Gene Dmel\lawc

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General Information

Symbol

Dmel\lawc

Species

D. melanogaster

Name

leg arista wing complex

Annotation symbol

CG32711

Feature type

protein_coding_gene

FlyBase ID

FBgn0262976

Gene Model Status

Current

Stock availability

8 publicly available

Genomic Location

Chromosome (arm)

Recombination map

1-23.0

Cytogenetic map

7D18-7F1

Sequence location

X:8,302,041..8,305,757 [-]

Genomic Maps

Select View:

modENCODE GBrowse

Summary Information

Automatically generated summary

See sections below for more information

The gene leg arista wing complex is referred to in FlyBase by the symbol Dmel\lawc (CG32711, FBgn0262976). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 19 alleles are reported. The phenotypes of these alleles are annotated with: eye; adult thorax; macrochaeta; mesothoracic tergum; scutellar bristle; wing; arista; thorax; scutellum. It has 4 annotated transcripts and 4 annotated polypeptides. Gene sequence location is X:8302041..8305757.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2011_10

FB2012_01

Sequence features

BKN33169

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7D18-7F1

Left limit from inclusion within Df(1)RA2 (FBrf0111197) Right limit from non-inclusion within Df(1)KA14 (FBrf0111197)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7F-7F

(determined by in situ hybridisation)

(Simonova et al., 1992)

7E4-7E4

(Perrimon et al., 1989)

Experimentally Determined Recombination Data

Location

1-23.0

(Simonova et al., 1992, Simonova et al., 1997)

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\lawc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Existence of gene as protein-coding supported by FBrf0207164.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

FBtr0071248

1069

FBtr0302081

1329

FBtr0307286

2698

lawc-RD

FBtr0307287

1867

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

lawc-PA

FBpp0071191

8.0

8.25

NP_727260

AAN09231

lawc-PB

FBpp0291291

8.0

8.25

NP_001162700

ACZ95235

lawc-PC

FBpp0298287

8.0

8.25

lawc-PD

FBpp0298288

8.0

8.25

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q8SXG2

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Untitled Document detailed view

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

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modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_05

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

cell lethal | germline clone

lawc^EF520

lethal

lawc^EF520

lethal | larval stage | recessive

lawc^EF520

lethal | recessive

lawc^EF520

semi-lethal | pupal stage, with Scer\GAL4^pnr-MD237

lawc^GD15874

semi-lethal | recessive

lawc^p1

semi-viable

lawc^pdel

viable

Sterility

Allele

fertile

Other Phenotypes

Allele

body color defective, with Scer\GAL4^pnr-MD237

lawc^GD15874

enhancer of variegation, with bw^D

lawc^p1

enhancer of variegation, with In(1)w^m4

lawc^p1

enhancer of variegation, with y^v2

lawc^p1

visible

lawc^p1

visible | homeotic

Phenotype manifest in

Allele

adult thorax

lawc^p1

adult thorax & macrochaeta

lawc^p1

arista

eye

lawc^p1

leg | ectopic

lawc^p1

macrochaeta

lawc^p1

macrochaeta | ectopic

lawc^p1

mesothoracic tergum, with Scer\GAL4^pnr-MD237

lawc^GD15874

scutellar bristle

lawc^p1

scutellum

lawc^p1

tarsal segment | ectopic

lawc^unspecified

thorax

lawc^pdel

wing

lawc^p1

Classical Alleles ( 16 )

For All Classical Alleles Show

Allele of lawc	Class	Mutagen	Stocks	Known lesion
lawc^EF520	loss of function allele	ethyl methanesulfonate	2	--
lawc^EY08588		P-element activity	1	--
lawc^f06410		piggyBac transposase	1	--
lawc^KG09043		P-element activity	1	--
lawc⁺¹⁰		P-element activity	0	Yes
lawc^5-SZ-3663			0	--
lawc^d04751		P-element activity	0	--
lawc^DC771		ethyl methanesulfonate	0	--
lawc^EC240		ethyl methanesulfonate	0	--
lawc^EF250			0	--
lawc^G262		X ray	0	--
lawc^HF382		X ray	0	--
lawc^p1		PM hybrid dysgenesis	0	Yes
lawc^P1R30			0	--
lawc^pdel			0	Yes
lawc^unspecified			0	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of lawc	Mutagen	Stocks	Known lesion
lawc^GD15874	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
lawc^KK113169	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
lawc^t6.5	in vitro construct - genomic fragment	0	Yes

Aneuploid Aberrations

Disrupted in

Df(1)RA2

(Zorin et al., 1999)

Not disrupted in

Df(1)KA14

(Zorin et al., 1999)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

characterization construct

P{lawc.t6.5}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}lawc^EY08588

P{XP}lawc^d04751

miscellaneous insertions

P{}lawc^p1a

P{}lawc^p1b

P{RS5}lawc^5-SZ-3663

P{SUPor-P}lawc^KG09043

PBac{WH}lawc^f06410

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

There is no information supporting a biological process or molecular function term for this gene.

(Based on a review of available data before: 2006)

Terms Based on Experimental Evidence ( 2 terms )

Molecular Function ( 0 terms)

Biological Process ( 0 terms)

Cellular Component

CV term

Evidence

References

polytene chromosome interband

inferred from direct assay

(Brandt and Corces, 2008)

polytene chromosome puff

inferred from direct assay

(Brandt and Corces, 2008)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

lawc allele

Gene

References

lawc^EF250

Snr1

(Marenda et al., 2004)

unspecified

External Data

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0262976

Orthologs

Genome-wide drosophilid orthologs

Dere\GG19054

Dsec\GM21398

Dsim\GD24572

Dyak\GE17458

Curated drosophilid orthologs

Dpse\GA17096

Dsim\CG32711

(Montchamp-Moreau et al., 2006)

Linkouts

Stocks & Reagents

Stocks Listed in FlyBase ( 8 )

Bloomington

4682

lawc^EF520/FM7a

16475

y¹ P{SUPor-P}lawc^KG09043

17477

y¹ w^67c23 P{EPgy2}lawc^EY08588

107835

v103446

v48418

w¹¹¹⁸; P{GD15874}v48418

v48419

w¹¹¹⁸; P{GD15874}v48419/CyO

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 21 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones