A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\RpII140

General Information
SymbolDmel\RpII140SpeciesD. melanogaster
NameRNA polymerase II 140kD subunitAnnotation symbolCG3180
Feature typeprotein_coding_geneFlyBase IDFBgn0262955
Gene Model StatusCurrent Stock availability 11 publicly available
Also Known AsDmRP140, wimp, PolII, pol II, RNA Pol II, RNAP II, rpII140/wimp, H5, RNApolII
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map88A9-88A9Sequence location3R:9,951,515..9,955,548 [+]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene RNA polymerase II 140kD subunit is referred to in FlyBase by the symbol Dmel\RpII140 (CG3180, FBgn0262955). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed RNA polymerase activity. Based on sequence similarity, it is predicted to be involved in the biological process: transcription from RNA polymerase II promoter. 66 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum; capitellum. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA-directed RNA polymerase, subunit 2; DNA-directed RNA polymerase, subunit 2, domain 6; RNA polymerase Rpb2, OB-fold; RNA polymerase Rpb2, domain 2; RNA polymerase Rpb2, domain 3; RNA polymerase Rpb2, domain 4; RNA polymerase Rpb2, domain 5; RNA polymerase Rpb2, domain 7; RNA polymerase, beta subunit, conserved site; RNA polymerase, beta subunit, protrusion. Gene sequence location is 3R:9951515..9955548.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
RpII140: RNA polymeraseII-140 kd subunit
The structural gene for the 140-kd subunit of RNA polymerase II [RNA nucleotidyl transferase (EC 2.7.7.6)]. The gene is highly conserved judging from shared sequence homology with the yeast 150-kd subunit gene.
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2012_01
References
Greenleaf, 1983, J. Biol. Chem. 258(22): 13403--13406
Pérez-Lluch et al., 2011, Nucleic Acids Res. 39(11): 4628--4639
Sequence features
BKN22741
HFA16831
FB2011_10
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
88A9-88A9  
Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
88A10-88A10  
(determined by in situ hybridisation)  
(Ranz et al., 1997)
88A-88B  
(determined by in situ hybridisation)  
(Hamilton, 1990)
88A10-88B2  
(determined by in situ hybridisation)  
(Hamilton et al., 1993)
88A-88B  
(determined by in situ hybridisation)  
(Parkhurst and Ish-Horowicz, 1991)
88A-88B  
(determined by in situ hybridisation)  
(Falkenburg et al., 1987)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\RpII140 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0082891 FBtr0082909 FBtr0082892 FBtr0082908 FBpp0082352 FBpp0082370 FBpp0082353 FBpp0082369 FBti0044920 FBti0101690 FBti0126081 FBti0042654
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
RpII140-RA
FBtr0082892
 NM_057358
  3773
  1176
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
RpII140-PA  
FBpp0082353  
134.0  
1176  
7.04  
  NP_476706
  AAF55024
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
DNA-directed RNA polymerase, subunit 2 (IPR015712)
DNA-directed RNA polymerase, subunit 2, domain 6 (IPR007120)
RNA polymerase, beta subunit, conserved site (IPR007121)
RNA polymerase Rpb2, domain 7 (IPR007641)
RNA polymerase Rpb2, domain 2 (IPR007642)
RNA polymerase, beta subunit, protrusion (IPR007644)
RNA polymerase Rpb2, domain 3 (IPR007645)
RNA polymerase Rpb2, domain 4 (IPR007646)
RNA polymerase Rpb2, domain 5 (IPR007647)
RNA polymerase Rpb2, OB-fold (IPR014724)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA202158
 
AA264905
 
AA390597
 
AA391748
 
AA392309
 
AA438298
 
AA439595
 
AA439745
 
AA440900
 
AA441251
 
AA539529
 
AA567870
 
AA801692
 
AA817209
 
AA941145
 
AA949469
 
AA951261
 
AA951541
 
AA952152
 
AE014297
AAF55024
 
AC007904
 
AI061750
 
AI108044
 
AI113716
 
AI295348
 
AI455019
 
AI455265
 
AI512737
 
AI515237
 
AI515742
 
AI516406
 
AI518260
 
AI518320
 
AI519108
 
AI519619
 
AI520027
 
AI531621
 
AI532204
 
AI532962
 
AI533230
 
AI534138
 
AI534827
 
AI534857
 
AI542502
 
BF504705
 
BG638945
 
BI173529
 
BI232368
 
BI237933
 
BI357527
 
BI361652
 
BI364901
 
BI365645
 
BI372057
 
BI372928
 
BI374655
 
BI375160
 
BI483800
 
BI577206
 
BI579322
 
BI605708
 
BI615820
 
BQ103157
 
BT003265
AAO25022
 
CO177602
 
CO186347
 
CO270995
 
CO279283
 
CO280740
 
CO296706
 
CO305529
 
CO312894
 
CO314613
 
CO318283
 
CO333971
 
EC088335
 
EC089873
 
EC194642
 
EC204316
 
EC208826
 
EC213913
 
EC221653
 
EC225543
 
EC245236
 
EV588294
 
EV598254
 
M62972
AAA28476
 
M62973
 
X05709
CAA29180
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view 140up-RA RpII140-RA CG14356-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
[an error occurred while processing this directive]
modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(The modENCODE Consortium, 2010)
hide External Data & Images
Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal | embryonic stage | germline clone | maternal effect | recessive
lethal | embryonic stage | recessive
lethal | heat sensitive
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal | recessive | heat sensitive
semi-lethal, with Scer\GAL4pnr-MD237
viable
Other Phenotypes
Allele
visible, with Scer\GAL4pnr-MD237
visible | dominant | homeotic | male
wild-type
Phenotype manifest in
Allele
adult abdominal segment 5 | ectopic | male
adult abdominal segment 6 | male
capitellum
cephalopharyngeal skeleton | germline clone | maternal effect
embryonic abdominal segment | germline clone | maternal effect
embryonic segment | germline clone | maternal effect
filzkorper | germline clone | maternal effect
mesothoracic tergum, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
hide Classical Alleles ( 54 )
For All Classical Alleles Show

Allele of RpII140ClassMutagenStocksKnown lesion
RpII140wimp
2 --
RpII140A51 Yes
RpII140S111 Yes
RpII140S121 Yes
RpII140S11 Yes
RpII140Z361 --
RpII140Z431 Yes
RpII140Z451 Yes
RpII1403R-112-60 --
RpII1403R-92-380 --
RpII140AS
0 --
RpII140brie0 --
RpII140M160 --
RpII140M210 --
RpII140M250 --
RpII140M280 --
RpII140M370 --
RpII140M380 --
RpII140M390 Yes
RpII140M30 --
RpII140M440 --
RpII140M460 --
RpII140M40 --
RpII140M500 --
RpII140M50 --
RpII140M60 --
RpII140M80 --
RpII140S1R10 --
RpII140S1R20 --
RpII140S1R30 --
RpII140S1R40 --
RpII140S1R50 --
RpII140S1R60 --
RpII140S20 Yes
RpII140S2R0 --
RpII140S50 Yes
RpII140S60 Yes
RpII140S70 Yes
RpII140S80 Yes
RpII140S8R
0 --
RpII140unspecified
0 --
RpII140wimpRQ0 --
RpII140Z190 Yes
RpII140Z200 --
RpII140Z220 --
RpII140Z240 --
RpII140Z310 --
RpII140Z340 --
RpII140Z390 --
RpII140Z30 --
RpII140Z500 --
RpII140Z510 --
RpII140Z50 --
RpII140Z70 --
hide Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show

Allele of RpII140ClassMutagenStocksKnown lesion
RpII140GD42332 Yes
RpII140+tcos150 Yes
RpII140+tcos920 Yes
RpII140-IN0 Yes
RpII140a.cKa0 Yes
RpII140cKa0 Yes
RpII140cos500 Yes
RpII140DNAP0 Yes
RpII140KK1026750 Yes
RpII140M0 Yes
RpII140S0 Yes
RpII140SM0 Yes
hide Aneuploid Aberrations
Disrupted in
(Christensen et al., 2008.9.29)
(Ryder, 2004.4.26)
(Ryder, 2004.4.26)
(Breen and Harte, 1991)
(Jarman and Collett, 1998)
(Mortin et al., 1992, Jarman and Collett, 1998)
(Breen and Harte, 1991, Mortin et al., 1992, Jarman and Collett, 1998)
(Jarman and Collett, 1998)
Not disrupted in
(Jarman and Collett, 1998, Mortin et al., 1992)
(Jarman and Collett, 1998)
(Breen and Harte, 1991)
(Jarman and Collett, 1998)
(Mortin et al., 1992, Jarman and Collett, 1998)
(Jarman and Collett, 1998)
(Breen and Harte, 1991)
(Mortin et al., 1992, Breen and Harte, 1991)
(Breen and Harte, 1991, Mortin et al., 1992)
(Breen and Harte, 1991, Mortin et al., 1992)
(Breen and Harte, 1991)
(Jarman and Collett, 1998)
(Breen and Harte, 1991)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
UAS construct
P{GD4233}
NA
P{KK102675}
NA
reporter construct
P{lacZRpII140.468}
No
characterization construct
P{cos15}
NA
P{cos50}
NA
P{cos92}
NA
P{RpII140DNAP.K}
NA
P{RpII140-IN.K}
NA
P{RpII140M.K}
NA
P{RpII140S.K}
NA
P{RpII140SM.K}
NA
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
hide Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term
Evidence
References
DNA-directed RNA polymerase II, core complex
inferred from direct assay
(Greenleaf, 1983, Hamilton et al., 1993)
hide Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term
Evidence
References
DNA binding
inferred from electronic annotation with InterPro:IPR007120, InterPro:IPR007121, InterPro:IPR007641, InterPro:IPR007642, InterPro:IPR007644, InterPro:IPR007645, InterPro:IPR007646, InterPro:IPR007647
(FlyBase Curators et al., 2004-)
DNA-directed RNA polymerase activity
inferred from sequence or structural similarity with human POLR2B AND inferred from sequence or structural similarity with Saccharomyces RPB2 AND inferred from sequence or structural similarity with worm C26E6.4
(Aoyagi and Wassarman, 2000)
non-traceable author statement
(Swiss-Prot Project Members, 1988.8.1)
ribonucleoside binding
inferred from electronic annotation with InterPro:IPR015712
(FlyBase Curators et al., 2004-)
Biological Process
CV term
Evidence
References
transcription from RNA polymerase II promoter
inferred from sequence or structural similarity with human POLR2B AND inferred from sequence or structural similarity with Saccharomyces RPB2 AND inferred from sequence or structural similarity with worm C26E6.4
(Aoyagi and Wassarman, 2000)
non-traceable author statement
(Swiss-Prot Project Members, 1988.8.1)
Cellular Component
CV term
Evidence
References
DNA-directed RNA polymerase II, core complex
inferred from sequence or structural similarity with human POLR2B AND inferred from sequence or structural similarity with Saccharomyces RPB2
(Aoyagi and Wassarman, 2000)
non-traceable author statement
(Swiss-Prot Project Members, 1988.8.1)
hide Sequence Ontology: Class of Gene
gene
 
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
RpII140 allele
Gene
References
RpII140M
RpII215
(Kim et al., 1994, Krasnoselskaya et al., 1998)
RpII140S1
RpII215
(Kim et al., 1994, Krasnoselskaya et al., 1998)
RpII140S8
RpII215
(Mortin, 1990)
RpII140S11
RpII215
(Kim et al., 1994, Krasnoselskaya et al., 1998)
RpII140S12
RpII215
(Kim et al., 1994, Krasnoselskaya et al., 1998)
RpII140wimp
ct
(Jackson and Blochlinger, 1997)
Rho1
(Magie et al., 1999)
Sir2
(Rosenberg and Parkhurst, 2002)
RpII140Z36
su(RpII140Z36)S1
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S2
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S3
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S4
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S5
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S6
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S7
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S8
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S9
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S10
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S11
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S12
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S13
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S14
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S15
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S16
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S17
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S18
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S19
(Krasnoselskaya et al., 1998)
su(RpII140Z36)S20
(Krasnoselskaya et al., 1998)
unspecified
bcd
(Parkhurst and Ish-Horowicz, 1991)
BicD
(Parkhurst and Ish-Horowicz, 1991)
brm
(Armstrong et al., 2005)
cact
(Parkhurst and Ish-Horowicz, 1991)
da
(Parkhurst and Ish-Horowicz, 1991)
dl
(Parkhurst and Ish-Horowicz, 1991)
eve
(Parkhurst and Ish-Horowicz, 1991)
exu
(Parkhurst and Ish-Horowicz, 1991)
ftz
(Parkhurst and Ish-Horowicz, 1991)
gt
(Parkhurst and Ish-Horowicz, 1991)
h
(Parkhurst and Ish-Horowicz, 1991)
kni
(Parkhurst and Ish-Horowicz, 1991)
Kr
(Parkhurst and Ish-Horowicz, 1991)
oc
(Parkhurst and Ish-Horowicz, 1991)
opa
(Parkhurst and Ish-Horowicz, 1991)
os
(Parkhurst and Ish-Horowicz, 1991)
prd
(Parkhurst and Ish-Horowicz, 1991)
RpII215
(Kim et al., 1994, Krasnoselskaya et al., 1998)
run
(Parkhurst and Ish-Horowicz, 1991)
sc
(Parkhurst and Ish-Horowicz, 1991)
sisA
(Parkhurst and Ish-Horowicz, 1991)
slp1
(Parkhurst and Ish-Horowicz, 1991)
sna
(Parkhurst and Ish-Horowicz, 1991)
Sxl
(Parkhurst and Ish-Horowicz, 1991)
trk
(Parkhurst and Ish-Horowicz, 1991)
twi
(Parkhurst and Ish-Horowicz, 1991)
hide External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
 
 
 
 
Linkouts
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 11 )
Bloomington
35505
RpII140Z36 red1 e1/TM3, Sb1
34757
ras1 v1 RpII215K1; RpII140S1
34758
ras1 v1 RpII215K1; RpII140S11
34759
ras1 v1 RpII215K1; RpII140S12
34752
RpII140Z43 red1 e1/TM3, Sb1 Ser1
34754
RpII140Z45 red1 e1/TM3, Sb1 Ser1
34753
y1 w*; RpII140A5 red1 e1/TM3, Sb1 Ser1
5874
ru1 h1 th1 st1 cu1 RpII140wimp sr1 es ca1/TM3, Sb1
Kyoto
108474
ru1 h1 th1 st1 cu1 RpII140wimp sr1 es ca1/TM3, Sb1
VDRC
v45959
w1118 P{GD4233}v45959
v45960
w1118; P{GD4233}v45960
hide Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 81 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: RpII140 Rpb2
(FlyBase, 1992-)
Additional comments
Mutants selected by Mortin, (1990) as extragenic suppressors of RpII215K1.
 
hide Other Comments
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly long spindles with misaligned chromosomes when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA.
(Goshima et al., 2007)
Suppressor mutations isolated on the basis of restoring viability to RpII215 and RpII140 mutants identify discrete domains in either subunit. The suppressor domain is required for viability and functioning of RNA polymerase II. The mutations recovered are not random and might provide insights into possible mechanisms for mutagenesis in eukaryotes.
(Krasnoselskaya et al., 1998)
Used in a phylogenetic analysis, the tree in inferred by parsimony method from RpoB sequences, or homologous, multiple alignment.
(Mollet et al., 1998)
Sequences important for the transcription of RpII140 are located in the untranslated leader of the divergently transcribed 140up gene.
(Wiedemann et al., 1997)
Deletion analysis of the RpII140 protein shows that a region in the N-terminal part of the protein (amino acids 357-504) shows strong DNA binding, and the C-terminal part of the protein (amino acids 860-1160) shows some weak DNA binding.
(Kontermann and Bautz, 1994)
Ecol\lacZ RpII140 fusion proteins expressing overlapping fragments of RpII140 identify a protein segment that has the potential to bind DNA nonspecifically.
(Kontermann et al., 1993)
Upstream of RpII140 is a gene, 140up, which is transcribed in the opposite direction. Both genes are characterised by multiple transcription start sites. Gel retardation assays with in vitro transcribed and translated Tbp reveals two regions in the RpII140 promoter region that bind Tbp. Transient transfection assays with Tbp and Ecol\CAT driven by the RpII140 promoter result in 2-3 fold increase in Ecol\CAT activity, promoter deletion analysis identifies three regions important for transcription.
(Oldenburg et al., 1993)
The technique of paramagnetic particle-mediated selection of terminated run-on transcripts was used to examine RNA polymerase II pausing and 5' cap formation at high resolution on the heat shock genes Hsp70A, Hsp70B, Hsp26 and Hsp27. Results demonstrate that polymerases pause over a narrow region of each heat shock gene, not at a defined point. 5' capping occurs over a region coincidental with that of pausing.
(Rasmussen and Lis, 1993)
Protein complexes of RNA polymerase II localise to major developmental puffs and heat shock puffs.
(Weeks et al., 1993)
Three RpII140 alleles cause a dominant enhancement of the Ubx effect: transformation of the capitellum to wing. The alleles do not enhance the Ubx effect of RpII15 alleles.
(Mortin et al., 1992)
The initiating ATGs of the divergently transcribed 140up and RpII140 are only 467bp apart, and a central 309bp fragment from this region can direct transcription in either orientation.
(Sitzler et al., 1991)
A TATA-dependent protein-DNA complex is found in fractionated embryonic nuclear extracts. DNase I footprint analysis identifies polypeptides (including Taf12, Tbp and RpII140) that require the Hsp70Bb TATA element for binding to regions of the Hsp70Bb promoter.
(Gilmour et al., 1990)
RpII140 has been cloned and sequenced.
(Falkenburg et al., 1987)
The structural gene for the 140kD subunit of RNA polymerase II (RNA nucleotidyl transferase). The gene is highly conserved judging from shared sequence homology with the yeast 150kD subunit gene.
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/Swiss-Prot
•
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
DNA-directed RNA polymerase, subunit 2 (IPR015712)
DNA-directed RNA polymerase, subunit 2, domain 6 (IPR007120)
RNA polymerase, beta subunit, conserved site (IPR007121)
RNA polymerase Rpb2, domain 7 (IPR007641)
RNA polymerase Rpb2, domain 2 (IPR007642)
RNA polymerase, beta subunit, protrusion (IPR007644)
RNA polymerase Rpb2, domain 3 (IPR007645)
RNA polymerase Rpb2, domain 4 (IPR007646)
RNA polymerase Rpb2, domain 5 (IPR007647)
RNA polymerase Rpb2, OB-fold (IPR014724)
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Synonyms & Secondary IDs ( 38 )
Reported As
Symbol Synonym
CG3180
(Aoyagi and Wassarman, 2000, Goshima et al., 2007, Keleman et al., 2009.8.5)
DmRP140
(Sitzler, 1991.12.12, Falkenburg, 1999.7.13, Wiedemann et al., 1997, Kontermann and Bautz, 1994, Kontermann and Bautz, 1992, Seifarth et al., 1991, Sitzler et al., 1991, Kontermann et al., 1989, Falkenburg et al., 1987)
H5
(Leatherman et al., 2002, Robertson et al., 1999)
II
(Shaiu and Hsieh, 1998)
l(3)RplII140
(Zeidler et al., 1996)
pol II
(Zhang and Gilmour, 2006)
Pol II
(Kim, 2004, Boehm et al., 2003, Hendrix et al., 2008)
PolII
(Zhang et al., 2004, Chen et al., 2008, Piel et al., 2008)
polII
(Gu et al., 2002, Lis, 1998, Bentley, 1998)
Pol IIc
(Srinivasan et al., 2005)
PolIIc
(Mounkes and Fuller, 1998)
RNAP
(Ma, 2005)
RNAP II
(Leatherman and Jongens, 2003, Mollet et al., 1998, Seydoux and Dunn, 1997)
RNA Pol II
(Meehan et al., 2001, Mito et al., 2005)
RNA pol II
(Farkas et al., 2000, Gilfillan et al., 2006)
RNA polII
(Leclerc et al., 2000)
RNApolII
(Sauer et al., 1995, Sauer et al., 1995)
RNA Pol IIc
(Armstrong et al., 2002)
RP140
(Bergman and Kreitman, 2001)
Rpb2
 
RPB2_DROME
(Storm and Sonnhammer, 2003)
RPII140
(Breen and Harte, 1991, Corona et al., 2007)
RpII140
(Altenhein et al., 2006, Goshima et al., 2007, Lindsley and Zimm, 1992, Christensen et al., 2008.9.29, Somma et al., 2008, Ayroles et al., 2009, Worringer et al., 2009, Tolhuis et al., 2011, Tanaka et al., 2011)
rpII140/wimp
(Luschnig et al., 2004, Luschnig et al., 2004)
RpII140wimp
(Gutierrez et al., 2004)
Rpll140
(Ogasawara et al., 2007)
unnamed
(Magie et al., 1999)
wimp
(Magie and Parkhurst, 2005, Jackson and Blochlinger, 1997, Parkhurst et al., 1991, Parkhurst and Ish-Horowicz, 1991, Lipshitz, 1991, Liu et al., 2009)
Name Synonym
150kDa polypeptide
(Gilmour et al., 1990)
RNA Pol II second largest subunit
(Kavi and Birchler, 2007)
RNA pol II second largest subunit
(Kavi and Birchler, 2008)
RNA polymerase II
(Heinkoff et al., 2004, Shore et al., 2003, Chao and Price, 2001, Mizuguchi et al., 2001, Chao et al., 2000, Mahowald, 2001, Kal et al., 2000, Reim et al., 1999, Pham et al., 1999, Schock et al., 1999, Gu, 1998, Peng et al., 1998, Peng et al., 1998, Sandaltzopoulos and Becker, 1998, Hansen et al., 1997, Kephart et al., 1992, Visa et al., 1991, Spencer and Groudine, 1990, Wampler et al., 1990, Visa et al., 1988, Morcillo and MacIntyre, 2001, Robertson et al., 1999, Bentley, 1998, Redhouse and White, 2007, Yao et al., 2006, Silverman et al., 2008, Ratnaparkhi and Courey, 2008)
RNA polymerase II 140kD subunit
 
RNA polymeraseII-140 kd subunit
(Lindsley and Zimm, 1992)
RNA polymerase II 140 kD subunit
(Tolhuis et al., 2011)
RNA polymerase II second largest subunit
(Sitzler, 1999.8.31)
RNA polymerase subunit IIc
(Wang and Lindquist, 1998)
Rpb2
 
subunit IIc of RNA Pol II
(Deuring et al., 2000)
wimp
(Abreu-Blanco et al., 2011)
Secondary FlyBase IDs
  • FBgn0003276
  • FBgn0083157
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hide Recent research papers ( 4 )
Abreu-Blanco et al., 2011, J. Cell Biol. 193(3): 455--464
Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. [FBrf0213583]
Pérez-Lluch et al., 2011, Nucleic Acids Res. 39(11): 4628--4639
Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing. [FBrf0213882]
Tanaka et al., 2011, Development 138(12): 2523--2532
Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. [FBrf0213769]
Tolhuis et al., 2011, PLoS Genet. 7(3): e1001343
Interactions among Polycomb Domains Are Guided by Chromosome Architecture. [FBrf0213356]
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