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Gene Dmel\rdx

General Information
Symbol	Dmel\rdx	Species	D. melanogaster
Name	roadkill	Annotation symbol	CG12537
Feature type	protein_coding_gene	FlyBase ID	FBgn0262907
Gene Model Status	Current	Stock availability	48 publicly available
Also Known As	CG9924, hib, l(3)88Aa
Genomic Location
Chromosome (arm)	3R	Recombination map	3-50.3
Cytogenetic map	88A3-88A5	Sequence location	3R:9,793,674..9,857,777 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene roadkill is referred to in FlyBase by the symbol Dmel\rdx (CG12537, FBgn0262907). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: lateral inhibition; eye morphogenesis; establishment of ommatidial planar polarity; regulation of proteolysis; negative regulation of smoothened signaling pathway; positive regulation of JNK cascade; cellularization; positive regulation of apoptosis; negative regulation of protein import into nucleus; protein ubiquitination. 80 alleles are reported. The phenotypes of these alleles are annotated with: eye; trichogen cell; retina; interommatidial bristle; cell cycle; mesothoracic tergum; tormogen cell; wing; imaginal disc; ommatidial precursor cluster. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; MATH; TRAF-like; TRAF-type. Gene sequence location is 3R:9793674..9857777.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(3)88Aa Homozygous larvae die in third instar; discs reported as missing, probably rudimentary (see Szabad and Bryant, l982, Dev. Biol. 93: 240-56). Mitotic chromosomes fuzzy and swollen; 27% of cells polyploid; chromosome breaks observed (Gatti and Baker, 1989, Genes Dev. 3: 438-53).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Grad et al., 2004, Bioinformatics 20(16): 2738--2750 Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226
FB2012_01	Sequence features HFA14526 BKN31898 HFA16580 BKN27670 Controlled Vocabulary Terms ectoderm embryonic stage 11 lateral inhibition segmentally repeated Unknown in situ
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88A3-88A5   Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347; Left limit from inclusion within Df(3R)red-P52 (FBrf0056267) Right limit from in situ hybridisation (FBrf0067338)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88A-88B   (determined by in situ hybridisation)   (Lukacsovich et al., 2001) 88A4-88A5   (determined by in situ hybridisation)   (Spradling et al., 1999) 88A-88A     (Sekelsky et al., 1999) 66B10-66B11   82A3--5   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-50.3 (Gatti and Baker, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rdx for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 25aa in length.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rdx-RA FBtr0301632  NM_169565   2963   406 rdx-RB FBtr0301633  NM_169566   2982   374 rdx-RC FBtr0301634  NM_142068   2802   403 rdx-RD FBtr0100852  NM_169564   2795   403 rdx-RE FBtr0100361  NM_142069   4160   829
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rdx-PA   FBpp0290846   45.8   406   5.93     NP_731876   AAF55007 rdx-PB   FBpp0290847   42.3   374   5.97     NP_731877   AAN14348 rdx-PC   FBpp0290848   45.3   403   6.32     NP_650325   AAN14346 rdx-PD   FBpp0100174   45.3   403   6.32     NP_731875   AAN14347 rdx-PE   FBpp0099767   89.7   829   7.66     NP_650326   AAF55008
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) BTB/POZ (IPR013069) TRAF-like (IPR008974) MATH (IPR002083) BTB/POZ-like (IPR000210) TRAF-type (IPR013322)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA203005   AA246832   AA264697   AA567477   AA696584   AA949217   AE014297 AAF55007   AE014297 AAF55008   AE014297 AAN14346   AE014297 AAN14347   AE014297 AAN14348   AC007441   AQ034055   AW941299   AX094079   AX094453   AY121682 AAM52009   BF487043   BG638514   BG639587   BG639593   BI164054   BI170893   BI172499   BI213189   BI214467   BI228106   BI238120   BI356634   BI358186   BI365576   BI368242   BI371014   BI373288   BI483175   BI483881   BI563517   BI565420   BI579638   BI580404   BI582636   BI585783   BI586507   BI613124   BI617811   BI634403   BP541605   BP557549   BP557550   BQ103212   BQ103586   BT012443   BT021321 AAX33469   BT099706   CA805761   CA806346   CL844472   CO155858   CO177287   CO189178   CO190366   CO190749   CO262055   CO262056   CO263921   CO267217   CO268929   CO272164   CO273608   CO273892   CO277986   CO281027   CO283248   CO283340   CO284160   CO284310   CO284319   CO284921   CO290680   CO292301   CO292348   CO293551   CO299123   CO301264   CO301723   CO301749   CO303551   CO307907   CO311278   CO316604   CO317074   CO323639   CO330996   CO331131   CO339134   CO341450   CZ467841   CZ469664   CZ470910   CZ472156   CZ472900   CZ474519   CZ475441   CZ475900   CZ476240   CZ476424   CZ476608   CZ476609   CZ487246   CZ487247   DQ507278 ABG24573   EC062593   EC063616   EC064094   EC066590   EC068449   EC071804   EC072005   EC072532   EC073643   EC083745   EC087210   EC087644   EC194510   EC199686   EC204026   EC207140   EC208578   EC217748   EC218472   EC222030   EC223181   EC223205   EC224276   EC225025   EC225755   EC226519   EC227468   EC227972   EC230105   EC233073   EC241360   EC243109   EC243906   EC244789   EC249017   EC255482   EC260426   EC261151   EV576719   EV578264   EV584094   EV594392   EV598612   GH738892   GH738897   GH743094   GH758615   GH764716   GH779405   GH779579   GH779610   GH779772   GH787961   GH835042   GH853812   GH856556   GH860819   GH869017   GH893291   GH906664   GH909560   GH911155   GH920407   GH931878   GH940728   GO254446   GO254555
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFP2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   ectoderm | segmentally repeated & striped   (Von Ohlen and Hooper, 1999) Comment:two stripes per segment
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal rdx2 rdx3 lethal (with Df(3R)293γ7) rdx11 lethal (with rdx1) rdx2 rdx3 rdx4 rdx5 rdx6 lethal (with rdx2) rdx1 rdx3 rdx4 rdx5 rdx6 lethal (with rdx3) rdx1 rdx2 rdx4 rdx5 rdx6 lethal (with rdx4) rdx1 rdx2 rdx3 rdx5 rdx6 lethal (with rdx5) rdx1 rdx2 rdx3 rdx4 rdx6 lethal (with rdx6) rdx1 rdx2 rdx3 rdx4 rdx5 lethal | embryonic stage rdx6 lethal | first instar larval stage rdx1 rdx4 rdx5 lethal | larval stage | recessive rdx88Aa-1 lethal | pupal stage, with Scer\GAL4pnr-MD237 rdxGD7750 lethal | recessive rdx11 rdx02731 rdx03477 rdx03479 rdx07560 rdxGTD74-94.1 rdxj1D1 rdxj1E11 rdxj4C7 rdxM2 rdxM19 rdxM23 rdxM30 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 rdxGD7750 rdxGD13540 viable rdxCB03517 rdxEY11582 rdxEY15242 rdxEY16412 viable | germline clone rdx1 rdx4 Sterility Allele fertile rdxEY11582 rdxEY15242 rdxEY16412 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 rdxGD13540 meiotic cell cycle defective rdxP19 mitotic cell cycle defective rdx88Aa-1 mitotic cell cycle defective | germline clone rdx6 visible, with Scer\GAL4pnr-MD237 rdxGD7750 rdxGD13540 visible | somatic clone rdxΔ6 Phenotype manifest in Allele cell cycle rdx88Aa-1 chaeta | supernumerary, with Scer\GAL4pnr-MD237 rdxGD7750 rdxGD13540 embryo | germline clone rdx6 eye rdxΔ6 imaginal disc rdx88Aa-1 interommatidial bristle rdxunspecified rdx5 mesothoracic tergum, with Scer\GAL4pnr-MD237 rdxGD7750 rdxGD13540 ommatidial precursor cluster rdxunspecified rdx5 retina rdx5 tormogen cell, with Scer\GAL4pnr-MD237 rdxGD7750 trichogen cell, with Scer\GAL4pnr-MD237 rdxGD13540 wing, with Scer\GAL4Bx-MS1096 rdxA.Scer\UAS:T:Myc wing | somatic clone rdx5 wing vein | ectopic, with Scer\GAL4Bx-MS1096 rdxA.Scer\UAS:T:Myc
Classical Alleles ( 70 )
For All Classical Alleles Show
Allele of rdx Class Mutagen Stocks Known lesion rdx03477 hypomorphic allele - molecular evidence P-element activity 2 Yes rdx1 P-element activity 1 Yes rdx5-SZ-3461 1 -- rdx88Aa-1 N-methyl-N'-nitro-N-nitrosoguanidine 1 -- rdxBG00563 P-element activity 1 -- rdxc00609 1 -- rdxc02298 piggyBac transposase 1 -- rdxc04993 piggyBac transposase 1 -- rdxCB-0018-3 1 -- rdxd00814 1 -- rdxd01317 P-element activity 1 -- rdxd02587 P-element activity 1 -- rdxd05421 P-element activity 1 -- rdxd07737 P-element activity 1 -- rdxd08353 1 -- rdxd08815 P-element activity 1 -- rdxd09180 P-element activity 1 -- rdxe02813 1 -- rdxEY02061b 1 -- rdxEY06724 P-element activity 1 -- rdxEY11582 P-element activity 1 -- rdxEY15242 P-element activity 1 -- rdxEY16412 P-element activity 1 -- rdxEY19897 P-element activity 1 -- rdxf04694 piggyBac transposase 1 -- rdxKG07915 1 -- rdxM2 ethyl methanesulfonate 1 -- rdxMB09381 1 -- rdxMI02928 1 -- rdxNP0440 1 -- rdxNP0994 1 -- rdxNP2105 1 -- rdxNP2691 1 -- rdxNP3538 1 -- rdxNP4601 1 -- rdxNP4729 1 -- rdxNP4809 1 -- rdxNP6549 1 -- rdxNP6601 1 -- rdxNP7452 1 -- rdxUM-8036-3 1 -- rdxUM-8183-3 1 -- rdx11 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes rdx02731 P-element activity 0 -- rdx03479 P-element activity 0 -- rdx07560 P-element activity 0 -- rdx2 0 Yes rdx3 0 Yes rdx4 0 Yes rdx5 ethyl methanesulfonate 0 Yes rdx6 ethyl methanesulfonate 0 Yes rdxc06670 piggyBac transposase 0 -- rdxCB03517 P-element activity 0 Yes rdxd06943 P-element activity 0 -- rdxd07502 0 -- rdxd08457 P-element activity 0 -- rdxGTD74-94.1 P-element activity 0 Yes rdxj1D1 P-element activity 0 -- rdxj1E11 P-element activity 0 -- rdxj4C7 P-element activity 0 -- rdxM19 ethyl methanesulfonate 0 -- rdxM23 ethyl methanesulfonate 0 -- rdxM30 ethyl methanesulfonate 0 -- rdxNP4650 0 -- rdxNP7488 0 -- rdxP19 Delta2-3 0 Yes rdxS1357 natural population 0 Yes rdxunspecified 0 -- rdxΔ14 recombination FLPase SCEI endonuclease 0 Yes rdxΔ6 recombination FLPase SCEI endonuclease 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rdx Class Mutagen Stocks Known lesion rdxGD13540 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes rdxGD7750 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes rdxKK107670 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rdxKK111898 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rdxA.Scer\UAS:T:Myc 0 Yes rdxA.Scer\UAS 0 Yes rdxdsRNA.Scer\UAS.cZa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes rdxScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes rdxScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rdxScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)293γ5 (Mortin et al., 1992, Jarman and Collett, 1998) Df(3R)293γ7 (Jarman and Collett, 1998, Seong et al., 2010) Df(3R)Exel6171 (Ryder, 2004.4.26) Df(3R)Exel6288 (Ryder, 2004.4.26) Df(3R)M49 (Mortin et al., 1992, Jarman and Collett, 1998) Df(3R)rdx4 (Kent et al., 2006) Df(3R)red1 (Kent et al., 2006) Df(3R)red3l (BDGP Project Members, 1994-1999, Spradling et al., 1999, Jarman and Collett, 1998) Df(3R)red-P52 (Jarman and Collett, 1998, Mortin et al., 1992, Seong et al., 2010) Df(3R)ry506-85C (BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)l26c (Jarman and Collett, 1998) Df(3R)M36 (Jarman and Collett, 1998, Mortin et al., 1992) Df(3R)red-P1 (Jarman and Collett, 1998, Mortin et al., 1992) Df(3R)red-P6 (Mortin et al., 1992) Df(3R)red-P93 (Mortin et al., 1992) Df(3R)su(Hw)7 (Jarman and Collett, 1998) Df(3R)su(Hw)V (Mortin et al., 1992) Df(3R)urd (Jarman and Collett, 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7750} NA P{GD13540} NA P{KK107670} NA P{KK111898} NA P{UAS-HA-HIB} NA P{UAS-rdx.Flag} NA P{UAS-rdx.RNAi.Z} NA P{UAS-rdx.S} NA P{UAS-rdx-A.Myc} NA P{UAS-rdx-A} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}rdxEY02061b NA P{EPgy2}rdxEY06724 NA P{EPgy2}rdxEY11582 NA P{EPgy2}rdxEY15242 NA P{EPgy2}rdxEY16412 NA P{EPgy2}rdxEY19897 NA P{GSV1}EP-149EP-149 NA P{XP}rdxd00814 NA P{XP}rdxd01317 NA P{XP}rdxd02587 NA P{XP}rdxd05421 NA P{XP}rdxd06943 NA P{XP}rdxd07502 NA P{XP}rdxd07737 NA P{XP}rdxd08353 NA P{XP}rdxd08457 NA P{XP}rdxd08815 NA P{XP}rdxd09180 NA miscellaneous insertions Mi{MIC}rdxMI02928 NA P{GT1}rdxBG00563 NA P{GTD-b}rdxGTD74-94.1 NA P{PTT-GB}rdxCB03517 NA P{RS3}rdxCB-0018-3 NA P{RS3}rdxUM-8036-3 NA P{RS3}rdxUM-8183-3 NA P{RS5}rdx5-SZ-3461 NA P{SUPor-P}rdxKG07915 NA PBac{PB}rdxc00609 NA PBac{PB}rdxc02298 NA PBac{PB}rdxc04993 NA PBac{PB}rdxc06670 NA PBac{RB}rdxe02813 NA PBac{WH}rdxf04694 NA insertion of enhancer trap P{lacW}rdx1 No P{lacW}rdx2 No P{lacW}rdx3 No P{lacW}rdxj1D1 No P{lacW}rdxj1E11 No P{lacW}rdxj4C7 No P{lacW}rdxP19 No P{PZ}rdx02731 No P{PZ}rdx03477 No P{PZ}rdx03479 No P{PZ}rdx07560 No insertion of enhancer trap binary system Mi{ET1}Cyp6d5MB09381 No P{GawB}rdxNP0440 No P{GawB}rdxNP0994 No P{GawB}rdxNP2105 No P{GawB}rdxNP2691 No P{GawB}rdxNP3538 No P{GawB}rdxNP4601 No P{GawB}rdxNP4650 No P{GawB}rdxNP4729 No P{GawB}rdxNP4809 No P{GawB}rdxNP6549 No P{GawB}rdxNP6601 No P{GawB}rdxNP7452 No P{GawB}rdxNP7488 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:P19538 (assigned by UniProtKB) (Zhang et al., 2006) inferred from physical interaction with UniProtKB:Q9V475 (assigned by UniProtKB) (Zhang et al., 2006)
Biological Process
CV term Evidence References
cellularization inferred from mutant phenotype (Kent et al., 2004) establishment of ommatidial planar polarity inferred from mutant phenotype (Kent et al., 2006) eye morphogenesis inferred from mutant phenotype (Kent et al., 2006) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) negative regulation of protein import into nucleus inferred from mutant phenotype (Seong et al., 2010) negative regulation of smoothened signaling pathway inferred from mutant phenotype (Zhang et al., 2006) positive regulation of apoptosis inferred from genetic interaction with egr (Liu et al., 2009) positive regulation of JNK cascade inferred from mutant phenotype (Liu et al., 2009) protein ubiquitination inferred from mutant phenotype (Zhang et al., 2006, Liu et al., 2009) regulation of proteolysis inferred from mutant phenotype (Liu et al., 2009)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Seong et al., 2010) inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rdx allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0262907
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA11684   Dpse\GA22127
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 48 )
Harvard	- P{XP}rdxd00814 - P{XP}rdxd01317 - P{XP}rdxd02587 - P{XP}rdxd05421 - P{XP}rdxd07737 - P{XP}rdxd08353 - P{XP}rdxd08815 - P{XP}rdxd09180 - PBac{PB}rdxc00609 - PBac{PB}rdxc02298
VDRC	v106945 P{KK111898}VIE-260B v107294 P{KK107670}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR10E03 BACR25B05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 147 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE09049 RE09961 RE34508 RE74593
Other clones	DPiM_RE34508
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21715 HL01322 LD03571 LD05822 LD08515 RE03624 RE12503 RE15011 RE18541 RE20284 RE25547 RE42823 RE44875 RE50936 RE54175 RE57811 RE60546 RE66024 RE66842 RE73704 RH20912 RH25441 RH26465 RH34163 RH38452 RH42210 RH48255 RH63191 SD03009 SD03038
Other clones	8034 11436 11733 16363 16409 28838 34247 37537 46810 47010 55694 58131 58420 71655 73942 78199 81133 97375 101135 108335 122097 150074 161521 162973 175904 193865 214221.39 214345.31 525646 CK01.16C.H11 CK01.17C.D1 CK01.26A.D7 CK01.59A.G11 CK01.65A.H2 CK01.121D.E9 CK01.122D.H10 Dmel_dig_013838_0594_1996 Dmel_dig_019007_0676_2958 Dmel_dig_019623_0680_3175 Dmel_neb_001109_0692_3676 Dmel_neb_012179_0957_0453 EK043338 EK047921 EK049516 EK053061 EK074747 EK084122 EK084146 EK093117 EK106041 EK111564 EK112547 EK127959 EK136862 EK149131 EK155752 EK162707 EK162909 EK165409 EK165737 EK165756 EK167560 EK174562 EK180610 EK181956 EK182060 EK191014 EK199754 EK199907 EK203362 EK224025 EK242059 EK256136 EK265358 EK267047 EK297164 EK298442 EN06854 EP00929 EP12453 ESG012d.E21_G02 ESG0119c.B21_F01 FGC003D12 FGM309H09 GM07940 LD28030 RP01001 RP01042 RP01420 RP01585 RP001000984 RP001008552 RP001013110 RP001019171 RP001039781 RP001055569 RP003049641 RP003087325 RP003116919 RP003151865 RP003163100 RP003177820 RP003251266 RP003292745 RP003305576 RP003444742 RP003467861 RP003482443 RP003606232 RP003665759 UUGC0612 UUGC0994
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41704 41705
Antibody Information
Other Information
Discoverer
Etymology
	One allele generates embryos with mitotic defects that often fail to completely cellularize, hence, the name "roadkill". (Kent et al., 2004)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: rdx CG9924 (Kent et al., 2006)
Source for database merge of	Source for merge of: CG9924 BEST:GM07940 (Rana, 2004.7.8) Source for merge of: CG12537 anon-WO0118547.577 (FlyBase Genome Annotators, 2005, FlyBase, 1996-) Source for merge of: l(3)88Aa l(3)03477 (Jarman and Collett, 1998) Source for merge of: l(3)dsl6 l(3)SG40 (Shearn, 1995.5.3) Source for merge of: rdx CG9924 (Wang, 2007.3.16) Source for merge of: rdx mei-P19 (Seong et al., 2010)
Additional comments	Source for merge of CG12537 anon-WO0118547.577 was sequence comparison (date:051113). (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
Other Comments
	rdx is expressed in response to hh. (Kent et al., 2006) Area matching Drosophila EST AA696584 (inverted). (Davies, 2001.3.15) Identification: In a genetic screen for meiotic mutants. (Sekelsky et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142068 NM_142069 NM_169564 NM_169565 NM_169566 RefSeq (Proteins) • NP_650325 NP_650326 NP_731875 NP_731876 NP_731877 DDBJ / EMBL / GenBank • AA696584 AAF55007 AAF55007.2 AAF55007.3 AAF55008 AAM52009 AAN14346 AAN14346.1 AAN14347 AAN14347.1 AAN14348 AAN14348.1 AAX33469 ABG24573 AC007441 AQ034055 AW941299 AX094079 AX094453 AY121682 BI238120 BI580404 BT021321 CL844472 CZ467841 CZ469664 CZ470910 CZ472156 CZ472900 CZ474519 CZ475441 CZ475900 CZ476240 CZ476424 CZ476608 CZ476609 CZ487246 CZ487247 DQ507278 Entrez Gene - A searchable database of RefSeq genes. • 41704 UniProtKB/TrEMBL • Q9VFP2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) BTB/POZ (IPR013069) TRAF-like (IPR008974) MATH (IPR002083) BTB/POZ-like (IPR000210) TRAF-type (IPR013322)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0262907 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41704 41705
Synonyms & Secondary IDs ( 28 )
Reported As
Symbol Synonym	anon-WO0118547.577   BEST:GM07940   CG9924 (Seong et al., 2010, Li et al., 2007, Wang, 2007.3.16, Kent et al., 2006, Buszczak et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Zhang et al., 2006, Arama et al., 2007, Liu et al., 2009, Hayden and Bosco, 2008, Grad et al., 2004) CG10235 (Kent et al., 2006) CG12537 (Giot et al., 2003, Lim et al., 2004, González et al., 2008, Keleman et al., 2009.8.5) Dromel_CG9924_FBtr0082871_rdx_mORF (Hayden and Bosco, 2008) D-SPOP (Liu et al., 2009) hib (Wang, 2007.3.16, Chien-Hsiang et al., 2007, Huang et al., 2008, Zhang et al., 2006, Ou et al., 2007) HIB (Kim et al., 2010, Jia et al., 2010) l(3)88Aa (Jarman and Collett, 1998, BDGP Project Members, 1994-1999, Lindsley and Zimm, 1992, Mortin et al., 1992, Szabad and Bryant, 1982, Shearn et al., 1971, ) l(3)2004 (Gatti and Baker, 1989, ) l(3)03477 (Spradling et al., 1999, ) l(3)A6   l(3)dsl-6 (Cohen, 1993) l(3)dsl6   l(3)j1D1   l(3)j4C7   l(3)SG40   mei-P19   rdx (Seong et al., 2010, Wang, 2007.3.16, Chien-Hsiang et al., 2007, Ou et al., 2007, González et al., 2008, Baker et al., 2009, González et al., 2010, Gan et al., 2010, Kim et al., 2010) Rdx (Hayden and Bosco, 2008) Spop (Arama et al., 2007)
Name Synonym	CG9924   hedegehog-induced BTB protein (Wang, 2007.3.16) hedgehog- induced BTB protein (Kim et al., 2010) Hh-induced MATH and BTB domain containing protein (Zhang et al., 2006) meiotic P19   roadkill (Kent et al., 2006, Von Ohlen and Hooper, 1999, Wang, 2007.3.16, Baker et al., 2009, Kim et al., 2010) Roadkill (Hayden and Bosco, 2008)
Secondary FlyBase IDs
	FBgn0002364 FBgn0004722 FBgn0010801 FBgn0011314 FBgn0011366 FBgn0026625 FBgn0038192 FBgn0038193 FBgn0044329 FBgn0061865 FBgn0086364 FBpp0082336 FBtr0082873
References ( 64 )
Generate a list of	All references relating to this gene ( 64 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 3 ) FlyBase analysis  ( 4 ) Computer file  ( 4 ) Book  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] González et al., 2010, PLoS Genet. 6(4): e1000905 Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. [FBrf0210506] Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. [FBrf0214177] Kim et al., 2010, Dev. Biol. 346(2): 247--257 Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. [FBrf0211875] Seong et al., 2010, PLoS ONE 5(12): e15365 Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. [FBrf0212658] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...