FB2021_01, released Feb 18, 2021

Gene: Dmel\HSPBAP1

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General Information
Symbol
Dmel\HSPBAP1
Species
D. melanogaster
Name
HSPB1 associated protein 1
Annotation Symbol
CG43320
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263025
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:27,695,235..27,696,531 [+]
Recombination map

3-94

RefSeq locus
NT_033777 REGION:27695235..27696531
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables 2-oxoglutarate-dependent dioxygenase activity
inferred from biological aspect of ancestor with PANTHER:PTN004362614
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (0 terms)
There is no information supporting a Biological Process term for this gene. (Based on a review of available data on: 2011-03-10 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Shalaby et al., 2017)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\HSPBAP1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
nuclear_gene
(FlyBase Genome Annotators, 2011)
protein_coding_gene
(FlyBase Genome Annotators, 2011)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
HSPBAP1-RA
FBtr0306924
NM_143324
1297
398
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
HSPBAP1-PA
FBpp0297777
45.8
398
6.43
NP_651581
AAF56739
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HSPBAP1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Shalaby et al., 2017)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\HSPBAP1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of HSPBAP1
Transgenic constructs containing regulatory region of HSPBAP1
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation
Gene disrupted in
Df(3R)HSPBAP1-KO
(Shalaby et al., 2017)
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HSPBAP1
11 of 15
Yes
Yes
Hsap\HIF1AN
2 of 15
No
Yes
Hsap\KDM8
2 of 15
No
No
Hsap\TYW5
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hspbap1
11 of 15
Yes
Yes
Mmus\Hif1an
2 of 15
No
Yes
Mmus\Kdm8
2 of 15
No
No
Mmus\Jmjd7
1 of 15
No
No
Mmus\Tyw5
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Hspbap1
7 of 13
Yes
Yes
Rnor\Hif1an
2 of 13
No
Yes
Rnor\Kdm8
2 of 13
No
No
Rnor\Tyw5
2 of 13
No
Yes
Rnor\Jmjd7
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\hspbap1
6 of 12
Yes
Yes
Xtro\hif1an
2 of 12
No
Yes
Xtro\kdm8
2 of 12
No
No
Xtro\jmjd7
1 of 12
No
No
Xtro\tyw5
1 of 12
No
Yes
Danio rerio (Zebrafish) (5)
Drer\hspbap1
11 of 15
Yes
Yes
Drer\hif1an
2 of 15
No
Yes
Drer\kdm8
2 of 15
No
No
Drer\tyw5
2 of 15
No
Yes
Drer\jmjd7
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\jmjd-5
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT5G19840
2 of 9
Yes
Yes
Atha\JMJD5
2 of 9
Yes
No
Atha\AT3G26135
1 of 9
No
Yes
Atha\AT3G45880
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BWB )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011582
Drosophila simulans
Dsim\GD21348
Drosophila sechellia
Dsec\GM16352
Drosophila erecta
Dere\GG11570
Drosophila yakuba
Dyak\GE23755
Drosophila ananassae
Dana\GF16299
Drosophila pseudoobscura pseudoobscura
Dpse\GA11879
Drosophila persimilis
Dper\GL13765
Drosophila willistoni
Dwil\GK11766
Drosophila virilis
Dvir\GJ10471
Drosophila mojavensis
Dmoj\GI22022
Drosophila grimshawi
Dgri\GH16531
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150855 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019678
Glossina morsitans
Tsetse fly
Gmor\GMOY005677
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12570
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014267
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011976
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011977
Anopheles gambiae
Malaria mosquito
Agam\AGAP004022
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009723
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08P6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005044
Danaus plexippus
Monarch butterfly
Dple\DPOGS204161-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009907
Apis florea
Little honeybee
Aflo\3824172500
Apis mellifera
Western honey bee
Amel\GB48645
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25212
Bombus terrestris
Buff-tailed bumblebee
Bter\15216274
Linepithema humile
Argentine ant
Lhum\LH11922
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001c85
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011684
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12489
Tribolium castaneum
Red flour beetle
Tcas\TC009187
Pediculus humanus
Human body louse
Phum\PHUM459500
Rhodnius prolixus
Kissing bug
Rpro\RPRC005244
Cimex lectularius
Bed bug
Clec\CLEC011838
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009091
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11375
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08KS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012789
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63951.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g06220
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303695
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DDY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_019490gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hspbap1
Gallus gallus
Domestic chicken
Ggal\HSPBAP1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
JMJD5
4 of 10
JMJD7
3 of 10
CG43319
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HSPBAP1; HSPB1 associated protein 1
11 of 15
608263
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-94

      Cytogenetic map
      98B1-98B1
      Sequence location
      3R:27,695,235..27,696,531 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      98B1-98B1
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-94

      (FlyBase, 2016)

      3-91.5

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (4)
      Genomic Clones (17)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: HSPBAP1 CG43320

                (Shalaby et al., 2017)
                Source for database merge of
                Additional comments

                Annotation CG12879 split into CG43319 and CG43320 in release 5.36 of the genome annotation.

                (FlyBase Genome Annotators, 2011)

                Gene order: In direction of increasing cytology: CG12879+ CG12876- CG12879+ CG12876- btz+ CG12428- CG12877+

                (van Eeden et al., 2001)
                Other Comments
                Origin and Etymology
                Discoverer
                Etymology

                The gene is named 'HSPBAP1' based on the closest human ortholog.

                (Shalaby et al., 2017)
                Identification
                External Crossreferences and Linkouts ( 10 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                Synonyms and Secondary IDs (4)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (29)