FB2019_05, released Oct 15, 2019

Gene: Dmel\SERCA

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General Information
Symbol
Dmel\SERCA
Species
D. melanogaster
Name
Sarco/endoplasmic reticulum Ca(2+)-ATPase
Annotation Symbol
CG3725
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263006
Gene Model Status
Current
Stock Availability
27 publicly available
Enzyme Name (EC)
P-type H(+)-exporting transporter (7.1.2.1)
P-type Ca(2+) transporter (7.2.2.10)
Gene Snapshot
Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As
Ca-P60A, dSERCA, Calcium ATPase at 60A, Kum, CaP60A
Key Links
Genomic Location
Cytogenetic map
60A11-60A12
Sequence location
2R:23,925,077..23,935,884 [-]
Recombination map
2-105
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (P22700)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding
Predictions / Assertions
ATP binding; calcium transmembrane transporter activity, phosphorylative mechanism; proton-exporting ATPase activity, phosphorylative mechanism
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out) (7.1.2.1)
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2) (7.2.2.10)
Summaries
Gene Group (FlyBase)
HALOACID DEHALOGENASES -
The Haloacid Dehalogenase (HAD) family members are hydrolases characterized by a conserved α/β-domain Rossmann fold-like domain and three additional domains: squiggle, flap and cap domains, that contribute to substrate specificity. HADs are aspartate-nucleophile hydrolases, using a aspartate residue for nucleophilic attack. This family includes phosphoesterases, ATPases, phosphonatases, dehalogenases and sugar phosphomutases. (Adapted from FBrf0228712).
SARCO(ENDO)PLASMIC RETICULUM CALCIUM TRANSPORTING P-ATPASES -
Sarco(endo)plasmic reticulum Ca[2+] transporting ATPases (SERCA) are type IIA P-ATPases that utilize the hydrolysis of ATP to drive the transmembrane transport of Ca[2+] from the cytoplasm to the lumen of organelle. (Adapted from FBrf0224947).
Protein Function (UniProtKB)
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
(UniProt, P22700)
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\SERCA or the JBrowse view of Dmel\SERCA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SERCA-RA
FBtr0072215
NM_057484
3890
1002
SERCA-RB
FBtr0072213
NM_166633
3385
1020
SERCA-RC
FBtr0072217
NM_166634
3395
1020
SERCA-RD
FBtr0072214
NM_166635
3259
1020
SERCA-RE
FBtr0072212
NM_166636
3310
1020
SERCA-RF
FBtr0072218
NM_166637
3839
1020
SERCA-RG
FBtr0072211
NM_166638
3269
1020
SERCA-RH
FBtr0072216
NM_166639
5028
1020
SERCA-RI
FBtr0343281
NM_001299867
6306
999
Additional Transcript Data and Comments
Reported size (kB)
4.5 (northern blot)
(Varadi et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
SERCA-PA
FBpp0072124
109.6
1002
4.99
NP_476832
AAF47101
SERCA-PB
FBpp0072122
111.7
1020
5.06
NP_726381
AAF47103
SERCA-PC
FBpp0072126
111.7
1020
5.06
NP_726382
AAF47104
SERCA-PD
FBpp0072123
111.7
1020
5.06
NP_726383
AAM68278
SERCA-PE
FBpp0072121
111.7
1020
5.06
NP_726384
AAM68279
SERCA-PF
FBpp0072127
111.7
1020
5.06
NP_726385
AAM68280
SERCA-PG
FBpp0072120
111.7
1020
5.06
NP_726386
AAM68281
SERCA-PH
FBpp0072125
111.7
1020
5.06
NP_726387
AAF47102
SERCA-PI
FBpp0309946
109.3
999
5.10
NP_001286796
AHN56591
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1020 aa isoforms: SERCA-PB, SERCA-PC, SERCA-PD, SERCA-PE, SERCA-PF, SERCA-PG, SERCA-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
1002 (aa); 110 (kD)
(Magyar and Varadi, 1990)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with SclA and SclB.
(UniProt, P22700)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SERCA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (26 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein binding
inferred from physical interaction with UniProtKB:Q9VWB9
(Moraru et al., 2017)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR030332
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
calcium transmembrane transporter activity, phosphorylative mechanism
inferred from biological aspect of ancestor with PANTHER:PTN000643382
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Magyar and Varadi, 1990)
proton-exporting ATPase activity, phosphorylative mechanism
inferred from biological aspect of ancestor with PANTHER:PTN001943383
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (16 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
adaptive thermogenesis
inferred from mutant phenotype
(Moraru et al., 2017)
calcium ion transport from cytosol to endoplasmic reticulum
inferred from mutant phenotype
(Moraru et al., 2017)
cellular calcium ion homeostasis
inferred from mutant phenotype
(Banerjee et al., 2006)
fatty acid beta-oxidation
inferred from mutant phenotype
(Bi et al., 2014)
flight behavior
inferred from genetic interaction with FLYBASE:Itpr; FB:FBgn0010051
(Banerjee et al., 2006)
heart contraction
inferred from mutant phenotype
(Abraham and Wolf, 2013)
intestinal stem cell homeostasis
inferred from mutant phenotype
(Roti et al., 2013)
lipid biosynthetic process
inferred from mutant phenotype
(Bi et al., 2014)
neuromuscular synaptic transmission
inferred from mutant phenotype
(Sanyal et al., 2005)
ovarian follicle cell development
inferred from mutant phenotype
(Jia et al., 2015)
positive regulation of ATPase-coupled calcium transmembrane transporter activity
inferred from genetic interaction with FLYBASE:RyR; FB:FBgn0011286
(Abraham and Wolf, 2013)
positive regulation of lipid storage
inferred from mutant phenotype
(Bi et al., 2014)
regulation of sequestering of calcium ion
inferred from mutant phenotype
(Sanyal et al., 2005)
stabilization of membrane potential
(Banerjee et al., 2006)
stem cell differentiation
inferred from mutant phenotype
(Roti et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
calcium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000643382
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular calcium ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000643382
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
endoplasmic reticulum membrane
inferred from direct assay
(Moraru et al., 2017)
sarcoplasmic reticulum
inferred from direct assay
(Sanyal et al., 2005)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
endoplasmic reticulum
inferred from sequence or structural similarity with UniProtKB:Q93084
(assigned by UniProt )
(Magyar and Varadi, 1990)
integral component of membrane
inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR005782
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
sarcoplasmic reticulum
inferred from sequence or structural similarity with UniProtKB:Q93084
(Magyar and Varadi, 1990)
sarcoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000643383
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
hindgut anlage
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
salivary gland body primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Varadi et al., 1989)
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
salivary pump muscle 13
(Magyar et al., 1995)
ocellus | vicinity of
(Magyar et al., 1995)
ganglion cell of ocellus
(Magyar et al., 1995)
cibarial muscle
(Magyar et al., 1995)
adult optic lobe
(Magyar et al., 1995)
pharyngeal muscle
(Magyar et al., 1995)
adult central nervous system
(Magyar et al., 1995)
tubular muscle
(Magyar et al., 1995)
skeletal muscle of mesothorax
(Magyar et al., 1995)
adult stage | female
oocyte
(Magyar et al., 1995)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult heart
(Qian et al., 2008)
Additional Descriptive Data
In situ hybridization to sections of adult flies shows that Ca-P60A transcripts are detected in each tissue tested, generally at a low level. High transcript levels are observed in the central nervous system and in muscles. Strong expression is apparent in the visual system, in ganglion cells around the ocelli, and in the antennal center. It is also apparent in the muscles of the proboscis, the cibarial pump, the lateral pharyngeal muscles, and the salivary muscles. High expression is also seen in some muscles of the mesothorax and in the jump muscles. Finally, elevated levels are observed in oocytes.
(Magyar et al., 1995)
Ca-P60A transcripts are present in adult-males and females. None are detected in embryos, larvae, or pupae.
(Varadi et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval somatic muscle
(Panz et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
sarcoplasmic reticulum
(Panz et al., 2012)
Subcellular Localization
CV Term
Evidence
References
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
endoplasmic reticulum membrane
inferred from direct assay
(Moraru et al., 2017)
sarcoplasmic reticulum
inferred from direct assay
(Sanyal et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\SERCA in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 42 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SERCA
Transgenic constructs containing regulatory region of SERCA
Deletions and Duplications ( 12 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4tin.CΔ4
lethal (with Df(2R)BSC601)
lethal (with Df(2R)BSC610)
lethal (with Df(2R)bw-S46)
lethal (with SERCAKum170)
lethal (with SERCAKum295)
lethal (with SERCAKumP52)
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
decreased cell size | somatic clone
flight defective, with Scer\GAL4elav.PLu
heat stress response defective
heat stress response defective | dominant
hypoactive | larval stage | recessive
locomotor behavior defective, with Scer\GAL4elav.PLu
locomotor rhythm defective | heat sensitive, with Scer\GAL4repo.PU, Scer\GAL80ts.αTub84B
neurophysiology defective | heat sensitive
neurophysiology defective | heat sensitive, with Scer\GAL4Mef2.PR
neurophysiology defective | larval stage
paralytic | adult stage | dominant | heat sensitive
paralytic | adult stage | heat sensitive, with Scer\GAL4Mef2.PR
paralytic | dominant
paralytic | dominant | larval stage | heat sensitive
paralytic | heat sensitive
paralytic | larval stage | heat sensitive, with Scer\GAL4how-24B
paralytic | larval stage | heat sensitive, with Scer\GAL4Mef2.PR
paralytic | larval stage | heat sensitive, with Scer\GAL4Mhc.PW
paralytic | larval stage | heat sensitive, with Scer\GAL4αTub84B.PL
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage | recessive
some die during pharate adult stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
uncoordinated | dominant | heat sensitive
uncoordinated | heat sensitive
uncoordinated | heat sensitive, with Scer\GAL4Mef2.PU
Phenotype manifest in
Allele
adult fat body, with Scer\GAL4ppl.PP
adult fat body | somatic clone
adult heart
adult heart, with Scer\GAL4tin.CΔ4
dorsal medial indirect flight muscle | heat sensitive
dorsal medial indirect flight muscle | heat sensitive, with Scer\GAL4Mef2.PR
embryonic/larval heart | P-stage, with Scer\GAL4NP1029
embryonic/larval neuromuscular junction | heat sensitive
eye | somatic clone
leg | somatic clone
lipid droplet, with Scer\GAL4ppl.PP
lipid droplet | somatic clone
neuron | larval stage
ommatidium | somatic clone
photoreceptor | somatic clone
wing, with Scer\GAL4elav.PLu
wing | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATP2A1
14 of 15
Yes
Yes
Hsap\ATP2A2
12 of 15
No
Yes
Hsap\ATP2A3
11 of 15
No
Yes
Hsap\ATP2C1
3 of 15
No
No
Hsap\ATP2C2
3 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atp2a1
14 of 15
Yes
Yes
Mmus\Atp2a2
12 of 15
No
Yes
Mmus\Atp2a3
10 of 15
No
Yes
Mmus\Atp2c1
3 of 15
No
No
Mmus\Atp2c2
2 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Atp2a2
12 of 13
Yes
Yes
Rnor\Atp2a1
7 of 13
No
Yes
Rnor\Atp2a3
6 of 13
No
Yes
Rnor\Atp2c1
1 of 13
No
No
Rnor\Atp2c2
1 of 13
No
No
Rnor\LOC102549389
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\atp2a1
10 of 12
Yes
Yes
Xtro\atp2a2
6 of 12
No
Yes
Xtro\atp2a3
1 of 12
No
Yes
Xtro\atp2c1
1 of 12
No
No
Xtro\atp2c2
1 of 12
No
No
Danio rerio (Zebrafish) (7)
Drer\atp2a1
14 of 15
Yes
Yes
Drer\atp2a1l
14 of 15
Yes
Yes
Drer\atp2a2a
11 of 15
No
Yes
Drer\atp2a2b
11 of 15
No
Yes
Drer\si:dkey-28b4.8
8 of 15
No
Yes
Drer\atp2a3
7 of 15
No
Yes
Drer\atp2c1
3 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\sca-1
15 of 15
Yes
Yes
Cele\pmr-1
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\ECA3
9 of 9
Yes
Yes
Atha\ECA1
3 of 9
No
Yes
Atha\ECA2
3 of 9
No
Yes
Atha\ECA4
3 of 9
No
Yes
Atha\AT5G53010
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\PMR1
4 of 15
Yes
No
Scer\ENA1
3 of 15
No
No
Scer\ENA2
3 of 15
No
Yes
Scer\ENA5
3 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cta3
2 of 12
Yes
Yes
Spom\pmr1
2 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901LU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\SERCA
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005486
Drosophila simulans
Dsim\GD24994
Drosophila sechellia
Dsec\GM15491
Drosophila erecta
Dere\GG19978
Drosophila yakuba
Dyak\GE11511
Drosophila ananassae
Dana\GF12053
Drosophila pseudoobscura pseudoobscura
Dpse\GA17643
Drosophila persimilis
Dper\GL10916
Drosophila willistoni
Dwil\GK15853
Drosophila virilis
Dvir\GJ21881
Drosophila mojavensis
Dmoj\GI20714
Drosophila grimshawi
Dgri\GH20185
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500X3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020576
Glossina morsitans
Tsetse fly
Gmor\GMOY009244
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10054
Mayetiola destructor
Hessian fly
Mdes\Mdes004075
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006582
Anopheles darlingi
American malaria mosquito
Adar\ADAC006307
Anopheles gambiae
Malaria mosquito
Agam\Ca-P60A
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018021
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00WR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006603
Danaus plexippus
Monarch butterfly
Dple\DPOGS212152-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012531
Apis florea
Little honeybee
Aflo\2160511572
Apis mellifera
Western honey bee
Amel\GB49320
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17386
Bombus terrestris
Buff-tailed bumblebee
Bter\15213238
Linepithema humile
Argentine ant
Lhum\LH11170
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002615
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002486
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02891
Tribolium castaneum
Red flour beetle
Tcas\TC012671
Pediculus humanus
Human body louse
Phum\PHUM554600
Rhodnius prolixus
Kissing bug
Rpro\RPRC014771
Cimex lectularius
Bed bug
Clec\CLEC001645
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008535
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09266
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00V6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001172
Ixodes scapularis
Black-legged tick
Isca\ISCW009225
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80445.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58607.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g02100
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_65262
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01LE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Serca_1
Ciona intestinalis
Vase tunicate
Cint\LOC100180619
Ciona intestinalis
Vase tunicate
Cint\LOC100182988
Ciona intestinalis
Vase tunicate
Cint\LOC100180638
Ciona intestinalis
Vase tunicate
Cint\LOC100175957
Gallus gallus
Domestic chicken
Ggal\ATP2A2
Gallus gallus
Domestic chicken
Ggal\ATP2A3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
SPoCk
5 of 10
CG45062
2 of 10
Atpα
1 of 10
CG45063
1 of 10
JYalpha
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
SERCAJF01948
model of  heart disease
CEA
(Kuo et al., 2014)
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
SERCAUAS.Tag:MYC
ameliorates  neurodegenerative disease
modeled by trpP365
(Huang et al., 2016)
SERCAwt.tinC
ameliorates  dilated cardiomyopathy
modeled by wupAhdp-2
(Abraham and Wolf, 2013)
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
14 of 15
108730
ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
12 of 15
108740
ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
11 of 15
601929
      ATP2C1; ATPase secretory pathway Ca2+ transporting 1
      3 of 15
      604384
      ATP2C2; ATPase secretory pathway Ca2+ transporting 2
      3 of 15
      613082
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          SERCA - ATPsynβ
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - ATPsynγ
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Agpat3
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Akt1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          SERCA - Arf79F
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Arl8
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Atpα
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CCT3
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CCT6
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CDC50
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG10425
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG11857
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG13220
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG1416
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG15098
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG2064
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG2065
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG2070
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG30344
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG3164
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG31729
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG33303
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG5854
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - CG6550
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Chc
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Cnx99A
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Cp1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Cyp12d1-p
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Desat1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Dredd
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Fukuyama et al., 2012)
          SERCA - Droj2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Dsor1
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          SERCA - FASN1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Fatp1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - GCS2β
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Gfat2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Gp210
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Gp93
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Hel25E
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Hsp83
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Idh3a
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Karyβ3
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - KdelR
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Kr-h2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Ldh
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - MRP
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Mcad
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Mec2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Mhc
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Mpcp2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Nfs1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Ost48
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - OstΔ
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - PCB
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Pdk1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          SERCA - Pi3K68D
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Pp2A-29B
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Prm
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Rab1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Rab2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Rab5
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Rab6
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Raf
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          SERCA - Ranbp9
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Rap1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - RpS10b
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Rpt1
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Sc2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - SclA
          anti tag coimmunoprecipitation, western blot
          (Magny et al., 2013)
          SERCA - SclB
          anti tag coimmunoprecipitation, western blot
          (Magny et al., 2013)
          SERCA - ScsβA
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - ScsβG
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Sec61α
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Seipin
          anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
          (Bi et al., 2014)
          SERCA - Spindly
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - SsRβ
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Surf4
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - THADA
          anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot
          (Moraru et al., 2017)
          SERCA - Tapδ
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Tm2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Tspo
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - UQCR-C2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - Vha68-2
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - ZnT63C
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - blw
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - cathD
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - ds
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          SERCA - egg
          two hybrid
          (Stabell et al., 2006)
          SERCA - fax
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - fj
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          SERCA - hpo
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          SERCA - jagn
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - ksr
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          SERCA - mats
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          SERCA - mt:CoII
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - ox
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - porin
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - sima
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          SERCA - spidey
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - sstn
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Liu et al., 2015)
          SERCA - wal
          experimental knowledge based
          (Guruharsha et al., 2011)
          SERCA - wts
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          SERCA|comt
          suppressible
          CrebB
          (Freeman et al., 2010)
          SERCA|comt
          suppressible
          kay
          (Freeman et al., 2010)
          SERCA|comt
          suppressible
          NFAT
          (Freeman et al., 2011)
          SERCA|comt
          suppressible
          Raf
          (Freeman et al., 2010)
          SERCA|comt
          suppressible
          Ras85D
          (Freeman et al., 2010)
          SERCA
          suppressible
          RyR
          (Abraham and Wolf, 2013)
          SERCA
          enhanceable
          Seipin
          (Bi et al., 2014)
          SERCA|comt
          suppressible
          Sh
          (Freeman et al., 2010)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Bx
          enhanceable
          SERCA
          (Bronstein et al., 2010)
          Gαq|Itpr
          suppressible
          SERCA
          (Banerjee et al., 2006)
          Gαq|Itpr|Plc21C
          suppressible
          SERCA
          (Banerjee et al., 2006)
          Itpr
          suppressible
          SERCA
          (Banerjee et al., 2006)
          mbl
          suppressible
          SERCA
          (Picchio et al., 2013)
          N
          enhanceable
          SERCA
          (Periz and Fortini, 1999)
          Seipin
          enhanceable
          SERCA
          (Bi et al., 2014)
          Seipin
          suppressible
          SERCA
          (Bi et al., 2014)
          trp
          suppressible
          SERCA
          (Huang et al., 2016)
          wupA
          suppressible
          SERCA
          (Abraham and Wolf, 2013)
          External Data
          Subunit Structure (UniProtKB)
          Interacts with SclA and SclB.
          (UniProt, P22700 )
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Gene Group - Pathway Membership (FlyBase)
          External Data
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-105
          Cytogenetic map
          60A11-60A12
          Sequence location
          2R:23,925,077..23,935,884 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          60A11-60A12
          Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          60A11-60A12
          (Oh et al., 2003)
          60A8-60A11
          (determined by in situ hybridisation)
          (Spradling et al., 1999)
          60A8-60A11
          (Beaton, 1997.12.27, BDGP Project Members, 1994-1999)
          60A-60A
          (determined by in situ hybridisation)
          (Magyar and Varadi, 1990)
          Experimentally Determined Recombination Data
          Location
          2-105
          (FlyBase, 2016)
          2-109.8
          (Comeron et al., 2012)
          2-106
          (Krishnan and Basole, 1999.4.2)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (27)
          Genomic Clones (20)
          cDNA Clones (521)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for identity of: SERCA Ca-P60A
            (FlyBase, 2009-)
            Source for database merge of
            Source for merge of: Ca-P60A CG3725
            (Bayraktaroglu, 2000.4.13)
            Source for merge of: Ca-P60A Kum
            (Sanyal et al., 2005)
            Source for merge of: Ca-P60A l(2)SH0211
            (Bronstein et al., 2010)
            Additional comments
            Changed symbol from 'Ca-P60A' to 'SERCA' to reflect preferred usage in the literature.
            (FlyBase, 2009-)
            Other Comments
            Treatment of S2 cells with dsRNA made from templates generated with primers directed against this gene significantly increases the resting Ca2+ concentration, reduces the store release transient upon addition of thapsigargin, and strongly suppresses Ca2+ influx upon readdition of external Ca2+.
            (Zhang et al., 2006)
            One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
            (Inlow and Restifo, 2004)
            1 allele of l(2)SH0211 recovered in a P-insertion screen.
            (Oh et al., 2003)
            Area matching Drosophila organellar-type Ca-ATPase gene, Acc. No. X84681.
            (Davies, 2001.3.15)
            Flies carrying Ca-P60A mutations paralyse within 3 minutes at 40oC and remain immobile up to two days on shifting back to the permissive temperature.
            (Krishnan and Basole, 1999)
            Ca-P60A is essential for cell viability and tissue morphogenesis during development. Ca-P60A function is required for intracellular trafficking of the N receptor.
            (Periz and Fortini, 1999)
            Ca-P60A show neither a maternal nor a zygotic neurogenic phenotype.
            (Periz and Fortini, 1999)
            Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.
            (Axelsen and Palmgren, 1998)
            There is a single Ca-P60A gene in the Drosophila genome.
            (Varadi et al., 1989)
            Origin and Etymology
            Discoverer
            Etymology
            The gene is named "Kumbhakarna" based on the mutant phenotype; when restored to the permissive temperature, "Kumbhakarna" mutants show prolonged paralysis of 6-48 hours, the duration of paralysis depending on the duration of prior exposure to the restrictive temperature. "Kumbhakarna" is a mythological hero who slept for 6 months of the year.
            (Sanyal et al., 2005)
            Identification
            External Crossreferences and Linkouts ( 83 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Linkouts
            ApoDroso - Functional genomic database for photoreceptor development, survival and function
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (35)
            Reported As
            Symbol Synonym
            17136664
            (Burroughs et al., 2006)
            A4UZU0_DROME
            (Fukuyama et al., 2012)
            ATC1_DROME
            (Fukuyama et al., 2012)
            CA-P60A
            (Bassett et al., 1997)
            CG3725
            (Kolkhof et al., 2017, Çiçek et al., 2016, Aradska et al., 2015, Hosono et al., 2015, Hoffmann et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Bronstein et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Venkiteswaran and Hasan, 2009, Cermelli et al., 2006, Fry et al., 2004)
            Ca-ATPase
            (Varadi, 1995.2.27)
            Ca-P60
            (Kaushik et al., 2012, Farkas et al., 2008, Farkas et al., 2007)
            Ca-P60A
            (Al-Ramahi et al., 2018, Zanet et al., 2016, Aradska et al., 2015, Chen et al., 2015, Dent et al., 2015, Jia et al., 2015, Kaneko and Cook, 2015.1.21, Liu et al., 2015, Ugrankar et al., 2015, Wójtowicz et al., 2015, Bi et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Magny et al., 2013, Magny et al., 2013, Roti et al., 2013, Short and Lazzaro, 2013, Yin et al., 2013, Zhang et al., 2013, Zhu et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Li et al., 2011, Bronstein et al., 2010, Buffin and Gho, 2010, Freeman et al., 2010, Chorna et al., 2009, Qian and Bodmer, 2009, Tan et al., 2009, Venkiteswaran and Hasan, 2009, Qian et al., 2008, Dietzl et al., 2007, Shakiryanova et al., 2007, Banerjee et al., 2006, Cermelli et al., 2006, Dorus et al., 2006, Montana and Littleton, 2006, Stabell et al., 2006)
            Ca-p
            Ca2+ATPase
            (Magyar et al., 1995)
            CaP60A
            (Abraham and Wolf, 2013, Ng et al., 2011, Shakiryanova et al., 2011, Klose et al., 2010, Monier et al., 2007, Sanyal et al., 2005)
            Kum
            (Chakraborty and Hasan, 2012, Desai-Shah and Cooper, 2009, Venkiteswaran and Hasan, 2009, Nair et al., 2007, Banerjee et al., 2006, Sanyal et al., 2005, Krishnan and Basole, 1999, Krishnan and Basole, 1999.4.2)
            SERCA
            (Brodskiy et al., 2019, Bruels et al., 2019, Gokhale et al., 2019, Sunderhaus et al., 2019, He et al., 2018, Musselman and Kühnlein, 2018, Reuveny et al., 2018, Bower et al., 2017, Couso and Patraquim, 2017, Moraru et al., 2017, Rogoyski et al., 2017, Transgenic RNAi Project members, 2017-, Lin et al., 2016, Li and Dijkers, 2015, Bi et al., 2014, Bischof and FlyORF project members, 2014.6.20, Kuo et al., 2014, Abraham and Wolf, 2013, Neckameyer and Argue, 2013, Roti et al., 2013, Chakraborty and Hasan, 2012, Panz et al., 2012, Cammarato et al., 2011, Ng et al., 2011, Chen et al., 2010, Dijkers and O'Farrell, 2007, Farkas et al., 2007, Rosenbaum et al., 2006, Southall et al., 2006, Zhang et al., 2006, Joshi et al., 2005, Joshi et al., 2004, Harteneck, 2003, Vazquez-Martinez et al., 2003, Towers and Sattelle, 2002, Mushegian et al., 1998)
            SERCA2
            (Nelson et al., 2005)
            Serca
            (Sellier et al., 2018, Picchio et al., 2013)
            Serca2a
            (Neely et al., 2010)
            dSERCA
            (Zhu et al., 2017, Cannon and Bodmer, 2016, Bi et al., 2014, Kaneko et al., 2014, Kaneko et al., 2014, Picchio et al., 2013, Chorna and Hasan, 2012, Li et al., 2011, Klose et al., 2010, Venkiteswaran and Hasan, 2009, Shakiryanova et al., 2007, Sanyal et al., 2006, Sanyal et al., 2005)
            dserca
            (Nair et al., 2007)
            kum
            (Freeman et al., 2011)
            l(2)SH0211
            l(2)k08308ab
            (BDGP Project Members, 1994-1999)
            l(2)k09025
            (Spradling et al., 1999, Beaton, 1997.12.27, BDGP Project Members, 1994-1999)
            serca
            (Huang et al., 2016)
            Name Synonyms
            Ca2+ ATPase
            (Vazquez-Martinez et al., 2003)
            Calcium ATPase at 60A
            (Hoffmann et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Buffin and Gho, 2010, Qian and Bodmer, 2009, Qian et al., 2008, Cermelli et al., 2006)
            Kumbhakarna
            (Krishnan and Basole, 1999)
            Sarco/endoplasmic reticulum Ca(2+)-ATPase
            Serca
            (Chakraborty et al., 2018)
            calcium ATPase
            (Zhou et al., 2003)
            calcium ATPase at 60A
            (Hosamani et al., 2016)
            endoplasmic reticulum-specific calcium-transporting ATPase
            (Hosamani et al., 2016)
            lethal (2) SH0211
            organellar-type Ca-ATPase
            (Varadi, 1995.2.9)
            sarco endoplasmic reticulum calcium-ATPase
            (Picchio et al., 2013)
            sarco/endoplasmic reticulum-type Ca-2+-ATPase
            (Magyar, 1991.3.12)
            sarcoplasmic endoplasmic reticulum calcium ATPase type 2
            (Nelson et al., 2005)
            Secondary FlyBase IDs
            • FBgn0004551
            • FBgn0004119
            • FBgn0004241
            • FBgn0022016
            • FBgn0022044
            • FBgn0026413
            • FBgn0034932
            • FBgn0065896
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (189)