogaster
Name	axotactin	Annotation symbol	CG43225
Feature type	protein_coding_gene	FlyBase ID	FBgn0262870
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	CG32234, CG13717
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64B12-64B13	Sequence location	3L:4,629,604..4,687,317 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene axotactin is referred to in FlyBase by the symbol Dmel\axo (CG43225, FBgn0262870). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: transmission of nerve impulse. 17 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Concanavalin A-like lectin/glucanase, subgroup; Concanavalin A-like lectin/glucanases superfamily; EGF-like, conserved site; Epidermal growth factor-like domain; Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain; Laminin G domain; Proteinase inhibitor I2, Kunitz metazoa. Gene sequence location is 3L:4629604..4687317.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64B12-64B13   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64C-64C     (Yuan, 1999.2.18) 64C1-64C3   (determined by in situ hybridisation)   (Yuan and Ganetzky, 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\axo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Gene merge based on RNAseq data. Gene merge based on EST/cDNA and RNAseq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) axo-RB FBtr0302646  NM_001259701   7556   2148 axo-RC FBtr0306206  NM_001259702   7036   2179 axo-RD FBtr0306207  NM_001259703   6867   2070 axo-RF FBtr0333591  NM_001274493   7662   2147 axo-RG FBtr0333592  NM_001274494   7145   2179 axo-RH FBtr0333593  NM_001274495   6976   2070 axo-RI FBtr0333594  NM_079917   7256   2047
Additional Transcript Data & Comments
Reported size (kB)	7.5 (northern blot) (Yuan and Ganetzky, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein axo-PB   FBpp0291786   237.3   2148   5.84     NP_001246630   AFH04301 axo-PC   FBpp0297315   241.6   2179   5.72     NP_001246631   AFH04302 axo-PD   FBpp0297316   229.1   2070   5.45     NP_001246632   AFH04303 axo-PF   FBpp0305768   237.2   2147   5.84     NP_001261422   AGB94117 axo-PG   FBpp0305769   241.6   2179   5.72     NP_001261423   AGB94118 axo-PH   FBpp0305770   229.1   2070   5.45     NP_001261424   AGB94119 axo-PI   FBpp0305771   226.8   2047   5.45     NP_524656   AAF47929
Additional Polypeptide Data & Comments
Reported size (kDa)	1685 (aa) (Yuan and Ganetzky, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EGF-like, conserved site (IPR013032) Epidermal growth factor-like domain (IPR000742) Concanavalin A-like lectin/glucanase, subgroup (IPR013320) Laminin G domain (IPR001791) Proteinase inhibitor I2, Kunitz metazoa (IPR002223) Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain (IPR002181) Concanavalin A-like lectin/glucanases superfamily (IPR008985)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47929   AF129420 AAD29408   AE014296 AFH04301   AE014296 AFH04302   AE014296 AFH04303   AE014296 AGB94117   AE014296 AGB94118   AE014296 AGB94119   AI062961   BE975462   BF492923   BT015185   BT029922   CL526207   CO270266   CO330988   EC070879   EC239528   EL871679   EL871932   EL875471   EL875472   EL875580   FF579049   GO271090   GO271166
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZ96 Q9VZA0 Q9XYX0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 17   interface glial cell   (Yuan and Ganetzky, 1999) presumptive embryonic/larval central nervous system | segmentally repeated   (Yuan and Ganetzky, 1999) medial intersegmental nerve root glial cell   (Yuan and Ganetzky, 1999) glial cell | subset   (Yuan and Ganetzky, 1999) larval stage   embryonic/larval central nervous system | segmentally repeated   (Yuan and Ganetzky, 1999) medial intersegmental nerve root glial cell   (Yuan and Ganetzky, 1999) interface glial cell   (Yuan and Ganetzky, 1999) glial cell | subset   (Yuan and Ganetzky, 1999)
Additional Descriptive Data
	axo transcript is detected starting at embryonic stage 13 in the developing nervous system in a segmentally repeated pattern corresponding to a subset of glial cells, including the longitudinal glia and segmental boundary cells. This pattern is retained through third larval instar. (Yuan and Ganetzky, 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic brain   (Yuan and Ganetzky, 1999) neuron   • axon (Yuan and Ganetzky, 1999) presumptive embryonic/larval peripheral nervous system | restricted   (Yuan and Ganetzky, 1999) ventral nerve cord   (Yuan and Ganetzky, 1999) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	axo protein is expressed in axonal tracts of the ventral nerve cord, brain, and parts of the PNS. Comparison to axo transcript expression suggests that axo protein is secreted from glia and subsequently localized to axonal tracts. (Yuan and Ganetzky, 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    11 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    11 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    18 adult male 01day    11 adult male 05day    11 adult male 30day    9 adult female 01day    8 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    4 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    5 embryonic S3    1 leg disc CME L1    4 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable axoEY10301 viable, with Scer\GAL4pnr-MD237 axoGD2309 axoGD6017 axoGD15215 Sterility Allele fertile axoEY10301 Other Phenotypes Allele neurophysiology defective | recessive | heat sensitive axoP12 paralytic | recessive | heat sensitive axoP12 visible, with Scer\GAL4pnr-MD237 axoGD15215 Phenotype manifest in Allele axon | heat sensitive axoP12 trichogen cell, with Scer\GAL4pnr-MD237 axoGD15215
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of axo Class Mutagen Stocks Known lesion axoEY10301 P-element activity 1 -- axoMB02106 1 -- axoMI02093 1 -- axoMI04170 1 -- axo28 0 Yes axoP12-R1 0 -- axoP12-R2 0 -- axoP12 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of axo Class Mutagen Stocks Known lesion axoGD15215 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes axoGD6017 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes axoGD2309 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes axoKK106532 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes axoKK109522 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes axoKK111197 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes axoNIG.13717R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes axoNIG.18296R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes axoNIG.32234R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel7208 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6017} NA P{KK106532} NA P{NIG.13717R} NA P{NIG.18296R} NA P{NIG.32234R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}axoEY10301 NA miscellaneous insertions Mi{MIC}axoMI02093a NA Mi{MIC}axoMI02093b NA Mi{MIC}axoMI04170 NA P{}axoP12 NA insertion of enhancer trap binary system Mi{ET1}axoMB02106 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
transmission of nerve impulse inferred from mutant phenotype (Yuan and Ganetzky, 1999)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase inhibitor activity inferred from electronic annotation with InterPro:IPR002223 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
neuron recognition inferred from sequence or structural similarity with UniProtKB:Q9UHC6 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity (Yuan and Ganetzky, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions axo allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262870
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PZJRW Dipteran inclusive ortholog search EOG67D9Q1 Insect inclusive ortholog search EOG64XHBK Arthropod inclusive ortholog search EOG6Z34VG Metazoa inclusive ortholog search EOG6GN6PN
Orthologs in Drosophila Species (EOG6PZJRW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\axo     Drosophila simulans   Dsim\GD13240 Y   Drosophila sechellia   Dsec\GM13958 Y   Drosophila erecta   Dere\GG14167 Y   Drosophila yakuba   Dyak\GE20595 Y   Drosophila ananassae   Dana\GF24721 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14879 Y   Drosophila persimilis   Dper\GL17936 Y   Drosophila willistoni   Dwil\GK17598 Y   Drosophila virilis   Dvir\GJ15482 Y   Drosophila mojavensis   Dmoj\GI14154     Drosophila mojavensis   Dmoj\GI12577 Y   Drosophila grimshawi   Dgri\GH15794 Y
Orthologs in non-Drosophila Dipterans (EOG67D9Q1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004587   Anopheles gambiae Malaria mosquito  Agam\AGAP006513   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006837   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019170
Orthologs in non-Dipteran Insects (EOG64XHBK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54538   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017828   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18754   Atta cephalotes Leafcutter ant  Acep\ACEP13336   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22869   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17480   Linepithema humile Argentine ant  Lhum\LH18341   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13545   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15390   Solenopsis invicta Red fire ant  Sinv\SINV24351   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007428   Bombyx mori Silkmoth  Bmor\BGIBMGA012092   Pediculus humanus Human body louse  Phum\PHUM158570   Tribolium castaneum Red flour beetle  Tcas\TC011508
Orthologs in non-Insect Arthropods (EOG6Z34VG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_330735   Ixodes scapularis Deer tick  Isca\ISCW017726
Orthologs in non-Arthropod Metazoa (EOG6GN6PN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\itx-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012138gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015404gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (40) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13240 Drosophila simulans Dsim\GD13242 Drosophila simulans Dsim\GD13244 Drosophila sechellia Dsec\GM13958 Drosophila sechellia Dsec\GM13959 Drosophila sechellia Dsec\GM13960 Drosophila sechellia Dsec\GM13962 Drosophila erecta Dere\GG14167 Drosophila erecta Dere\GG14168 Drosophila erecta Dere\GG14169 Drosophila erecta Dere\GG14171 Drosophila yakuba Dyak\GE20595 Drosophila yakuba Dyak\GE20596 Drosophila yakuba Dyak\GE20597 Drosophila yakuba Dyak\GE20599 Drosophila ananassae Dana\GF20089 Drosophila ananassae Dana\GF20090 Drosophila ananassae Dana\GF24721 Drosophila ananassae Dana\GF24723 Drosophila pseudoobscura pseudoobscura Dpse\GA14879 Drosophila pseudoobscura pseudoobscura Dpse\GA28335 Drosophila pseudoobscura pseudoobscura Dpse\GA28336 Drosophila persimilis Dper\GL17936 Drosophila persimilis Dper\GL17937 Drosophila persimilis Dper\GL17939 Drosophila willistoni Dwil\GK17598 Drosophila willistoni Dwil\GK17600 Drosophila willistoni Dwil\GK17601 Drosophila willistoni Dwil\GK17603 Drosophila virilis Dvir\GJ15482 Drosophila virilis Dvir\GJ15483 Drosophila virilis Dvir\GJ15485 Drosophila mojavensis Dmoj\GI12577 Drosophila mojavensis Dmoj\GI12578 Drosophila mojavensis Dmoj\GI12579 Drosophila mojavensis Dmoj\GI12581 Drosophila grimshawi Dgri\GH15794 Drosophila grimshawi Dgri\GH15795 Drosophila grimshawi Dgri\GH15797 Drosophila grimshawi Dgri\GH15799
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	24012 w1118; Mi{ET1}axoMB02106 17660 y1 w67c23; P{EPgy2}axoEY10301 41476 y1 w*; Mi{MIC}axoMI04170/TM3, Sb1 Ser1 32826 y1 w*; Mi{MIC}axoMI02093a Mi{MIC}axoMI02093b, axoMI02093
VDRC	v106338 P{KK109522}VIE-260B v106616 P{KK106532}VIE-260B v107491 P{KK111197}VIE-260B v16809 w1118; P{GD2309}v16809 v18866 w1118; P{GD6017}v18866 v18867 w1118; P{GD6017}v18867 v42374 w1118; P{GD15215}v42374 v42375 w1118; P{GD15215}v42375
Genomic Clones ( 1 )
	BACR23H09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH69543
Other clones	IP05277
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01280 GH02352
Other clones	193836 Arica_10_B05 bs43d06 CK01.108D.F7 EK098124 EK297057 FB59-CG18296-RA IP03746 IP03946 IP05477 IP05577
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43923
Antibody Information
	polyclonal (Yuan and Ganetzky, 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: axo CG13717 (FlyBase Genome Annotators, 2011) Source for merge of: axo CG18296 (Misra, 2000.4.6) Source for merge of: CG13715 CG32234 axo (FlyBase Genome Annotators, 2010)
Additional comments	Annotations CG42664 and CG13717 merged as CG43225 in release 5.34 of the genome annotation. (FlyBase Genome Annotators, 2011) Annotations CG13715, CG18296 and CG32234 merged as CG42664 in release 5.25 of the genome annotation. (FlyBase Genome Annotators, 2010)
Other Comments
	New annotation (CG32234) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) axo appears to be a component of a glial-neuronal signaling mechanism that helps to determine the membrane electrical properties of target axons. (Yuan and Ganetzky, 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079917 NM_001259701 NM_001259702 NM_001259703 NM_001274493 NM_001274494 NM_001274495 RefSeq (Proteins) • NP_524656 NP_001246630 NP_001246631 NP_001246632 NP_001261422 NP_001261423 NP_001261424 DDBJ / EMBL / GenBank • AAD29408 AAF47925 AAF47929 AF129420 AFH04301 AFH04302 AFH04303 AGB94117 AGB94118 AGB94119 CL526207 Entrez Gene - A searchable database of RefSeq genes. • 38566 38568 43923 317932 UniProtKB/TrEMBL • Q9VZ96 Q9VZA0 Q9XYX0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EGF-like, conserved site (IPR013032) Epidermal growth factor-like domain (IPR000742) Concanavalin A-like lectin/glucanase, subgroup (IPR013320) Laminin G domain (IPR001791) Proteinase inhibitor I2, Kunitz metazoa (IPR002223) Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain (IPR002181) Concanavalin A-like lectin/glucanases superfamily (IPR008985)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262870 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43923
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	axo (Hazelett et al., 2012, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) CG13715   CG13717 (Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) CG18296 (Keleman et al., 2009.8.5) CG32234 (Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) CG42664 (FlyBase Genome Annotators, 2010) CG43225 (FlyBase Genome Annotators, 2011) CT1277 (Hynes and Zhao, 2000)
Name Synonym	axotactin (Yuasa and Hiromi, 2007)
Secondary FlyBase IDs
	FBgn0026729 FBgn0035562 FBgn0035564 FBgn0035566 FBgn0052234 FBgn0261546
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 3 )
	Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...